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MRWRASSAPSISAPPIATGCCTPAASPPQTCCGAKTPVSRMRPTRCCCPAAPTGEDAVADILHYCSDHGI AVVPFGGGTSVVGGLDPVRNDFRAVISLDMRRFDRLHRIDEVSGEAELEAGVTGPEAERLLGEHGFSLGH FPQSFEFATIGGFAATRSSGQDSAGYGRFNDMILGLRMITPVGVLDLGRVPASAAGPDLRQLAIGSEGVF GVITRVRLRVHRIPESTRYEAWSFPDFATGVAALRTITQTGTGPTVVRLSDEAETGVNLATTEAIGETQI TGGCLGITVFEGTQEHTESRHAETRALLAARGGTSLGEGPARAWERGRFAAPYLRDSLLAAGALCETLET ATVWSNTPVLKAAVTEALTTSLAASGTPALVMCHVSHVYPTGASLYFTVVAGQRGDPIEQWLAAKKAASD AIMATGGTITHHHAVGSDHRPWMRAEVGDLGVTLLRTIKATLDPAGILNPGKLIP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2251 | - | - | 100% (475) | POSSIBLE FLAVOPROTEIN |
| M. tuberculosis H37Rv | Rv3107c | agpS | 2e-82 | 39.73% (438) | alkyldihydroxyacetonephosphate synthase AgpS |
| M. tuberculosis H37Rv | Rv2280 | - | 3e-23 | 25.39% (449) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2275 | - | 0.0 | 98.15% (433) | flavoprotein |
| M. gilvum PYR-GCK | Mflv_2772 | - | 0.0 | 78.30% (424) | alkylglycerone-phosphate synthase |
| M. leprae Br4923 | MLBr_02631 | - | 2e-23 | 26.67% (435) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3884 | - | 1e-153 | 62.50% (424) | flavoprotein |
| M. marinum M | MMAR_3344 | - | 0.0 | 84.91% (424) | flavoprotein |
| M. avium 104 | MAV_2186 | - | 0.0 | 76.36% (461) | flavoprotein |
| M. smegmatis MC2 155 | MSMEG_4334 | - | 0.0 | 79.25% (424) | flavoprotein |
| M. thermoresistible (build 8) | TH_1507 | - | 0.0 | 77.12% (424) | flavoprotein |
| M. ulcerans Agy99 | MUL_1298 | - | 0.0 | 84.20% (424) | flavoprotein |
| M. vanbaalenii PYR-1 | Mvan_3761 | - | 0.0 | 78.77% (424) | alkylglycerone-phosphate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2251|M.tuberculosis_H37Rv -----------MRWRASSAPSISAPP------------------------
Mb2275|M.bovis_AF2122/97 -----------MKWDAWGDPAAAKPLSDGVRSLLKQVVGLADSEQPELDP
MMAR_3344|M.marinum_M -----------MKWNAWGDPAAAKPLSDGIRALLKQVVGLEDSGEAELGA
MUL_1298|M.ulcerans_Agy99 -----------MKWNAWGDPAAAKPLSDGIRALLKQVVGLEDSDEAELGA
MAV_2186|M.avium_104 -MTHPERLLPPMKWNAWGDPAAAKPLSEGIRSLLQQAVGIEGSRAAEPRP
Mflv_2772|M.gilvum_PYR-GCK ----------MMQWNAWGDPDAAKPLSPGIRSLLHQALGIDGTPLDEPTL
Mvan_3761|M.vanbaalenii_PYR-1 ----------MMQWNAWGDPAAAKPLSPAIRALLGQALGIDGADIDEPTL
MSMEG_4334|M.smegmatis_MC2_155 -----------MKWNAWGDPQAAKPLSDGIRALLQQALGVTDSP-AQISP
TH_1507|M.thermoresistible__bu MSAPENHLSPPMKWNAWGDPAAARPLSDGIRSLLREALGVEGPPTPDLSP
MAB_3884|M.abscessus_ATCC_1997 ----------MMEWDAWGVAEKRQTLSPQVKALLASALGIPEREPVHRDE
MLBr_02631|M.leprae_Br4923 --------------------------------------------------
Rv2251|M.tuberculosis_H37Rv ---------------------IATGCCTPAASPPQTCCGAKTPVSRMR--
Mb2275|M.bovis_AF2122/97 AQVQLRPSALSGADHDALARIVGTEYFRTADRDRLLHAGGKSTPDLLRRK
MMAR_3344|M.marinum_M DQVKLRPCALSQSDQDALAKIVGPEYMRTADRDRLLRAGGKSTPDMLRRK
MUL_1298|M.ulcerans_Agy99 DQVKLRPCALSQSDQDALAKIVGPEYMRTADRDRLLRAGGKSTPDMLRRK
MAV_2186|M.avium_104 EQVRLRPSTLSPADREALAAIVGPEYCRTADSDRLLHAGGKSTIDLLSRN
Mflv_2772|M.gilvum_PYR-GCK DQVRLRPSALSPGDRDGLSAIIGAEHVTVDDRARLLRAGGKSTLDLLRRR
Mvan_3761|M.vanbaalenii_PYR-1 EQVRLRPSALSPADLDGLSAVVGAANVTTDDQARLLRAGGKSTLDLLRRR
MSMEG_4334|M.smegmatis_MC2_155 EDITLRPSALTAADRDALAAVVGEQYCRTDDTARLLHAGGKSTLDLLRRN
TH_1507|M.thermoresistible__bu DQVRLRPSALSDADRDALAGVVGADFCRVDEHSRLLHAGGKSTLDLLRRR
MAB_3884|M.abscessus_ATCC_1997 SHVTLTPNSLTDAQRAALGGLLGAEHVSTDHGARLRHSGGKSTPDLLRRR
MLBr_02631|M.leprae_Br4923 -------------MLRSLAAVVGSSHVIADPDVLIAHSIDHTG-------
:. . ::
Rv2251|M.tuberculosis_H37Rv -------PTRCCCPAAPTGEDAVADILHYCSDHGIAVVPFGGGTSVVGGL
Mb2275|M.bovis_AF2122/97 DTGVQDAPDAVLLPGGPNGEDAVADILHYCSDHGIAVVPFGGGTSVVGGL
MMAR_3344|M.marinum_M DTGIQDAPDAVLLPG---DDQAVAEILRYCSDQGIAIVPFGGGTNVTGGL
MUL_1298|M.ulcerans_Agy99 DTGIQDAPDAVLLPG---DDQAVAEILRYCSDQGIAIVPFGGGTNVTGAL
MAV_2186|M.avium_104 GPGPQDAPDAVLLPG---DDESVAAILRYCSQHRIAVVPFGGGTSVVGGL
Mflv_2772|M.gilvum_PYR-GCK DFGVQDAPDAVLLPG---GEDEIAEVLRYCAHRSIAVVPFGGGTSVVGGV
Mvan_3761|M.vanbaalenii_PYR-1 DFGVQDAPDAIVLPG---GDRDVAEVLRFCGERSIAVVPFGGGTSVVGGL
MSMEG_4334|M.smegmatis_MC2_155 TSGVQDAPDAILLPG---DEDAVAAILRYCTEHRIAIVPFGGGTSVVGGL
TH_1507|M.thermoresistible__bu QPE-QDAPDAVVLPA---DEDQIAEILRICGSRRIAVVPFGGGTSVVGGL
MAB_3884|M.abscessus_ATCC_1997 STGVQNAPDAIVYPA---SHDEVSALLTLCEEQGIAVVPFGGGTSVVGGL
MLBr_02631|M.leprae_Br4923 --RYRGQARALVRPG---TAEQVTEVLRVCRDVGAHVTVQGGRTSLVAGT
. *. :: :* * :. ** *.:...
