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MTTGNSVPTTTLGDDLSVSAIGFGAMALTPVYGEVDDDESLATLHRCLDLGVTFIDTANVYGSGNNERLI AKLLADRRDEVTLATKFGIEGNPAERASGSPKVRGDAEYVRTCIDASLQRLQTDVVDLYYMHRRDMSVPI QETVGAMAELVAAGKVRHLGLSEVTAQELRAAVRIHPIAAVQSEWSIWSRDVERNVVPAAAELGVGFVPY SPLGRGFLTGTVRSAADLESPNDFRKTMPRFGADSLEANLAVVETIRSIAEAVEATPAQVALAWLRYRAD AFGVASVPIPGTRRASRVQENVESLDVTLTPEQLESLDAAGATVSGDRYSDTSWLSVGRE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4565 | - | - | 100% (340) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_2920 | - | 4e-69 | 44.41% (313) | aldo/keto reductase |
| M. smegmatis MC2 155 | MSMEG_2429 | - | 5e-61 | 41.85% (325) | aldo/keto reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 3e-26 | 32.62% (282) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_0942 | - | 7e-29 | 30.98% (326) | aldo/keto reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 3e-26 | 32.62% (282) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 9e-43 | 35.96% (317) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 3e-80 | 49.24% (329) | aldo/keto reductase |
| M. marinum M | MMAR_2086 | - | 7e-42 | 35.20% (321) | oxidoreductase |
| M. avium 104 | MAV_2496 | - | 4e-80 | 50.80% (313) | aldo/keto reductase |
| M. thermoresistible (build 8) | TH_1364 | - | 2e-13 | 24.70% (328) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_2745 | - | 5e-25 | 31.00% (300) | hypothetical protein MUL_2745 |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 2e-42 | 36.97% (330) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4120c|M.abscessus_ATCC_199 ----------------------MKHTWLG-ELSVSRIGLGAMSMSAYYRA
MAV_2496|M.avium_104 ----------------------MKQAQLG-GLQVGRLGLGAMGMSVAY--
MSMEG_4565|M.smegmatis_MC2_155 ----------------MTTGNSVPTTTLGDDLSVSAIGFGAMALTPVY--
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGKG--
MMAR_2086|M.marinum_M ------------------MAAASATLTLGGDLTVNRLGFGAMRLTGDG--
Mvan_2555|M.vanbaalenii_PYR-1 --------------MTSGSSRTAPTFLLGGELPVNRLGFGAMRLTGPG--
Mflv_0942|M.gilvum_PYR-GCK -----------------MTTAIQTTLTLGGELPVPRMGYGAMQLAGPG--
Mb2320|M.bovis_AF2122/97 ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
Rv2298|M.tuberculosis_H37Rv ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
MUL_2745|M.ulcerans_Agy99 ----------------------MKHLEVDGIGNVSRIGLGTWQFGSRE--
TH_1364|M.thermoresistible__bu ------------MTSSPGEAAATPTVTLNDDRSMPVLGLGVGELSDDE--
:. : :* *. :
MAB_4120c|M.abscessus_ATCC_199 IGSESGPDEATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGRAIAGRR
MAV_2496|M.avium_104 --AGAGTDDAESIRTVHRAIELGVTLIDTAEVYGPYINEELLARALRGRR
MSMEG_4565|M.smegmatis_MC2_155 ----GEVDDDESLATLHRCLDLGVTFIDTANVYGSGNNERLIAKLLADRR
MLBr_00458|M.leprae_Br4923 -VWGPPVDRYEAVRVLRRAVELGVNFIDTADSYGPYVSEEIIAEAL-HPY
MMAR_2086|M.marinum_M -VWGPPADRAEAVRVLRRAAELGVNFIDTADSYGPYVSEEIIHEAL-HPY
Mvan_2555|M.vanbaalenii_PYR-1 -VWGPPADRDECLRVLRRAVDLGVDFIDTADSYGPYISEDLIREAL-HPY
Mflv_0942|M.gilvum_PYR-GCK -VLGLPDDVDNAVDVLRRAVDHGVRFFDTANAYGPRTVNQIIGRALGTPA
Mb2320|M.bovis_AF2122/97 WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDR
Rv2298|M.tuberculosis_H37Rv WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDR
MUL_2745|M.ulcerans_Agy99 WGYGDRYASGAARDIVARACALGVTLFDTAEVYGLGKSERILGEALGDER
TH_1364|M.thermoresistible__bu -----------AERAVAAALEAGYRLIDTAASYGNEAGVGRAIAASGLPR
. : . * ::*** **
MAB_4120c|M.abscessus_ATCC_199 DEVVLATKFGLVSHGNGASQVLDSTPGN---ISTAVEGSLRRLGVDHIDL
MAV_2496|M.avium_104 DRVVLATKFGLISHTG--RDGLDSSPAN---IRVAVDGSLRRLATDHIDL
MSMEG_4565|M.smegmatis_MC2_155 DEVTLATKFGIEGNPAERASGSPKVRGDAEYVRTCIDASLQRLQTDVVDL
MLBr_00458|M.leprae_Br4923 KGLVIATKAGLLRTGRDVWIPL----GNPSYLRQELEMSLRRLNVDTIDL
MMAR_2086|M.marinum_M TGLVIATKAGLLRTGPGVWVPL----GNPSYLRQECEMSLRRLGVDTIDL
Mvan_2555|M.vanbaalenii_PYR-1 DGVVIATKAGLLRTAPDVWEPL----GFPAYLRQECEMSLRRLGTDTIDL
Mflv_0942|M.gilvum_PYR-GCK DDLVIGNKVGAVRGPAGEWLQD----SRPEILRTQVEEALLDMRADASAL
Mb2320|M.bovis_AF2122/97 TEVVVASKVFPVAPFP-------------AVIKNRERASARRLQLNRIPL
Rv2298|M.tuberculosis_H37Rv TEVVVASKVFPVAPFP-------------AVIKNRERASARRLQLNRIPL
MUL_2745|M.ulcerans_Agy99 AEVVVASKIMPVAPFP-------------AVVKQRERASARRLQLDRIPL
TH_1364|M.thermoresistible__bu EEIFVTTKLATTDQGFQ-------------SSQDAVRASLERLGLEYVDL
: : .* : : : *
MAB_4120c|M.abscessus_ATCC_199 YYQHRVDPN---------VAIEDTIGAVAELVQQGKVRYIGLSEAAAGTI
MAV_2496|M.avium_104 YYQHRLDRQ---------TPIEDTVGALAELVAAGKIRHIGLSEVGVNSI
MSMEG_4565|M.smegmatis_MC2_155 YYMHRRDMS---------VPIQETVGAMAELVAAGKVRHLGLSEVTAQEL
MLBr_00458|M.leprae_Br4923 FQLHRIDPN---------FPLADQVGELFTLKNEGKIRHIGLSEINLDQL
MMAR_2086|M.marinum_M FQLHRIDRN---------YPLADQVGELLALKNEGKIRHIGLSEIDVDQL
Mvan_2555|M.vanbaalenii_PYR-1 FQLHRIAPK---------FPAEDQIGELAKLQQEGKVRHIGLSEVSVDQL
Mflv_0942|M.gilvum_PYR-GCK TYLRLAGDIRGVGEGPGEVPLEESLGALVELRDQGKIRHIGLSGASPAAL
Mb2320|M.bovis_AF2122/97 YQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNYSLARW
Rv2298|M.tuberculosis_H37Rv YQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNYSLARW
MUL_2745|M.ulcerans_Agy99 YQIHQPNPV---------VPDSVIMPGIRELLDIGRIGAAGVSNYSLARW
TH_1364|M.thermoresistible__bu YLIHWPAGE--------QGKYVDSWGGFLKIREDGLTRSIGVSNFDEEYL
: . : * *:*
MAB_4120c|M.abscessus_ATCC_199 RRAHAVH--PITALQNEYSLWTRDIEDEILPTIRELGIGLVAYSPLGRG-
MAV_2496|M.avium_104 RRAHAVH--PITAVQSEYSLWTRDQEDEILPVLRELGIGFVAYSPLGRG-
MSMEG_4565|M.smegmatis_MC2_155 RAAVRIH--PIAAVQSEWSIWSRDVERNVVPAAAELGVGFVPYSPLGRG-
MLBr_00458|M.leprae_Br4923 TAAQQIT--EIVSVQNMYNLSARA-AEPLLDAVTSRGIGFIPWSPLAAG-
MMAR_2086|M.marinum_M EAAQQIT--EIVSVQNMYNLAARG-AEPLLEAATSQGIAFIPWFPLASG-
Mvan_2555|M.vanbaalenii_PYR-1 TAARAVA--PIVSVQNMYNLTMRA-AEPVLDACEADGIAFIPWFPLAAG-
Mflv_0942|M.gilvum_PYR-GCK ERAQQIT--TIAAVQNRFNLIDRS-GVEVLAACERDGIAFVPYFPLATG-
