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MRTKTLGTLTTSAVGLGCMAMSGPYGEADRAESIATVQAALDAGITLLDTADFYGSGHNEMLLAEALRGR ARDTYLLSVKFGAQIGPGVTWLGFDARSVAVKSAVAYSLQRLGTDHIDICRPARLDPAVPIEETVGAIGE LVDAGYVRHIGLSEVGSDTIRRAASVRPIADLQIEYSLMSRGIENDILDTCRELGIGITAYGVLSRGLLS GHWTPGGGREGDARSAYPRFSGANFERNLALVDALRGVADELGVSAAQAAIAWVATRGDDVVPLIGARTR TRLSEALGAVDLTLTGEQLARIESAVPADEVAGDRYTAQQMAALDSERVPADHP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2429 | - | - | 100% (334) | aldo/keto reductase |
| M. smegmatis MC2 155 | MSMEG_2920 | - | 1e-67 | 47.71% (306) | aldo/keto reductase |
| M. smegmatis MC2 155 | MSMEG_4565 | - | 5e-61 | 41.85% (325) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 6e-20 | 27.72% (303) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_0942 | - | 2e-21 | 29.10% (299) | aldo/keto reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 6e-20 | 27.72% (303) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 6e-25 | 26.82% (302) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 2e-72 | 47.32% (336) | aldo/keto reductase |
| M. marinum M | MMAR_2086 | - | 1e-26 | 29.04% (303) | oxidoreductase |
| M. avium 104 | MAV_2496 | - | 1e-67 | 46.39% (332) | aldo/keto reductase |
| M. thermoresistible (build 8) | TH_1525 | - | 4e-08 | 23.30% (279) | 2,5-diketo-D-gluconic acid reductase A |
| M. ulcerans Agy99 | MUL_2745 | - | 4e-22 | 29.55% (308) | hypothetical protein MUL_2745 |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 1e-28 | 30.92% (304) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4120c|M.abscessus_ATCC_199 ----------------------MKHTWLG-ELSVSRIGLGAMSMSAYYRA
MAV_2496|M.avium_104 ----------------------MKQAQLG-GLQVGRLGLGAMGMSVAY--
MSMEG_2429|M.smegmatis_MC2_155 ----------------------MRTKTLG-TLTTSAVGLGCMAMSGPY--
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGKG--
MMAR_2086|M.marinum_M ------------------MAAASATLTLGGDLTVNRLGFGAMRLTGDG--
Mvan_2555|M.vanbaalenii_PYR-1 --------------MTSGSSRTAPTFLLGGELPVNRLGFGAMRLTGPG--
Mflv_0942|M.gilvum_PYR-GCK -----------------MTTAIQTTLTLGGELPVPRMGYGAMQLAGPG--
Mb2320|M.bovis_AF2122/97 ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
Rv2298|M.tuberculosis_H37Rv ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
MUL_2745|M.ulcerans_Agy99 ----------------------MKHLEVDGIGNVSRIGLGTWQFGSRE--
TH_1525|M.thermoresistible__bu -----------------VNMTTVPAITLNNGAQIPQVGFGVYQIPPDQ--
:. :* * :
MAB_4120c|M.abscessus_ATCC_199 IGSESGPDEATSIDTLRRALDLGVSLIDTAEIYG--PFVNEELVGRAIAG
MAV_2496|M.avium_104 --AGAGTDDAESIRTVHRAIELGVTLIDTAEVYG--PYINEELLARALRG
MSMEG_2429|M.smegmatis_MC2_155 ----GEADRAESIATVQAALDAGITLLDTADFYG--SGHNEMLLAEALRG
MLBr_00458|M.leprae_Br4923 -VWGPPVDRYEAVRVLRRAVELGVNFIDTADSYG--PYVSEEIIAEAL--
MMAR_2086|M.marinum_M -VWGPPADRAEAVRVLRRAAELGVNFIDTADSYG--PYVSEEIIHEAL--