Rv2251|M.tuberculosis_H37Rv DPVRNDFRAVISLDMRRFDRLHRIDEVSGEAELEAGVTGPEAERLLGEHG
Mb2275|M.bovis_AF2122/97 DPVRNDFRAVISLDMRRFDRLHRIDEVSGEAELEAGVTGPEAERLLGEHG
MMAR_3344|M.marinum_M DPNRGQFSAVISLDLRRFNELHSLDEVSGIAELGAGVTGPDAERLLGERG
MUL_1298|M.ulcerans_Agy99 DPNRGQFSAVISLDLRRFNELHSLDEVSGIADLGAGVTGPDAERLLGERG
MAV_2186|M.avium_104 TPERAGFGAAVAVDLRRFDQLISLDPVSGLAVLGAGVTGPDAEKLLGAHG
Mflv_2772|M.gilvum_PYR-GCK DPLRGDFKAVVSLDLRRLDELHSLDDVSWEAELGAGLTGPEAERLLGERG
Mvan_3761|M.vanbaalenii_PYR-1 DPTRGDFKAVVSLDLRRLDELHSLDEVSWEAELGAGLTGPDAERLLGERG
MSMEG_4334|M.smegmatis_MC2_155 DPLRGEFGAVVSLDLRRLDALHHLDEISGEAELGAGVTGPQAEELLGAHG
TH_1507|M.thermoresistible__bu DPIRGEFGSVVALDLRRLNRLIWLDEVSQLAELSAGMTGPAAEETLRARG
MAB_3884|M.abscessus_ATCC_1997 DPERGAFGAVIAIDLRRMSGLLSLDEVSGTAVLLPGTTGPEAEELLGAQG
MLBr_02631|M.leprae_Br4923 VPEHN----DVLLSTERLRSISEVDTVERRLRVGAGATLTAVQNAATAAG
* : : :. .*: : :* :. : .* * . .:. *
Rv2251|M.tuberculosis_H37Rv FSLGHFPQSFEFATIGGFAATRSSGQDSAGYGRFNDMILGLRMITPVGVL
Mb2275|M.bovis_AF2122/97 FSLGHFPQSFEFATIGGFAATRSSGQDSAGYGRFNDMILGLRMITPVGVL
MMAR_3344|M.marinum_M FSLGHFPQSFEYATIGGFAATRSSGQDSAGYGRFNDMIIGLRMITPAGVL
MUL_1298|M.ulcerans_Agy99 FSLGHFPQSFEYATIGGFAATRSSGQDSAGYGRFNDMIIGLRMITPAGVL
MAV_2186|M.avium_104 FSLGHFPQSFEYATIGGFAATRSSGQDSAGYGRFNDMVRGLRVITPVGTM
Mflv_2772|M.gilvum_PYR-GCK FSLGHYPQSFLFATIGGFAATRSSGQDSAGYGRFNDMVRGLRAVTPAGVL
Mvan_3761|M.vanbaalenii_PYR-1 FSLGHFPQSFCFATIGGFAATRSSGQDSAGYGRFDDMVRGLRAVTPAGVL
MSMEG_4334|M.smegmatis_MC2_155 FSLGHFPQSFQFATIGGFAATRSSGQNSAGYGRFDDMVRGLRAVTPAGVL
TH_1507|M.thermoresistible__bu FSLGHFPQSFEFASIGGFAATRSSGQNSAGYGRFNDMVRGVRAITPTGVL
MAB_3884|M.abscessus_ATCC_1997 FSLGHFPQSFRFASIGGFAATRSSGQASSGYGRFDAMVDAVRIATPRGDL
MLBr_02631|M.leprae_Br4923 LVFGVDLCARATATVGGMASTNAGGLRTVRYGNMGEQVIGLEVALPDGSL
: :* : *::**:*:*.:.* : **.:. : .:. * * :
Rv2251|M.tuberculosis_H37Rv DLGRVPA--SAAGPDLRQLAIGSEGVFGVITRVRLRVHRIPESTRYEAWS
Mb2275|M.bovis_AF2122/97 DLGRVPA--SAAGPDLRQLAIGSEGVFGVITRVRLRVHRIPESTRYEAWS
MMAR_3344|M.marinum_M DLGRVAA--SAAGPDLRQLAIGSEGVFGVITKVRLRVHPVPETTRYEAWS
MUL_1298|M.ulcerans_Agy99 DLGRVAA--SAAGPDLRQLAIGSEGVFGVITKVRLRVHPVPETTRYEAWS
MAV_2186|M.avium_104 DLGRGPE--SAAGPDLRQLLIGSEGTLGVITRVRLRVHRIPQAVRYEAWS
Mflv_2772|M.gilvum_PYR-GCK DLGRAPE--SAAGPDLRQLLIGSEGAFGIITRVRVRVHPVPEVTRYEAWS
Mvan_3761|M.vanbaalenii_PYR-1 DLGRAPA--SAAGPDLRQLLLGSEGTFGIITRVRVRVHPVPEATRYEAWS
MSMEG_4334|M.smegmatis_MC2_155 DLGRAPA--SAAGPDLRQLLLGSEGVFGVITRVRVRVHPVPESTRYEAWS
TH_1507|M.thermoresistible__bu DLGRAPE--SAAGPDLRHLLIGSEGVFGVITRVRVRVRPVPEAVRYEAWS
MAB_3884|M.abscessus_ATCC_1997 NLGRAPA--SAAGPDLRQLFLGSEGALGIITEVTLRVHRLPEETWYQGWS
MLBr_02631|M.leprae_Br4923 LCRHSLARFDNTGYNLPALFVGAEGTLGVITALDLRLHPAPAHRVTAVCG
: . :* :* * :*:**.:*:** : :*:: * .
Rv2251|M.tuberculosis_H37Rv FPDFATGVAALRTITQTGTGPTVVRLSDEAETGVNLATTEAIGETQITGG
Mb2275|M.bovis_AF2122/97 FPDFATGVAALRTITQTGTGPTVVRLSDEAETGVNLATTEAIGETQITGG
MMAR_3344|M.marinum_M FPDFSTGVAALRAITQTGTGPTVVRLSDEAETGINLATHESIGENQVTGG
MUL_1298|M.ulcerans_Agy99 FPDFSTGVAALRAITQTGTGPTVVRLSDEAETGINLATHESIGENQVTGG
MAV_2186|M.avium_104 FPDFETGAAALRAVTQNGTGPTVIRLSDEAETGVNLATTEAIGESRITGG
Mflv_2772|M.gilvum_PYR-GCK FPDFATGADALRAVVQTGTGPTVIRLSDEAETGVNLATTENIGEQKITGG
Mvan_3761|M.vanbaalenii_PYR-1 FPDFATGADALRAVAQTGTGPTVIRLSDEAETGVNLATTESIGEQQVTGG
MSMEG_4334|M.smegmatis_MC2_155 FPDFATGADALRAVVQTGTGPTVIRLSDEAETGVNLATTDNIGEQSITGG
TH_1507|M.thermoresistible__bu FPDFATGTAALRAVTQIGTGPTVIRLSDEAETGVNLATTDNIGDQSITGG
MAB_3884|M.abscessus_ATCC_1997 FPSFEAGAQALRTLVQSDAAPTVLRLSDEAESGLNLALAKDIGGKNPAAG
MLBr_02631|M.leprae_Br4923 FSDLGALVDASRAFRDVYGIAALELIDGRASS----LIREHLGVSSPVDG
*..: : . * *:. : .:: :...*.: . :* . *
Rv2251|M.tuberculosis_H37Rv CLGITVFEGTQEHTESRHAETRALLAARGGTSLGEGPARAWERGRFAAPY
Mb2275|M.bovis_AF2122/97 CLGITVFEGTQEHTESRHAETRALLAARGGTSLGEGPARAWERGRFAAPY
MMAR_3344|M.marinum_M CLGLTLFEGTKEHTESRHAETRASLEAHGGKSLGEGPAQSWEHGRFSAPY
MUL_1298|M.ulcerans_Agy99 CLGLTLFEGTKEHTESRHAETRASLEAHGGKSLGEGPAQGWEHGRFSAPY
MAV_2186|M.avium_104 CLCITMFEGTEQHVDSRHAETRALLAAQGGTSLGDGPARAWERGRFGAPY
Mflv_2772|M.gilvum_PYR-GCK CLAITAFEGTEAHVASRHAETRDLLAAKGGTSLGEAPAKAWEHGRFNAPY
Mvan_3761|M.vanbaalenii_PYR-1 CLAITAFEGTEAHVASRHAETRDLLAASGGTSLGEGPARAWEHGRFNAPY
MSMEG_4334|M.smegmatis_MC2_155 CLAVTVFEGSPEHTASRHAETRALLERLGGTSLGEVPARAWEHGRFGAPY
TH_1507|M.thermoresistible__bu CLAITVFEGTAAHAESRHAETAAVLAAHGGTSLGEEPARAWEHGRFSAPY
MAB_3884|M.abscessus_ATCC_1997 VLAITTVEGTHGHVAARSAEVAAVLSAAGGTALGDEPAKAWDHGRFDAPY
MLBr_02631|M.leprae_Br4923 DWLLLVELAADHDQTNRLAELSMAVQMCGVPAVG--VDAGAQQRLWRVRE
: .: . * ** : * ::* . :: : .
Rv2251|M.tuberculosis_H37Rv LRDSLLAAGALCETLETATVWSNTPVLKAAVTEALTTSLAASGTPALVMC
Mb2275|M.bovis_AF2122/97 LRDSLLAAGALCETLETATVWSNTPVLKAAVTEALTTSLAASGTPALVMC
MMAR_3344|M.marinum_M LRDSLLAAGALCETLETATDWSNIAAVKAAVTEALTTSLAESGTPALVMC
MUL_1298|M.ulcerans_Agy99 LRDSLLAASALCETLETATDWSNIAAVKAAVTEALTTSLAESGTPALVMC
MAV_2186|M.avium_104 LRDSLLAAGALCETLETATDWSNISALKAAVTQALTTALAQTGTPALVMC
Mflv_2772|M.gilvum_PYR-GCK LRDALLSAGALCETLETATNWSNVAALKAAVTEALTRSLEDSGTPALVLC
Mvan_3761|M.vanbaalenii_PYR-1 LRDALLSAGALCETLETATNWSNVAALKAAVTEALTGSLAESGTPALVLC
MSMEG_4334|M.smegmatis_MC2_155 LRDSLLAAGALCETLETATNWSNVAALKTAVTEALTATLAESGTQALVLC
TH_1507|M.thermoresistible__bu LRDSLLSAGALCETLETATTWSNIPTLKAAVTDALTSTLGESGTSALVMC
MAB_3884|M.abscessus_ATCC_1997 LRDALIDAGAVVETLETATSWQNLANLRTAVTTALAETLGAQGTPPLVLC
MLBr_02631|M.leprae_Br4923 SLAEVLGVYGPPLKFDVSLPLSAISGFAKEAATLIDAQVSDVQEALPVLF
:: . . .::.: . . . .: : : *:
Rv2251|M.tuberculosis_H37Rv HVSHVYPTGASLYFTVVAGQRGDPIEQWLAAKKAASDAIMATGGTITHHH
Mb2275|M.bovis_AF2122/97 HVSHVYPTGASLYFTVVAGQRGDPIEQWLAAKKAASDAIMATGGTITHHH
MMAR_3344|M.marinum_M HVSHVYPTGASLYFTVVAGQRGNPIEQWMAAKKAASDAMMATGATITHHH
MUL_1298|M.ulcerans_Agy99 HVSHVYPTGASLYFTVVAGQRGNPIEQWMAAKKAASDAMMATGATITHHH
MAV_2186|M.avium_104 HISHVYPTGASLYFTVVAGQRGDPIEQWKTAKKAASDAIMATGGTITHHH
Mflv_2772|M.gilvum_PYR-GCK HISHVYPTGASLYFTVVAAQRGNPIEQWRKAKAAASDAMVRTGATITHHH
Mvan_3761|M.vanbaalenii_PYR-1 HISHVYPTGASLYFTVVAAQRGNPIEQWRNAKAAASEAMLRSGATITHHH
MSMEG_4334|M.smegmatis_MC2_155 HISHVYPTGASLYFTVVAAQRGDAAEQWRKAKTAASEAMVRNGATITHHH
TH_1507|M.thermoresistible__bu HISHVYPTGASLYFTVVAAQRGNPIEQWRTAKAAASDAMMRHGGTITHHH
MAB_3884|M.abscessus_ATCC_1997 HISHTYRTGASLYFTVVCAAAEDALTQWGRAKQAAGDAIVAAGGTITHHH
MLBr_02631|M.leprae_Br4923 G----HVGEGNLHLNVLR----CPPDREKTLTAAMMELIAQAGGNVSSEH
: ..*::.*: . : . * : : *..:: .*
Rv2251|M.tuberculosis_H37Rv AVGSDHRPWMRAEVGDLGVTLLRTIKATLDPAGILNPGKLIP---
Mb2275|M.bovis_AF2122/97 AVGSDHRPWMRAEVGDLGVTLLRTIKATLDPAGILNPGKLIP---
MMAR_3344|M.marinum_M AVGADHRPWMRDEVGDLGVQLLRAVKATLDPAGILNPGKLIP---
MUL_1298|M.ulcerans_Agy99 AVGADHRPWMRDEVGDLGVQLLRAVKATLDPAGILNPGKLIP---
MAV_2186|M.avium_104 AVGTDHRPWMPEEIGELGVQVLRAVKDTLDPAGILNPGKLIP---
Mflv_2772|M.gilvum_PYR-GCK AVGADHRPWMTDEVGGLGVSVLRAVKSVLDPAGILNPGKLIP---
Mvan_3761|M.vanbaalenii_PYR-1 AVGADHRPWMRDEIGDLGVTVLRAVKEALDPAGILNPGKLIP---
MSMEG_4334|M.smegmatis_MC2_155 AVGADHRPWMTEEVGDLGVAVLRAVKATLDPAGILNPGKLIP---
TH_1507|M.thermoresistible__bu AVGADHRPWMRDEVGGLGVDILRAVKATLDPAGILNPGKLIP---
MAB_3884|M.abscessus_ATCC_1997 AVGRDHQPWLADEVGELGIEILQAVKRTVDPRGILNPGKLIPVQG
MLBr_02631|M.leprae_Br4923 GVGSNKRAYLRMSRDPADIAAMRTIKAALDPTGYLNAAVLFD---
.** :::.:: . . .: ::::* .:** * **.. *: