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TPGRRWTRLCTAGAAAAVMCLLSGCVTVVGGTATRDPAAPPPGAAVTEVDLDNLLLPVTELGDIVGSDDL TVTVELDQFNDSSAAMDDPDCLAAAFGAQERVYAGTGWTAVRDQIVREPGSFSPHWIEQVVVLFTSDLHA RDFFDQSRETWRGCVGTLTTYDIDQMPLEWVVGEVTAEESTISQLSVPETAVRGGCHHALSVAANLVAEA WACGEGVEDQASEIVDQIVANIE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4554 | - | - | 100% (234) | serine/threonine-protein kinase PknH, putative |
| M. smegmatis MC2 155 | MSMEG_4598 | lppH | 3e-12 | 29.74% (232) | putative lipoprotein lpph |
| M. smegmatis MC2 155 | MSMEG_4595 | - | 9e-08 | 24.54% (216) | serine/threonine-protein kinase PknH, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1297c | pknH | 7e-30 | 33.48% (221) | transmembrane serine/threonine-protein kinase H |
| M. gilvum PYR-GCK | Mflv_2675 | - | 4e-45 | 40.74% (216) | hypothetical protein Mflv_2675 |
| M. tuberculosis H37Rv | Rv1266c | pknH | 9e-30 | 33.48% (221) | transmembrane serine/threonine-protein kinase H |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2422c | - | 1e-06 | 25.36% (209) | hypothetical protein MAB_2422c |
| M. marinum M | MMAR_4171 | - | 2e-28 | 29.36% (235) | transmembrane serine/threonine-protein kinase |
| M. avium 104 | MAV_1417 | - | 3e-31 | 33.64% (220) | serine/threonine-protein kinase PknE |
| M. thermoresistible (build 8) | TH_3756 | - | 4e-19 | 28.64% (220) | PUTATIVE putative conserved lipoprotein LppH |
| M. ulcerans Agy99 | MUL_4150 | lppH | 5e-21 | 30.56% (216) | lipoprotein LppH |
| M. vanbaalenii PYR-1 | Mvan_3878 | - | 7e-47 | 42.22% (225) | hypothetical protein Mvan_3878 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAE
Rv1266c|M.tuberculosis_H37Rv MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAE
MMAR_4171|M.marinum_M MSDAQGSRVGSTFGPYRLTRLLGRGGMGEVYEAEHTVKEWTVAVKLMSET
MAV_1417|M.avium_104 MSDERSSKVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLLNES
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_2422c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 FSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD
Rv1266c|M.tuberculosis_H37Rv FSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD
MMAR_4171|M.marinum_M FSKDPVFRERMKREARITGRLQEPHVVPIHDYGEIDGQMYLEMRLIEGTD
MAV_1417|M.avium_104 FSSDPVFRERMKREARTAGRLQEPHVVPVHDYGEIDGQMFLEMRLVEGTD
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_2422c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 LDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRD
Rv1266c|M.tuberculosis_H37Rv LDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRD
MMAR_4171|M.marinum_M LDNLLKRFGPLTPPRAVAIITQVASALDAAHAAGVMHRDVKPQNILVTRE
MAV_1417|M.avium_104 LDSVLKRFGPLPPPRAVAIITQIASALDAAHAAGVMHRDVKPQNILVTRD
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_2422c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
Rv1266c|M.tuberculosis_H37Rv DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
MMAR_4171|M.marinum_M DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
MAV_1417|M.avium_104 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSDAEVTYRADIYA
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_2422c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 LACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVV
Rv1266c|M.tuberculosis_H37Rv LACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVV
MMAR_4171|M.marinum_M LACVLHECLTGSPPYRADSASMLVTAHMMDPIPQPSTVRAGIPKAFDTVI
MAV_1417|M.avium_104 LACVLFECLTGSAPYRADSAGVLVSAHVMDPIPAPSARRPGVPKAFDAVI
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_2422c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPG--
Rv1266c|M.tuberculosis_H37Rv ARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPAPP
MMAR_4171|M.marinum_M ARGMAKQPGDRYASAGDLALAAHEALSNPDQDHAADILRRSQEATLPGPP
MAV_1417|M.avium_104 ARGMAKKPEDRYASAGDLALAAKEALSTPDQDRAATILRRSQEAALPAAG
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_2422c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ---------TAAVTAQPPTMPTVTPPPIQAAP------------------
Rv1266c|M.tuberculosis_H37Rv KPVPPPTMPATAMAPRQPPAPPVTPPGVQPAPKPSYTPPAQPGPAG----
MMAR_4171|M.marinum_M DPAAPPTMPATAAAPPARPGPAATPPRPAPTPQQPPYYPAAAAPAAGSPP
MAV_1417|M.avium_104 QR-------DAGASTVLAPPPAVNTRQPGSAAS-----------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_2422c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 -----------------------------------------------MAD
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ------------------------------TGQPSWAPNSGPMPASGPTP
Rv1266c|M.tuberculosis_H37Rv -------------------------QRPGPTGQPSWAPNSGPMPASGPTP
MMAR_4171|M.marinum_M SGPSAVAGPPRGVAPSGPAGPSGPIPRPPAAGQPGWQQASGPIPASQPTP
MAV_1417|M.avium_104 ------------------------------QAGRGWTPESGPIPAAG-QP
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_2422c|M.abscessus_ATCC_199 ---------------------------------MRYGMTLGCAVTTAVLM
Mflv_2675|M.gilvum_PYR-GCK -------------------------------------------MTALMLP
Mvan_3878|M.vanbaalenii_PYR-1 NGLVNNVGAVRCAYAAG-------------------------AGLAASVL
MSMEG_4554|M.smegmatis_MC2_155 ---MTPGRRWTRLCTAG-------------------------AAAAVMCL
Mb1297c|M.bovis_AF2122/97 TPQYYQGGGWG-APPSG---GPSPWAQTP-----RKTNPWPLVAGAAAVV
Rv1266c|M.tuberculosis_H37Rv TPQYYQGGGWG-APPSG---GPSPWAQTP-----RKTNPWPLVAGAAAVV
MMAR_4171|M.marinum_M SPPYYQGAGWGGAPPPGQPAGPSTWNQGPQGPGPRGRNPWPIVA-AVAIV
MAV_1417|M.avium_104 GPPYYQGGNANWAAAPAQFAGPPPWGRPP-----PKRRVWPIVA-AVVAV
TH_3756|M.thermoresistible__bu ----------------------------------------------MGVL
MUL_4150|M.ulcerans_Agy99 ----MRQRVAALAALVG----------------------------GAGML
MAB_2422c|M.abscessus_ATCC_199 AGCTQPSEGIKPVAAPS----------------------------TTTAE
Mflv_2675|M.gilvum_PYR-GCK MTACVETVDGTALRGHGAGLTD-VAPLDESRLDSVLVGIDEINSIMGATG
Mvan_3878|M.vanbaalenii_PYR-1 LCACVSTVEGAAVRHPGAATLD-VPPLDEAALDRVLLSVDELNSIMGSIR
MSMEG_4554|M.smegmatis_MC2_155 LSGCVTVVGGTATRDP-AAPPP-GAAVTEVDLDNLLLPVTELGDIVGSDD
Mb1297c|M.bovis_AF2122/97 LVLVLGAIGIWIANRP-KPVQP-PQPVAEERLSALLLNSSEVNAVMGSSS
Rv1266c|M.tuberculosis_H37Rv LVLVLGAIGIWIAIRP-KPVQP-PQPVAEERLSALLLNSSEVNAVMGSSS
MMAR_4171|M.marinum_M LVLIVGGIGVWMITQPPKPSPP-PKPIAEDRLSSLLLSPAEVNSVMGASN
MAV_1417|M.avium_104 LVVIAGGVGVWLVIRP-KPEPPQAAPLTSDRLGALLLSASEVNAVMGSST
TH_3756|M.thermoresistible__bu VAGCGSTGHAESTTAPSTTKTLIPRPLVERELPGLLLSPEQVNAAMGTTD
MUL_4150|M.ulcerans_Agy99 VTGCTNIVDGN-AVAADMSGPLNQTPIAVSALDDLLLDVSQIDSALGATS
MAB_2422c|M.abscessus_ATCC_199 MPMTAGTSAPPSVPTTTKAPAPPPLVVTPDKIESILGSRADVGKILGTTL
: : : :* ::. :*:
Mflv_2675|M.gilvum_PYR-GCK MEVTGELDEMSDHSADVSDPDCLGAVYGAEAPVYEGTDWTAVRD---QVA
Mvan_3878|M.vanbaalenii_PYR-1 MKVSSELDEMTDHTAEVSNPDCLGTVYAAEEPAYAGTGWTAVRD---QVA
MSMEG_4554|M.smegmatis_MC2_155 LTVTVELDQFNDSSAAMDDPDCLAAAFGAQERVYAGTGWTAVRD---QIV
Mb1297c|M.bovis_AF2122/97 MQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAING---LIS
Rv1266c|M.tuberculosis_H37Rv MQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAING---LIS
MMAR_4171|M.marinum_M IQPGKPITSMDASPVTLSLPECQGALYTSQDPVYSGTGYTAISG---LVA
MAV_1417|M.avium_104 MEPGKPITATDSSSVTVSVPDCQGALYTTQDPVYAGSGYSAVNG---LVS
TH_3756|M.thermoresistible__bu MAIISSQTSLSDHSNTMAPPECLALDGAGEADVYADSGYRAAR----DHS
MUL_4150|M.ulcerans_Agy99 MKVWFNAKAMWDWSKNISDKNCLAVDGPAQDEVYAGTGWTAMRGQRMDDS
MAB_2422c|M.abscessus_ATCC_199 EYDNNDSSPPTDQIG--GAPDCAALDIPTAS--QLGSEWTTYRWN---YY
:* . .: : :
Mflv_2675|M.gilvum_PYR-GCK REPGAGNDHWVEQAVVLYPEERNARDFLESSQ--AVWRDCAN---NALGV
Mvan_3878|M.vanbaalenii_PYR-1 REPDGDNDHWVEQTAVIYPAARNAQDFFDRSS--VTWQDCAN---ATITT
MSMEG_4554|M.smegmatis_MC2_155 REPGSFSPHWIEQVVVLFTSDLHARDFFDQSR--ETWRGCVG-TLTTYDI
Mb1297c|M.bovis_AF2122/97 SEPGDNYEHWVNQAVVAFPTADKARAFVQTSA--DKWKNCAG-KTVTVTN
Rv1266c|M.tuberculosis_H37Rv SEPGDNYEHWVNQAVVAFPTADKARAFVQTSA--DKWKNCAG-KTVTVTN
MMAR_4171|M.marinum_M SEPGDNNDHWVNQAVVSFPSAAKASSFVETMA--GKWKNCAG-KTVTVTN
MAV_1417|M.avium_104 SEPGDNYDHWVNQAVVLFPSADKAKSFLQTSL--QKWKGCAG-QTVTVTN
TH_3756|M.thermoresistible__bu LNNGDNFTHYAKQAVVLFPLAETARAFFEASA--EQWPACHEYRHT----
MUL_4150|M.ulcerans_Agy99 VDDSKRRKHYAIQAVVAFPSAHDASAFYNSSV--RSWGNCSNRRFTDVST
MAB_2422c|M.abscessus_ATCC_199 RETKDRTAYIVSQVAVLYPTREEAATAFVHAFPKSAAKTCVG-----AEI
: : *..* :. * *
Mflv_2675|M.gilvum_PYR-GCK G--DYLWELGAVEAADLMLTQVTTQ--EGADGWSCQHALSLVSNVTVEAW
Mvan_3878|M.vanbaalenii_PYR-1 GDGDYLWELDAAQVDDTVLTQRVTQ--DGADGWACQHALSVVSNLTVEAW
MSMEG_4554|M.smegmatis_MC2_155 DQMPLEWVVGEVTAEESTISQLSVP--ETAVRGGCHHALSVAANLVAEAW
Mb1297c|M.bovis_AF2122/97 KAKTYRWTFADVKGSPPTITVIDTQ--EGAEGWECQRAMSVANNVVVDVN
Rv1266c|M.tuberculosis_H37Rv KAKTYRWTFADVKGSPPTITVIDTQ--EGAEGWECQRAMSVANNVVVDVN
MMAR_4171|M.marinum_M KSKTYRWTFAQVVGSPPRITMLETQ--EGAEGWECQRAMSVANNVIVDIN
MAV_1417|M.avium_104 KSKTYRWTFAQVQGAPPKITLMDTQ--EGADGWECQRALSVANNVIVDIN
TH_3756|M.thermoresistible__bu -QSGTKWYVAELTRDGDILKAITVQRDAGHPGWGCGRALVLRNNIIGDVN
MUL_4150|M.ulcerans_Agy99 DQPDTIWTVSDVVNDNGMLSTSQVQ-EAGD-GWTCQRALTVRNNVAIDVV
MAB_2422c|M.abscessus_ATCC_199 TKQDQKWTISNIAEISDNTAKWTQLQALQRTPWRCFFDFRNKNNVLFGAY
* . * : *:
Mflv_2675|M.gilvum_PYR-GCK ACGYDITDE-AARIADAMIRNAAG----
Mvan_3878|M.vanbaalenii_PYR-1 ACGYSISDE-AAEIAVAMIENAATK---
MSMEG_4554|M.smegmatis_MC2_155 ACGEGVEDQ-ASEIVDQIVANIE-----
Mb1297c|M.bovis_AF2122/97 ACGYQITNQ-AGQIAAKIVDKVNKE---
Rv1266c|M.tuberculosis_H37Rv ACGYRITNQ-AGQIAAKIVDKVNKE---
MMAR_4171|M.marinum_M SCGYHITDQ-GGALADKIVDKIHKETKY
MAV_1417|M.avium_104 ACGYRITDQ-GDQIADKIVAKIDNE---
TH_3756|M.thermoresistible__bu TCS-ADPGDSAVRIAQQIGENVDAVW--
MUL_4150|M.ulcerans_Agy99 TCAYSQSGSVAADVAQQIAAKAAKQ---
MAB_2422c|M.abscessus_ATCC_199 LCQYGDGVPGVTTITDRIAAWIPQ----
* :. :