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WAAVHVDWLTSFVAVAERGAFLAAAQDLGRVQSRVSEHVAKLERELGVVLVDRTVRPVRLTVAGEIFLGR AKDVLATLDSARAEMAALRGTTYGTVRLACMASAAAAFVSRLIDRFGKVEHNIEVQVLEGPTATLPEMLH RHEADLAIVPHAYVANVPELQWVPLWDEPLRVLVPPTHRLAAMSSVPLAELAGEDVVTPGSGAGARGVSP EIAALFVAAGVQVGAGRRVASPHTLVSMVRSGLGVGVLSELAVRLTGADGIVVLPFEEPSAVRHAVLAWL RERRNTDAVQRLFDFVVAARVPDGAVRVSAGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4609 | - | - | 100% (313) | transcriptional regulator LysR family protein |
| M. smegmatis MC2 155 | MSMEG_0104 | - | 6e-29 | 32.88% (295) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_6677 | - | 4e-26 | 32.22% (270) | transcriptional regulator, LysR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 3e-13 | 30.80% (250) | oxidative stress response regulatory protein OXYS |
| M. gilvum PYR-GCK | Mflv_3565 | - | 3e-22 | 30.36% (280) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 3e-13 | 30.80% (250) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02041 | oxyR | 2e-20 | 31.02% (245) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2707 | - | 1e-20 | 31.51% (238) | putative transcriptional regulator |
| M. marinum M | MMAR_2756 | oxyR | 6e-19 | 28.32% (286) | hydrogen peroxide-inducible genes activator, OxyR |
| M. avium 104 | MAV_1538 | - | 9e-25 | 30.63% (271) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_0172 | - | 6e-11 | 23.78% (307) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 2e-18 | 27.97% (286) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_1027 | - | 8e-23 | 33.87% (248) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2707|M.abscessus_ATCC_1997 ---------------MAEGDYEWYITLAELQNVTAAADQLRLAQPTLTRM
MAV_1538|M.avium_104 ---------------MAVGDYEWFITLAELQHVTAAAEQLHVAQPTLTRM
MMAR_2756|M.marinum_M MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MUL_2998|M.ulcerans_Agy99 -----MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MLBr_02041|M.leprae_Br4923 --------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQA
Mb0121|M.bovis_AF2122/97 ---------------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSA
Rv0117|M.tuberculosis_H37Rv ---------------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSA
Mflv_3565|M.gilvum_PYR-GCK ---------------MELRQLEYFVAIVEEGGFTRAASRERVAQPAVSAQ
Mvan_1027|M.vanbaalenii_PYR-1 --------------MFSLARLSCFVAVAEELHFGRAAERLHMTQPPLSRQ
MSMEG_4609|M.smegmatis_MC2_155 -----------MWAAVHVDWLTSFVAVAERGAFLAAAQDLGRVQSRVSEH
TH_0172|M.thermoresistible__bu ---------------MTPAQLRAFSAVVRLGSVRAAAQELGMSDAGISMH
: ::.. . **. :. ::
MAB_2707|M.abscessus_ATCC_1997 LARLERRLGVQLFDRHGKRLALNPFGRIFYQHARRAQLELDSARRAIDDL
