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MTLRTDADGQPVTLDLTGETSPYPFFEYMRRTDPVWHGALMDHGQMPEELRPNDEWVLFGYDGVFQAFRD GRIFTSAGYDKTIGLVMGHTILAMGGREHHDHRSLVAKAFRATALERWEPSVIGPVCDQLIDEIRADGHA DLVKALTFEFPTRIISTLLGLPREDLDLFRRLSFDLISIPTDIVAGFNAATELHGYFLDQVEQRRRKLTD DIIGDLVAAEIDGEKLDDEAIIAFLRLLLPAGLETTYRSSGNLLYLLLTHPEQLTMVQRDRSLIPIAIEE GLRFETPLTMVMRTTTEEVDIGGKTIPPDAQIDLCMGSANRDESRWPDPNRFDIRRTRHAHIAFAGGIHM CLGMHLARLETRVMLNSLFDRVTNLAFTPDDGTGVQSRIIGLTFRSPNKLPVTFTPAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3860 | cyp187A4 | - | 100% (408) | cytochrome P450 187A4 Cyp187A4 |
| M. ulcerans Agy99 | MUL_3872 | cyp187A5 | e-119 | 57.29% (384) | cytochrome P450 187A5 Cyp187A5 |
| M. ulcerans Agy99 | MUL_0475 | cyp123A3 | 8e-41 | 29.55% (396) | cytochrome P450 123A3 Cyp123A3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 1e-42 | 31.22% (378) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_4339 | - | 1e-114 | 53.07% (407) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 2e-42 | 31.22% (378) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-33 | 32.28% (285) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 3e-43 | 30.49% (387) | cytochrome P450 |
| M. marinum M | MMAR_3996 | cyp187A4 | 0.0 | 99.51% (408) | cytochrome P450 187A4 Cyp187A4 |
| M. avium 104 | MAV_1615 | - | 0.0 | 85.37% (410) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2240 | - | 1e-120 | 55.96% (386) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_2944 | - | 1e-121 | 56.88% (385) | PUTATIVE cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_2007 | - | 1e-115 | 54.15% (386) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3860|M.ulcerans_Agy99 --------------------------MTLRTDADGQPVT--LDLTGETSP
MMAR_3996|M.marinum_M --------------------------MTLRTDADGQPVT--LDLTGETSP
MAV_1615|M.avium_104 --------------------------MPLSTGPTGQPVVPTLDFTGETSP
Mflv_4339|M.gilvum_PYR-GCK ----------------------------MRVDTPVQD-VEMDGPIDLRDP
Mvan_2007|M.vanbaalenii_PYR-1 ------------------------------METPVQD-LAKDEPIDLRDP
MSMEG_2240|M.smegmatis_MC2_155 ------------------------------MDSRIRDDPAVDTAALLRDP
TH_2944|M.thermoresistible__bu -------------------------------------MTAAKPAGYLRDP
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
.*
MUL_3860|M.ulcerans_Agy99 YPFFEYMRRTDPVWHGALMDHGQMPEELRPNDEWVLFGYDGVFQAFRDGR
MMAR_3996|M.marinum_M YPFFEYMRRTDPVWHGALMDHGQMPEELRPNDEWVLFGYDGVFQAFRDDR
MAV_1615|M.avium_104 YPFFEHMRRTDPVWHGSLADASQLPEELRPEDEWVLFDYESVSQAFRDDR
Mflv_4339|M.gilvum_PYR-GCK YPMFARHRAEGGVFRGSVMDWSKTPESLMPEKLYAAVSFDAVNRVFRDGK
Mvan_2007|M.vanbaalenii_PYR-1 YPMFARRRAEGGVFRGSVMDWSRTPDSLRPENLYAAVSFDAVNRVFRDGK
MSMEG_2240|M.smegmatis_MC2_155 YPIFARYRAQAGVFRGSVMDWSKTPKELMPEHQYAAMSFDAVNTVFRDGK
TH_2944|M.thermoresistible__bu YPFFAERRRGSGVFHGTVIDYSRTPESLRPTDGYAAMSFDAVNRVLRDGR
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDS--TALSNAYGVSL
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDS--TALSNAYGVSL
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNS--EALSNANGVSM
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHP--LSASDRLKATL
:* : : . . .
MUL_3860|M.ulcerans_Agy99 IFTSAGYDKTIGLVMGHTILAMGGREHHDHRSLVAKAFRATALERWEPSV
MMAR_3996|M.marinum_M IFTSAGYDKTIGLVMGHTILAMGGREHHDHRSLVAKAFRATALERWEPSV
MAV_1615|M.avium_104 IFSSHKYDETIGLVMGHTILAMGGREHHDHRNLVAKAFRATALERWEPSV
Mflv_4339|M.gilvum_PYR-GCK VFNSKIYDATIGLFIGPTILAMEGKPHWEHRNLVSAAFKTRSLARWEPEI
Mvan_2007|M.vanbaalenii_PYR-1 VFNSHIYDSTIGLFIGPTILAMEGKTHWEHRNLVSAAFKTRSLARWEPEI
MSMEG_2240|M.smegmatis_MC2_155 TFNSKIYDSTIGLFIGPSILAMEGKTHRDHRNLVSAAFKSKSLARWEPEI
TH_2944|M.thermoresistible__bu VFSSALYDTTIGLFTGPTLLAMEGGTHRAHRNLISAAFKTKALARWEPSI
Mb0789c|M.bovis_AF2122/97 DPSSRTS----EAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQV
Rv0766c|M.tuberculosis_H37Rv DPSSRTS----EAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQV
MAB_1216c|M.abscessus_ATCC_199 DKASFGP----HAKLVMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQV
MLBr_02088|M.leprae_Br4923 AQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDI
: ::: : * * *:: .* . : * .:
MUL_3860|M.ulcerans_Agy99 IGPVCDQLIDEIRADG--HADLVKALTFEFPTRIISTLLGLPREDLDLFR
MMAR_3996|M.marinum_M IGPVCDQLIDEIRADG--HADLVKALTFEFPTRIISTLLGLPREDLDLFR
MAV_1615|M.avium_104 IGPVCEQLVDEIKNDG--HADLVKAVTFEFPTRIISTLLGLPAEDLDLFR
Mflv_4339|M.gilvum_PYR-GCK VRPVVNGLIDEFIDRG--SADLVRDFTFEFPTRVISRLLGLPEDDLPWFR
Mvan_2007|M.vanbaalenii_PYR-1 VRPVVNELIDEFIDDG--RADLVRDFTFEFPTRVISRLLGLPEEDLPWFR
MSMEG_2240|M.smegmatis_MC2_155 ARPICEALVDEFVDTG--SADLVRDYTFEFPTRVISKLLGLPEEDLPWFR
TH_2944|M.thermoresistible__bu VRPIVNALIDEFIDTG--TADLVRDFTFEFPTRVISRMLGLPEEDLPTFR
Mb0789c|M.bovis_AF2122/97 LELARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIR
Rv0766c|M.tuberculosis_H37Rv LELARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIR
MAB_1216c|M.abscessus_ATCC_199 VALARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMGVPESDRARIR
MLBr_02088|M.leprae_Br4923 AALVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLLGVPYEDAPEFG
* *.: : :. :*. ::*:* * :
MUL_3860|M.ulcerans_Agy99 RLSFDLISIP-----------TDIVAGFNAATELHGYFLDQVEQRRRKLT
MMAR_3996|M.marinum_M RLSFDLISIP-----------TDIVAGFNAATELHGYFLDQVEQRRRKLT
MAV_1615|M.avium_104 RLSLDLISIP-----------TDIEAGLNAATELYDYFLKQVEQRRRKPT
Mflv_4339|M.gilvum_PYR-GCK KRAVELISYT-----------INHKRAFEASAALKDYFLAQIEKRRCAPT
Mvan_2007|M.vanbaalenii_PYR-1 KRAVELISYA-----------VNYKKAFEASAALKDYFLGQIDKRRSAPT
MSMEG_2240|M.smegmatis_MC2_155 RRAVELISYS-----------VKYKRAFEASAALKDYFLDQIERRRSRPT
TH_2944|M.thermoresistible__bu RWAVQLISYT-----------VDYQRAFEASAALKDYFLEQMESRRSKPT
Mb0789c|M.bovis_AF2122/97 ALADAVLHREDGVADVP-------PPAMAASIELMRYYADLIAEFRRRPA
Rv0766c|M.tuberculosis_H37Rv ALADAVLHREDGVADVP-------PPAMAASIELMRYYADLIAEFRRRPA
MAB_1216c|M.abscessus_ATCC_199 ELADGVMHREDGLADVP-------PEAIQASFDLMTYYIEMVRERRRRPT
MLBr_02088|M.leprae_Br4923 RVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPG
: :: : *. * * : *
MUL_3860|M.ulcerans_Agy99 DDIIGDLVAAEIDGEKLDDEAIIAFLRLLLPAGLETTYRSSGNLLYLLLT
MMAR_3996|M.marinum_M DDIIGDLVAAEIDGEKLDDEAIIAFLRLLLPAGLETTYRSSGNLLYLLLT
MAV_1615|M.avium_104 DDIIGDLVAAEIDGEKLTDEAIIAFLRLLLPAGLETTYRSSGNLLYLLLT
Mflv_4339|M.gilvum_PYR-GCK DDIIGDLVSAEIDGEHLTDEAIFSFLRLLLPAGLETTYRSSGNLLYLLLT
Mvan_2007|M.vanbaalenii_PYR-1 EDIIGDLVSAEIDGERLTDEAIFSFLRLLLPAGLETTFRSSGNLLYLLLT
MSMEG_2240|M.smegmatis_MC2_155 EDIIGDLVTAEIDGEKLTDEAIYSFLRLLLPAGLETTYRSSGNLLYLLLT
TH_2944|M.thermoresistible__bu DDMIGDLVTAEIDGEKLSDEAIYSFLRLLLPAGLETTYRSSGNLIYLLLT
Mb0789c|M.bovis_AF2122/97 NNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAAH
Rv0766c|M.tuberculosis_H37Rv NNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAAH
MAB_1216c|M.abscessus_ATCC_199 EDLTSALLQAEIDGDRLTDEEVLAFLFLMVIAGNETTTKLLANAVYWGHR
MLBr_02088|M.leprae_Br4923 EDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLR
::: . *: : .*::* :: : : *:: ** *** . .* :
MUL_3860|M.ulcerans_Agy99 HPEQLTMVQRDRSLIPIAIEEGLRFETPLTMVMRTTTEEVDIGGKTIPPD
MMAR_3996|M.marinum_M HPEQLAMVQRDRSLIPIAIEEGLRFETPLTMVMRTTTEEVDIGGKTIPPD
MAV_1615|M.avium_104 HPEQLAMVYRDRSLIPMAIEEGLRFETPLTMVTRTTTEEVEIGGKTIPAN
Mflv_4339|M.gilvum_PYR-GCK HRDQFDAVDADHELIGQAIEEGLRYETPLTTVQRFTTEDTELEGVPIPAG
Mvan_2007|M.vanbaalenii_PYR-1 HRDQFEAVNADHALIGAAIEEGLRYETPLTTVQRFANEDTEIDGVEIPAG
MSMEG_2240|M.smegmatis_MC2_155 HPDQFAAVQNDHDLIGAAIEEGLRYETPLTTVQRSATKDTELEGVQIPAG
TH_2944|M.thermoresistible__bu HPEQFAAVAADPGLIPQAIEEGLRHETPLTTVQRLTTEDTELCGAAIPAG
Mb0789c|M.bovis_AF2122/97 HPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTIPEG
Rv0766c|M.tuberculosis_H37Rv HPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTIPEG
MAB_1216c|M.abscessus_ATCC_199 NPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDTKIPAG
MLBr_02088|M.leprae_Br4923 NPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEG
: * : : :** **.:.. : * . .: : :. .
MUL_3860|M.ulcerans_Agy99 AQIDLCMGSANRDESRWPDPNRFDIRRTR-HAHIAFAGGIHMCLGMHLAR
MMAR_3996|M.marinum_M AQIDLCMGSANRDESRWPDPNRFDIRRTR-HAHIAFAGGIHMCLGMHLAR
MAV_1615|M.avium_104 AQIDMCMGSANRDETRWTDPNAFDIRRPR-QAHIAFAGGIHMCLGMHLAR
Mflv_4339|M.gilvum_PYR-GCK AVIDVCIGSANRDEKRWERSEEFDIFRKR-VPHLSFAAGEHTCMGLHLAR
Mvan_2007|M.vanbaalenii_PYR-1 SVIDVCIGSANRDESRWERAEQFDIFRTR-TPHISFAAGEHTCMGLHLAR
MSMEG_2240|M.smegmatis_MC2_155 AVIDVCIGSANRDENRWERPEEFDIFRKR-IPHITFAAGEHTCMGLHLAR
TH_2944|M.thermoresistible__bu AVVDTCIGSANRDETRWDRPEEFDIFRDR-VPHLSFAAGEHTCMGLHLAR
Mb0789c|M.bovis_AF2122/97 EVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGAHLAR
Rv0766c|M.tuberculosis_H37Rv EVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGAHLAR
MAB_1216c|M.abscessus_ATCC_199 DILLLLPGSANRDDRVFDDADQYRIGREIGAKLVSFGSGAHFCLGAHLAR
MLBr_02088|M.leprae_Br4923 DTMVLLLAAANRDPAVYSRPDEFDPDRPS-SRHLAFAVGSHFCLGAALAR
: .:**** : .: : * ::*. * * *:* ***
MUL_3860|M.ulcerans_Agy99 LETRVMLNSLFDRVTNLAFTPDDGTGVQSRIIGLTFRSPNKLPVTFTPAA
MMAR_3996|M.marinum_M LETRVMLNSLFDRVTNLAFTPDDGTGVQSRIIGLTFRSPNKLPVTFTPAA
MAV_1615|M.avium_104 LETRVMLNSLFDRVRDLAFVPDDGTGEESKIVGLTFRSPNKLPVTFAPAA
Mflv_4339|M.gilvum_PYR-GCK METRVAVETLLTRLSDIRLVTDD----DPHIHGQPFRSPTALPVTFSPAA
Mvan_2007|M.vanbaalenii_PYR-1 METRVAAETLLSRLSAIELLTDG----DPHIHGQPFRSPTALPVTFTPSR
MSMEG_2240|M.smegmatis_MC2_155 METRVAMETLLNRVTDLRLIADD----DPHIFGQPFRSPTAIPVTFRPAG
TH_2944|M.thermoresistible__bu METRVALETLLSRVHDLRLVTDG----DPHIFGQPFRSPTAIPVTFDPVR
Mb0789c|M.bovis_AF2122/97 MEARVALGALLRRIRNYEVDDDNV----VRVHSSNVRGFAHLPISVQAR-
Rv0766c|M.tuberculosis_H37Rv MEARVALGALLRRIRNYEVDDDNV----VRVHSSNVRGFAHLPISVQAR-
MAB_1216c|M.abscessus_ATCC_199 MEAKVALTELFTRISGYEIDERNS----VRVHSSNVRGFAHLPMTVQLRE
MLBr_02088|M.leprae_Br4923 LEATVTLSAISARFPQVQLAG-EL----VYKPNVAMRGMSALPVQV----
:*: * : *. . . .*. :*: .
MUL_3860|M.ulcerans_Agy99 ---
MMAR_3996|M.marinum_M ---
MAV_1615|M.avium_104 ---
Mflv_4339|M.gilvum_PYR-GCK AK-
Mvan_2007|M.vanbaalenii_PYR-1 ARP
MSMEG_2240|M.smegmatis_MC2_155 ---
TH_2944|M.thermoresistible__bu ---
Mb0789c|M.bovis_AF2122/97 ---
Rv0766c|M.tuberculosis_H37Rv ---
MAB_1216c|M.abscessus_ATCC_199 GR-
MLBr_02088|M.leprae_Br4923 ---