Mvan_2555|M.vanbaalenii_PYR-1 -VWGPPADRDECLRVLRRAVDLGVDFIDTADSYG--PYISEDLIREAL--
Mflv_0942|M.gilvum_PYR-GCK -VLGLPDDVDNAVDVLRRAVDHGVRFFDTANAYG--PRTVNQIIGRALG-
Mb2320|M.bovis_AF2122/97 WGYGDRYATGAARDIVKRARALGVTLFDTAEIYG--LGKSERILGEALG-
Rv2298|M.tuberculosis_H37Rv WGYGDRYATGAARDIVKRARALGVTLFDTAEIYG--LGKSERILGEALG-
MUL_2745|M.ulcerans_Agy99 WGYGDRYASGAARDIVARACALGVTLFDTAEVYG--LGKSERILGEALG-
TH_1525|M.thermoresistible__bu -----------TAAAVRTALDAGYRHIDTAQMYGNERGVAEGIRDAGLD-
: * * :***: ** : : .:
MAB_4120c|M.abscessus_ATCC_199 R-RDEVVLATKFGLVSHGNGASQVLDSTPGNISTAVEGSLRRLGVDHIDL
MAV_2496|M.avium_104 R-RDRVVLATKFGLISHTG--RDGLDSSPANIRVAVDGSLRRLATDHIDL
MSMEG_2429|M.smegmatis_MC2_155 RARDTYLLSVKFGAQIGPGVTWLGFDARSVAVKSAVAYSLQRLGTDHIDI
MLBr_00458|M.leprae_Br4923 HPYKGLVIATKAGLLRTGRDVWIPL-GNPSYLRQELEMSLRRLNVDTIDL
MMAR_2086|M.marinum_M HPYTGLVIATKAGLLRTGPGVWVPL-GNPSYLRQECEMSLRRLGVDTIDL
Mvan_2555|M.vanbaalenii_PYR-1 HPYDGVVIATKAGLLRTAPDVWEPL-GFPAYLRQECEMSLRRLGTDTIDL
Mflv_0942|M.gilvum_PYR-GCK TPADDLVIGNKVGAVRGPAGEWLQD-SRPEILRTQVEEALLDMRADASAL
Mb2320|M.bovis_AF2122/97 DDRTEVVVASKV----------FPVAPFPAVIKNRERASARRLQLNRIPL
Rv2298|M.tuberculosis_H37Rv DDRTEVVVASKV----------FPVAPFPAVIKNRERASARRLQLNRIPL
MUL_2745|M.ulcerans_Agy99 DERAEVVVASKI----------MPVAPFPAVVKQRERASARRLQLDRIPL
TH_1525|M.thermoresistible__bu --RGEVFITSKLN----------NPYHRPDDARRAFDRTLTELGSDYVDL
.: * . : : : :
MAB_4120c|M.abscessus_ATCC_199 YYQHRVDPN---------VAIEDTIGAVAELVQQGKVRYIGLSEAAAGTI
MAV_2496|M.avium_104 YYQHRLDRQ---------TPIEDTVGALAELVAAGKIRHIGLSEVGVNSI
MSMEG_2429|M.smegmatis_MC2_155 CRPARLDPA---------VPIEETVGAIGELVDAGYVRHIGLSEVGSDTI
MLBr_00458|M.leprae_Br4923 FQLHRIDPN---------FPLADQVGELFTLKNEGKIRHIGLSEINLDQL
MMAR_2086|M.marinum_M FQLHRIDRN---------YPLADQVGELLALKNEGKIRHIGLSEIDVDQL
Mvan_2555|M.vanbaalenii_PYR-1 FQLHRIAPK---------FPAEDQIGELAKLQQEGKVRHIGLSEVSVDQL
Mflv_0942|M.gilvum_PYR-GCK TYLRLAGDIRGVGEGPGEVPLEESLGALVELRDQGKIRHIGLSGASPAAL
Mb2320|M.bovis_AF2122/97 YQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNYSLARW
Rv2298|M.tuberculosis_H37Rv YQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNYSLARW
MUL_2745|M.ulcerans_Agy99 YQIHQPNPV---------VPDSVIMPGIRELLDIGRIGAAGVSNYSLARW
TH_1525|M.thermoresistible__bu FLIHWPLPMHYDG------DFVSTWKTLEEFAADGRARSIGVSNFEPAHL
: : * *:*
MAB_4120c|M.abscessus_ATCC_199 RRAHAVH--PITALQNEYSLWTRDIEDEILPTIRELGIGLVAYSPLGRGF
MAV_2496|M.avium_104 RRAHAVH--PITAVQSEYSLWTRDQEDEILPVLRELGIGFVAYSPLGRGF
MSMEG_2429|M.smegmatis_MC2_155 RRAASVR--PIADLQIEYSLMSRGIENDILDTCRELGIGITAYGVLSRGL
MLBr_00458|M.leprae_Br4923 TAAQQIT--EIVSVQNMYNLSARA-AEPLLDAVTSRGIGFIPWSPLAAGP
MMAR_2086|M.marinum_M EAAQQIT--EIVSVQNMYNLAARG-AEPLLEAATSQGIAFIPWFPLASGP
Mvan_2555|M.vanbaalenii_PYR-1 TAARAVA--PIVSVQNMYNLTMRA-AEPVLDACEADGIAFIPWFPLAAGP
Mflv_0942|M.gilvum_PYR-GCK ERAQQIT--TIAAVQNRFNLIDRS-GVEVLAACERDGIAFVPYFPLATGG