MAV_1538|M.avium_104 LARLEQRLGVALFDRHGRRLSLNTYGRIFYEHARRAQLELDSARRAIADL
MMAR_2756|M.marinum_M LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MUL_2998|M.ulcerans_Agy99 LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MLBr_02041|M.leprae_Br4923 LAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGE
Mb0121|M.bovis_AF2122/97 IAKLERELNVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAV
Rv0117|M.tuberculosis_H37Rv IAKLERELNVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAV
Mflv_3565|M.gilvum_PYR-GCK IRRLERSVGQPLLTRTSREVRLTRAGEALLPHARAALAAVRDGRAAVDDV
Mvan_1027|M.vanbaalenii_PYR-1 VQQLENELGVQLIDRTTRNVTLTPAGAAFLPDARRILQLAEGAAQTVKRI
MSMEG_4609|M.smegmatis_MC2_155 VAKLERELGVVLVDRTVRPVRLTVAGEIFLGRAKDVLATLDSARAEMAAL
TH_0172|M.thermoresistible__bu IAQLRKELDDPLFHRTKNGLSFTPGGLRLASRAVDILGLQRQTAIEVTEA
: *. :. *. * .. * : *
MAB_2707|M.abscessus_ATCC_1997 ANPAEGEIRLGFLHTFGPTLIAGLIAGFATTSPHVRFVLEQGAAGSLDDL
MAV_1538|M.avium_104 ADPAVGEIRLAYLSSFGSTVVPRLIARFKESSPRVTFTLEEGAAESIADR
MMAR_2756|M.marinum_M ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVRVIEDQTERLLTA
MUL_2998|M.ulcerans_Agy99 ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVRVIEDQTERLLTA
MLBr_02041|M.leprae_Br4923 SDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLPTLTLRVVEDQTEHLLTA
Mb0121|M.bovis_AF2122/97 RSGITGTLRLGTVPTASTTASLVLSAFCSAHPLAKVQVCSRLAATELYRR
Rv0117|M.tuberculosis_H37Rv RSGITGTLRLGTVPTASTTASLVLSAFCSAHPLAKVQVCSRLAATELYRR
Mflv_3565|M.gilvum_PYR-GCK AGLLRGSVAIGTV-TLHPMNVAHLIAEFHADHPDVEITLGTATSDVLIAE
Mvan_1027|M.vanbaalenii_PYR-1 PAGDLGTVVVGFTAASAHAVLPRLLERARERLPDVKLDLREMVTAAQIEG
MSMEG_4609|M.smegmatis_MC2_155 RGTTYGTVRLACMASAAAAFVSRLIDRFGKVEHNIEVQVLEGPTATLPEM
TH_0172|M.thermoresistible__bu AHGRR-LLRIAASHAFAEHAAPGLIDLFSSRADDLSVELTVEPVSRFRDL
: .. : :
MAB_2707|M.abscessus_ATCC_1997 VATGDLDVAIVSPRPRRAN--LGWRNLFRQRLGVAVPTDHRLAQAQ-DVS
MAV_1538|M.avium_104 VRSGGVDIGVVSPRPVERT--LAWRSLFRQRLGVAVPDGHRFARGA-AVS
MMAR_2756|M.marinum_M LREGSLDTALIALPADYGG--LTEIPIYEEDFVLALPPGHPMADRH-GVP
MUL_2998|M.ulcerans_Agy99 LREGSLDTALIALPADYGG--LTEIPIYEEDFVLALPPGHPMADRH-GVP
MLBr_02041|M.leprae_Br4923 LREGALDAAMIALPVETAG--IAEIPIYDEDFVLALPPGHPLSGKR-RVP
Mb0121|M.bovis_AF2122/97 LREFELDAVIVHPETQDSDD-VDLVPLYEEQYVLLSPADMLPPGTS-TLV
Rv0117|M.tuberculosis_H37Rv LREFELDAVIVHPETQDSDD-VDLVPLYEEQYVLLSPADMLPPGTS-TLV
Mflv_3565|M.gilvum_PYR-GCK LGDGRLDLAIVSIAVDEDLPGLEVAVITDEAVEAAVADGHPLAHRR-SLS
Mvan_1027|M.vanbaalenii_PYR-1 LMTGELDLGMARPPLKRPG--LVSRPLLHEQLLAALPEGHPLADMTRELT
MSMEG_4609|M.smegmatis_MC2_155 LHRHEADLAIVPHAYVANVPELQWVPLWDEPLRVLVPPTHRLAAMS-SVP
TH_0172|M.thermoresistible__bu LESRAVDVTLG-PAVREPGPAIVVRPFLNYQIIAVTSPSNPLAAAT--PT
: * : : : . .
