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TDLASVDYFSDPAVAQDPYEYYDFLRSRGPVTTEPHYGVVAVTGYQEVMAAFKDHDSFSAVNAIGGPFPP LPFTPEGDDITEQIEAHRHLFPIHEHMVVMDPPAHERARSLLSKLLTPRRLKENEDFMWQLVDRQLDAII GNQADEGRCEFLSEYAKPFATSAIIDLLGVPEEDRAEFLEALGAAPREGARVGALDGEPVGLDPLQYLDC KFAGYLAERRREPRGDVLSGMATATYPDGSTPDLMEVVKPATFLFAAGQETVTKLLSSAVQTLAERPEFQ ERLRKEPDLIPVFIEEALRTQSPTKVDFRLARKTTTLGGVEIKAGTVLMLCLGAANRDPRKFEDPHEFRI DRPNVREHIAFGRGIHTCAGAPLARVEGQITVRRMLDRLRDIRIDATRHGPADSRTYAYEPTFLLRGLTK LHIEYTPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6030 | - | - | 100% (429) | cytochrome p450 |
| M. smegmatis MC2 155 | MSMEG_4780 | - | e-158 | 61.27% (426) | cytochrome p450 |
| M. smegmatis MC2 155 | MSMEG_4823 | - | e-117 | 47.76% (425) | cytochrome p450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1912c | cyp140 | 1e-46 | 33.41% (434) | cytochrome p450 140 CYP140 |
| M. gilvum PYR-GCK | Mflv_1587 | - | 0.0 | 80.42% (429) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1880c | cyp140 | 1e-46 | 33.41% (434) | cytochrome p450 140 CYP140 |
| M. leprae Br4923 | MLBr_02088 | - | 9e-35 | 27.44% (430) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 3e-44 | 31.25% (400) | cytochrome P450 |
| M. marinum M | MMAR_4694 | cyp150A6 | 1e-164 | 63.64% (429) | cytochrome P450 150A6 Cyp150A6 |
| M. avium 104 | MAV_0849 | - | 0.0 | 75.52% (429) | cytochrome p450 |
| M. thermoresistible (build 8) | TH_4142 | - | 0.0 | 81.65% (387) | PUTATIVE cytochrome p450 |
| M. ulcerans Agy99 | MUL_0314 | cyp150A6 | 1e-162 | 62.94% (429) | cytochrome P450 150A6 Cyp150A6 |
| M. vanbaalenii PYR-1 | Mvan_5170 | - | 0.0 | 81.59% (429) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1587|M.gilvum_PYR-GCK -------------------------------MTDLATVDFFSDYAISQDP
Mvan_5170|M.vanbaalenii_PYR-1 -------------------------------MTDLASADFFSDYALSQDP
MSMEG_6030|M.smegmatis_MC2_155 -------------------------------MTDLASVDYFSDPAVAQDP
TH_4142|M.thermoresistible__bu -------------------------------MTDLAAVDYFSDEAVSQNP
MAV_0849|M.avium_104 -------------------------------MTDLAQVDYFTDADVAQDP
MMAR_4694|M.marinum_M -------------------------------MSSYESIDFFTDPSLIPDP
MUL_0314|M.ulcerans_Agy99 -------------------------------MSSYESIDFFTDPSLIPDP
Mb1912c|M.bovis_AF2122/97 ---------MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDP
Rv1880c|M.tuberculosis_H37Rv ---------MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
* :*
Mflv_1587|M.gilvum_PYR-GCK YAYWDFLREQSPVYREPHYGVVAVTGYKEVLAAFKDHDSFSAVNAIGGPF
Mvan_5170|M.vanbaalenii_PYR-1 HPYWDHLREQNPVYREPHYGVVAVTGYQEVLAAFKDHDSFSAVNAIGGPF
MSMEG_6030|M.smegmatis_MC2_155 YEYYDFLRSRGPVTTEPHYGVVAVTGYQEVMAAFKDHDSFSAVNAIGGPF
TH_4142|M.thermoresistible__bu YEYYEYLRSQGPVFREPHHGVVAVTGYEEVLAAFKNHECFSAVNAIGGPF
MAV_0849|M.avium_104 YDYWDYLREQGPVFREPHYGVVAVTGYQEVQAAFKDVESFSAVNAIGGPF
MMAR_4694|M.marinum_M HPYFDYLRSQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPF
MUL_0314|M.ulcerans_Agy99 HPYFDYLRRQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPF
Mb1912c|M.bovis_AF2122/97 VPFYDEVRSHGALVRN-------RANYLTVDHRLAHDLLRS--DDFRVVS
Rv1880c|M.tuberculosis_H37Rv VPFYDEVRSHGALVRN-------RANYLTVDHRLAHDLLRS--DDFRVVS
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSAS--DRLKATL
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALS--NANGVSM
: : .: : . . *
Mflv_1587|M.gilvum_PYR-GCK PPLPFTPEGDDITEQIEAHRHLFPIYEHMVVMDPPAHERARSLLNKLLTP
Mvan_5170|M.vanbaalenii_PYR-1 PPLPFTPEGDDITEQIEAHRHLFPIHEHLVVMDPPAHERARSLLNKLLTP
MSMEG_6030|M.smegmatis_MC2_155 PPLPFTPEGDDITEQIEAHRHLFPIHEHMVVMDPPAHERARSLLSKLLTP
TH_4142|M.thermoresistible__bu PPLPFEPEGDDISEQIEAHRHEFPIHEHMVVMDPPQHTRARSLLTKLLTP
MAV_0849|M.avium_104 PPLPFTPEGDDISELIEAHRHEFPIFEHMVVMDPPEHDKARSLLGRLLTP
MMAR_4694|M.marinum_M PPLPFAPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTP
MUL_0314|M.ulcerans_Agy99 PPLPFTPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTP
Mb1912c|M.bovis_AF2122/97 FGENLPPPLRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTS
Rv1880c|M.tuberculosis_H37Rv FGENLPPPLRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTS
MLBr_02088|M.leprae_Br4923 AQQAIAA----------GAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAP
MAB_1216c|M.abscessus_ATCC_199 DKASFGP--------------HAKLVMSFLAMDDPEHLRLRALVSKGFTP
: . :: :: * * : * : ::.
Mflv_1587|M.gilvum_PYR-GCK RRLKENEDYMWRLVDSQIDQVID----KGRCEFLTEYAKPFATSAIIDLL
Mvan_5170|M.vanbaalenii_PYR-1 RRLKENEDYMWQLVDSQIDQVIG----KGRCEFLSEYAKPFATSAIIDLL
MSMEG_6030|M.smegmatis_MC2_155 RRLKENEDFMWQLVDRQLDAIIGNQADEGRCEFLSEYAKPFATSAIIDLL
TH_4142|M.thermoresistible__bu RRLKENEDFMWQLADRQLDEFIA----AGRCEFLSEYAKPFATMAIIDLL
MAV_0849|M.avium_104 RRLQENKDYIWQLADRQFDEFIA----NGHCEFLSEYAKPFATLAIADLL
MMAR_4694|M.marinum_M SRLKQNEEFMWRLADRQLDEFLG----AGECEFISEYAKPFATLVIADLL
MUL_0314|M.ulcerans_Agy99 SRLKQNEEFMWRLADRQLDEFLG----AAECEFISEYAKPFATLVIADLL
Mb1912c|M.bovis_AF2122/97 RAVSALRDLVEQTAINLLDR--FAEQ-PGIVDVVGRYCSQLPIVVISEIL
Rv1880c|M.tuberculosis_H37Rv RAVSALRDLVEQTAINLLDR--FAEQ-PGIVDVVGRYCSQLPIVVISEIL
MLBr_02088|M.leprae_Br4923 KVVQALEGDIAALVDSLLDK--GAA--AGQFDVIADLAFPLAVAVICRLL
MAB_1216c|M.abscessus_ATCC_199 RRIRELEGQVVALARTHLDRALANAS-DRSFDFIAEYAGKLPMDVISELM
: . : . :* :.: . :. .* ::
Mflv_1587|M.gilvum_PYR-GCK GVPEEDRPEFLAALGAEQPDGARVGALDGE-----PVGLDPLQYLDDKFL
Mvan_5170|M.vanbaalenii_PYR-1 GVPEEDRPEFLAALGAEQPDGARVGALDGE-----PVGLDPLQYLDDKFA
MSMEG_6030|M.smegmatis_MC2_155 GVPEEDRAEFLEALGAAPREGARVGALDGE-----PVGLDPLQYLDCKFA
TH_4142|M.thermoresistible__bu GVPEEDRAEFRQALGADARPGSRVGALDGE-----PVGLNPLEYLDDKFS
MAV_0849|M.avium_104 GVPDEDRPQIRRNLGAGNAPGARVGALDHE-----PVGSNPLQYLDDLFS
MMAR_4694|M.marinum_M GVPEDDRKDFRVVLGADRMG--RVGALDHE-----SVGVNPLQWLDDKFS
MUL_0314|M.ulcerans_Agy99 GVPEDDRKDFRVVLGADRMG--RVGALDHE-----SVGVNPLQWLDDKFS
Mb1912c|M.bovis_AF2122/97 GVPEHDRPRVLEFGELAAPSLD--IGIPWRQYLRVQQGIRG---FDCWLE
Rv1880c|M.tuberculosis_H37Rv GVPEHDRPRVLEFGELAAPSLD--IGIPWRQYLRVQQGIRG---FDCWLE
MLBr_02088|M.leprae_Br4923 GVPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLE
MAB_1216c|M.abscessus_ATCC_199 GVPESDRARIRELADGVMHREDGLADVP-------PEAIQASFDLMTYYI
*** * . : :
Mflv_1587|M.gilvum_PYR-GCK GYLTERRREPRGDVLSGMATAVYPDG--STPDLIEVVKPATFLFAAGQET
Mvan_5170|M.vanbaalenii_PYR-1 GYLAERRREPRGDVLSGMATAVYPDG--STPELIEVVKPATFLFAAGQET
MSMEG_6030|M.smegmatis_MC2_155 GYLAERRREPRGDVLSGMATATYPDG--STPDLMEVVKPATFLFAAGQET
TH_4142|M.thermoresistible__bu EYIAERRREPRGDVLSGMAAATYPDG--STPELLEVVRPATFLFAAGQET
MAV_0849|M.avium_104 GYIADRRERPRDDVLTGLATATYPDG--STPPLLEVVRPATFLFAAGQET
MMAR_4694|M.marinum_M AYIEDRRRQPRNDVLTALATATYPDG--STPEVIDVVRSATFLFAAGQET
MUL_0314|M.ulcerans_Agy99 AYIEDRRRRPRNDVLTALATATYPDG--STPEIIDVVRWATFLFAAGQET
Mb1912c|M.bovis_AF2122/97 GHLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFET
Rv1880c|M.tuberculosis_H37Rv GHLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFET
MLBr_02088|M.leprae_Br4923 QLVKCRRGTPGEDLISRLIELDESGD---QLTEEEIIATCGLLLVAGHET
MAB_1216c|M.abscessus_ATCC_199 EMVRERRRRPTEDLTSALLQAEIDGD---RLTDEEVLAFLFLMVIAGNET
: * * *: : : .. :: ::. ** **
Mflv_1587|M.gilvum_PYR-GCK VTKLLSAAMKTLGEHPEYQPYLREHPDRIPAFIEESLRMHSPTKIDFRLV
Mvan_5170|M.vanbaalenii_PYR-1 VTKLLSAAVKTLAEQPEYQRILRAHPDRIPTFIEESLRMNAPTKVDFRLV
MSMEG_6030|M.smegmatis_MC2_155 VTKLLSSAVQTLAERPEFQERLRKEPDLIPVFIEEALRTQSPTKVDFRLA
TH_4142|M.thermoresistible__bu VTKLLSSAIKTLGERPEYQQMLRENRSLIPTFIEESLRMESPTKVDFRLA
MAV_0849|M.avium_104 VTKLLSAAVQVLGDQPELQAQLRADRGLIGPFIEEALRMQSPTKVDFRLA
MMAR_4694|M.marinum_M TAKLLTAAMRVLGDRPDIQRRLRENRSLIPNFIEESLRMDSPVKSDSRLA
MUL_0314|M.ulcerans_Agy99 TAKQLTAAMRVLGDRPDIQRQLRENRSLIPNFIEESLRMDSPVKSDSRLA
Mb1912c|M.bovis_AF2122/97 TVNLLGNGIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVA
Rv1880c|M.tuberculosis_H37Rv TVNLLGNGIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVA
MLBr_02088|M.leprae_Br4923 TVNLIANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVA
MAB_1216c|M.abscessus_ATCC_199 TTKLLANAVYWGHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTV
..: : .: *. : . :** ** ... : * .
Mflv_1587|M.gilvum_PYR-GCK RKTTTLGGMHLKAGTIVMLCLGAANRDPAKFDDPHEFRPDRKNVREHIAF
Mvan_5170|M.vanbaalenii_PYR-1 RKTTTLGGVHLKAGTIVMLCLGAANRDPRKFEDPHEFRPERKNVREHIAF
MSMEG_6030|M.smegmatis_MC2_155 RKTTTLGGVEIKAGTVLMLCLGAANRDPRKFEDPHEFRIDRPNVREHIAF
TH_4142|M.thermoresistible__bu RKTTELGGVRIAAGTVLMLCLGAANRDPRKFEQPHEFRPDRRNVREHIAF
MAV_0849|M.avium_104 RKTTTLGGVHIPAGTVIMLCLGAANRDPRKFENPNEFRIDRKNVREHIAF
MMAR_4694|M.marinum_M RKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDRPNVREHMAF
MUL_0314|M.ulcerans_Agy99 RKRTTVGGLDIAAGTVVMVLSGAANRDPRRFEDPHEFRLDRPNVREHMAF
Mb1912c|M.bovis_AF2122/97 CRDVEVAGVRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAF
Rv1880c|M.tuberculosis_H37Rv CRDVEVAGVRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAF
MLBr_02088|M.leprae_Br4923 AKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLAF
MAB_1216c|M.abscessus_ATCC_199 AEDITVYDTKIPAGDILLLLPGSANRDDRVFDDADQYRIGREIGAKLVSF
. : : * ::: .:**** : ...: * . ::*
Mflv_1587|M.gilvum_PYR-GCK GRGIHTCAGAPLARVEGQITVRRWLD------------------------
Mvan_5170|M.vanbaalenii_PYR-1 GRGIHTCAGAPLARVEGQITVRRWLD------------------------
MSMEG_6030|M.smegmatis_MC2_155 GRGIHTCAGAPLARVEGQITVRRMLD------------------------
TH_4142|M.thermoresistible__bu GRGIHSCAGAPLARVEGRITVERVLXGADRPFSRRLRLHGRSRSGGLRRT
MAV_0849|M.avium_104 GRGIHTCAGAPLARVEGQITINRLLD------------------------
MMAR_4694|M.marinum_M ARGVHSCPGGPLARVEGRVSLERILD------------------------
MUL_0314|M.ulcerans_Agy99 ARGVHSCPGGPLARVEGRVSLERILD------------------------
Mb1912c|M.bovis_AF2122/97 STGRHFCLGAALARAEGEVGLRTFFD------------------------
Rv1880c|M.tuberculosis_H37Rv STGRHFCLGAALARAEGEVGLRTFFD------------------------
MLBr_02088|M.leprae_Br4923 AVGSHFCLGAALARLEATVTLSAISA------------------------
MAB_1216c|M.abscessus_ATCC_199 GSGAHFCLGAHLARMEAKVALTELFT------------------------
. * * * *. *** *. : :
Mflv_1587|M.gilvum_PYR-GCK ------------------RTSEIRLDEA-----------------VHGPA
Mvan_5170|M.vanbaalenii_PYR-1 ------------------RTDEIHLDES-----------------VHGPA
MSMEG_6030|M.smegmatis_MC2_155 ------------------RLRDIRIDAT-----------------RHGPA
TH_4142|M.thermoresistible__bu GDRHRITGVTRHARGWSRREGDVQLGQAPQQKRRLVPVRAVTGGSVHGVV
MAV_0849|M.avium_104 ------------------RTSELRINEA-----------------KHGPA
MMAR_4694|M.marinum_M ------------------RMLDIAINED-----------------RHGPA
MUL_0314|M.ulcerans_Agy99 ------------------RMLDIAINED-----------------RHGPA
Mb1912c|M.bovis_AF2122/97 ------------------RFPDVRAAG-----------------------
Rv1880c|M.tuberculosis_H37Rv ------------------RFPDVRAAG-----------------------
MLBr_02088|M.leprae_Br4923 ------------------RFPQVQLAG-----------------------
MAB_1216c|M.abscessus_ATCC_199 ------------------RISGYEIDER----------------------
*
Mflv_1587|M.gilvum_PYR-GCK G-------DHRFSYDPTFLLRG------LSELRIEYTAAS-----
Mvan_5170|M.vanbaalenii_PYR-1 G-------QHHFAYDPTFLLRG------LSQLNIEFTAAT-----
MSMEG_6030|M.smegmatis_MC2_155 D-------SRTYAYEPTFLLRG------LTKLHIEYTPA------
TH_4142|M.thermoresistible__bu DRQIAHPVQHPFHGDPPXGGGGGERPISTGPPRRPNRPATPT---
MAV_0849|M.avium_104 S-------SRQYRYESTFLLRG------LTELHIEFTQAG-----
MMAR_4694|M.marinum_M D-------DRRYTYEPTYILRG------LTELHITFTPAG-----
MUL_0314|M.ulcerans_Agy99 D-------DRRYTYEPTYILRG------LTELHITFTPAG-----
Mb1912c|M.bovis_AF2122/97 ----------AGSRRDTRVLRG------WSTLPVTLGPARSMVSP
Rv1880c|M.tuberculosis_H37Rv ----------AGSRRDTRVLRG------WSTLPVTLGPARSMVSP
MLBr_02088|M.leprae_Br4923 ----------ELVYKPNVAMRG------MSALPVQV---------
MAB_1216c|M.abscessus_ATCC_199 ----------NSVRVHSSNVRG------FAHLPMTVQLREGR---
*