Mb2320|M.bovis_AF2122/97 RKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGL
Rv2298|M.tuberculosis_H37Rv RKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGL
MUL_2745|M.ulcerans_Agy99 KKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPLAQGL
TH_1525|M.thermoresistible__bu DLLAAET--STVPAVNQVEIHPYFGNNDVRRYCAEHGIAVEAWAPIAKGR
. .: : . . .: :. *
MAB_4120c|M.abscessus_ATCC_199 LTGAIGSRDQLAEGDFRREQPRFSAENFDANLALVEEVRSVASSIGATSA
MAV_2496|M.avium_104 LTGAIRSAHELPDTDYRRTNPRFAEQNFAHNLRCADELRDIAADVGATPA
MSMEG_2429|M.smegmatis_MC2_155 LSGHWTPGGGR-EGDARSAYPRFSGANFERNLALVDALRGVADELGVSAA
MLBr_00458|M.leprae_Br4923 LAAP------------------------------DGPLQRIAVNHHATPS
MMAR_2086|M.marinum_M LAAP------------------------------DGPLRKIADDHHATPS
Mvan_2555|M.vanbaalenii_PYR-1 LAAA------------------------------DGPLHRIAAEHHATPS
Mflv_0942|M.gilvum_PYR-GCK LGD-------------------------------DDELRRPGERLGVPMS
Mb2320|M.bovis_AF2122/97 LGGKYGLENRP--GGVRALNPLFGTENLRRIEPLLATLRAIAVDVDAKPA
Rv2298|M.tuberculosis_H37Rv LGGKYGLENRP--GGVRALNPLFGTENLRRIEPLLATLRAIAVDVDAKPA
MUL_2745|M.ulcerans_Agy99 LGGKYGVDNRP--AGVRAVNPLFGTENLRRIEPLLQTLRAVAIDVDAKPA
TH_1525|M.thermoresistible__bu VADD-------------------------------PVIAGIADRLGRTPA
: : . :
MAB_4120c|M.abscessus_ATCC_199 QVALAWLLARGDDIVPIPGTTKVSRVNENVGAVDIE--LLPEHLVRLECL
MAV_2496|M.avium_104 QVALAWLLAKGPDIVPIPGTKRVARLEENVGADALE--LTTEQLSRLDRL
MSMEG_2429|M.smegmatis_MC2_155 QAAIAWVATRGDDVVPLIGARTRTRLSEALGAVDLT--LTGEQLARIESA
MLBr_00458|M.leprae_Br4923 QLALAWLLKRSPVMLPIPGTSRVAHLEENVAAAEIS--LSDDEFEMLSAA
MMAR_2086|M.marinum_M QLALAWLLKRSPVMLPIPGTSRVAHLQENVAAAEIV--LSDQEFEALSVA
Mvan_2555|M.vanbaalenii_PYR-1 QLALAWLLKRSPVMLPIPGTSKVAHLEENVAAAQID--LTDAEFETLGNA
Mflv_0942|M.gilvum_PYR-GCK TIALAWLLRRSPVIVPIPGTKSVAHLRDNLSAAQVADQLTEDEVHALTAV
Mb2320|M.bovis_AF2122/97 QVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LSAQSRDALTDA
Rv2298|M.tuberculosis_H37Rv QVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LSAQSRDALTDA
MUL_2745|M.ulcerans_Agy99 QVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LSADARAALTEA
TH_1525|M.thermoresistible__bu QVTLRWHIQRGDIVLPKS--VTPERVRSNIALFDFE--LSDADMAAISAL
:: * ::. :: :. . * :
MAB_4120c|M.abscessus_ATCC_199 AAA---AGDRYNAEHLARLEG-----------
MAV_2496|M.avium_104 TPP---VGGHHADAQLAWIDR-----------
MSMEG_2429|M.smegmatis_MC2_155 VPADEVAGDRYTAQQMAALDSERVPADHP---
MLBr_00458|M.leprae_Br4923 GAQ-----------------------------
MMAR_2086|M.marinum_M GAAHGG--------------------------
Mvan_2555|M.vanbaalenii_PYR-1 GAAAS---------------------------
Mflv_0942|M.gilvum_PYR-GCK EDEQSATLSTMPSRMTDAFARVVSPPGSGRRR
Mb2320|M.bovis_AF2122/97 ARAFRPVSTGRFLTDMVREKVSRR--------
Rv2298|M.tuberculosis_H37Rv ARAFRPVSTGRFLTDMVREKVSRR--------
MUL_2745|M.ulcerans_Agy99 ARAFHPVSARRFLTDTVREKLGRR--------
TH_1525|M.thermoresistible__bu DKGEAGRMGPHPDKFDMI--------------