Mb2320|M.bovis_AF2122/97 RKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQG-
Rv2298|M.tuberculosis_H37Rv RKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQG-
MUL_2745|M.ulcerans_Agy99 KKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPLAQG-
TH_1364|M.thermoresistible__bu SDIIDLS--FVTPAVNQIELHPLLNQADLRKVHAERNVLTQAYSPLGVGN
:.. .: : . .: **. *
MAB_4120c|M.abscessus_ATCC_199 FLTGAIGSRDQLAEG-DFRREQPRFSAENFDANLALVEEVRSVASSIGAT
MAV_2496|M.avium_104 FLTGAIRSAHELPDT-DYRRTNPRFAEQNFAHNLRCADELRDIAADVGAT
MSMEG_4565|M.smegmatis_MC2_155 FLTGTVRSAADLESPNDFRKTMPRFGADSLEANLAVVETIRSIAEAVEAT
MLBr_00458|M.leprae_Br4923 PLAAP-------------------------------DGPLQRIAVNHHAT
MMAR_2086|M.marinum_M PLAAP-------------------------------DGPLRKIADDHHAT
Mvan_2555|M.vanbaalenii_PYR-1 PLAAA-------------------------------DGPLHRIAAEHHAT
Mflv_0942|M.gilvum_PYR-GCK GLGD--------------------------------DDELRRPGERLGVP
Mb2320|M.bovis_AF2122/97 LLGGKYG---LENRPGGVRALNPLFGTENLRRIEPLLATLRAIAVDVDAK
Rv2298|M.tuberculosis_H37Rv LLGGKYG---LENRPGGVRALNPLFGTENLRRIEPLLATLRAIAVDVDAK
MUL_2745|M.ulcerans_Agy99 LLGGKYG---VDNRPAGVRAVNPLFGTENLRRIEPLLQTLRAVAIDVDAK
TH_1364|M.thermoresistible__bu LLADPTIGAVAQAHGKSPAQVLLRWNLQLGNAVVVRSSNPDRMRENLAVF
* .
MAB_4120c|M.abscessus_ATCC_199 SAQVALAWLLARGDDI-----VPIPGTTKVSRVNENVGAVDIE--LLPEH
MAV_2496|M.avium_104 PAQVALAWLLAKGPDI-----VPIPGTKRVARLEENVGADALE--LTTEQ
MSMEG_4565|M.smegmatis_MC2_155 PAQVALAWLRYRADAFG-VASVPIPGTRRASRVQENVESLDVT--LTPEQ
MLBr_00458|M.leprae_Br4923 PSQLALAWLLKRSPVM-----LPIPGTSRVAHLEENVAAAEIS--LSDDE
MMAR_2086|M.marinum_M PSQLALAWLLKRSPVM-----LPIPGTSRVAHLQENVAAAEIV--LSDQE
Mvan_2555|M.vanbaalenii_PYR-1 PSQLALAWLLKRSPVM-----LPIPGTSKVAHLEENVAAAQID--LTDAE
Mflv_0942|M.gilvum_PYR-GCK MSTIALAWLLRRSPVI-----VPIPGTKSVAHLRDNLSAAQVADQLTEDE
Mb2320|M.bovis_AF2122/97 PAQVALAWLISLPGVV------AIPGASSVEQLEFNVAAADIELSAQSRD
Rv2298|M.tuberculosis_H37Rv PAQVALAWLISLPGVV------AIPGASSVEQLEFNVAAADIELSAQSRD
MUL_2745|M.ulcerans_Agy99 PAQVALAWLISLPGVV------AIPGASSVEQLEFNVAAADIELSADARA
TH_1364|M.thermoresistible__bu DFELTDDEMNTINGMDNGTRYRPDPXXGEGAAAEHQSADSAAGTAVPGHP
:: : . * . :
MAB_4120c|M.abscessus_ATCC_199 LVRLECLAAAA-GDRYNAEHLARLEG-------------
MAV_2496|M.avium_104 LSRLDRLTPPV-GGHHADAQLAWIDR-------------
MSMEG_4565|M.smegmatis_MC2_155 LESLDAAGATVSGDRYSDTSWLSVGRE------------
MLBr_00458|M.leprae_Br4923 FEMLSAAGAQ-----------------------------
MMAR_2086|M.marinum_M FEALSVAGAAHGG--------------------------
Mvan_2555|M.vanbaalenii_PYR-1 FETLGNAGAAAS---------------------------
Mflv_0942|M.gilvum_PYR-GCK VHALTAVEDEQSATLSTMPSRMTDAFARVVSPPGSGRRR
Mb2320|M.bovis_AF2122/97 ALTDAARAFRPVSTGRFLTDMVREKVSRR----------
Rv2298|M.tuberculosis_H37Rv ALTDAARAFRPVSTGRFLTDMVREKVSRR----------
MUL_2745|M.ulcerans_Agy99 ALTEAARAFHPVSARRFLTDTVREKLGRR----------
TH_1364|M.thermoresistible__bu VRRGGCARRQRRPGTAADHLLHRRSDGLSVEQVDHQR--