MAB_2707|M.abscessus_ATCC_1997 MVDLADEPFVAMH--PGFGMRRLLEELCAAAQFQPRIVLE-SSNLMTVAG
MAV_1538|M.avium_104 MVDLADEPFVTMH--PGFGMRRLLDELCAAAQFRPRVALQ-APNLTTAAS
MMAR_2756|M.marinum_M VAALSELPLLLLD--EGHCLRDQALDVCQNAGVRAELADTRAASLATAVQ
MUL_2998|M.ulcerans_Agy99 VAALSELPLLLLD--EGHCLRDQALDVCQNAGVRAEHADTRADSLATAVQ
MLBr_02041|M.leprae_Br4923 TTALAQLPLLLLD--EGHCLRDQTLDICRKSGVQAELANTRAASLATAVQ
Mb0121|M.bovis_AF2122/97 WRDAAQLPLALLT--ADMRDR-QVIDAAFADHAVSAIPQVETDSVASLFA
Rv0117|M.tuberculosis_H37Rv WRDAAQLPLALLT--ADMRDR-QVIDAAFADHAVSAIPQVETDSVASLFA
Mflv_3565|M.gilvum_PYR-GCK LEQLSRHPLISLP--AGTGLRTRLDTACAAAGLRPRIAFE-ATSPAELAE
Mvan_1027|M.vanbaalenii_PYR-1 LIDLDGQDFVMYSPVQARYFNELLISTFTIAGTTPRYVQY-VTQVHTMLV
MSMEG_4609|M.smegmatis_MC2_155 LAELAGEDVVTPGSGAGARGVSPEIAALFVAAGVQVGAGRRVASPHTLVS
TH_0172|M.thermoresistible__bu IAQLRAQSWMLGP---SAGGIDGDVAAMLRRLEIPEAAQRIFQSDSAAQE
.
MAB_2707|M.abscessus_ATCC_1997 LVAAGLGVTVLPVDAT---TYPPDLR----MLRLIDADAHRDVGIVWSSG
MAV_1538|M.avium_104 LVAAGLGISLVPIDGS---SYPSGVS----VKPLADADAYRDVGMIWDSG
MMAR_2756|M.marinum_M CVNGGLGVTLIPQSAVSVEAARSRVG----LAHFAAPTPGRRIGLVYRAS
MUL_2998|M.ulcerans_Agy99 CVNGGLGVTLIPQSAVSVEAARSRVG----LTHFAAPTPGRRIGLVYRAS
MLBr_02041|M.leprae_Br4923 CVTGGLGVTLLPQSAAPVESVRSKLG----LAQFAAPCPGRRIGLAFRSA
Mb0121|M.bovis_AF2122/97 QVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNAL
Rv0117|M.tuberculosis_H37Rv QVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNAL
Mflv_3565|M.gilvum_PYR-GCK LARHGLGVAILPQSMARGGSGLHALR--------LAPELRGRLVWAWRAD
Mvan_1027|M.vanbaalenii_PYR-1 LVRSGIGIALVPASAATLHPEGVVFR---------TIGAFRERPVELDAV
MSMEG_4609|M.smegmatis_MC2_155 MVRSGLGVGVLSELAVRLTGADGIVV-----LPFEEPSAVRHAVLAWLRE
TH_0172|M.thermoresistible__bu EVQRIGGVTLSIGFAVAKDLAAGRLAR------IKGVQATAEWCVSTLSS
. :
MAB_2707|M.abscessus_ATCC_1997 -------QPLSRPVRNFISHAVAST-------------------
MAV_1538|M.avium_104 -------RPLPRSARDFIAGAAAVGHGGW---------------
MMAR_2756|M.marinum_M SGRDEAYRQLAAIMGESISNEQQVRLVN----------------
MUL_2998|M.ulcerans_Agy99 SGRDEAYRQLAAIMGESISNEQQVRLVN----------------
MLBr_02041|M.leprae_Br4923 SGRSASYRQIAKIIGELISTEHHVRLVA----------------
Mb0121|M.bovis_AF2122/97 GPGSPVARALITCAQALALNEFFDTQLRGITRRR----------
Rv0117|M.tuberculosis_H37Rv GPGSPVARALITCAQALALNEFFDTQLRGITRRR----------
Mflv_3565|M.gilvum_PYR-GCK G-ANPAARVLGERARAMAVSPGSGAPAVVPGA------------
Mvan_1027|M.vanbaalenii_PYR-1 WRGDSTNPALLRVLKDVLPQQEWTT-------------------
MSMEG_4609|M.smegmatis_MC2_155 RRNTDAVQRLFDFVVAARVPDGAVRVSAGS--------------
TH_0172|M.thermoresistible__bu AARQPAASELVRFITTPRCTQAMIRGTSEGVTRFRPKVHVTLWS
: