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MSLRSAPVDGFRLAFDRHGIRGGPPVVLLHGWPGTRRDHRHVVPLLTDVADVIVPDLRGFGGSDKHAVSV QHFYSASAQAASIVGLVNELGLTGVVLAGYDVGSRVAQGVARMHPHLVKALVLSPPLPGVGDRVLSPHAI HEYWYQAFHQLPIAERMIDGNPDAVREYVRHFWDHWSGPGFRLAEDELDRLVADYALPGSFTASLGWYRA GAGTVAQSLAELPPDRAVKIHPTTDVLWPQHDPLFPLEWADRLEHYFVDVRLHTAEHAGHFTPLECPDEF AALIRGALGRAPN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3891 | - | - | 100% (293) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_6708 | - | 3e-21 | 30.51% (295) | epoxide hydrolase |
| M. smegmatis MC2 155 | MSMEG_6720 | - | 5e-20 | 30.20% (298) | epoxide hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1155 | ephC | 9e-15 | 29.21% (291) | epoxide hydrolase EphC |
| M. gilvum PYR-GCK | Mflv_1415 | - | 1e-12 | 33.59% (131) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1124 | ephC | 9e-15 | 29.21% (291) | epoxide hydrolase EphC |
| M. leprae Br4923 | MLBr_02297 | - | 2e-12 | 27.68% (271) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2499c | - | 7e-19 | 29.17% (288) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_5114 | ephA | 5e-16 | 27.44% (317) | epoxide hydrolase EphA |
| M. avium 104 | MAV_5163 | - | 5e-17 | 27.01% (274) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_0992 | ephA | 8e-18 | 31.25% (240) | PROBABLE EPOXIDE HYDROLASE EPHA (EPOXIDE HYDRATASE) |
| M. ulcerans Agy99 | MUL_4193 | ephA | 4e-16 | 25.55% (317) | epoxide hydrolase EphA |
| M. vanbaalenii PYR-1 | Mvan_0326 | - | 1e-14 | 26.79% (280) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5114|M.marinum_M ---------------------------------------MVATSTERLVD
MUL_4193|M.ulcerans_Agy99 ---------------------------------------MVATSTERLVD
TH_0992|M.thermoresistible__bu ----------------------------------------VITPSERSVE
Mflv_1415|M.gilvum_PYR-GCK -------------------------------------------MQSRMVH
Mb1155|M.bovis_AF2122/97 ---------------------------MRAGRGERESTWRTTMAEPHWID
Rv1124|M.tuberculosis_H37Rv ---------------------------MRAGRGERESTWRTTMAEPHWID
MAB_2499c|M.abscessus_ATCC_199 --MISRRGFSKVALLTAVGATALGACSNGASVD--PTRPRTEFPPLKQVD
Mvan_0326|M.vanbaalenii_PYR-1 MNGFSRRDFGLLAT-AAAGAVTLTACTSTPATAGPPPAPRNQLGPIKQID
MAV_5163|M.avium_104 ----------------------------------MVTMPELDGVEHRYVD
MLBr_02297|M.leprae_Br4923 -------------------MAMSNPSVTRIAGPWHHLDVHANGIRFHVVE
MSMEG_3891|M.smegmatis_MC2_155 -------------------------------------------MSLRSAP
:
MMAR_5114|M.marinum_M TNGVR--LRVTEAGERGAPVVILAHGFPELAYSWRHQIPVLAEAGYHVLA
MUL_4193|M.ulcerans_Agy99 TNGVR--LRVTEAGERGAPVVILAHGFPELAYSWRHQIPVLAEAGYHVLA
TH_0992|M.thermoresistible__bu TNGVR--LRLVEAGERGDPLVVLAHGFPELAYSWRHQIPALVDAGYHVMA
Mflv_1415|M.gilvum_PYR-GCK TNGIT--LRVFEAGERSAPVVVLCHGFPELAFTWRHQISALAAAGFHVLA
Mb1155|M.bovis_AF2122/97 VKGPNGDLKALTWGPAGAPVALCLHGFPDTAYGWRKVAPRLAESGWHVVA
Rv1124|M.tuberculosis_H37Rv VKGPNGDLKALTWGPAGAPVALCLHGFPDTAYGWRKVAPRLAESGWHVVA
MAB_2499c|M.abscessus_ATCC_199 AGLLN--VGYVDEGPSDGPPVILLHGWPYDIHSYLDVVPLLTTKGFRVLV
Mvan_0326|M.vanbaalenii_PYR-1 AGDLN--VGYAEAGPPDGQPVILLHGWPYDIHSYADVTAILAAQGFRVIV
MAV_5163|M.avium_104 LGDDVT-IHVADAGPASGPAVMLVHGFPQNWWEWRALIGPLAADGYRVLC
MLBr_02297|M.leprae_Br4923 AVPTQPAGQDCAPSATARPLVMLLHGFGSFWWSWRHQLRGLTEA--RLVA
MSMEG_3891|M.smegmatis_MC2_155 VDGFR--LAFDRHGIRGGPPVVLLHGWPGTRRDHRHVVPLLTDVA-DVIV
. .: **: *. ::
MMAR_5114|M.marinum_M PDQRGYGGSSRPEAIEDYD--IHQLTADLVGLLDDVG-AERAAWVGHDWG
MUL_4193|M.ulcerans_Agy99 PDQRGYGGSSRPEAIEDYD--IHQLTADLVGLLDDVG-AERAAWVGHDWG
TH_0992|M.thermoresistible__bu PDQRGYGGSSAPEAIEAYD--ITRLTADLMGLLDDIG-AEKAAFIGHDWG
Mflv_1415|M.gilvum_PYR-GCK PDQRGYGGSDKPGDAGVYN--VAELTADVVGLLDDVG-AERAALVGHDFG
Mb1155|M.bovis_AF2122/97 PFMRGYAPSSIP-ADGSYH--VGALMHDALRVRSAAGGTERDVIIGHDWG
Rv1124|M.tuberculosis_H37Rv PFMRGYAPSSIP-ADGSYH--VGALMHDALRVRSAAGGTERDVIIGHDWG
MAB_2499c|M.abscessus_ATCC_199 PYLRGYGSTRFRSGDTFHNGQQAALATDVIDFMDALK-IPSAILGGFDWG
Mvan_0326|M.vanbaalenii_PYR-1 PHLRGFGTTRFRSANTVRNGQQAALAHDAISLMDALN-IPDAILGGYDWG
MAV_5163|M.avium_104 PDLRGAGWSSAPRSSYRKD----EMADDLAGVLDRLG-VRSVDLVAHDWG
MLBr_02297|M.leprae_Br4923 VDLRGYGGSDKP--PRGYDG--WTLAGDTAGLIRALG-HSSATLVGHAEG
MSMEG_3891|M.smegmatis_MC2_155 PDLRGFGGSDKHAVSVQHFYSASAQAASIVGLVNELG-LTGVVLAGYDVG
** . : . . .. *
MMAR_5114|M.marinum_M AVVVWNAPLLHPDRVAAVAGLSVPV----LPRAQVPPIQAFRQRFG---E
MUL_4193|M.ulcerans_Agy99 AVVVWNAPLLHPDRVAAVAGLSVPV----LPRAQVPPIQAFRQRFG---E
TH_0992|M.thermoresistible__bu ALVVWNAALLYPDRVAAVAGLSVPP----VPRSLTRPTEAFRALVGE--D
Mflv_1415|M.gilvum_PYR-GCK AVVAWGAPLLEPDRFSAVAGLSLPP----VPRPQVPTTQAFRRVFG---D
Mb1155|M.bovis_AF2122/97 AIAATGLAAMPDSPFAKAVIMSVPPSAAFRPLGRVPERGRLLRELPHQLL
Rv1124|M.tuberculosis_H37Rv AIAATGLAAMPDSPFAKAVIMSVPPSAAFRPLGRVPERGRLLRELPHQLL
MAB_2499c|M.abscessus_ATCC_199 ARNADIVAAIWPDRVTALVAVSGYII---VNLEANQQPLSPQAEWG----
Mvan_0326|M.vanbaalenii_PYR-1 GRTANAVAALWPQRCTGLVAVSGYIV---VNLATNLEPLAPQSEYG----
MAV_5163|M.avium_104 GPVAFIMMLRHPEKVTGFFGVNTSAP------FVKRSLSTIRNVWR----
MLBr_02297|M.leprae_Br4923 GLACWATALLHPRLVRAIALINSPHP------AALRRSMLTHRNQG--YA
MSMEG_3891|M.smegmatis_MC2_155 SRVAQGVARMHPHLVKALVLSPPLPG-------VGDRVLSPHAIHE----
.
MMAR_5114|M.marinum_M HFFYILYFQQPGVADAELNGDPART--MRRMIGGQRSPTDQGAALRMVAP
MUL_4193|M.ulcerans_Agy99 HFFYILYFQQPGVADAELNGDPART--MRRMIGGQRSPTDQGAALRMVAP
TH_0992|M.thermoresistible__bu NFFYILYFQEPGVADAELDGDPART--MRRMFGGLTS--DPDAAHRMLQP
Mflv_1415|M.gilvum_PYR-GCK RFMYILYFQEPGPADAELARDPATT--FRRLFALTTG-----GAEMVGDA
Mb1155|M.bovis_AF2122/97 RSWYILYFQLPWLPERSASWVVPLL--WRRWSPGYHA-----------EE
Rv1124|M.tuberculosis_H37Rv RSWYILYFQLPWLPERSASWVVPLL--WRRWSPGYHA-----------EE
MAB_2499c|M.abscessus_ATCC_199 -WWYQYYFATE--RGLHGYRHNTRD--FNKLIWHNAS-------------
Mvan_0326|M.vanbaalenii_PYR-1 -WWYQYYFATP--RGELGYRRNTKD--FNRLIWTNAS-------------
MAV_5163|M.avium_104 -FWYQIPISLPVIGPRVIS-TPDSR--FVRLLGSWVG-------------
MLBr_02297|M.leprae_Br4923 LLPTLLRYQLPIWPERLLTRNNAAE--IERLVRSRSS-------------
MSMEG_3891|M.smegmatis_MC2_155 -YWYQAFHQLP-IAERMIDGNPDAVREYVRHFWDHWS-------------
: .
MMAR_5114|M.marinum_M GPEGFIDRLPEPDTPPSWISRDELDHYISEFTRTG-FTGGLNWYRN-FDR
MUL_4193|M.ulcerans_Agy99 GPEGFIDRLPEPDAPPSWISRDELDHYISEFTRTG-FTGGLNWYRN-FDR
TH_0992|M.thermoresistible__bu GPAGFIDRLPEPEALPDWLTAEELDHYIAEFTRTG-FTGGLNWYRN-MDR
Mflv_1415|M.gilvum_PYR-GCK GPQGFLDRIPEPGGLPDWISQADFDVYVDEFTRGG-FTGPLNWYRC-FDR
Mb1155|M.bovis_AF2122/97 DLRHVDAAIGTPEGR-----RAALGPYRATMRN----TRAPADYAD-LNR
Rv1124|M.tuberculosis_H37Rv DLRHVDAAIGTPEGR-----RAALGPYRATMRN----TRAPADYAD-LNR
MAB_2499c|M.abscessus_ATCC_199 -PTWKFDDDTYARSAAAFDNPDHVDIVIHNYRWRLGLARGESRYDA-VEA
Mvan_0326|M.vanbaalenii_PYR-1 -PLWHFDDAAYDMAARAFDNPDHADIVIHNYRWRLSLAPGESRYDA-DEQ
MAV_5163|M.avium_104 ----GGYTLPE----------EDVRLYLECMRQPGHAEAGSRWYRS-FQT
MLBr_02297|M.leprae_Br4923 ------AKWQACEDFAVTIDHLRIAIQIPAAAHCALEYQRWAVRSQ-LRN
MSMEG_3891|M.smegmatis_MC2_155 -------------GPGFRLAEDELDRLVADYALPGSFTASLGWYRAGAGT
MMAR_5114|M.marinum_M ---NWETTADLEGATITVPSLFMAGTKDPVLSFARSDRASEVITGPYREV
MUL_4193|M.ulcerans_Agy99 ---NWETTADLEGATITVPSLFMAGTKDPVLSFARSDRASEVITGPYREV
TH_0992|M.thermoresistible__bu ---NWELTEHLAGATITAPALFLAGAADPVLGFMRPERATEVAVGPYRQV
Mflv_1415|M.gilvum_PYR-GCK ---NWELTAETPAPTIEVPALFVGGTEDATLAYTPRDRVREVVTGDYREV
Mb1155|M.bovis_AF2122/97 ---LWTEAPKLP-------VLYLHGHDDGCATSAFTHWTARVLPAGSEVA
Rv1124|M.tuberculosis_H37Rv ---LWTEAPKLP-------VLYLHGHDDGCATSAFTHWTARVLPAGSEVA
MAB_2499c|M.abscessus_ATCC_199 ---KLATKPTIAVPTITIGSDFDGPTKD-------GTAYRKMFTGKYAHR
Mvan_0326|M.vanbaalenii_PYR-1 ---RLAAKPPIEVPTITIGSDFDGPAKD-------GSTYRALYTGPYQHR
MAV_5163|M.avium_104 REMLSWMRGEYDGARVHVPVRWLSGTEDPVLTPDLLDGYAERID-DFQLE
MLBr_02297|M.leprae_Br4923 ---EGRKFMKSMSRPFSVPLLHVRGDADPYLLADSVDRTRRYAP-HGRYV
MSMEG_3891|M.smegmatis_MC2_155 VAQSLAELPPDRAVKIHPTTDVLWPQHDPLFPLEWADRLEHYFV-DVRLH
*
MMAR_5114|M.marinum_M MVEGAGHWLQQERPDEVNATLLDFLKGVQW----
MUL_4193|M.ulcerans_Agy99 MVEGAGHWLQQERPDEVNATLLDFLKGVQW----
TH_0992|M.thermoresistible__bu LLDGAGHWVQQERPQEVNAALIDFLRGLELQ---
Mflv_1415|M.gilvum_PYR-GCK MIDGAGHWLTEERPDEVSRVLVDFLTTVR-----
Mb1155|M.bovis_AF2122/97 VVEHAGHFLQLEQPDKIAELIVAFIGSPG-----
Rv1124|M.tuberculosis_H37Rv VVEHAGHFLQLEQPDKIAELIVAFIGSPG-----
MAB_2499c|M.abscessus_ATCC_199 VLDGIGHNVPQEAPQEFANAIIAAHAL-------
Mvan_0326|M.vanbaalenii_PYR-1 VLDGIGHNVPQEAPQEFASAITDVTRQ-------
MAV_5163|M.avium_104 LVDGVGHWIVDQRPDLVLDRVRAFLRRET-----
MLBr_02297|M.leprae_Br4923 SVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS
MSMEG_3891|M.smegmatis_MC2_155 TAEHAGHFTPLECPDEFAALIRGALGRAPN----
. ** : *: . :