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TATGTPPGIEDVLALSPLQQGLYSLAGLTEEDTGADPYVIAMAADIEGAVDPALLRSCAEAMLVRHPNLR ASFFQGNLTRPVAVVPTAVDLPWRHVTAPTAEAAAAIEAEERTRRFDLGRGPLIRFLLIEMPAQRWRLVV TAHHIAIDGWSLPVFVGEYITLYAADGDTAVFPAAPRPYRDYIGWLAGRDHDASRARWRAHLDGLDGPTL LAPALSGREAEPGLPARTEVTLDEQASAEIFDGARARGVTVNTLFQMAWAAILSAFTDRTDVVYGVTVSG RPDELSGVESMVGLFINTVPLRIRLDPAGSVGEQCLAVQREAADLRDHSYLSHTEIRALGGIGELFDTLL VYENFPPGGLVGSDEFPLGSDGDGAVLRPSALESLSHFPVTIAAHPTHGRLTVLVETLDGALGMLDPHAL GRRVLTVVQRLLRSWDRPVRDVAVTLDDEVATVAPTDTAVRPGGFHTAFTEAAAQRLGSIALTWDGGELT YRQLDEAADRVAAELRRRGVGTETPVPIRLPRGPEYVVAMLGVLKAGGLIVPLDPAMPDERVDEIIRQTH PDGRQPAIVDDAFVAAVRAADAELPADYRPAHVHPGQGAYIVFTSGTTGKPKGVIGTHQALLAYAADHAR NVLRPAAQRVGHPLRVAHAWSFTFDAAWQPLVALLDGHANHIVGDDVQRDAEALVETIGRHAIDMIDTTP SMFTQLRAAGLLSTVPLAVLALGGEAIDTALWQAIQAECERTWMSAHNCYGPTEATVEAVVAAIADHRDP CIGKPTDPTAAYVLDSWLRPVPAGVAGELYLAGGQLTRGYVGRPGETAARFVADPFTLGARMYRTGDVVR RTPDGALQFLGRSDDQVKIRGFRVEPGEVAAALHRHPQVRHAHVALRRHRSGPRLVAYVVTDASLADAAG ELRRMLAATLPRYLVPHHILLVDEIPLTTNGKVDDARLAALDSGRQSGGFQGPATDTERVVAEVLAEVLD TRAVDVTAEFLDLGLDSIVALTVVQAVRRRGLALRARLMLECANVRELAAAIDADAHHAAVDHTPEDSGP IPLLPNGSWLYQYGEPRRLAQTEAFRLPEGTTAAQLRTLLRTVVDGHEVLRTRLDRVTRTLVPHGPRDVL TEAVGVGTLADAVAEQAALSVDRIDPQQGSMLDAVWLRHPDAPGGVFILTAHVLALDPASWRIVVGELET AWHALASGREPTPVREHTSLRRWSRMLSERALKLDTVDFWHRQFDGADPDIGARRVDPATDRMRDIAVEM TFADADLTARLLTGGVPVTEVLAAATARTVTAWRRERGQPTPAPLLALETHGRADAVVSADLGEDPHQVD TGDTAGLLSMIYPLRVTAGDARGVAELVAAIPGDPIDYGLLRHLREDTAESLGVHRDPQLLLNYLGRIEL DSADHALLQDRSLLSGVTPIPEPDVAVRHELTIMAAVIDRDGSAVLGAQWRTLPDILSAAEVGTLQTMWL DALREVVE*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_4510 | - | - | 100% (1479) | peptide synthetase mbtf |
M. smegmatis MC2 155 | MSMEG_0019 | - | 0.0 | 32.93% (1564) | amino acid adenylation |
M. smegmatis MC2 155 | MSMEG_3715 | - | e-147 | 35.51% (1056) | linear gramicidin synthetase subunit C |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2400c | mbtF | 0.0 | 61.92% (1476) | peptide synthetase MBTF (peptide synthase) |
M. gilvum PYR-GCK | Mflv_2697 | - | 0.0 | 60.88% (1475) | amino acid adenylation domain-containing protein |
M. tuberculosis H37Rv | Rv2379c | mbtF | 0.0 | 61.86% (1476) | peptide synthetase MBTF (peptide synthase) |
M. leprae Br4923 | MLBr_02353 | - | 2e-24 | 24.40% (545) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_2123 | - | 0.0 | 41.04% (1535) | putative peptide synthetase MbtF |
M. marinum M | MMAR_3690 | mbtF | 0.0 | 42.06% (1550) | non-ribosomal peptide synthetase MbtF |
M. avium 104 | MAV_2014 | - | 0.0 | 59.71% (1494) | putative sulfotransferase |
M. thermoresistible (build 8) | TH_4360 | - | 0.0 | 66.27% (679) | PUTATIVE amino acid adenylation domain |
M. ulcerans Agy99 | MUL_3633 | mbtF | 0.0 | 42.06% (1550) | non-ribosomal peptide synthetase MbtF |
M. vanbaalenii PYR-1 | Mvan_3844 | - | 0.0 | 53.75% (1507) | amino acid adenylation domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_4510|M.smegmatis_MC2_155 -----MTATGTPPGIEDVLALSPLQQGLYSLAGLTEEDTG-----ADPYV TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 MGPVAVTRADARGAIDDVMALSPLQQGLFSRATLVAAESGSEAAEADPYV Rv2379c|M.tuberculosis_H37Rv MGPVAVTRADARGAIDDVMALSPLQQGLFSRATLVAAESGSEAAEADPYV MAV_2014|M.avium_104 ---MTAAETDVAPDIEDVMALSPLQEGLYSLTTLAEFADGQ--PADDPYV Mflv_2697|M.gilvum_PYR-GCK ------MTAAKTGAIADVMALSPLQQGLYSLTAMSD--------GDDPYL Mvan_3844|M.vanbaalenii_PYR-1 --MTQIQQSVEPPVIEDVLALSPLQQGLFSMATLSEGRD------DDPYV MMAR_3690|M.marinum_M -------MTAAAPQIEDVLALSPLQEGLFALHQLAEDG-------VDLYS MUL_3633|M.ulcerans_Agy99 -------MTAAAPQIEDVLALTPLQEGLFALHQLAEDG-------VDLYS MAB_2123|M.abscessus_ATCC_1997 -----MTGTEQQPQIEDVLALSPLQEGFFALSQLADES-------VDLYS MLBr_02353|M.leprae_Br4923 -----MITPDNAIAVVGMAGKFPGANDVSAFWTNLRRGKESIVTLSEQEL MSMEG_4510|M.smegmatis_MC2_155 IAMAADIEGAVDPALLRSCAEAMLVRHPNLRASFFQGNLTRPVAVVPTAV TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 IAMAADAAGPLDIALLRDCAAAMLTRHPNLRASFLHGNLSRPVQVIPSSA Rv2379c|M.tuberculosis_H37Rv IAMAADAAGPLDIALLRDCAAAMLTRHPNLRASFLHGNLSRPVQVIPSSA MAV_2014|M.avium_104 IGMAADITGTLDVALLRDCAEKMLVRHPNLRASFFSRGIPRPVQIVPSRV Mflv_2697|M.gilvum_PYR-GCK IGMSADITGALDVSLLHDCAAAVLARHPNLRAGFFQGDLKRPVQVIPEKV Mvan_3844|M.vanbaalenii_PYR-1 IAMTADATGDLDARLLRECAAELLDRHANLRASFVKGNLSRAVQVIPKRV MMAR_3690|M.marinum_M MQFVVDIDGPVDLELLRRSAQAMLDRHPNLRAAFWDRDVPKPVQIVPVHA MUL_3633|M.ulcerans_Agy99 MQFVVDIDGPVDLELLRRSAQAMLDRHPNLRAAFWDRDVPKPVQIVPVHA MAB_2123|M.abscessus_ATCC_1997 MQFVADIDGGLDVDLLHRSAQALLTRHPNLRAAFWDRGLPKPVQIVPTHA MLBr_02353|M.leprae_Br4923 RDNGVSDKALADPAYVRR--APLLDGIDEFDADFFG-LPPLAAQVLDPQH MSMEG_4510|M.smegmatis_MC2_155 DLPWRHVTAPTAEAAAAIEAEERTRRFDLGRGPLIRFLLIEMPA-QRWRL TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 EVLWRHVRAHPSEVG-ALAAEERRRRFDVGRGPLIRFLLIELPD-ECWHL Rv2379c|M.tuberculosis_H37Rv EVLWRHVRAHPSEVG-ALAAEERRRRFDVGRGPLIRFLLIELPD-ECWHL MAV_2014|M.avium_104 ELPWRSVTASPAEVP-MLETAERRRPFDLERGPAIRFLLIELPD-AHWRL Mflv_2697|M.gilvum_PYR-GCK EVLWRHVRCDGTEVE-PLEREERARRFDLGRGPAMRFLLLETGQ-QRWRF Mvan_3844|M.vanbaalenii_PYR-1 DLPWRHVTVAGDAELEAAERLERTTPFTLARGPVIRFLLIEAP--QRWRF MMAR_3690|M.marinum_M ALPWSERVATPAEFD-SIARSERRRPFDLSRGPALRVVVLSVPGETKRRM MUL_3633|M.ulcerans_Agy99 ALPWSERVATPAEFD-SIARSERRRPFDLSRGPALRVVVLSVPGETKRRM MAB_2123|M.abscessus_ATCC_1997 DIPWEEREAQPTEFD-EIALRERLRPFNLGKGPAIRLVLLTVPGESRHRM MLBr_02353|M.leprae_Br4923 RLFLQCAWHALEDAG--CDPAQFDGSIGVYGTSSPSGYLLHNLLSHRDPH MSMEG_4510|M.smegmatis_MC2_155 VVTAHHIAIDGWSLPVFVGEYITLYAADGDTAVFPAAPRPYRDYIGWLAG TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 VIVAHHIVIDGWSLPLFVSELLALYRAGGHVAALPAAPRPYRDYIGWLAG Rv2379c|M.tuberculosis_H37Rv VIVAHHIVIDGWSLPLFVSELLALYRAGGHVAALPAAPRPYRDYIGWLAG MAV_2014|M.avium_104 VLTAHHIVIDGWSLPVFVNELMTLYRAGGDRSALPAAPRPYRDYIGWLAG Mflv_2697|M.gilvum_PYR-GCK VITAHHIVIDGWSLSLLVSELLALYRAAGNTSALPDAPRPYRDYIGWLAA Mvan_3844|M.vanbaalenii_PYR-1 VVTAHHILIDGWSLPLFMGELLTLYRAGGDVTALPDPPRPYRDYIGWLAG MMAR_3690|M.marinum_M IFTAHHILVDGWSLAVFFTELLAVYRAGGAADALP-AARPYRDYIVWLAK MUL_3633|M.ulcerans_Agy99 IFTAHHILVDGWSLAVFFTELLAVYRAGGAADALP-AARPYRDYIVWLAN MAB_2123|M.abscessus_ATCC_1997 IVTSHHILMDGWAIAIFFSELLAVYQAGGSLAGLP-AVRPYRDYIAWLNA MLBr_02353|M.leprae_Br4923 TVLAEGLNFDQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTACSSSLVA MSMEG_4510|M.smegmatis_MC2_155 RDHDASRARWRAHLDGLDGPTLLAPALSGREAEPG----LPARTEVTLDE TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 RDQTASRAMWADHLNGLDGPTLLSPALADTPVQPG----IPGRTEVRLDR Rv2379c|M.tuberculosis_H37Rv RDQTASRAMWADHLNGLDGPTLLSPALADTPVQPG----IPGRTEVRLDR MAV_2014|M.avium_104 RDLQASQRVWREHLAGLPGPTLLAASLGSAEATGGQRTALPRTTELRMPA Mflv_2697|M.gilvum_PYR-GCK RDQDHARSLWRAHLADLDGPTLLAPALGAATIGDG----LPGMVELTADP Mvan_3844|M.vanbaalenii_PYR-1 RDEETGRALWRRHLAGVDGPTLLTPALTSSAPTPG----RPRLTEVRLDA MMAR_3690|M.marinum_M QDRSAALAGWMDYLRGVSEP--LMVAYEATAGQS-----KPGKTELLLPA MUL_3633|M.ulcerans_Agy99 QDRSAALAGWMDYLRGVSEP--LMVAYEATAGQS-----KPGKTELLLPA MAB_2123|M.abscessus_ATCC_1997 QDTTEATARWTRYLGTVSGP--LMLADGAVAAHDN----VPEKSQFLLAP MLBr_02353|M.leprae_Br4923 LHLACLSLLSGECDMALAGGSSLCIPHRVGYWHSP----------GSMVS MSMEG_4510|M.smegmatis_MC2_155 QASAEIFDGARARGVTVNTLFQMAWAAILSAFTDRTDVVYGVTVSGRPDE TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 EATAELADAARTRGVTISTLVQMAWATTLSAFTGRGDVTFGVTVSGRPSE Rv2379c|M.tuberculosis_H37Rv EATAELADAARTRGVTISTLVQMAWATTLSAFTGRGDVTFGVTVSGRPSE MAV_2014|M.avium_104 EATARLAAETRSRGITVNTLMQMAWALVLSRLTDTRDVVFGVTVSGRPPE Mflv_2697|M.gilvum_PYR-GCK SITEAVVDAARARGVTVNSLVQLAWALTLSSLTDRDDITFGVTVSGRPDD Mvan_3844|M.vanbaalenii_PYR-1 ETTRQLAEAARSRGVTMNTLIQMAWATVLSVITDRTDVSFGVTVSGRPGE MMAR_3690|M.marinum_M ADTARLRQWAGRHGLTLNTAVLFAWAVVLSRLTDRRDVVFGTVVSGRPDQ MUL_3633|M.ulcerans_Agy99 ADTARLRQWAGRHGLTLNTTVLFAWAVVLSRLTDRRDVVFGTVVSGRPDQ MAB_2123|M.abscessus_ATCC_1997 EETARLRQWAAANGLTLNTVTAFAWALVLGRLTDRTDVVFGTIVSGRPKE MLBr_02353|M.leprae_Br4923 AVGHCRPFDVRADGTVFGSGVALVALKPLQAAIDASDRIHAVILG----- MSMEG_4510|M.smegmatis_MC2_155 LSGVESMVGLFINTVPLRIRLDPAGSVGEQCLAVQREAADLRDHSYLSHT TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 LSGVETMIGLFINTVPLRVRLDARATVGGQCAVLQRQFAMLRDHSYLGFN Rv2379c|M.tuberculosis_H37Rv LSGVETMIGLFINTVPLRVRLDARATVGGQCAVLQRQFAMLRDHSYLGFN MAV_2014|M.avium_104 LTGVETMVGLFINTVPLRVRLDPAATVGEQCRAVQRDAALLREHSYLGHA Mflv_2697|M.gilvum_PYR-GCK LAGVESMIGLFVNTVPLRVRLDPALTAGAQCRALQQDAATLRDHSYLGHA Mvan_3844|M.vanbaalenii_PYR-1 LAGVERMVGLFINTVPLRVRLDPAAPAGEQCLALQREAAALRDHGYLSHS MMAR_3690|M.marinum_M LPGVETMVGLFINAVPVVHYVSGTEAVVAQCTQVQRQSSAMRDVSYLSLS MUL_3633|M.ulcerans_Agy99 LLGVETMVGLFINAVPVVHYVSGTEAVVAQCTQVQRQSSAMRDVSYLSLS MAB_2123|M.abscessus_ATCC_1997 LPDVERMVGLFINSVPMVHHIDYSASVVEQCVQLQREAAAMRDIGYLSLS MLBr_02353|M.leprae_Br4923 --------SAINNDGSMKMGYAAPNPAAQADVIAEAHAVAGIDSSTVSYV MSMEG_4510|M.smegmatis_MC2_155 EIRALGG-IGELFDTLLVYENFPPGGLVGSDEFPLGSDGDGAVLRPSALE TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 EFRAIAG-IGEMFDTLLVYENFPPGEVVGTAEFVAN----GVTFRPVALE Rv2379c|M.tuberculosis_H37Rv EFRAIAG-IGEMFDTLLVYENFPPGEVVGTAEFVAN----GVTFRPVALE MAV_2014|M.avium_104 QLRALGG-IGEMFDTLLVYENFPMDGLTAGGELSAG----GATFRPSALQ Mflv_2697|M.gilvum_PYR-GCK ELRALAG-VGELFDTLLVYENFPPGAVAGAGTLEAA----GATFTPVALQ Mvan_3844|M.vanbaalenii_PYR-1 ELRALGG-IGELFDTLLVYENFPPGGLVGQARFEAN----GATFVPSALE MMAR_3690|M.marinum_M EIQREHG-RGPLFDSLFVFENAPIDDAIRPATTPDG-----AQFLPVEME MUL_3633|M.ulcerans_Agy99 EIQREHG-RGPLFDSLFVFENAPIDDAIRPATTPDG-----AQFLPVEME MAB_2123|M.abscessus_ATCC_1997 TLQRAEG-SAALFDTLFVFENAPIGDVVQEVEMADG-----ARFRPVEME MLBr_02353|M.leprae_Br4923 ETHGTGTPLGDPIEIQGLKTAFEVSQIPRPGPCVLG------------SV MSMEG_4510|M.smegmatis_MC2_155 SLSHFPVTIAAHPTHGRLTVLVETLDGALGMLDPHALGRRVLTVVQRLLR TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 SLSHFPVTVAAHRSTGELTLLVEVLDGALGTMAPESLGRRVLAVLQRLVS Rv2379c|M.tuberculosis_H37Rv SLSHFPVTVAAHRSTGELTLLVEVLDGALGTMAPESLGRRVLAVLQRLVS MAV_2014|M.avium_104 TLSHFPIAVAAHMEGGELVVLIEVVDGALGVIPADAVGRRLLTTAERLLR Mflv_2697|M.gilvum_PYR-GCK SLAHFPVTIAAHLTDGRLTVLVEAKDGALGQITPRALGTRLLATVSRIVE Mvan_3844|M.vanbaalenii_PYR-1 SLSHFPVTIAAHLADDELTVFVEVIDGALGALRPGDLGRRVLHTAQRLIS MMAR_3690|M.marinum_M SLTHYPLTVVSHLREDELLVLIEAIAEALPYLPAAEIGERMLTVLRQLPD MUL_3633|M.ulcerans_Agy99 SLTHYPLTVVSHLREDELLVLIEAIAEALPYLPAAEIGERMLTVLRQLPD MAB_2123|M.abscessus_ATCC_1997 SLAHYPLTVVSHMHGDSLLVLIEAIPQALPHVSGASVGERLVSVLRQLPD MLBr_02353|M.leprae_Br4923 KSNIGHLEVAAGIAGLIKTILCLKNKAIPATLHYTSPNRELRLDQTPFVV MSMEG_4510|M.smegmatis_MC2_155 SWDRPVRDVAVTLDDEVATVAP--TDTAVRP-GGFHTAFTEAAAQRLGSI TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 RWDRPLRDVDILLDGEHDPTAPGLPDVTTSA-PAVHTRFAEIAAAQPDSV Rv2379c|M.tuberculosis_H37Rv RWDRPLRDVDILLDGEHDPTAPGLPDVTTSA-PAVHTRFAEIAAAQPDSV MAV_2014|M.avium_104 HWERPLRAVSVLFDDEAAPLRAAGPIAPPSP-KCLPARFADVVAQTPDAP Mflv_2697|M.gilvum_PYR-GCK GWDRPLREISISPDDHPVPVPVSEAAPTPSPSTGVHTRFTETASARLGSV Mvan_3844|M.vanbaalenii_PYR-1 CWDAPLRSVGVLLPAEHTPAPMVREPLTANS---IHDRFAGIAGDRLGSV MMAR_3690|M.marinum_M IGDGTPDDLDIRTAAELKAHGLLAARSAPTFDTTVWEMFERQVQATPDAV MUL_3633|M.ulcerans_Agy99 IGDGTPDDLDIRTAAELKAHGLLAARSAPTFDTTVWEMFERQVQTTPDAV MAB_2123|M.abscessus_ATCC_1997 IGGGTPDALELLTARER-AEIVVTASAADPSVVSVWDLFEREAQAHPESL MLBr_02353|M.leprae_Br4923 QSNYGPWKWDGVRRAGVSSFGVGGTNVHVVLEEASVEASTVAASTGPQVI MSMEG_4510|M.smegmatis_MC2_155 ALTWDGG----ELTYRQLDEAADRVAAELRRRGVGTETPVPIRLPRGPEY TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 AVSWADG----QLTYRELDALADRLATGLRRADVSRETPVAVALSRGPRY Rv2379c|M.tuberculosis_H37Rv AVSWADG----QLTYRELDALADRLATGLRRADVSRETPVAVALSRGPRY MAV_2014|M.avium_104 AVSWAQG----SLTYRELDEATNRLAAQLVALGVEPETPVAIKLSRGPRY Mflv_2697|M.gilvum_PYR-GCK ALSWDGG----ALTYRQLDEAADRLAAVLTASGVRTETPVAVRLRRGADY Mvan_3844|M.vanbaalenii_PYR-1 ALTWEAGGDSGTLTYRQLDEAADRMAVALTAAGVGPETSVAVLLSRGPDY MMAR_3690|M.marinum_M ALTAAAG---VRHTYAELHARACRLAGELAEHGVGPETVVALVLPRSERS MUL_3633|M.ulcerans_Agy99 ALAAAGG---VRHTYAELHARACRLAGELAEHGVGPETVVALVLPRSERS MAB_2123|M.abscessus_ATCC_1997 ALVADAG---TRYTYAQLRGAVSRLCAELIESGVTPETTVALALPRSADS MLBr_02353|M.leprae_Br4923 LLSAQTA--------AALGESREALATVLEKPGAPDLSDVAYTLAGRRKH MSMEG_4510|M.smegmatis_MC2_155 VVAMLGVLKAGGLIVPLDPAMPDERVDEIIRQTHPDGRQPAIVDDAFVAA TH_4360|M.thermoresistible__bu VIAMLAILKAGGVIVPLDPSMPGHRIAEILRQTS----APIVVDQAVSDA Mb2400c|M.bovis_AF2122/97 VAAMLAVLKAGGMIVPLDPAMPGERVAEILRQTS----APVVIDEGVFAA Rv2379c|M.tuberculosis_H37Rv VAAMLAVLKAGGMIVPLDPAMPGERVAEILRQTS----APVVIDEGVFAA MAV_2014|M.avium_104 VVAMLAVLKAGGMCVPMEPGMPAPRVNSILRQSG----ASIVLDEERIDE Mflv_2697|M.gilvum_PYR-GCK VVAMFAVLKAGGAIVPLDPAMPADRIEVILRRAG----VTVVVDEDTVAR Mvan_3844|M.vanbaalenii_PYR-1 VVTMLGVLKAGGVIVPLDPAMPAERISDILEQSR----ASVVVDDAFVAA MMAR_3690|M.marinum_M IVAILGVLAAGGAYLPVDVTLPSARVESIVRQAS----PALAITEADYSQ MUL_3633|M.ulcerans_Agy99 IVAILGVLAAGGAYLPVDVTLPSARVESIVRQAS----PALAITEADYSQ MAB_2123|M.abscessus_ATCC_1997 IIAILAVLAAGAAYVPVDIGLPAARVESILRQSN----PTLVITVDRHRD MLBr_02353|M.leprae_Br4923 NITMAAVVRD--REHAVTVLRAAEHDNVFVGESG----ADTGRSAAASIT :: .:: .: . : :: .: MSMEG_4510|M.smegmatis_MC2_155 VRAADAELPADYRP---------------AHVHPGQGAYIVFTSGTTGKP TH_4360|M.thermoresistible__bu VRAS----SAAWSP---------------PPVHPGQAAYTVFTSGTTGVP Mb2400c|M.bovis_AF2122/97 SVGAD--ILEDDRA---------------ITVPVDQAAYVIFTSGTTGTP Rv2379c|M.tuberculosis_H37Rv SVGAD--ILEEDRA---------------ITVPVDQAAYVIFTSGTTGTP MAV_2014|M.avium_104 LLEAGRSQHGGFEP---------------PDIPPAQAAYVVFTSGTTGEP Mflv_2697|M.gilvum_PYR-GCK ATAEP---PAQYRP---------------AETLPGQAAYVVFTSGTTGEP Mvan_3844|M.vanbaalenii_PYR-1 VPDVEP--PAGYRP---------------AEVTADRAAYIVFTSGTTGRP MMAR_3690|M.marinum_M LVGTAVPTLALDDPAAVESISRRSAAAPTVDRRPEQSAYVIFTSGSTGEP MUL_3633|M.ulcerans_Agy99 LVGTAVPTLALDDPAAVDSISRRSAAAPTVDRRPEQSAYVIFTSGSTGEP MAB_2123|M.abscessus_ATCC_1997 IAGRGYQVLILDDPETAARISGRSESGHAVVVHRDQSAYLIFTSGSTGEP MLBr_02353|M.leprae_Br4923 TLGSDRVVFLFPGQ---------------GAQHVGMAKGLYDTESVFAEH . *.. . MSMEG_4510|M.smegmatis_MC2_155 KGVIGTHQALLAYAADHARNVLRPAAQRVGHPLRVAHAWSFTFDAAWQPL TH_4360|M.thermoresistible__bu KGVVGTHDALLAYADDHARNVLRPAAARLGRPLRIAHAWSFTFDAAWQPL Mb2400c|M.bovis_AF2122/97 KGVIGTHRALSAYADDHIERVLRPAAQRLGRPLRIAHAWSFTFDAAWQPL Rv2379c|M.tuberculosis_H37Rv KGVIGTHRALSAYADDHIERVLRPAAQRLGRPLRIAHAWSFTFDAAWQPL MAV_2014|M.avium_104 KGVIGTHGAVGAYADDHLDRVLRPAAAALGRPLRIAHAWSFAFDAAWQPL Mflv_2697|M.gilvum_PYR-GCK KGVIGTHRALLAYADDHIGAILRPAADRVGRPLRIAHAWSFTFDAAWQPL Mvan_3844|M.vanbaalenii_PYR-1 KGVVGTHGAVLGYAEDHAEQVLRPAAARIGRPLRVGHAWSFTFDAAWQPL MMAR_3690|M.marinum_M KGVVGTNAAVLSYFADHAERVYRAARARLGRPLRIAHAWSLSFDASWQPM MUL_3633|M.ulcerans_Agy99 KGVAGTNAAVLSYFADHAERVYRAARARLGRPLRIAHAWSLSFDASWQPM MAB_2123|M.abscessus_ATCC_1997 KGVVGTHAALMSYFADHRDRVYRPATARLGRKLRIAHAWSLSFDASWQPM MLBr_02353|M.leprae_Br4923 FDTCSAGFREAMDDLDLHSAIFNGTAIDLER-IDRSQPALFTVEYALAKL .. .: * : . : : : : .:. ::.: : : MSMEG_4510|M.smegmatis_MC2_155 VALLDGHANHIVGDDVQRDAEALVETIGRHAIDMIDTTPSMFTQLRAAGL TH_4360|M.thermoresistible__bu AALFEGHAVHIIGDDVQRDAEALVDTIDRHRVDMIDITPSMFEQLRAFGL Mb2400c|M.bovis_AF2122/97 VALLDGHAVHIVDDHRQRDAGALVEAIDRFGLDMIDTTPSMFAQLHNAGL Rv2379c|M.tuberculosis_H37Rv VALLDGHAVHIVDDHRQRDAGALVEAIDRFGLDMIDTTPSMFAQLHNAGL MAV_2014|M.avium_104 VALLDGHGVHVVDEATQTDAEALVALIAEHGVDMIDTTPSMFAQLQAFGL Mflv_2697|M.gilvum_PYR-GCK AALLDGHSVHIVDDATQRDAEALVDTIARFGVDMIDTTPSMFARLRDVGL Mvan_3844|M.vanbaalenii_PYR-1 AALLDGHSVHLLGEESQRDAEALVYRIGRFGIDMLDTTPSMFAQLHDVGL MMAR_3690|M.marinum_M VGLLDGHEIHLFDAEEMRDADRLVEGIAIGQIDMIDTTPSMFVQLSAAGL MUL_3633|M.ulcerans_Agy99 VGLLDGHEIHLFDADEMRDADRLVEGIAIGQIDMIDTTPSMFVQLSAAGL MAB_2123|M.abscessus_ATCC_1997 IGLLDGHAVHLFDAEAMRDASLLVRGMAERGVDMIDTTPSMLAQLSAAGL MLBr_02353|M.leprae_Br4923 VESFGVGAGAYIG--YSTGEYIAATLAGVFDLETAIKTVSLRARLMHESP : .. . . :: * *: :* . MSMEG_4510|M.smegmatis_MC2_155 LSTVPLAVLALGGEAIDTALWQAIQAECERTWMSAHNCYGPTEATVEAVV TH_4360|M.thermoresistible__bu LGRVPLAVLALGGEAVGIGTWRFIRDECERTGMAAYNCYGPTETTVEAVV Mb2400c|M.bovis_AF2122/97 LDRAPLAVLALGGEALGAATWRMIQQNCARTAMTAFNCYGPTETTVEAVV Rv2379c|M.tuberculosis_H37Rv LDRAPLAVLALGGEALGAATWRMIQQNCARTAMTAFNCYGPTETTVEAVV MAV_2014|M.avium_104 LSEAPLTVLALGGEALGNAAWARIRNACNTTTMSAYNCYGPTETTVEAVV Mflv_2697|M.gilvum_PYR-GCK LSTVPLAVLALGGEAVDPGLWQQIRQECARTGMSAFNCYGPTETTVEAVV Mvan_3844|M.vanbaalenii_PYR-1 LSTVPLAVLALGGEAVSPATWRLIGDECARTGMTAFNCYGPTETTVEAVV MMAR_3690|M.marinum_M LDHN-LSVLALGGEAINTGLWDQLR---GLSQMAVYNCYGPTEMTVEAVV MUL_3633|M.ulcerans_Agy99 LDHN-LSVLALGGEAINTGLWDQLR---GLSQMAVYNCYGPTEMTVEAVV MAB_2123|M.abscessus_ATCC_1997 LDHE-LAVLALGGEAIETALWDRLR---SLSDTAVYNCYGPTETTVEAVV MLBr_02353|M.leprae_Br4923 PGAMVAVALGPEDITEYLAEYSAKGVELSAVNDPGNCVVAGPKDQIRAFS . .*. . : . : . . .: :.*. MSMEG_4510|M.smegmatis_MC2_155 AAIADHRDPC-IGKPTDPTAAYVLDSWLRPVPAGVAGELYLAG-----GQ TH_4360|M.thermoresistible__bu GRFAAHEQPV-IGLPTRHTRAYVLDAWLRPVPDGVAGELYLAG-----AQ Mb2400c|M.bovis_AF2122/97 AAVAEHARPV-IGRPTCTTRAYVMDSWLRPVPDGVAGELYLAG-----AQ Rv2379c|M.tuberculosis_H37Rv AAVAEHARPV-IGRPTCTTRAYVMDSWLRPVPDGVAGELYLAG-----AQ MAV_2014|M.avium_104 AAIAEHAEPS-IGRPTRHTRGYVLDSELRPVPCGATGELYLGG-----AQ Mflv_2697|M.gilvum_PYR-GCK AEIGAHERPT-IGRPTAPTRAYVLDSWLRPVPSGAAGELYLAG-----GQ Mvan_3844|M.vanbaalenii_PYR-1 APIDGYQRPS-IGQPTRTMRTYVLDAWLRPVPDGVAGELYLSG-----RQ MMAR_3690|M.marinum_M AAVKDYRKPT-IGTANAGTFGYVFDSALRMVPDGVVGELYLSG-----AQ MUL_3633|M.ulcerans_Agy99 AAVKDYRKPT-IGTANAGTFGYVFDSALRMVPDGVVGELYLSG-----AQ MAB_2123|M.abscessus_ATCC_1997 AAVKEYPAPT-IGTPNQGMVGYVLDSRLRPVPDGAVGELYLAG-----AQ MLBr_02353|M.leprae_Br4923 QRLDEVGIPVRRVRATHAFHTSSMEPMLREFSEFLSRQQLRVPNTPLLSN . * .. ::. ** .. : : MSMEG_4510|M.smegmatis_MC2_155 LTRGYVGRPGETAARFVADPFTLGARMYRTGDVVRRTPDGALQFLGRSD- TH_4360|M.thermoresistible__bu LTRGYLGRAGETATRFVPDPFDPGRRMYRTGDVVRRTADGALQYLGRSD- Mb2400c|M.bovis_AF2122/97 LTRGYLGRPAETAARFVAEPNGRGSRMYRTGDVVRRLPDGGLEFLGRSD- Rv2379c|M.tuberculosis_H37Rv LTRGYLGRPAETAARFVAEPNGRGSRMYRTGDVVRRLPDGGLEFLGRSD- MAV_2014|M.avium_104 LARGYLGRAGETASRFVADPFAASERMYRTGDLVRRLPDGSLQYVGRAD- Mflv_2697|M.gilvum_PYR-GCK LTRGYLGRPGETAARFVPDPFVPGARMYRTGDVVRRAVDGTLAFLGRSD- Mvan_3844|M.vanbaalenii_PYR-1 LTRGYLGRAAETAGRFVADPFTPGQRMYRTGDVVRRGADGGLQFLGRAD- MMAR_3690|M.marinum_M LARGYVGRPGMTAARFVADPLRPGQRMYRTGDLVRRLSHGGYAYVGRAD- MUL_3633|M.ulcerans_Agy99 LARGYVGRPGMTAARFVADPLRPGQRMYRTGDLVRRLSHGGYAYVGRAD- MAB_2123|M.abscessus_ATCC_1997 LARGYAGKPAVTAAAFVADPRRAGQRMYRTGDLVRRLPHGGFAYLGRAD- MLBr_02353|M.leprae_Br4923 LTGTWMSEQQVTDPENWTRQISSTIRFADELDVVLSQSGRVLVEVGPGGS *: : .. * . *: *:* :* .. MSMEG_4510|M.smegmatis_MC2_155 -DQVKIRGFRVEPGEVAAALHRHPQVRHAHVALRRHRSGPRLVAYVVTDA TH_4360|M.thermoresistible__bu -DQVKIRGFRVEPGEVAAVLQTHPAVRAAHVAVRRHRSGPRLVGYVATGG Mb2400c|M.bovis_AF2122/97 -DQVKIRGFRVEPGEIAAVLNGHHAVHGCHVTARGHASGPRLTAYVAGGP Rv2379c|M.tuberculosis_H37Rv -DQVKIRGFRVEPGEIAAVLNGHHAVHGCHVTARGHASGPRLTAYVAGGP MAV_2014|M.avium_104 -AQVKIRGHRVEPGEIAAALESHPAVRHAGVLVRHRDGAPRLTGYVATHE Mflv_2697|M.gilvum_PYR-GCK -TQVKIRGFRVEPGEVAAVLRTHPAVGQAYVAVRPHRDGHRLTAYVTGEP Mvan_3844|M.vanbaalenii_PYR-1 -NQVKIRGFRVEPGEIAAVLSGHPAVTDAHVVVDRVGTQTRLIAYVAAAT MMAR_3690|M.marinum_M -TQVKIRGYRVEVGEIEAALRGQPGVHDAAVSVLRQQDRTSLVGFVVWQD MUL_3633|M.ulcerans_Agy99 -TQVKIRGYRVEVGEIEAALRGQPGVHDAAVSVLRQQDRTSLVGFVVWQD MAB_2123|M.abscessus_ATCC_1997 -SQVKIRGYRVEVGEIESALRLQPDIQTAAVTVVRRAGGASLVGFVVCEK MLBr_02353|M.leprae_Br4923 LTGSAMRHPRWSSGHRAVRLMRHPLQNVDDHDTFLRALGELWSAGIEVDW :* * . *. * : . : MSMEG_4510|M.smegmatis_MC2_155 SLADAAG--ELRRMLAATLP--RYLVPHHILLVDEIPLTTNGKVDDARLA TH_4360|M.thermoresistible__bu AEVDVD---ELRRMLVARLP--RYLVPHRVTVLDQLPLTPHGKIDDAALA Mb2400c|M.bovis_AF2122/97 QPPPVA---ELRAMLLERLP--RYLVPHHIVVLDELPLTPHGKIDENALA Rv2379c|M.tuberculosis_H37Rv QPPPVA---ELRAMLLERLP--RYLVPHHIVVLDELPLTPHGKIDENALA MAV_2014|M.avium_104 AAPDTPSPAELRGMLSARLP--RYMVPQRIIMVDEIPLTPNGKLDETALA Mflv_2697|M.gilvum_PYR-GCK QLR------ELRAWLGRRLP--RYLMPNAIVAVDRIPLTAHGKIDEPALV Mvan_3844|M.vanbaalenii_PYR-1 PPAVAD----LRELMAKRLP--RYMVPQRVVVLDELPLTSHGKIDEAALA MMAR_3690|M.marinum_M NMHEDLI--KLRAGLTERLP--SYMVPARIVTLPRLPVNANGKLDGHALD MUL_3633|M.ulcerans_Agy99 NMHEDLI--KLRAGLTERLP--SYMVPARIVTLPRLPVNANGKLDGHALD MAB_2123|M.abscessus_ATCC_1997 DTFDSAR--TMMR-LADRLP--SYMMPSRLVPLPQLPVTVNGKLDGGALE MLBr_02353|M.leprae_Br4923 APQRSVMP-HLVSLPGYPFARQRHWVEPRYTIWAQIPGASSGSPVDSSVD : :. : : .:* *. : MSMEG_4510|M.smegmatis_MC2_155 ALDSG----RQSGGFQGPATDTERVVAEVLAEVLDTRAVDVTAEFLDLGL TH_4360|M.thermoresistible__bu AHDDA----TGSP-VAEPETPTEKALVEAVVDLLGPTPVDVDAELLSLGV Mb2400c|M.bovis_AF2122/97 AIN------VTEGPATPPQTPTELVLAEAFADVMETSNVDVTAGFLQMGL Rv2379c|M.tuberculosis_H37Rv AIN------VTEGPATPPQTPTELVLAEAFADVMETSNVDVTAGFLQMGL MAV_2014|M.avium_104 AVDNA----EAVDGAATPQTGTESALAELIAELLGQPRVDVTADFLALGL Mflv_2697|M.gilvum_PYR-GCK ALEP-----AADGAATRPQTPTEVELAAVLAEVLGVGEIDVTADFLELGL Mvan_3844|M.vanbaalenii_PYR-1 GIA------VEDAPSAAPETPTETALVELMAEVLGDDGIDVEADFLEMGL MMAR_3690|M.marinum_M RLAEDALTSVSGGTAVSASTDTERVLCELFEEQLN-AVPHIDDDLFLFGM MUL_3633|M.ulcerans_Agy99 RLAEDALTSVSGGTAVSASTDTERVLCELFEEQLN-AVPHIDDDLFLFGM MAB_2123|M.abscessus_ATCC_1997 RLAREALSGGAVGEQAQPATATECVLCECCAELFDGTAPGIDEDFFSLGV MLBr_02353|M.leprae_Br4923 SAT--------VEGVRGGESQTEATLQRIWSQCLGVSSVDRNANFFDLGG : ** : : : :: :* MSMEG_4510|M.smegmatis_MC2_155 DSIVALTVVQAVRRRGLALRARLMLECANVRELAAAIDADAHHAAVDHTP TH_4360|M.thermoresistible__bu DSIVALSVVQAARRRGLALRARLMLECGSIRELAAAIDAEANAAPDTESA Mb2400c|M.bovis_AF2122/97 DSIVALSVVQAARRRGIALRARLMVECDTIRELAAAIDSDAAWQAPAN-- Rv2379c|M.tuberculosis_H37Rv DSIVALSVVQAARRRGIALRARLMVECDTIRELAAAIDSDAAWQAPAN-- MAV_2014|M.avium_104 DSIMALSVVQAARARGIALRARLVLDCTSIRELAEAIDAESTPAAGEVD- Mflv_2697|M.gilvum_PYR-GCK DSIVALSVVQTARRRGVVMRAKLMLDCATVRELAAAIDDAGSGPPSAD-- Mvan_3844|M.vanbaalenii_PYR-1 DSIVALTLVQAARRRGLEMRARLMLECNTIRELATAIDSGAHDHAPAAVT MMAR_3690|M.marinum_M DSIVAISLVHKARRQGLRVDPRMVLTATTIRQLGAAIDAAVDSQDAPAD- MUL_3633|M.ulcerans_Agy99 DSIVAISLVHKARRQGLRVDPRMVLTATTIRQLGAAIDAAVDSQDAPAD- MAB_2123|M.abscessus_ATCC_1997 DSIVAISLVNKARKRDLVITPRMVLAAPTIRQLAALVDTRGHVDSLAGE- MLBr_02353|M.leprae_Br4923 DSLMAISISMAAANEGMTITPQDMYEHPTLASLTAAVDASFASSGLAKPP **::*::: . ..: : .: : .: .* :* MSMEG_4510|M.smegmatis_MC2_155 EDSG--PIPLLPNGSWLYQYGEPRRLAQTEAFRLPEGTTAAQLRTLLRTV TH_4360|M.thermoresistible__bu DAGAGEPIPVLPAVHWLYQHGDPRRLAQTEAIRLPDGITGADLRTLLTTV Mb2400c|M.bovis_AF2122/97 --DAGEPIPVLPNTHWLYEYGDPRRLAQTEVIRLPDRITRERLDAVLAAV Rv2379c|M.tuberculosis_H37Rv --DAGEPIPVLPNTHWLYEYGDPRRLAQTEVIRLPDRITRERLDAVLAAV MAV_2014|M.avium_104 --DGTGPMPLLPNGRWLYEHGQPRRLAQTEAIRVPQTLRRDQLETALAGI Mflv_2697|M.gilvum_PYR-GCK --EGSGPIALLPNAHWLYEFGDPRRLASTEALRLPRGITGPQIRALLQSV Mvan_3844|M.vanbaalenii_PYR-1 -DDRFGEVMPAPIMSWMYECGNYRRFTQNVLVSLPADITDSRLEQILQAL MMAR_3690|M.marinum_M --ADYGAVRPLPMVSWLYEYGNYRRFTHTVLLRLPSGIDRSSIELMLQLL MUL_3633|M.ulcerans_Agy99 --ADYGAVLPLPMVSWLYEYGNYRRFTHTVLLRLPSGIDRSSIELMLQLL MAB_2123|M.abscessus_ATCC_1997 --ADYGEVPPLPVVSWMYESEIYRRLSLSVLVRLPAGIDRPGIERMLQLL MLBr_02353|M.leprae_Br4923 EAAAHPAVPPNIAYFLERGLCDTGRWRVPLILRLDPKIGSDDIRAVLTAV : * . : : * : MSMEG_4510|M.smegmatis_MC2_155 VDGHEVLRTRLDR--VTRTLVPHGP---RDVLTEAVGV------GTLADA TH_4360|M.thermoresistible__bu VASHEVLRTRLDR--TTMTLVPQHDGDIGDRLREVTVR------GDLTAA Mb2400c|M.bovis_AF2122/97 VDGHEVLRCRFDR--DAMALVAQPK---TDILSEVWVS------GELVTA Rv2379c|M.tuberculosis_H37Rv VDGHEVLRCRFDR--DAMALVAQPK---TDILSEVWVS------GELVTA MAV_2014|M.avium_104 IDGHEVLRSRVDR--ATMTLVPGPAPDIGKELEEVAVV------GDLRAA Mflv_2697|M.gilvum_PYR-GCK VDAHPVLRTRLDR--AAMTLVDGGF---DLPLTEIEVG------DEGSAA Mvan_3844|M.vanbaalenii_PYR-1 LDRHDMLRAILD---ERGRLVTRPPGAVRVADVLRVVD------AAAHTV MMAR_3690|M.marinum_M LDGHDTLRSILTETPEGPRLVTREPAAVRAEDVLTRITLPEGSDDELASA MUL_3633|M.ulcerans_Agy99 LDGHDTLRSILTETPEGPRLVTREPAAVRAEDVLTRIRLPEGSDDELASA MAB_2123|M.abscessus_ATCC_1997 LDGFTMLRSTLVDTPDGARVVTREPGVVRGESVLSRVELPTG--ESAHAA MLBr_02353|M.leprae_Br4923 VNHHDVLRLSLVDNDGMWEQHIAATGEFTRLLTQTLPDG----VAAGSAE : . ** . MSMEG_4510|M.smegmatis_MC2_155 VAEQAALSVDRIDPQQGSMLDAVWLR---HPDAPGGVFILTAHVLALDPA TH_4360|M.thermoresistible__bu VAEQVDLSVRTLDPEGGRLWSAVWLR---PEQGPG-VLVWTAHVIAMDPA Mb2400c|M.bovis_AF2122/97 VAEQTLGVLASLDPQAGRLLSAVWLR---EPDGPG-VLVLTAHVLAMDPA Rv2379c|M.tuberculosis_H37Rv VAEQTLGALASLDPQAGRLLSAVWLR---EPDGPG-VLVLTAHVLAMDPA MAV_2014|M.avium_104 VADRAARAIDRLDPERGVLLGAVWLR---PADGDG-VLLLTAHVIALDPA Mflv_2697|M.gilvum_PYR-GCK VARHAAAALEHLDPQRGPLWGAVWLRGSDDADSTSSVLLLTAHVLAMDPV Mvan_3844|M.vanbaalenii_PYR-1 LAAEVVAALDRIDPTSGAMVQAVWFR-----HGPP-VLALCVHHLSTDVV MMAR_3690|M.marinum_M VAHAARVVTDQIDPSAGAMVRAIWFRGTEHRADPANILLLTAHHLAVDVV MUL_3633|M.ulcerans_Agy99 VAHAARVVTDQIDPSAGAMVRAIWFRGTEHRADPANMLLLTAHHLAVDVV MAB_2123|M.abscessus_ATCC_1997 ITNAARQAFDSLDPRSGAMMRAVWLAS----RDSGDVLLLTVHHLAMDVV MLBr_02353|M.leprae_Br4923 ERAVVSSILAELIASQSDLNEPLTAVQITTAHGGPHYLGLAVHQMVIDDA . : . . : .: : .* : * . MSMEG_4510|M.smegmatis_MC2_155 SWRIVVGELETAWHALASGREPTPVREHTSLRRWSRMLSERALKLDT--- TH_4360|M.thermoresistible__bu SWRVVLGDLDAGWHALSAGRPS---------------------------- Mb2400c|M.bovis_AF2122/97 SWRIVLGELDAGLHALAAGRAPSPARENTSYRQWSRLLAQRAKALDS--- Rv2379c|M.tuberculosis_H37Rv SWRIVLGELDAGLHALAAGRAPSPARENTSYRQWSRLLAQRAKALDS--- MAV_2014|M.avium_104 SWRVVLGELGAALTAAATGHSPAAVREHTSYRRWAHALTARAHRLDT--- Mflv_2697|M.gilvum_PYR-GCK SWQIVIGELDAGWHALAGGRAPAALGEHTGYRQWSNLLRERAESSDG--- Mvan_3844|M.vanbaalenii_PYR-1 SWYLILGALAQIDATLAAGHAPDPAAEYTTYREWTRRLYQRSRTEAVERR MMAR_3690|M.marinum_M SWHIMLGDLAAAWRSLQAGTPPKILPEFTSYRRWCELMWHRASAPQVQDQ MUL_3633|M.ulcerans_Agy99 SWHIMLGDLAAAWRSLQAGTPPKILPEFTSYRRWCELMWHRASAPQVQDQ MAB_2123|M.abscessus_ATCC_1997 SWHIVLGYLADAWIAVRSGTAPKAPMEFTSYRQWSQLMHQRASSHDVLRQ MLBr_02353|M.leprae_Br4923 SRQILGTDIITAFGQRLAGEEITLEPVTTGWREWSLRCAALATHPAALDT * :: : * MSMEG_4510|M.smegmatis_MC2_155 VDFWHRQFDGADPDIGARRVDPATDR---MRDIAVEMTFADADLTARLLT TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 VDFWVAELEGADPPLGARRVAPQTDR---VGELAITMSISDADLTARLLS Rv2379c|M.tuberculosis_H37Rv VDFWVAELEGADPPLGARRVAPQTDR---VGELAITMSISDADLTARLLS MAV_2014|M.avium_104 VGFWASELDGDDPDLGARRVDPARDR---ARDLLVRNVATDADLTRRLLE Mflv_2697|M.gilvum_PYR-GCK LQFWLDQLGGPDPALGARRVRPDTDR---AGDVRVTVTVTGADVTARLLA Mvan_3844|M.vanbaalenii_PYR-1 RGFWVEQLAGSDPLLGRRLPDPRHDT---WSTLQSTDVVTDAGATRAILD MMAR_3690|M.marinum_M RDYWAALVREPDPALGLRYPDPTRDT---WSTLQLTRAAIPVDVTERVLG MUL_3633|M.ulcerans_Agy99 RDYWAALVREPDPELGLRYPDPTRDT---WSTLQLTRAAIPVDVTERVLG MAB_2123|M.abscessus_ATCC_1997 RDYWAEQVSGADPELGSRHADPSRDT---WGTLQTTAVPTPVAVTTRLLA MLBr_02353|M.leprae_Br4923 RSFWIENANKVNLWLADVSLNTDVIQPPGADDLIRMPCTLSVEQTSELDD MSMEG_4510|M.smegmatis_MC2_155 ----GGVPVTEVLAAATARTVTAWRRERGQPTPA-PLLALETHGRADAVV TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 ----TGRSMTDLLATAAARMVTAWRRQRGQQTPA-PLLALETHGRADVHV Rv2379c|M.tuberculosis_H37Rv ----TGRSMTDLLATAAARMVTAWRRQRGQQTPA-PLLALETHGRADVHV MAV_2014|M.avium_104 ----SGLPLPTLLVAATAATVTRWRRQRGQSTPP-PLLALETHGRADSLV Mflv_2697|M.gilvum_PYR-GCK ----GPHPVLDVLVAALGRTITEWRGRRNQPTPP-PLVALETHGRA-ALA Mvan_3844|M.vanbaalenii_PYR-1 RLDGASLEVRDFLLTALTLTLASWRIERGQPAHHGALVALEGHGREDALV MMAR_3690|M.marinum_M AVR-RDQGVRELLLAATAMAVASWRRVRAQDPAAGVLVALEGHGRADAVL MUL_3633|M.ulcerans_Agy99 AVR-RDQGVRELLLAATAMAVASWRRVRAQDPAAGVLVALEGHGRADAVL MAB_2123|M.abscessus_ATCC_1997 SLN-KPEGVYSFLLSALAVTVASWRKLRGQDSTAGTLVSLEGHGRADGEL MLBr_02353|M.leprae_Br4923 ARRRFRRSIQAIVLAALGRTIAQTVGDG--------VVAVELEGEGRSVL MSMEG_4510|M.smegmatis_MC2_155 SADLGEDPHQVDTGDTAGLLSMIYPLRVTAGDA----------------- TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 DK-------TADTSDTVGLLSAIYPLRIHCDGA----------------- Rv2379c|M.tuberculosis_H37Rv DK-------TADTSDTVGLLSAIYPLRIHCDGA----------------- MAV_2014|M.avium_104 DG---PGAHTIDTGDTVGLLSSIYPIRVDAADP----------------- Mflv_2697|M.gilvum_PYR-GCK EADTADTADTADTSDTVGLLSAIYPLRLHEDSP----------------- Mvan_3844|M.vanbaalenii_PYR-1 GG-------GVDTSATVGWFTSVYPVRLGAGEAAIDVDTAARNPAAARSL MMAR_3690|M.marinum_M DT---------DTTNTVGWFTNAFPVRLGAGAAAVDIEQAERDPVAAQDL MUL_3633|M.ulcerans_Agy99 DT---------DTTNTVGWFTNAFPVRLGAGAAAVDIEQAERDPVAAQDL MAB_2123|M.abscessus_ATCC_1997 DT---------DTSGTVGWFTTVYPVRVAAGEAAIDVDRMENDVNAARQL MLBr_02353|M.leprae_Br4923 RP-------DVDVRRTIGWFTNYYPIPLVCVKGQ-----------GALAQ MSMEG_4510|M.smegmatis_MC2_155 -RGVAELVAAIPGDPIDYGLLRHLREDTAESLGVHRDPQLLLNYLGRIEL TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 -TDFAR----IPGSGIDYGLLRYLRADTAERLRAHREPQLLLNYLGSLHV Rv2379c|M.tuberculosis_H37Rv -TDFAR----IPGSGIDYGLLRYLRADTAERLRAHREPQLLLNYLGSLHV MAV_2014|M.avium_104 -RRVADKLAAIPGDGLDYGLLRYLRDDTAERLAALPSPQLLLNYLGAAHT Mflv_2697|M.gilvum_PYR-GCK -GATTELIAGVPAGGIDYGLLRYLRPDTSEVLKAHPEPQILLNYLGRTDL Mvan_3844|M.vanbaalenii_PYR-1 LRAVIQQLAEVPDKGLDYGLLRYTRRD--ETLRALPEPQVEFNYIGRYDL MMAR_3690|M.marinum_M VHSVVSHLEAIPNDGLDYGLLRY--VDGVAELVDAVDPQIQFSYLGRLDL MUL_3633|M.ulcerans_Agy99 VHSVVSHLEAIPNDGLDYGLLRY--VDGVAELVDAVDPQIQFSYLGRLDL MAB_2123|M.abscessus_ATCC_1997 LAGVARHIDEIPYQGLDYGLLRY--VRGCEELSSARDPQIQFNYVGRMDI MLBr_02353|M.leprae_Br4923 LDAVHNTLKSIPHYGIGYGLLRYMYAPTGRVFSAQRTPDIHFRYVGVVPE MSMEG_4510|M.smegmatis_MC2_155 DSAD----HALLQDRSLLSGVTPIPEPDVAVRHELTIMAAVIDRDGSAVL TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 GVG------DLAVDRALLADVGQLPEPEQPVRHELTVLAALLGPADAPVL Rv2379c|M.tuberculosis_H37Rv GVG------DLAVDRALLADVGQLPEPEQPVRHELTVLAALLGPADAPVL MAV_2014|M.avium_104 DGG-----TGLTLERELLAGLSPIPEPDLAVRHELTIAAMVLTYGGQRVL Mflv_2697|M.gilvum_PYR-GCK VPS-----GAIVADRLLLSGLSTVPEPNAAVRHELTVVAAVVAHGDEPAL Mvan_3844|M.vanbaalenii_PYR-1 SADQTSQAWSLITDETLNAHMPAAAEPDLPLRYTFDVISVISGGADGPQL MMAR_3690|M.marinum_M GGVA-DQPWSLLTG-PYLDALPIDPEPDLPLRFALNLSVFVGVTAEGTQL MUL_3633|M.ulcerans_Agy99 GGVA-DQPWSLLTG-PYLDALPIDPEPDLPLRFALNLSVFVGVTAEGTQL MAB_2123|M.abscessus_ATCC_1997 SGID-DQPWSLITD-ARSLAVPPDSEPDLPLRFAINIGSAVMTTPEGPQL MLBr_02353|M.leprae_Br4923 PPS------VDATVQFDSDMTIPVQEPVPGMGHAIELRTYRFGGSLHLDW MSMEG_4510|M.smegmatis_MC2_155 GAQWRTLPDILSAAEVGTLQTMWLDALREVVE------------------ TH_4360|M.thermoresistible__bu -------------------------------------------------- Mb2400c|M.bovis_AF2122/97 ATRWRTLPDILSADDVATLQSLWQGALAEITA------------------ Rv2379c|M.tuberculosis_H37Rv ATRWRTLPDILSADDVATLQSLWQGALAEITA------------------ MAV_2014|M.avium_104 AAQWRTLPDILTDTDITALQELWVDSLREMVT------------------ Mflv_2697|M.gilvum_PYR-GCK VAQWRVLPEILSDTDVEEMQTIWQDTLREVL------------------- Mvan_3844|M.vanbaalenii_PYR-1 RTSWRWSTALSTSTEVDRLTALWQQAVTVLGEAL---------------- MMAR_3690|M.marinum_M IGNWRWSDAVFERSDIDHLTGLWQRGIAALAAGLD--------------- MUL_3633|M.ulcerans_Agy99 IGNWRWSDAVFERSDIDHLTGLWQRGIAALAAGLD--------------- MAB_2123|M.abscessus_ATCC_1997 LTNWQLSSALFTPADASRLAQLWQRSVAALAGALDG-------------- MLBr_02353|M.leprae_Br4923 WYDIRRIPQVTAEALAQSFPVTLSKLIQEGIATQKDAHDESEMAGAPQAG MSMEG_4510|M.smegmatis_MC2_155 ----------- TH_4360|M.thermoresistible__bu ----------- Mb2400c|M.bovis_AF2122/97 ----------- Rv2379c|M.tuberculosis_H37Rv ----------- MAV_2014|M.avium_104 ----------- Mflv_2697|M.gilvum_PYR-GCK ----------- Mvan_3844|M.vanbaalenii_PYR-1 ----------- MMAR_3690|M.marinum_M ----------- MUL_3633|M.ulcerans_Agy99 ----------- MAB_2123|M.abscessus_ATCC_1997 ----------- MLBr_02353|M.leprae_Br4923 VLVDLSTLDAG