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THPERLLPPMKWNAWGDPAAAKPLSEGIRSLLQQAVGIEGSRAAEPRPEQVRLRPSTLSPADREALAAIV GPEYCRTADSDRLLHAGGKSTIDLLSRNGPGPQDAPDAVLLPGDDESVAAILRYCSQHRIAVVPFGGGTS VVGGLTPERAGFGAAVAVDLRRFDQLISLDPVSGLAVLGAGVTGPDAEKLLGAHGFSLGHFPQSFEYATI GGFAATRSSGQDSAGYGRFNDMVRGLRVITPVGTMDLGRGPESAAGPDLRQLLIGSEGTLGVITRVRLRV HRIPQAVRYEAWSFPDFETGAAALRAVTQNGTGPTVIRLSDEAETGVNLATTEAIGESRITGGCLCITMF EGTEQHVDSRHAETRALLAAQGGTSLGDGPARAWERGRFGAPYLRDSLLAAGALCETLETATDWSNISAL KAAVTQALTTALAQTGTPALVMCHISHVYPTGASLYFTVVAGQRGDPIEQWKTAKKAASDAIMATGGTIT HHHAVGTDHRPWMPEEIGELGVQVLRAVKDTLDPAGILNPGKLIP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2186 | - | - | 100% (536) | flavoprotein |
| M. avium 104 | MAV_1405 | - | 5e-30 | 28.74% (435) | oxidoreductase, FAD-binding |
| M. avium 104 | MAV_5135 | - | 4e-25 | 25.56% (446) | FAD linked oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2275 | - | 0.0 | 78.64% (529) | flavoprotein |
| M. gilvum PYR-GCK | Mflv_2772 | - | 0.0 | 75.10% (526) | alkylglycerone-phosphate synthase |
| M. tuberculosis H37Rv | Rv2251 | - | 0.0 | 76.36% (461) | flavoprotein |
| M. leprae Br4923 | MLBr_01103 | - | 2e-28 | 26.67% (435) | putative oxidoreductase subunit |
| M. abscessus ATCC 19977 | MAB_3884 | - | 1e-180 | 58.94% (526) | flavoprotein |
| M. marinum M | MMAR_3344 | - | 0.0 | 77.00% (526) | flavoprotein |
| M. smegmatis MC2 155 | MSMEG_4334 | - | 0.0 | 76.24% (526) | flavoprotein |
| M. thermoresistible (build 8) | TH_1507 | - | 0.0 | 75.05% (537) | flavoprotein |
| M. ulcerans Agy99 | MUL_1298 | - | 0.0 | 76.62% (526) | flavoprotein |
| M. vanbaalenii PYR-1 | Mvan_3761 | - | 0.0 | 75.48% (526) | alkylglycerone-phosphate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2275|M.bovis_AF2122/97 -----------MKWDAWGDPAAAKPLSDGVRSLLKQVVGLADSEQPELDP
Rv2251|M.tuberculosis_H37Rv -----------MRWRASSAPSISAPP------------------------
MMAR_3344|M.marinum_M -----------MKWNAWGDPAAAKPLSDGIRALLKQVVGLEDSGEAELGA
MUL_1298|M.ulcerans_Agy99 -----------MKWNAWGDPAAAKPLSDGIRALLKQVVGLEDSDEAELGA
MAV_2186|M.avium_104 -MTHPERLLPPMKWNAWGDPAAAKPLSEGIRSLLQQAVGIEGSRAAEPRP
Mflv_2772|M.gilvum_PYR-GCK ----------MMQWNAWGDPDAAKPLSPGIRSLLHQALGIDGTPLDEPTL
Mvan_3761|M.vanbaalenii_PYR-1 ----------MMQWNAWGDPAAAKPLSPAIRALLGQALGIDGADIDEPTL
MSMEG_4334|M.smegmatis_MC2_155 -----------MKWNAWGDPQAAKPLSDGIRALLQQALGVTDSP-AQISP
TH_1507|M.thermoresistible__bu MSAPENHLSPPMKWNAWGDPAAARPLSDGIRSLLREALGVEGPPTPDLSP
MAB_3884|M.abscessus_ATCC_1997 ----------MMEWDAWGVAEKRQTLSPQVKALLASALGIPEREPVHRDE
MLBr_01103|M.leprae_Br4923 --------------------------------------------------
Mb2275|M.bovis_AF2122/97 AQVQLRPSALSGADHDALARIVGTEYFRTADRDRLLHAGGKSTPDLLRRK
Rv2251|M.tuberculosis_H37Rv ---------------------IATGCCTPAASPPQTCCGAKTPVSRMR--
MMAR_3344|M.marinum_M DQVKLRPCALSQSDQDALAKIVGPEYMRTADRDRLLRAGGKSTPDMLRRK
MUL_1298|M.ulcerans_Agy99 DQVKLRPCALSQSDQDALAKIVGPEYMRTADRDRLLRAGGKSTPDMLRRK
MAV_2186|M.avium_104 EQVRLRPSTLSPADREALAAIVGPEYCRTADSDRLLHAGGKSTIDLLSRN
Mflv_2772|M.gilvum_PYR-GCK DQVRLRPSALSPGDRDGLSAIIGAEHVTVDDRARLLRAGGKSTLDLLRRR
Mvan_3761|M.vanbaalenii_PYR-1 EQVRLRPSALSPADLDGLSAVVGAANVTTDDQARLLRAGGKSTLDLLRRR
MSMEG_4334|M.smegmatis_MC2_155 EDITLRPSALTAADRDALAAVVGEQYCRTDDTARLLHAGGKSTLDLLRRN
TH_1507|M.thermoresistible__bu DQVRLRPSALSDADRDALAGVVGADFCRVDEHSRLLHAGGKSTLDLLRRR
MAB_3884|M.abscessus_ATCC_1997 SHVTLTPNSLTDAQRAALGGLLGAEHVSTDHGARLRHSGGKSTPDLLRRR
MLBr_01103|M.leprae_Br4923 --------------MGVLTSLIAGLPDGMVVTDSAVTDGYRHDRALDPSA
:. * :
Mb2275|M.bovis_AF2122/97 DTGVQDAPDAVLLPGGPNGEDAVADILHYCSDHGIAVVPFGGGTSVVGGL
Rv2251|M.tuberculosis_H37Rv -------PTRCCCPAAPTGEDAVADILHYCSDHGIAVVPFGGGTSVVGGL
MMAR_3344|M.marinum_M DTGIQDAPDAVLLPG---DDQAVAEILRYCSDQGIAIVPFGGGTNVTGGL
MUL_1298|M.ulcerans_Agy99 DTGIQDAPDAVLLPG---DDQAVAEILRYCSDQGIAIVPFGGGTNVTGAL
MAV_2186|M.avium_104 GPGPQDAPDAVLLPG---DDESVAAILRYCSQHRIAVVPFGGGTSVVGGL
Mflv_2772|M.gilvum_PYR-GCK DFGVQDAPDAVLLPG---GEDEIAEVLRYCAHRSIAVVPFGGGTSVVGGV
Mvan_3761|M.vanbaalenii_PYR-1 DFGVQDAPDAIVLPG---GDRDVAEVLRFCGERSIAVVPFGGGTSVVGGL
MSMEG_4334|M.smegmatis_MC2_155 TSGVQDAPDAILLPG---DEDAVAAILRYCTEHRIAIVPFGGGTSVVGGL
TH_1507|M.thermoresistible__bu QP-EQDAPDAVVLPA---DEDQIAEILRICGSRRIAVVPFGGGTSVVGGL
MAB_3884|M.abscessus_ATCC_1997 STGVQNAPDAIVYPA---SHDEVSALLTLCEEQGIAVVPFGGGTSVVGGL
MLBr_01103|M.leprae_Br4923 G-----KPLAVVQPR---RTDEVQTVLRWASANRVPVVARGAGSGLSGGA
* * : :* . . :.:*. *.*:.: *.
Mb2275|M.bovis_AF2122/97 DPVRNDFRAVISLDMRRFDRLHRIDEVSGEAELEAGVTGPEAERLLGEHG
Rv2251|M.tuberculosis_H37Rv DPVRNDFRAVISLDMRRFDRLHRIDEVSGEAELEAGVTGPEAERLLGEHG
MMAR_3344|M.marinum_M DPNRGQFSAVISLDLRRFNELHSLDEVSGIAELGAGVTGPDAERLLGERG
MUL_1298|M.ulcerans_Agy99 DPNRGQFSAVISLDLRRFNELHSLDEVSGIADLGAGVTGPDAERLLGERG
MAV_2186|M.avium_104 TPERAGFGAAVAVDLRRFDQLISLDPVSGLAVLGAGVTGPDAEKLLGAHG
Mflv_2772|M.gilvum_PYR-GCK DPLRGDFKAVVSLDLRRLDELHSLDDVSWEAELGAGLTGPEAERLLGERG
Mvan_3761|M.vanbaalenii_PYR-1 DPTRGDFKAVVSLDLRRLDELHSLDEVSWEAELGAGLTGPDAERLLGERG
MSMEG_4334|M.smegmatis_MC2_155 DPLRGEFGAVVSLDLRRLDALHHLDEISGEAELGAGVTGPQAEELLGAHG
TH_1507|M.thermoresistible__bu DPIRGEFGSVVALDLRRLNRLIWLDEVSQLAELSAGMTGPAAEETLRARG
MAB_3884|M.abscessus_ATCC_1997 DPERGAFGAVIAIDLRRMSGLLSLDEVSGTAVLLPGTTGPEAEELLGAQG
MLBr_01103|M.leprae_Br4923 T----ALDDGIVLSTEKMRDIT-VDPVTRTAVCQPGLFNAEVKKAAAEHG
: : :. .:: : :* :: * .* .. .:. :*
Mb2275|M.bovis_AF2122/97 FSLGHFPQSFEFATIGGFAATRSSGQDSAGYGRFNDMILGLRMITPVGVL
Rv2251|M.tuberculosis_H37Rv FSLGHFPQSFEFATIGGFAATRSSGQDSAGYGRFNDMILGLRMITPVGVL
MMAR_3344|M.marinum_M FSLGHFPQSFEYATIGGFAATRSSGQDSAGYGRFNDMIIGLRMITPAGVL
MUL_1298|M.ulcerans_Agy99 FSLGHFPQSFEYATIGGFAATRSSGQDSAGYGRFNDMIIGLRMITPAGVL
MAV_2186|M.avium_104 FSLGHFPQSFEYATIGGFAATRSSGQDSAGYGRFNDMVRGLRVITPVGTM
Mflv_2772|M.gilvum_PYR-GCK FSLGHYPQSFLFATIGGFAATRSSGQDSAGYGRFNDMVRGLRAVTPAGVL
Mvan_3761|M.vanbaalenii_PYR-1 FSLGHFPQSFCFATIGGFAATRSSGQDSAGYGRFDDMVRGLRAVTPAGVL
MSMEG_4334|M.smegmatis_MC2_155 FSLGHFPQSFQFATIGGFAATRSSGQNSAGYGRFDDMVRGLRAVTPAGVL
TH_1507|M.thermoresistible__bu FSLGHFPQSFEFASIGGFAATRSSGQNSAGYGRFNDMVRGVRAITPTGVL
MAB_3884|M.abscessus_ATCC_1997 FSLGHFPQSFRFASIGGFAATRSSGQASSGYGRFDAMVDAVRIATPRGDL
MLBr_01103|M.leprae_Br4923 LWYPPDPSSFEICSIGGNVATNAGGLCCVKYGVTGDYVLGIQVVLADGTA
: *.** .:*** .**.:.* . ** . : .:: . *
Mb2275|M.bovis_AF2122/97 DLGRVP--ASAAGPDLRQLAIGSEGVFGVITRVRLRVHRIPESTRYEAWS
Rv2251|M.tuberculosis_H37Rv DLGRVP--ASAAGPDLRQLAIGSEGVFGVITRVRLRVHRIPESTRYEAWS
MMAR_3344|M.marinum_M DLGRVA--ASAAGPDLRQLAIGSEGVFGVITKVRLRVHPVPETTRYEAWS
MUL_1298|M.ulcerans_Agy99 DLGRVA--ASAAGPDLRQLAIGSEGVFGVITKVRLRVHPVPETTRYEAWS
MAV_2186|M.avium_104 DLGRGP--ESAAGPDLRQLLIGSEGTLGVITRVRLRVHRIPQAVRYEAWS
Mflv_2772|M.gilvum_PYR-GCK DLGRAP--ESAAGPDLRQLLIGSEGAFGIITRVRVRVHPVPEVTRYEAWS
Mvan_3761|M.vanbaalenii_PYR-1 DLGRAP--ASAAGPDLRQLLLGSEGTFGIITRVRVRVHPVPEATRYEAWS
MSMEG_4334|M.smegmatis_MC2_155 DLGRAP--ASAAGPDLRQLLLGSEGVFGVITRVRVRVHPVPESTRYEAWS
TH_1507|M.thermoresistible__bu DLGRAP--ESAAGPDLRHLLIGSEGVFGVITRVRVRVRPVPEAVRYEAWS
MAB_3884|M.abscessus_ATCC_1997 NLGRAP--ASAAGPDLRQLFLGSEGALGIITEVTLRVHRLPEETWYQGWS
MLBr_01103|M.leprae_Br4923 VRLGGPRLKDVAGLSLTKLFVGSEGTLGIITEVTLRLLPTQNTSSIVVAT
. ..** .* :* :****.:*:**.* :*: : :
Mb2275|M.bovis_AF2122/97 FPDFATGVAALRTITQTGTGPTVVRLSDEAETGVNLATTEAIGETQITGG
Rv2251|M.tuberculosis_H37Rv FPDFATGVAALRTITQTGTGPTVVRLSDEAETGVNLATTEAIGETQITGG
MMAR_3344|M.marinum_M FPDFSTGVAALRAITQTGTGPTVVRLSDEAETGINLATHESIGENQVTGG
MUL_1298|M.ulcerans_Agy99 FPDFSTGVAALRAITQTGTGPTVVRLSDEAETGINLATHESIGENQVTGG
MAV_2186|M.avium_104 FPDFETGAAALRAVTQNGTGPTVIRLSDEAETGVNLATTEAIGESRITGG
Mflv_2772|M.gilvum_PYR-GCK FPDFATGADALRAVVQTGTGPTVIRLSDEAETGVNLATTENIGEQKITGG
Mvan_3761|M.vanbaalenii_PYR-1 FPDFATGADALRAVAQTGTGPTVIRLSDEAETGVNLATTESIGEQQVTGG
MSMEG_4334|M.smegmatis_MC2_155 FPDFATGADALRAVVQTGTGPTVIRLSDEAETGVNLATTDNIGEQSITGG
TH_1507|M.thermoresistible__bu FPDFATGTAALRAVTQIGTGPTVIRLSDEAETGVNLATTDNIGDQSITGG
MAB_3884|M.abscessus_ATCC_1997 FPSFEAGAQALRTLVQSDAAPTVLRLSDEAESGLNLALAKDIGGKNPAAG
MLBr_01103|M.leprae_Br4923 FASVQAAVDAVLGVAAR-LRPAMLEFMDSVAINA-VEDTFRMGLDREAAA
*... :.. *: :. *:::.: *.. . : :* :..
Mb2275|M.bovis_AF2122/97 CLGITVFEGTQEHTESRHAETRALLAARGGTSLGEGPARAWERGRFAAPY
Rv2251|M.tuberculosis_H37Rv CLGITVFEGTQEHTESRHAETRALLAARGGTSLGEGPARAWERGRFAAPY
MMAR_3344|M.marinum_M CLGLTLFEGTKEHTESRHAETRASLEAHGGKSLGEGPAQSWEHGRFSAPY
MUL_1298|M.ulcerans_Agy99 CLGLTLFEGTKEHTESRHAETRASLEAHGGKSLGEGPAQGWEHGRFSAPY
MAV_2186|M.avium_104 CLCITMFEGTEQHVDSRHAETRALLAAQGGTSLGDGPARAWERGRFGAPY
Mflv_2772|M.gilvum_PYR-GCK CLAITAFEGTEAHVASRHAETRDLLAAKGGTSLGEAPAKAWEHGRFNAPY
Mvan_3761|M.vanbaalenii_PYR-1 CLAITAFEGTEAHVASRHAETRDLLAASGGTSLGEGPARAWEHGRFNAPY
MSMEG_4334|M.smegmatis_MC2_155 CLAVTVFEGSPEHTASRHAETRALLERLGGTSLGEVPARAWEHGRFGAPY
TH_1507|M.thermoresistible__bu CLAITVFEGTAAHAESRHAETAAVLAAHGGTSLGEEPARAWEHGRFSAPY
MAB_3884|M.abscessus_ATCC_1997 VLAITTVEGTHGHVAARSAEVAAVLSAAGGTALGDEPAKAWDHGRFDAPY
MLBr_01103|M.leprae_Br4923 MLVAGSDE--LGHAGTDEAKLIGAVFAENG---------ATQVSSTNDPD
* * *. : *: : .* . : . *
Mb2275|M.bovis_AF2122/97 LRDSLLAAGALCETLETATVWSNTPVLKAAVTEA--LTTSLAASGTPALV
Rv2251|M.tuberculosis_H37Rv LRDSLLAAGALCETLETATVWSNTPVLKAAVTEA--LTTSLAASGTPALV
MMAR_3344|M.marinum_M LRDSLLAAGALCETLETATDWSNIAAVKAAVTEA--LTTSLAESGTPALV
MUL_1298|M.ulcerans_Agy99 LRDSLLAASALCETLETATDWSNIAAVKAAVTEA--LTTSLAESGTPALV
MAV_2186|M.avium_104 LRDSLLAAGALCETLETATDWSNISALKAAVTQA--LTTALAQTGTPALV
Mflv_2772|M.gilvum_PYR-GCK LRDALLSAGALCETLETATNWSNVAALKAAVTEA--LTRSLEDSGTPALV
Mvan_3761|M.vanbaalenii_PYR-1 LRDALLSAGALCETLETATNWSNVAALKAAVTEA--LTGSLAESGTPALV
MSMEG_4334|M.smegmatis_MC2_155 LRDSLLAAGALCETLETATNWSNVAALKTAVTEA--LTATLAESGTQALV
TH_1507|M.thermoresistible__bu LRDSLLSAGALCETLETATTWSNIPTLKAAVTDA--LTSTLGESGTSALV
MAB_3884|M.abscessus_ATCC_1997 LRDALIDAGAVVETLETATSWQNLANLRTAVTTA--LAETLGAQGTPPLV
MLBr_01103|M.leprae_Br4923 EGEAFVAARRFCIPAVESKGSLLLEDVGVPLPALGKLVTGIAHISTERNL
:::: * . . :. : ..:. *. : .* :
Mb2275|M.bovis_AF2122/97 MCHVSHVYPTGASLYFTVVAGQRGDPIEQWLAAKKAASDAIMATGGTITH
Rv2251|M.tuberculosis_H37Rv MCHVSHVYPTGASLYFTVVAGQRGDPIEQWLAAKKAASDAIMATGGTITH
MMAR_3344|M.marinum_M MCHVSHVYPTGASLYFTVVAGQRGNPIEQWMAAKKAASDAMMATGATITH
MUL_1298|M.ulcerans_Agy99 MCHVSHVYPTGASLYFTVVAGQRGNPIEQWMAAKKAASDAMMATGATITH
MAV_2186|M.avium_104 MCHISHVYPTGASLYFTVVAGQRGDPIEQWKTAKKAASDAIMATGGTITH
Mflv_2772|M.gilvum_PYR-GCK LCHISHVYPTGASLYFTVVAAQRGNPIEQWRKAKAAASDAMVRTGATITH
Mvan_3761|M.vanbaalenii_PYR-1 LCHISHVYPTGASLYFTVVAAQRGNPIEQWRNAKAAASEAMLRSGATITH
MSMEG_4334|M.smegmatis_MC2_155 LCHISHVYPTGASLYFTVVAAQRGDAAEQWRKAKTAASEAMVRNGATITH
TH_1507|M.thermoresistible__bu MCHISHVYPTGASLYFTVVAAQRGNPIEQWRTAKAAASDAMMRHGGTITH
MAB_3884|M.abscessus_ATCC_1997 LCHISHTYRTGASLYFTVVCAAAEDALTQWGRAKQAAGDAIVAAGGTITH
MLBr_01103|M.leprae_Br4923 MISVIAHAGDGNTHPLIVYNPADATMTERAHRAFGEIMDMAVGLGGTITG
: : * : : * : * : : *.***
Mb2275|M.bovis_AF2122/97 HHAVGSDHRPWMRAEVGDLGVTLLRTIKATLDPAGILNPGKLIP---
Rv2251|M.tuberculosis_H37Rv HHAVGSDHRPWMRAEVGDLGVTLLRTIKATLDPAGILNPGKLIP---
MMAR_3344|M.marinum_M HHAVGADHRPWMRDEVGDLGVQLLRAVKATLDPAGILNPGKLIP---
MUL_1298|M.ulcerans_Agy99 HHAVGADHRPWMRDEVGDLGVQLLRAVKATLDPAGILNPGKLIP---
MAV_2186|M.avium_104 HHAVGTDHRPWMPEEIGELGVQVLRAVKDTLDPAGILNPGKLIP---
Mflv_2772|M.gilvum_PYR-GCK HHAVGADHRPWMTDEVGGLGVSVLRAVKSVLDPAGILNPGKLIP---
Mvan_3761|M.vanbaalenii_PYR-1 HHAVGADHRPWMRDEIGDLGVTVLRAVKEALDPAGILNPGKLIP---
MSMEG_4334|M.smegmatis_MC2_155 HHAVGADHRPWMTEEVGDLGVAVLRAVKATLDPAGILNPGKLIP---
TH_1507|M.thermoresistible__bu HHAVGADHRPWMRDEVGGLGVDILRAVKATLDPAGILNPGKLIP---
MAB_3884|M.abscessus_ATCC_1997 HHAVGRDHQPWLADEVGELGIEILQAVKRTVDPRGILNPGKLIPVQG
MLBr_01103|M.leprae_Br4923 EHGVGRLKRPWLDDYLGPDVMELNQRIKHALDPYGILNPGAAI----
.*.** ::**: :* : : : :* .:** ****** *