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MKWNAWGDPQAAKPLSDGIRALLQQALGVTDSPAQISPEDITLRPSALTAADRDALAAVVGEQYCRTDDT ARLLHAGGKSTLDLLRRNTSGVQDAPDAILLPGDEDAVAAILRYCTEHRIAIVPFGGGTSVVGGLDPLRG EFGAVVSLDLRRLDALHHLDEISGEAELGAGVTGPQAEELLGAHGFSLGHFPQSFQFATIGGFAATRSSG QNSAGYGRFDDMVRGLRAVTPAGVLDLGRAPASAAGPDLRQLLLGSEGVFGVITRVRVRVHPVPESTRYE AWSFPDFATGADALRAVVQTGTGPTVIRLSDEAETGVNLATTDNIGEQSITGGCLAVTVFEGSPEHTASR HAETRALLERLGGTSLGEVPARAWEHGRFGAPYLRDSLLAAGALCETLETATNWSNVAALKTAVTEALTA TLAESGTQALVLCHISHVYPTGASLYFTVVAAQRGDAAEQWRKAKTAASEAMVRNGATITHHHAVGADHR PWMTEEVGDLGVAVLRAVKATLDPAGILNPGKLIP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4334 | - | - | 100% (525) | flavoprotein |
| M. smegmatis MC2 155 | MSMEG_0374 | - | 2e-38 | 28.54% (452) | glycolate oxidase subunit |
| M. smegmatis MC2 155 | MSMEG_0301 | - | 9e-31 | 28.54% (424) | oxidoreductase, FAD-binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2275 | - | 0.0 | 76.37% (529) | flavoprotein |
| M. gilvum PYR-GCK | Mflv_2772 | - | 0.0 | 80.23% (526) | alkylglycerone-phosphate synthase |
| M. tuberculosis H37Rv | Rv2251 | - | 0.0 | 79.25% (424) | flavoprotein |
| M. leprae Br4923 | MLBr_02631 | - | 3e-27 | 24.69% (482) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3884 | - | 0.0 | 61.41% (526) | flavoprotein |
| M. marinum M | MMAR_3344 | - | 0.0 | 76.05% (526) | flavoprotein |
| M. avium 104 | MAV_2186 | - | 0.0 | 76.24% (526) | flavoprotein |
| M. thermoresistible (build 8) | TH_1507 | - | 0.0 | 78.52% (526) | flavoprotein |
| M. ulcerans Agy99 | MUL_1298 | - | 0.0 | 75.48% (526) | flavoprotein |
| M. vanbaalenii PYR-1 | Mvan_3761 | - | 0.0 | 81.18% (526) | alkylglycerone-phosphate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2772|M.gilvum_PYR-GCK ----------MMQWNAWGDPDAAKPLSPGIRSLLHQALGIDGTPLDEPTL
Mvan_3761|M.vanbaalenii_PYR-1 ----------MMQWNAWGDPAAAKPLSPAIRALLGQALGIDGADIDEPTL
MSMEG_4334|M.smegmatis_MC2_155 -----------MKWNAWGDPQAAKPLSDGIRALLQQALGVTDSP-AQISP
Mb2275|M.bovis_AF2122/97 -----------MKWDAWGDPAAAKPLSDGVRSLLKQVVGLADSEQPELDP
Rv2251|M.tuberculosis_H37Rv -----------MRWRASSAPSISAPP------------------------
MMAR_3344|M.marinum_M -----------MKWNAWGDPAAAKPLSDGIRALLKQVVGLEDSGEAELGA
MUL_1298|M.ulcerans_Agy99 -----------MKWNAWGDPAAAKPLSDGIRALLKQVVGLEDSDEAELGA
MAV_2186|M.avium_104 -MTHPERLLPPMKWNAWGDPAAAKPLSEGIRSLLQQAVGIEGSRAAEPRP
TH_1507|M.thermoresistible__bu MSAPENHLSPPMKWNAWGDPAAARPLSDGIRSLLREALGVEGPPTPDLSP
MAB_3884|M.abscessus_ATCC_1997 ----------MMEWDAWGVAEKRQTLSPQVKALLASALGIPEREPVHRDE
MLBr_02631|M.leprae_Br4923 --------------------------------------------------
Mflv_2772|M.gilvum_PYR-GCK DQVRLRPSALSPGDRDGLSAIIGAEHVTVDDRARLLRAGGKSTLDLLRRR
Mvan_3761|M.vanbaalenii_PYR-1 EQVRLRPSALSPADLDGLSAVVGAANVTTDDQARLLRAGGKSTLDLLRRR
MSMEG_4334|M.smegmatis_MC2_155 EDITLRPSALTAADRDALAAVVGEQYCRTDDTARLLHAGGKSTLDLLRRN
Mb2275|M.bovis_AF2122/97 AQVQLRPSALSGADHDALARIVGTEYFRTADRDRLLHAGGKSTPDLLRRK
Rv2251|M.tuberculosis_H37Rv ---------------------IATGCCTPAASPPQTCCGAKTPVSRMR--
MMAR_3344|M.marinum_M DQVKLRPCALSQSDQDALAKIVGPEYMRTADRDRLLRAGGKSTPDMLRRK
MUL_1298|M.ulcerans_Agy99 DQVKLRPCALSQSDQDALAKIVGPEYMRTADRDRLLRAGGKSTPDMLRRK
MAV_2186|M.avium_104 EQVRLRPSTLSPADREALAAIVGPEYCRTADSDRLLHAGGKSTIDLLSRN
TH_1507|M.thermoresistible__bu DQVRLRPSALSDADRDALAGVVGADFCRVDEHSRLLHAGGKSTLDLLRRR
MAB_3884|M.abscessus_ATCC_1997 SHVTLTPNSLTDAQRAALGGLLGAEHVSTDHGARLRHSGGKSTPDLLRRR
MLBr_02631|M.leprae_Br4923 -------------MLRSLAAVVGSSHVIADPDVLIAHSIDHTG-------
:. . ::
Mflv_2772|M.gilvum_PYR-GCK DFGVQDAPDAVLLPG---GEDEIAEVLRYCAHRSIAVVPFGGGTSVVGGV
Mvan_3761|M.vanbaalenii_PYR-1 DFGVQDAPDAIVLPG---GDRDVAEVLRFCGERSIAVVPFGGGTSVVGGL
MSMEG_4334|M.smegmatis_MC2_155 TSGVQDAPDAILLPG---DEDAVAAILRYCTEHRIAIVPFGGGTSVVGGL
Mb2275|M.bovis_AF2122/97 DTGVQDAPDAVLLPGGPNGEDAVADILHYCSDHGIAVVPFGGGTSVVGGL
Rv2251|M.tuberculosis_H37Rv -------PTRCCCPAAPTGEDAVADILHYCSDHGIAVVPFGGGTSVVGGL
MMAR_3344|M.marinum_M DTGIQDAPDAVLLPG---DDQAVAEILRYCSDQGIAIVPFGGGTNVTGGL
MUL_1298|M.ulcerans_Agy99 DTGIQDAPDAVLLPG---DDQAVAEILRYCSDQGIAIVPFGGGTNVTGAL
MAV_2186|M.avium_104 GPGPQDAPDAVLLPG---DDESVAAILRYCSQHRIAVVPFGGGTSVVGGL
TH_1507|M.thermoresistible__bu QPE-QDAPDAVVLPA---DEDQIAEILRICGSRRIAVVPFGGGTSVVGGL
MAB_3884|M.abscessus_ATCC_1997 STGVQNAPDAIVYPA---SHDEVSALLTLCEEQGIAVVPFGGGTSVVGGL
MLBr_02631|M.leprae_Br4923 --RYRGQARALVRPG---TAEQVTEVLRVCRDVGAHVTVQGGRTSLVAGT
. *. :: :* * :. ** *.:...
Mflv_2772|M.gilvum_PYR-GCK DPLRGDFKAVVSLDLRRLDELHSLDDVSWEAELGAGLTGPEAERLLGERG
Mvan_3761|M.vanbaalenii_PYR-1 DPTRGDFKAVVSLDLRRLDELHSLDEVSWEAELGAGLTGPDAERLLGERG
MSMEG_4334|M.smegmatis_MC2_155 DPLRGEFGAVVSLDLRRLDALHHLDEISGEAELGAGVTGPQAEELLGAHG
Mb2275|M.bovis_AF2122/97 DPVRNDFRAVISLDMRRFDRLHRIDEVSGEAELEAGVTGPEAERLLGEHG
Rv2251|M.tuberculosis_H37Rv DPVRNDFRAVISLDMRRFDRLHRIDEVSGEAELEAGVTGPEAERLLGEHG
MMAR_3344|M.marinum_M DPNRGQFSAVISLDLRRFNELHSLDEVSGIAELGAGVTGPDAERLLGERG
MUL_1298|M.ulcerans_Agy99 DPNRGQFSAVISLDLRRFNELHSLDEVSGIADLGAGVTGPDAERLLGERG
MAV_2186|M.avium_104 TPERAGFGAAVAVDLRRFDQLISLDPVSGLAVLGAGVTGPDAEKLLGAHG
TH_1507|M.thermoresistible__bu DPIRGEFGSVVALDLRRLNRLIWLDEVSQLAELSAGMTGPAAEETLRARG
MAB_3884|M.abscessus_ATCC_1997 DPERGAFGAVIAIDLRRMSGLLSLDEVSGTAVLLPGTTGPEAEELLGAQG
MLBr_02631|M.leprae_Br4923 VPEHN----DVLLSTERLRSISEVDTVERRLRVGAGATLTAVQNAATAAG
* : : :. .*: : :* :. : .* * . .:. *
Mflv_2772|M.gilvum_PYR-GCK FSLGHYPQSFLFATIGGFAATRSSGQDSAGYGRFNDMVRGLRAVTPAGVL
Mvan_3761|M.vanbaalenii_PYR-1 FSLGHFPQSFCFATIGGFAATRSSGQDSAGYGRFDDMVRGLRAVTPAGVL
MSMEG_4334|M.smegmatis_MC2_155 FSLGHFPQSFQFATIGGFAATRSSGQNSAGYGRFDDMVRGLRAVTPAGVL
Mb2275|M.bovis_AF2122/97 FSLGHFPQSFEFATIGGFAATRSSGQDSAGYGRFNDMILGLRMITPVGVL
Rv2251|M.tuberculosis_H37Rv FSLGHFPQSFEFATIGGFAATRSSGQDSAGYGRFNDMILGLRMITPVGVL
MMAR_3344|M.marinum_M FSLGHFPQSFEYATIGGFAATRSSGQDSAGYGRFNDMIIGLRMITPAGVL
MUL_1298|M.ulcerans_Agy99 FSLGHFPQSFEYATIGGFAATRSSGQDSAGYGRFNDMIIGLRMITPAGVL
MAV_2186|M.avium_104 FSLGHFPQSFEYATIGGFAATRSSGQDSAGYGRFNDMVRGLRVITPVGTM
TH_1507|M.thermoresistible__bu FSLGHFPQSFEFASIGGFAATRSSGQNSAGYGRFNDMVRGVRAITPTGVL
MAB_3884|M.abscessus_ATCC_1997 FSLGHFPQSFRFASIGGFAATRSSGQASSGYGRFDAMVDAVRIATPRGDL
MLBr_02631|M.leprae_Br4923 LVFGVDLCARATATVGGMASTNAGGLRTVRYGNMGEQVIGLEVALPDGSL
: :* : *::**:*:*.:.* : **.:. : .:. * * :
Mflv_2772|M.gilvum_PYR-GCK DLGRAPE--SAAGPDLRQLLIGSEGAFGIITRVRVRVHPVPEVTRYEAWS
Mvan_3761|M.vanbaalenii_PYR-1 DLGRAPA--SAAGPDLRQLLLGSEGTFGIITRVRVRVHPVPEATRYEAWS
MSMEG_4334|M.smegmatis_MC2_155 DLGRAPA--SAAGPDLRQLLLGSEGVFGVITRVRVRVHPVPESTRYEAWS
Mb2275|M.bovis_AF2122/97 DLGRVPA--SAAGPDLRQLAIGSEGVFGVITRVRLRVHRIPESTRYEAWS
Rv2251|M.tuberculosis_H37Rv DLGRVPA--SAAGPDLRQLAIGSEGVFGVITRVRLRVHRIPESTRYEAWS
MMAR_3344|M.marinum_M DLGRVAA--SAAGPDLRQLAIGSEGVFGVITKVRLRVHPVPETTRYEAWS
MUL_1298|M.ulcerans_Agy99 DLGRVAA--SAAGPDLRQLAIGSEGVFGVITKVRLRVHPVPETTRYEAWS
MAV_2186|M.avium_104 DLGRGPE--SAAGPDLRQLLIGSEGTLGVITRVRLRVHRIPQAVRYEAWS
TH_1507|M.thermoresistible__bu DLGRAPE--SAAGPDLRHLLIGSEGVFGVITRVRVRVRPVPEAVRYEAWS
MAB_3884|M.abscessus_ATCC_1997 NLGRAPA--SAAGPDLRQLFLGSEGALGIITEVTLRVHRLPEETWYQGWS
MLBr_02631|M.leprae_Br4923 LCRHSLARFDNTGYNLPALFVGAEGTLGVITALDLRLHPAPAHRVTAVCG
: . :* :* * :*:**.:*:** : :*:: * .
Mflv_2772|M.gilvum_PYR-GCK FPDFATGADALRAVVQTGTGPTVIRLSDEAETGVNLATTENIGEQKITGG
Mvan_3761|M.vanbaalenii_PYR-1 FPDFATGADALRAVAQTGTGPTVIRLSDEAETGVNLATTESIGEQQVTGG
MSMEG_4334|M.smegmatis_MC2_155 FPDFATGADALRAVVQTGTGPTVIRLSDEAETGVNLATTDNIGEQSITGG
Mb2275|M.bovis_AF2122/97 FPDFATGVAALRTITQTGTGPTVVRLSDEAETGVNLATTEAIGETQITGG
Rv2251|M.tuberculosis_H37Rv FPDFATGVAALRTITQTGTGPTVVRLSDEAETGVNLATTEAIGETQITGG
MMAR_3344|M.marinum_M FPDFSTGVAALRAITQTGTGPTVVRLSDEAETGINLATHESIGENQVTGG
MUL_1298|M.ulcerans_Agy99 FPDFSTGVAALRAITQTGTGPTVVRLSDEAETGINLATHESIGENQVTGG
MAV_2186|M.avium_104 FPDFETGAAALRAVTQNGTGPTVIRLSDEAETGVNLATTEAIGESRITGG
TH_1507|M.thermoresistible__bu FPDFATGTAALRAVTQIGTGPTVIRLSDEAETGVNLATTDNIGDQSITGG
MAB_3884|M.abscessus_ATCC_1997 FPSFEAGAQALRTLVQSDAAPTVLRLSDEAESGLNLALAKDIGGKNPAAG
MLBr_02631|M.leprae_Br4923 FSDLGALVDASRAFRDVYGIAALELIDGRASS----LIREHLGVSSPVDG
*..: : . * *:. : .:: :...*.: . :* . *
Mflv_2772|M.gilvum_PYR-GCK CLAITAFEGTEAHVASRHAETRDLLAAKGGTSLGEAPAKAWEHGRFNAPY
Mvan_3761|M.vanbaalenii_PYR-1 CLAITAFEGTEAHVASRHAETRDLLAASGGTSLGEGPARAWEHGRFNAPY
MSMEG_4334|M.smegmatis_MC2_155 CLAVTVFEGSPEHTASRHAETRALLERLGGTSLGEVPARAWEHGRFGAPY
Mb2275|M.bovis_AF2122/97 CLGITVFEGTQEHTESRHAETRALLAARGGTSLGEGPARAWERGRFAAPY
Rv2251|M.tuberculosis_H37Rv CLGITVFEGTQEHTESRHAETRALLAARGGTSLGEGPARAWERGRFAAPY
MMAR_3344|M.marinum_M CLGLTLFEGTKEHTESRHAETRASLEAHGGKSLGEGPAQSWEHGRFSAPY
MUL_1298|M.ulcerans_Agy99 CLGLTLFEGTKEHTESRHAETRASLEAHGGKSLGEGPAQGWEHGRFSAPY
MAV_2186|M.avium_104 CLCITMFEGTEQHVDSRHAETRALLAAQGGTSLGDGPARAWERGRFGAPY
TH_1507|M.thermoresistible__bu CLAITVFEGTAAHAESRHAETAAVLAAHGGTSLGEEPARAWEHGRFSAPY
MAB_3884|M.abscessus_ATCC_1997 VLAITTVEGTHGHVAARSAEVAAVLSAAGGTALGDEPAKAWDHGRFDAPY
MLBr_02631|M.leprae_Br4923 DWLLLVELAADHDQTNRLAELSMAVQMCGVPAVG--VDAGAQQRLWRVRE
: .: . * ** : * ::* . :: : .
Mflv_2772|M.gilvum_PYR-GCK LRDALLSAGALCETLETATNWSNVAALKAAVTEALTRSLEDSGTPALVLC
Mvan_3761|M.vanbaalenii_PYR-1 LRDALLSAGALCETLETATNWSNVAALKAAVTEALTGSLAESGTPALVLC
MSMEG_4334|M.smegmatis_MC2_155 LRDSLLAAGALCETLETATNWSNVAALKTAVTEALTATLAESGTQALVLC
Mb2275|M.bovis_AF2122/97 LRDSLLAAGALCETLETATVWSNTPVLKAAVTEALTTSLAASGTPALVMC
Rv2251|M.tuberculosis_H37Rv LRDSLLAAGALCETLETATVWSNTPVLKAAVTEALTTSLAASGTPALVMC
MMAR_3344|M.marinum_M LRDSLLAAGALCETLETATDWSNIAAVKAAVTEALTTSLAESGTPALVMC
MUL_1298|M.ulcerans_Agy99 LRDSLLAASALCETLETATDWSNIAAVKAAVTEALTTSLAESGTPALVMC
MAV_2186|M.avium_104 LRDSLLAAGALCETLETATDWSNISALKAAVTQALTTALAQTGTPALVMC
TH_1507|M.thermoresistible__bu LRDSLLSAGALCETLETATTWSNIPTLKAAVTDALTSTLGESGTSALVMC
MAB_3884|M.abscessus_ATCC_1997 LRDALIDAGAVVETLETATSWQNLANLRTAVTTALAETLGAQGTPPLVLC
MLBr_02631|M.leprae_Br4923 SLAEVLGVYGPPLKFDVSLPLSAISGFAKEAATLIDAQVSDVQEALPVLF
:: . . .::.: . . . .: : : *:
Mflv_2772|M.gilvum_PYR-GCK HISHVYPTGASLYFTVVAAQRGNPIEQWRKAKAAASDAMVRTGATITHHH
Mvan_3761|M.vanbaalenii_PYR-1 HISHVYPTGASLYFTVVAAQRGNPIEQWRNAKAAASEAMLRSGATITHHH
MSMEG_4334|M.smegmatis_MC2_155 HISHVYPTGASLYFTVVAAQRGDAAEQWRKAKTAASEAMVRNGATITHHH
Mb2275|M.bovis_AF2122/97 HVSHVYPTGASLYFTVVAGQRGDPIEQWLAAKKAASDAIMATGGTITHHH
Rv2251|M.tuberculosis_H37Rv HVSHVYPTGASLYFTVVAGQRGDPIEQWLAAKKAASDAIMATGGTITHHH
MMAR_3344|M.marinum_M HVSHVYPTGASLYFTVVAGQRGNPIEQWMAAKKAASDAMMATGATITHHH
MUL_1298|M.ulcerans_Agy99 HVSHVYPTGASLYFTVVAGQRGNPIEQWMAAKKAASDAMMATGATITHHH
MAV_2186|M.avium_104 HISHVYPTGASLYFTVVAGQRGDPIEQWKTAKKAASDAIMATGGTITHHH
TH_1507|M.thermoresistible__bu HISHVYPTGASLYFTVVAAQRGNPIEQWRTAKAAASDAMMRHGGTITHHH
MAB_3884|M.abscessus_ATCC_1997 HISHTYRTGASLYFTVVCAAAEDALTQWGRAKQAAGDAIVAAGGTITHHH
MLBr_02631|M.leprae_Br4923 G----HVGEGNLHLNVLR----CPPDREKTLTAAMMELIAQAGGNVSSEH
: ..*::.*: . : . * : : *..:: .*
Mflv_2772|M.gilvum_PYR-GCK AVGADHRPWMTDEVGGLGVSVLRAVKSVLDPAGILNPGKLIP---
Mvan_3761|M.vanbaalenii_PYR-1 AVGADHRPWMRDEIGDLGVTVLRAVKEALDPAGILNPGKLIP---
MSMEG_4334|M.smegmatis_MC2_155 AVGADHRPWMTEEVGDLGVAVLRAVKATLDPAGILNPGKLIP---
Mb2275|M.bovis_AF2122/97 AVGSDHRPWMRAEVGDLGVTLLRTIKATLDPAGILNPGKLIP---
Rv2251|M.tuberculosis_H37Rv AVGSDHRPWMRAEVGDLGVTLLRTIKATLDPAGILNPGKLIP---
MMAR_3344|M.marinum_M AVGADHRPWMRDEVGDLGVQLLRAVKATLDPAGILNPGKLIP---
MUL_1298|M.ulcerans_Agy99 AVGADHRPWMRDEVGDLGVQLLRAVKATLDPAGILNPGKLIP---
MAV_2186|M.avium_104 AVGTDHRPWMPEEIGELGVQVLRAVKDTLDPAGILNPGKLIP---
TH_1507|M.thermoresistible__bu AVGADHRPWMRDEVGGLGVDILRAVKATLDPAGILNPGKLIP---
MAB_3884|M.abscessus_ATCC_1997 AVGRDHQPWLADEVGELGIEILQAVKRTVDPRGILNPGKLIPVQG
MLBr_02631|M.leprae_Br4923 GVGSNKRAYLRMSRDPADIAAMRTIKAALDPTGYLNAAVLFD---
.** :::.:: . . .: ::::* .:** * **.. *: