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MRAGRGERESTWRTTMAEPHWIDVKGPNGDLKALTWGPAGAPVALCLHGFPDTAYGWRKVAPRLAESGWH VVAPFMRGYAPSSIPADGSYHVGALMHDALRVRSAAGGTERDVIIGHDWGAIAATGLAAMPDSPFAKAVI MSVPPSAAFRPLGRVPERGRLLRELPHQLLRSWYILYFQLPWLPERSASWVVPLLWRRWSPGYHAEEDLR HVDAAIGTPEGRRAALGPYRATMRNTRAPADYADLNRLWTEAPKLPVLYLHGHDDGCATSAFTHWTARVL PAGSEVAVVEHAGHFLQLEQPDKIAELIVAFIGSPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1124 | ephC | - | 100% (316) | PROBABLE EPOXIDE HYDROLASE EPHC (EPOXIDE HYDRATASE) |
| M. tuberculosis H37Rv | Rv3617 | ephA | 4e-25 | 28.57% (322) | epoxide hydrolase EphA |
| M. tuberculosis H37Rv | Rv1938 | ephB | 4e-13 | 26.04% (338) | epoxide hydrolase EphB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1155 | ephC | 0.0 | 100.00% (316) | epoxide hydrolase EphC |
| M. gilvum PYR-GCK | Mflv_0191 | - | 1e-75 | 46.69% (302) | alpha/beta hydrolase fold |
| M. leprae Br4923 | MLBr_02297 | - | 6e-12 | 28.11% (281) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4573c | - | 5e-69 | 45.86% (290) | epoxide hydrolase EphC |
| M. marinum M | MMAR_4334 | ephC | 1e-152 | 83.72% (301) | epoxide hydrolase EphC |
| M. avium 104 | MAV_1256 | - | 1e-145 | 79.47% (302) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_1998 | - | 6e-67 | 44.63% (298) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2114 | ephC | 1e-121 | 66.89% (302) | PROBABLE EPOXIDE HYDROLASE EPHC (EPOXIDE HYDRATASE) |
| M. ulcerans Agy99 | MUL_0144 | ephC | 1e-151 | 82.08% (307) | epoxide hydrolase EphC |
| M. vanbaalenii PYR-1 | Mvan_0714 | - | 2e-74 | 47.47% (297) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0191|M.gilvum_PYR-GCK ---------------MTDP---------QTLTLTLPHLTVTALSWGPPD-
Mvan_0714|M.vanbaalenii_PYR-1 ------------MAQVTAP---------QTLRLSLPHLDVAALSWGPPD-
MSMEG_1998|M.smegmatis_MC2_155 ---------------MTAP---------ERLTLDLPHLRFAALAWGPKD-
Rv1124|M.tuberculosis_H37Rv MRAGRGERESTWRTTMAEP---------HWIDVKGPNGDLKALTWGPAG-
Mb1155|M.bovis_AF2122/97 MRAGRGERESTWRTTMAEP---------HWIDVKGPNGDLKALTWGPAG-
MMAR_4334|M.marinum_M ---------------MPEP---------RWIDVPGPNGDLKALTWGRPE-
MUL_0144|M.ulcerans_Agy99 --------MTTTRPVMPEP---------RWIDVPGPNGDLKALTWGRPE-
MAV_1256|M.avium_104 -------------MKMAEP---------GWIDVTGPAGDLKALTWGPPD-
TH_2114|M.thermoresistible__bu -------------VTMTEP---------RWIDVRTPGADLRALVWEPAES
MAB_4573c|M.abscessus_ATCC_199 ---------------MAAD---------CYLTLDLPNVRLRALAWGPQD-
MLBr_02297|M.leprae_Br4923 -------------MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQP
:. : : . .:
Mflv_0191|M.gilvum_PYR-GCK -----------GRLVLCLHGFPDSAWGWRKFAPILAEHGFRVVAPFSRGY
Mvan_0714|M.vanbaalenii_PYR-1 -----------GRLVLCLHGFPDSAWGWRKFAPLLAERGMRVVAPFSRGY
MSMEG_1998|M.smegmatis_MC2_155 -----------GRLMLCLHGYPDSAWTWRHLGPHFAAQGFRVVAPFMRGY
Rv1124|M.tuberculosis_H37Rv -----------APVALCLHGFPDTAYGWRKVAPRLAESGWHVVAPFMRGY
Mb1155|M.bovis_AF2122/97 -----------APVALCLHGFPDTAYGWRKVAPRLAESGWHVVAPFMRGY
MMAR_4334|M.marinum_M -----------APMALCLHGFPDTAYGWRKLAPILVDSGWRVVAPFMRGY
MUL_0144|M.ulcerans_Agy99 -----------APMALCLHGFPDTADGWRKLAPILVDSGWRVVAPFMRGY
MAV_1256|M.avium_104 -----------GPLALCLHGFPDTPYGWRKLAPRLADAGWRVVAPFMRGY
TH_2114|M.thermoresistible__bu D---------NAPIALCLHGFPDTAHGWRKLAPLLADAGWRVVAPFNRGY
MAB_4573c|M.abscessus_ATCC_199 -----------GPLVICGHGFPDSAHTWRLLGPRLGAEGWRVVAPFTRGY
MLBr_02297|M.leprae_Br4923 AGQDCAPSATARPLVMLLHGFGSFWWSWRHQLRGLTEA--RLVAVDLRGY
: : **: . ** : ::** ***
Mflv_0191|M.gilvum_PYR-GCK APTGPAPDGDYHIGALMYDALAVHRELGAPDDAVLIGHDWGGFTAAGIAA
Mvan_0714|M.vanbaalenii_PYR-1 APTGPAPDGDYHIGALMYDALAVHRELGAPDDAVLIGHDWGAFTASAIAA
MSMEG_1998|M.smegmatis_MC2_155 APTELARDGDYGLGALMYDAVTLHEALGGTGDAVLVGHDWGGLASAGVAA
Rv1124|M.tuberculosis_H37Rv APSSIPADGSYHVGALMHDALRVRSAAGGTERDVIIGHDWGAIAATGLAA
Mb1155|M.bovis_AF2122/97 APSSIPADGSYHVGALMHDALRVRSAAGGTERDVIIGHDWGAIAATGLAA
MMAR_4334|M.marinum_M APSAIPADGSYHVGALMDDALRVRSAAGATEGDVLIGHDWGAIAAAGLAA
MUL_0144|M.ulcerans_Agy99 APSAIPADGSYHVGALMDDALRVRSAAGATEGDVLIGHDWGAIAAAGLAA
MAV_1256|M.avium_104 APSAIPSDGSYHVGALMDDALRVRAAAGGTENDVVIGHDWGAIAATGLAA
TH_2114|M.thermoresistible__bu APSSPAHDGSYHVGALMDDALRVLDAAGRTGRDLLIGHDWGAIAGAGLAA
MAB_4573c|M.abscessus_ATCC_199 APSEIPADAEYGLGALMQDVLDIHTVLGGDERAIYIGHDWGALVGNALAR
MLBr_02297|M.leprae_Br4923 GGSDKPPRG-YDGWTLAGDTAGLIRALG-HSSATLVGHAEGGLACWATAL
. : . . * :* *. : * :** *.:. . *
Mflv_0191|M.gilvum_PYR-GCK YPDSPFAEHITMAVAP---IGAVNRTRGPLT--RQLALLPKQLRNSWYIM
Mvan_0714|M.vanbaalenii_PYR-1 YPGSPFADHVSMAVPP---VGAINRTRGSLA--RQLRMMPRQLRNSWYIL
MSMEG_1998|M.smegmatis_MC2_155 YPKNPFGTVVSMGVPV---VAGM-RDAGNRR--RLAPLLPVQMRMSWYIL
Rv1124|M.tuberculosis_H37Rv MPDSPFAKAVIMSVPPSAAFRPLG-RVPERG--RLLRELPHQLLRSWYIL
Mb1155|M.bovis_AF2122/97 MPDSPFAKAVIMSVPPSAAFRPLG-RVPERG--RLLRELPHQLLRSWYIL
MMAR_4334|M.marinum_M MPDSPFSRAVIMSVPPAAAFRPLG-RVPDRG--RLARELPHQLLRSWYIL
MUL_0144|M.ulcerans_Agy99 MPDSPFSRAVIMSVPPAAAFRPLG-RVPDRG--RLARELPHQLLRSWYIL
MAV_1256|M.avium_104 MPDSPFAKAVLMSVPPSAAFRRRGGSAAERG--RLAAHLARQVFRSWYIM
TH_2114|M.thermoresistible__bu MPDSPFTRAVIMSVPPAASFRPLG-RVADPA--RLAARLPRQLLRSWYIM
MAB_4573c|M.abscessus_ATCC_199 SGRSPFARIVTMAVPP---FEVLGSNMASIGPGGWPAVLARQLFMSWYTL
MLBr_02297|M.leprae_Br4923 LHPRLVRAIALINSPHPAALRRSMLTHRNQG----YALLPTLLR---YQL
. : . . :. : * :
Mflv_0191|M.gilvum_PYR-GCK FFQLPELPERLLPRVIPRLWRDWGPQGYDTGAELA----DALAALPSPAH
Mvan_0714|M.vanbaalenii_PYR-1 FFQLPGLPERLLPRVIPRLWQDWGPAGYDTAAELD----DALAALPSPAH
MSMEG_1998|M.smegmatis_MC2_155 FQQIPWLSERNLGRVIPKLWRDWCPPGYDAREDLA----HLWEALPDTRR
Rv1124|M.tuberculosis_H37Rv YFQLPWLPERSASWVVPLLWRRWSP-GYHAEEDLR----HVDAAIGTPEG
Mb1155|M.bovis_AF2122/97 YFQLPWLPERSASWVVPLLWRRWSP-GYHAEEDLR----HVDAAIGTPEG
MMAR_4334|M.marinum_M YFQLPWLPERSASWVPRLLWRRWSP-TYYAEEDLR----HVDAAIGTAEG
MUL_0144|M.ulcerans_Agy99 YFQLPWLPERWASWVPRLLWRRWSP-TYYAEEDLR----HVDAAIGTAEG
MAV_1256|M.avium_104 YFQLPWLPERSASWVLPLLWRRWSP-GYRAEEDLR----HVDAAIGAPES
TH_2114|M.thermoresistible__bu YFQLPWLPDRSSKWVVPALWRHWSP-DYPADEDIE----LVRDAIGAPER
MAB_4573c|M.abscessus_ATCC_199 FHQLPLLPEWLLPWLLRLYWRRWSP-GYDARADLL----YTGEAMLQKGN
MLBr_02297|M.leprae_Br4923 PIWPERLLTRNNAAEIERLVRSRSSAKWQACEDFAVTIDHLRIAIQIPAA
* : . : : :: *:
Mflv_0191|M.gilvum_PYR-GCK RRAAVAYYRAMVRPSEPSGR-YADLHRWCFDV-PRVPILHLQGELDGAME
Mvan_0714|M.vanbaalenii_PYR-1 RRAAVSYYRAMVRPSRPGRM-YADLHKWCFEL-PRAPILHVQGKQDGAMQ
MSMEG_1998|M.smegmatis_MC2_155 RTAALAYYRAALRPWRRGS--HAELDRYAMTQNPISPMLVLHGRLDGAID
Rv1124|M.tuberculosis_H37Rv RRAALGPYRATMRNTRAPAD-YADLNRLWTEA-PKLPVLYLHGHDDGCAT
Mb1155|M.bovis_AF2122/97 RRAALGPYRATMRNTRAPAD-YADLNRLWTEA-PKLPVLYLHGHDDGCAT
MMAR_4334|M.marinum_M WRAALGPYRATIRNTRPPAR-YAELNRWWTEA-PQLPVLYLHGRDDGCAA
MUL_0144|M.ulcerans_Agy99 WRAALGPYRATIRNTRPPAR-YAELNRWWTEA-PQLPVLYLHGRDDGCAA
MAV_1256|M.avium_104 WRAALGPYRATIRNTAPPAQ-YATLHRLWTEE-PVLPCLYLHGRDDGCMT
TH_2114|M.thermoresistible__bu WRAALGYYRATIRNTRPPHR-YAELHQHWLSA-PRIPTLYLHGADDGCAT
MAB_4573c|M.abscessus_ATCC_199 RRAVIGYYRANIRGALFPARKYWPTQRSLLDG-ARTPMLYLHGRNDGCMT
MLBr_02297|M.leprae_Br4923 AHCALEYQRWAVRSQLRNEG--RKFMKSMSRP-FSVPLLHVRGDADPYLL
..: * :* : * * ::* *
Mflv_0191|M.gilvum_PYR-GCK AEYAAPIATALPAGSRVRIIDEAGHFLQIERPQVTADTVLDYLGDRRGPR
Mvan_0714|M.vanbaalenii_PYR-1 AGYAEPIGAVLPPGSRVVTIPAAGHFLQIERPAETAAAVLQYLGDRSGPR
MSMEG_1998|M.smegmatis_MC2_155 VRIGTLSASVLVPGSRHEVIDGAGHFMHLDRPDEVHALIADYANL-----
Rv1124|M.tuberculosis_H37Rv SAFTHWTARVLPAGSEVAVVEHAGHFLQLEQPDKIAELIVAFIGSPG---
Mb1155|M.bovis_AF2122/97 SAFTHWTARVLPAGSEVAVVEHAGHFLQLEQPDKIAELIVAFIGSPG---
MMAR_4334|M.marinum_M VAFTHWTERVLPPGSEVAVVEQAGHFLQLEQPETVAKLILPFIAPPG---
MUL_0144|M.ulcerans_Agy99 VAFTHWTERVLPPGSEVAVVEQAGHFLQLEQPEAVAKLILPFIAPPG---
MAV_1256|M.avium_104 SAFAHQVEKVLPPGSEVDIVEHAGHFLQLEQPDKVAGLVLGFIGSPG---
TH_2114|M.thermoresistible__bu PDYARWVEPVLPVGSAVAILDRAGHFLQLDRPDAVADHILRFAG------
MAB_4573c|M.abscessus_ATCC_199 YRLIDSARPDLPDRS-VEIINGGGHFVHLECPDVVYELVREFLGPPTSKV
MLBr_02297|M.leprae_Br4923 ADSVDRTRRYAPHGRYVSVSD-AGHFSHEEAPEEINRYLTRFLKQVHGPR
.*** : : * : :
Mflv_0191|M.gilvum_PYR-GCK --
Mvan_0714|M.vanbaalenii_PYR-1 --
MSMEG_1998|M.smegmatis_MC2_155 --
Rv1124|M.tuberculosis_H37Rv --
Mb1155|M.bovis_AF2122/97 --
MMAR_4334|M.marinum_M --
MUL_0144|M.ulcerans_Agy99 --
MAV_1256|M.avium_104 --
TH_2114|M.thermoresistible__bu --
MAB_4573c|M.abscessus_ATCC_199 E-
MLBr_02297|M.leprae_Br4923 LS