For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
AHPKALNDTPDTAQPGQPQTRNPTTPGDLPPLQFFARTVHAETSLGGVQFSENQRLVMNLAAANRDPRQF DDPESFDADRPRNPHVAFGGGLHSCQGQHIARAEMRAVLRVLLTRLPDVHLTGEVGEAGVLAGLMAVISL PVAFTPERSQT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4153 | - | - | 100% (152) | cytochrome P450 |
| M. smegmatis MC2 155 | MSMEG_4619 | - | 5e-17 | 38.14% (118) | putative cytochrome P450 126 |
| M. smegmatis MC2 155 | MSMEG_6030 | - | 2e-16 | 42.39% (92) | cytochrome p450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1912c | cyp140 | 1e-16 | 40.00% (120) | cytochrome p450 140 CYP140 |
| M. gilvum PYR-GCK | Mflv_0425 | - | 2e-20 | 40.17% (117) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1880c | cyp140 | 1e-16 | 40.00% (120) | cytochrome p450 140 CYP140 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-16 | 36.07% (122) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0101 | - | 6e-18 | 43.12% (109) | cytochrome P450 |
| M. marinum M | MMAR_3969 | cyp269A1 | 6e-18 | 34.07% (135) | cytochrome P450 269A1 Cyp269A1 |
| M. avium 104 | MAV_1615 | - | 7e-19 | 38.33% (120) | cytochrome P450 superfamily protein |
| M. thermoresistible (build 8) | TH_3611 | - | 4e-20 | 42.86% (105) | PUTATIVE putative cytochrome P450 |
| M. ulcerans Agy99 | MUL_3860 | cyp187A4 | 5e-17 | 35.54% (121) | cytochrome P450 187A4 Cyp187A4 |
| M. vanbaalenii PYR-1 | Mvan_5525 | - | 2e-18 | 46.24% (93) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1912c|M.bovis_AF2122/97 MKDK---------LHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDP
Rv1880c|M.tuberculosis_H37Rv MKDK---------LHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDP
Mvan_5525|M.vanbaalenii_PYR-1 MRSRPAV-----WLRWATVHGVPRAFLTVRARRGEPLARLILG---RGDR
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
Mflv_0425|M.gilvum_PYR-GCK -----------------MPADAITLGG---------ADLADPDTYLAGMP
MAB_0101|M.abscessus_ATCC_1997 -----------------MTTCPFTPG----------FDFTDPDLIQHRIP
MSMEG_4153|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1615|M.avium_104 -----------------MPLSTGPTG---------QPVVPTLDFTGETSP
MUL_3860|M.ulcerans_Agy99 -----------------MTLRTDADG---------QPVT--LDLTGETSP
TH_3611|M.thermoresistible__bu -----------------MVEPTGVKDPDQSIREAQARFNTGMGADGDASP
MMAR_3969|M.marinum_M -----------------MAYPETNTAT-----------DYPFTQPDALSA
Mb1912c|M.bovis_AF2122/97 VPFYDEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFGEN-LPPP
Rv1880c|M.tuberculosis_H37Rv VPFYDEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFGEN-LPPP
Mvan_5525|M.vanbaalenii_PYR-1 LALIEEIRAAGPLMRTPVVWATADYDVCRTVLRDNDFGVADPSETGLPDA
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLP-----GMPLTVFSSFSDCDEALRHPLSASDRLKA
Mflv_0425|M.gilvum_PYR-GCK YDAFRTLRREAPVAWHPQ---------VDKPGFWALTGYDEIYAVSRDSE
MAB_0101|M.abscessus_ATCC_1997 AEEFAYLRKTEPIWWNAQPRG---VAGFDDDGYWVVTKHADVKEVSRLNE
MSMEG_4153|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1615|M.avium_104 YPFFEHMRRTDPVWHGSLADASQLPEELRPEDEWVLFDYESVSQAFRDDR
MUL_3860|M.ulcerans_Agy99 YPFFEYMRRTDPVWHGALMDHGQMPEELRPNDEWVLFGYDGVFQAFRDGR
TH_3611|M.thermoresistible__bu YPLLRELRAQGAVHAG-WPEMGMFGNSGDGPPTFTAYTFDTVKAILTDNV
MMAR_3969|M.marinum_M PRDLGKLRQRCPVADVRFPSGDPAVVVTRYDDAKRVLDDPRVSRNMYRAD
Mb1912c|M.bovis_AF2122/97 LRWLER---------RTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFT
Rv1880c|M.tuberculosis_H37Rv LRWLER---------RTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFT
Mvan_5525|M.vanbaalenii_PYR-1 LLGLIR---------RVDPGLPNPVEPPAMLMTDPPQHTEYRKLVSRSFT
MLBr_02088|M.leprae_Br4923 TLAQQA---------IAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFA
Mflv_0425|M.gilvum_PYR-GCK TWSSQATGVFL----DVPAPEDSYQLALMMLTMDPPRHTALRALVSRGFT
MAB_0101|M.abscessus_ATCC_1997 VFSNSVNTTVVRYNEDITAEQLEIQRENLLIDMDEPKHRILRRIVSPLFT
MSMEG_4153|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1615|M.avium_104 IFSSHK-----------YDETIGLVMGHTILAMGGREHHDHRNLVAKAFR
MUL_3860|M.ulcerans_Agy99 IFTSAG-----------YDKTIGLVMGHTILAMGGREHHDHRSLVAKAFR
TH_3611|M.thermoresistible__bu TFSTRC-----------YADVVRPLQGPTILEMQEPEHAVYRRLHEFAFA
MMAR_3969|M.marinum_M AARLST------------TQLNMLELEFVSTLVDPPNHTRIRRLFAKALR
Mb1912c|M.bovis_AF2122/97 SRAVSALRDLVEQTAINLLDRFAEQPGIVDVVGRYCSQLPIVVISEILGV
Rv1880c|M.tuberculosis_H37Rv SRAVSALRDLVEQTAINLLDRFAEQPGIVDVVGRYCSQLPIVVISEILGV
Mvan_5525|M.vanbaalenii_PYR-1 PRSIAALDTRIGELTAELLDDLGRR-REVDLIADYAAQLPAAVISRMLGV
MLBr_02088|M.leprae_Br4923 PKVVQALEGDIAALVDSLLD-KGAAAGQFDVIADLAFPLAVAVICRLLGV
Mflv_0425|M.gilvum_PYR-GCK PRHVARLGARTA-DMARAIVDDALAHGQCEFVDEVAGALPSYVIAELLGI
MAB_0101|M.abscessus_ATCC_1997 PKAVNGLHARLV-ERAHGIVEEAAEKSSGNFVSDIASVLPMHAIADLVGI
MSMEG_4153|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1615|M.avium_104 ATALERWEPSVIGPVCEQLVDEIKNDGHADLVKAVTFEFPTRIISTLLGL
MUL_3860|M.ulcerans_Agy99 ATALERWEPSVIGPVCDQLIDEIRADGHADLVKALTFEFPTRIISTLLGL
TH_3611|M.thermoresistible__bu RSSMKRWDAELVGPLVARTIRKFKDAKRIDLVSAVFMPIPVRVIAALLGL
MMAR_3969|M.marinum_M RGRIEELRPRIVTIVDELLDAMLAGPMPADAVDALARPLPRQIIGEMFGF
Mb1912c|M.bovis_AF2122/97 PEHDRPRVLEFGELAAPSLD--IGIPWRQYLRVQQGIRG---FDCWLEGH
Rv1880c|M.tuberculosis_H37Rv PEHDRPRVLEFGELAAPSLD--IGIPWRQYLRVQQGIRG---FDCWLEGH
Mvan_5525|M.vanbaalenii_PYR-1 PDEDRARILGWGETGAALLD--IGIGWRPFRAAIDGLVD---VDTHLGAH
MLBr_02088|M.leprae_Br4923 PYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQL
Mflv_0425|M.gilvum_PYR-GCK PLEDGRRLYTLTDIMNTR-----------PLHDPELVAAQMQMFEYAAEL
MAB_0101|M.abscessus_ATCC_1997 PESDRQQVLDWTNQMFAYDD--------PAIGRDTATTATVSMLGYAYAM
MSMEG_4153|M.smegmatis_MC2_155 -------------------------------------------------M
MAV_1615|M.avium_104 PAEDLDLFRRLSLDLISIP-----------TDIEAGLNAATELYDYFLKQ
MUL_3860|M.ulcerans_Agy99 PREDLDLFRRLSFDLISIP-----------TDIVAGFNAATELHGYFLDQ
TH_3611|M.thermoresistible__bu PETDVPAFHRLAIDLLGFR-----------ADMDRALKASAEMKEYFVEI
MMAR_3969|M.marinum_M PPGEGDRAQYWAERLFSLS----------LHTAEEMAAGQQEFAAFICEL
Mb1912c|M.bovis_AF2122/97 LQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTV
Rv1880c|M.tuberculosis_H37Rv LQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTV
Mvan_5525|M.vanbaalenii_PYR-1 FRRLHQNGADG--TPFSSLALDG----SLSGRELISNAALLVGAGVETTV
MLBr_02088|M.leprae_Br4923 VKCRRGTPGEDLISRLIELDESGD---QLTEEEIIATCGLLLVAGHETTV
Mflv_0425|M.gilvum_PYR-GCK AARKRSEPGDDIATALLHAEVDGR---RLTDLEFNLFFLLLINAGGDTTR
MAB_0101|M.abscessus_ATCC_1997 AEERQLNPQDDILTGLVRGAYDDR---PLTPLEFAYFVIQLMVAGNETSR
MSMEG_4153|M.smegmatis_MC2_155 AHPKALNDTPDTAQ-----------------------------PGQPQTR
MAV_1615|M.avium_104 VEQRRRKPTDDIIGDLVAAEIDGE---KLTDEAIIAFLRLLLPAGLETTY
MUL_3860|M.ulcerans_Agy99 VEQRRRKLTDDIIGDLVAAEIDGE---KLDDEAIIAFLRLLLPAGLETTY
TH_3611|M.thermoresistible__bu LADKRRTPGDDMVSILAGAEIDGA---RMSDEQIYGFMRNLLPAGAETTA
MMAR_3969|M.marinum_M AEKRRAEPTGDFFSDLVAVSDVDDG--QLSHLELVYLAQALFAAGIDSTW
. .* :
Mb1912c|M.bovis_AF2122/97 NLLGNGIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTAR-VAC
Rv1880c|M.tuberculosis_H37Rv NLLGNGIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTAR-VAC
Mvan_5525|M.vanbaalenii_PYR-1 NLIGNGIAALLDHPDQLALLRDDPGLWPSAVEEILRYDSPVQMTAR-TAH
MLBr_02088|M.leprae_Br4923 NLIANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGR-VAA
Mflv_0425|M.gilvum_PYR-GCK NLVAAGTLALIEHPDQWRRLAADPSLMPTAVEEMLRWTSPVTVFSR-TAT
MAB_0101|M.abscessus_ATCC_1997 NAITHGVLAFADNPAQWRLYRERR--PSTAADEIIRWASPIIAFQR-TAL
MSMEG_4153|M.smegmatis_MC2_155 NPTTPGDLP------------------------------PLQFFAR-TVH
MAV_1615|M.avium_104 RSSGNLLYLLLTHPEQLAMVYRDRSLIPMAIEEGLRFETPLTMVTR-TTT
MUL_3860|M.ulcerans_Agy99 RSSGNLLYLLLTHPEQLTMVQRDRSLIPIAIEEGLRFETPLTMVMR-TTT
TH_3611|M.thermoresistible__bu RSTASLALGLLTHPRQLDAVRADRSLLPQAIEEGIRWETPLLNFMR-AVT
MMAR_3969|M.marinum_M VMISR-MIGLLLHKGCYGRLVADPKLIEPTVEEVLRYLPPSNLGALRYAV
. .
Mb1912c|M.bovis_AF2122/97 RDVEVAGVRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFS
Rv1880c|M.tuberculosis_H37Rv RDVEVAGVRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFS
Mvan_5525|M.vanbaalenii_PYR-1 RDTEIAGVGIRKGAVIVMLLGGANRDPKVFDRPQTFDITRANARDHLAFA
MLBr_02088|M.leprae_Br4923 KDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLAFA
Mflv_0425|M.gilvum_PYR-GCK RDTDVGGIRLREGERVAMFYPSANRDEKHFADPDRFDIGRMPNPHLAFGG
MAB_0101|M.abscessus_ATCC_1997 QDVELGGVQIRKDQRVGMFYASANFDEDVFDDPFAFNIERDPNPHLAFGG
MSMEG_4153|M.smegmatis_MC2_155 AETSLGGVQFSENQRLVMNLAAANRDPRQFDDPESFDADRPRNPHVAFGG
MAV_1615|M.avium_104 EEVEIGGKTIPANAQIDMCMGSANRDETRWTDPNAFDIRRPRQAHIAFAG
MUL_3860|M.ulcerans_Agy99 EEVDIGGKTIPPDAQIDLCMGSANRDESRWPDPNRFDIRRTRHAHIAFAG
TH_3611|M.thermoresistible__bu RDTEIGGVQVPQGATMMLNLGSANHDETRWDDPESFDIFRERKPHIGFGH
MMAR_3969|M.marinum_M EDIELDDAVIPKGTTIAVSTTAANRDPRFFDDPDEFLVDRSENRHVSFGH
: : . . : : .** * : * * *
Mb1912c|M.bovis_AF2122/97 TGRHFCLGAALARAEGEVGLRTFFDRFPDVRAAGAG-SRRDTRVLR--GW
Rv1880c|M.tuberculosis_H37Rv TGRHFCLGAALARAEGEVGLRTFFDRFPDVRAAGAG-SRRDTRVLR--GW
Mvan_5525|M.vanbaalenii_PYR-1 SGIHVCLGAALARIEGATALRELFTRYPDLHLTAPA-EPRDLVTLH--GY
MLBr_02088|M.leprae_Br4923 VGSHFCLGAALARLEATVTLSAISARFPQVQLAGEL-VYKPNVAMR--GM
Mflv_0425|M.gilvum_PYR-GCK GGTHFCLGASLARVEAAAIFRELITRTREIGLVGPV-ERVRSVLMN--GI
MAB_0101|M.abscessus_ATCC_1997 HGIHYCLGANLARLEIGIMFDALADRLPDLMPTGAP-TRFRSGWIN--GV
MSMEG_4153|M.smegmatis_MC2_155 -GLHSCQGQHIARAEMRAVLRVLLTRLPDVHLTGEVGEAGVLAGLM--AV
MAV_1615|M.avium_104 -GIHMCLGMHLARLETRVMLNSLFDRVRDLAFVPDDGTGEESKIVG--LT
MUL_3860|M.ulcerans_Agy99 -GIHMCLGMHLARLETRVMLNSLFDRVTNLAFTPDDGTGVQSRIIG--LT
TH_3611|M.thermoresistible__bu -GAHVCLGMHLARLETTKIFNALFDELPNLRLDPD---APEPYVSG--LM
MMAR_3969|M.marinum_M -GRFLCPGAWLARCEMQSLLRGLVTRVPTLELAADVNDLKVRTGMMNEGM
* . * * :** * : : . :
Mb1912c|M.bovis_AF2122/97 STLPVTLGPARSMVSP--
Rv1880c|M.tuberculosis_H37Rv STLPVTLGPARSMVSP--
Mvan_5525|M.vanbaalenii_PYR-1 RHLPVRLGRAATATRRAS
MLBr_02088|M.leprae_Br4923 SALPVQV-----------
Mflv_0425|M.gilvum_PYR-GCK RSMPAQFTPAVVPA----
MAB_0101|M.abscessus_ATCC_1997 VALPANYHGSGPRG----
MSMEG_4153|M.smegmatis_MC2_155 ISLPVAFTPERSQT----
MAV_1615|M.avium_104 FRSPNKLPVTFAPAA---
MUL_3860|M.ulcerans_Agy99 FRSPNKLPVTFTPAA---
TH_3611|M.thermoresistible__bu FRSPPRLDVIWD------
MMAR_3969|M.marinum_M LSLPVRW-----------
*