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SVPPGTQTLARGLAVIRAVADGARDLRGLVEHTGLGRSTTHRLVQLLVHEEFLRHVDGGYTLGPALIELG FKALHGNPLPVVARPFLEELSEQVHDTVHLGVVDGDSVLYLEKLPGTRGAEMRSRVGHRMPLTRTGVGMA LLLDSPERWEELYIADEDRVTVPTVVRRGELAERCAEFCTRMQTYAKSGSAMDLEDNEPGIRCVAAPVRD ASKAIVGAISVSATRPYMPAARMRGLVPVVRRSAARISSAMGYREAQAQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6174 | - | - | 100% (260) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_3784 | - | 1e-24 | 28.40% (250) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_2890 | - | 3e-22 | 34.33% (201) | putative transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3013 | - | 4e-18 | 32.93% (249) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0531 | - | 1e-22 | 34.84% (221) | regulatory protein, IclR |
| M. tuberculosis H37Rv | Rv2989 | - | 4e-18 | 32.93% (249) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0077 | - | 1e-21 | 34.33% (201) | IclR family transcriptional regulator |
| M. marinum M | MMAR_1725 | - | 1e-16 | 31.51% (219) | transcriptional regulatory protein |
| M. avium 104 | MAV_3024 | - | 2e-21 | 34.53% (223) | transcriptional regulator, IclR family protein |
| M. thermoresistible (build 8) | TH_3251 | - | 3e-23 | 34.76% (233) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_1967 | - | 2e-16 | 31.51% (219) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4411 | - | 5e-25 | 36.04% (222) | regulatory proteins, IclR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6174|M.smegmatis_MC2_155 --------------------MSVPPGTQTLARGLAVIRAVADG--ARDLR
Mflv_0531|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0077|M.abscessus_ATCC_1997 ----------------MTITADSATPSAVIDRVSLLLDAFDGP-GRLTLA
MAV_3024|M.avium_104 ------------------MPAPAETPTAVIDRISLVLDAFDGP-GRLTLA
TH_3251|M.thermoresistible__bu MTATLDQPTPNTTVKRTGTERTGETPSAVLDRISLVLDAFDGP-GRLTLA
Mvan_4411|M.vanbaalenii_PYR-1 ---MNQASIAIDPVRSSEHDSIHQSPTNSVRRTLQVLAAFDGSRTVLGVS
Mb3013|M.bovis_AF2122/97 --------------------MRQHSGIGVLDKAVGVLHAVAES--PCGLA
Rv2989|M.tuberculosis_H37Rv --------------------MRQHSGIGVLDKAVGVLHAVAES--PCGLA
MMAR_1725|M.marinum_M --------------------MRQDSGIGVIDKAVGLLRATAES--PCGLA
MUL_1967|M.ulcerans_Agy99 --------------------MRQDSGIGVIDKAVGLLRATAKS--PCGLA
MSMEG_6174|M.smegmatis_MC2_155 GLVEHTGLGRSTTHRLVQLLVH-EEFLRHVDGGYTLGPALIELGFKALHG
Mflv_0531|M.gilvum_PYR-GCK -MARRAGLPIATTHRLAAELVAGSALQRRADGQYVVGRLVWNAGLLAPVE
MAB_0077|M.abscessus_ATCC_1997 QLVRRTGLPRSSVHRMLERLVQ-LRWLRRDGRDYELGTRLVELGSLAVHQ
MAV_3024|M.avium_104 QIVRRTGLPRSSAHRMLERLVQ-LRWLRRSGRDYELGMRLVELGSLAVHQ
TH_3251|M.thermoresistible__bu QVVRRTGLPRSSAHRMLERLVQ-LRWLRRDGRDYELGMRLVELGSLAVHQ
Mvan_4411|M.vanbaalenii_PYR-1 EVAARADVPKSTAHRLLNVMSQ-QGFVRREGNRYRLGERLFELGARALEP
Mb3013|M.bovis_AF2122/97 ELCDRTDLPRATAYRLAAALEVHRLLGRGQDGHWRLGPAITELATHVDDP
Rv2989|M.tuberculosis_H37Rv ELCDRTDLPRATAYRLAAALEVHRLLGRGQDGHWRLGPAITELATHVDDP
MMAR_1725|M.marinum_M ELCERTGLPRATAYRLAAALEVHRLLGRDEDGRWGLGPAITELAAHVDDP
MUL_1967|M.ulcerans_Agy99 ELCERTGLPRATAYRLAAALEVHRLLGRDEDGRWGLGPAITELAAHVDDP
: ::.: ::.:*: : * . : :* : : . .
MSMEG_6174|M.smegmatis_MC2_155 NPLPVVARPFLEELSEQVHDTVHLGVVDGDSVLYLEKLPGTRGAEMRSRV
Mflv_0531|M.gilvum_PYR-GCK GQLRQVAEPFLYDVYAATLATVHLAVRDGDEVLYLERMMGRTSVPIVSAV
MAB_0077|M.abscessus_ATCC_1997 DRLHAAALPMLHELHRATGLVVHLSILDGADVVYLEKIGAGIGAAVATRI
MAV_3024|M.avium_104 DRLVRAATPLLVELHRATGLVVHLAVLDGPDVVYLEKVGDRLNSVIPSRV
TH_3251|M.thermoresistible__bu DRLHRAAIPRLHELHAATGLVVHLAVLDGSDVVYLEKVGSRLAAAIPTRV
Mvan_4411|M.vanbaalenii_PYR-1 RGLRERAIPFMAELHHSTLETIHLAVLRGDQVLYVEKIYGHGAAPCPTTV
Mb3013|M.bovis_AF2122/97 --LLVACAAVLPQLRDATGESVQVYRREGTSRVCVAALEPAAGLRDTVPV
Rv2989|M.tuberculosis_H37Rv --LLVACAAVLPQLRDATGESVQVYRREGTSRVCVAALEPAAGLRDTVPV
MMAR_1725|M.marinum_M --LLTAGATVLPRLRETTGESVQLYRREGTSRVCVAALEPPAGLRDTVPV
MUL_1967|M.ulcerans_Agy99 --LLTAGATVLPRLCETTGESVQLYRREGTSRVCVAALEPPAGLRDTVPV
* . : : . ::: * . : : : :
MSMEG_6174|M.smegmatis_MC2_155 GHRMPLTRTGVGMALLLDSP--ERWEELYIADEDRVTVPTVVRRGELAER
Mflv_0531|M.gilvum_PYR-GCK GSRLPMHCTGVGKVLLAHAP--EDVKDRVFATLTRITPYTIVSP------
MAB_0077|M.abscessus_ATCC_1997 GGRQPAHCTASGKAILAYR--AQILDG--CTALARKTRYSIGSA------
MAV_3024|M.avium_104 GGRQPAHCTAVGKAILAYR--DEATD---LDLGARPTKYSISSA------
TH_3251|M.thermoresistible__bu GGRRPANCAAVGKAILAYAEDDGVLSG--TGPLPRNTKYSISDP------
Mvan_4411|M.vanbaalenii_PYR-1 GGRNPATCTGLGKAILSSCS-EEAVDAILGSRLPRPTRNSLHTR------
Mb3013|M.bovis_AF2122/97 GARLPMTAGSGAKVLLAHTD---------AATQAAVLPKAVFSA------
Rv2989|M.tuberculosis_H37Rv GARLPMTAGSGAKVLLAHTD---------AATQAAVLPKAVFSA------
MMAR_1725|M.marinum_M GARLPMTAGSGAKVLLAHSD---------PATQQAVLPTAKFTD------
MUL_1967|M.ulcerans_Agy99 GARLPMTAGSGAKVLLAHSD---------PATQQAVLPTAKFTD------
* * * . . .:* :
MSMEG_6174|M.smegmatis_MC2_155 CAEFCTRMQTYAKSGSAMDLEDNEPGIRCVAAPVR-DASKAIVGAISVSA
Mflv_0531|M.gilvum_PYR-GCK -TVLSSQMQRIHREGVATTSEEMSLGACSLAVPVIRQTDDAVVAAIAVVV
MAB_0077|M.abscessus_ATCC_1997 -AQLRPELDKVRGHGVAFDREELQQGIGCVAAPIGS--IGDAVAAVSVCG
MAV_3024|M.avium_104 -PQLAAELAKVRAHGVAFEREESLLGFGCVAAPIGG--PGEAAAAVSVCG
TH_3251|M.thermoresistible__bu -ARLRAELAKVRAHGVAFDREESLPGIGCVAAPIGD--PGEAVAAISVCG
Mvan_4411|M.vanbaalenii_PYR-1 -QALHRNLTISREEGVAVDYEELRMGLACVSAPIIDRSTGAAVAALSISA
Mb3013|M.bovis_AF2122/97 -----RALAEVCRRGWAQSVAEREPGVASVSAPVRD-GRGVVIAAISVSG
Rv2989|M.tuberculosis_H37Rv -----RALAEVCRRGWAQSVAEREPGVASVSAPVRD-GRGVVIAAISVSG
MMAR_1725|M.marinum_M -----RVLAEVRRRGWAQSVAEREPGVASVSAPVRD-GRGVVVAAISVSG
MUL_1967|M.ulcerans_Agy99 -----RVLAEVRRRGWAQSVAEREPGVASVSAPVRD-GRGVVVAAISVSG
: * * : * .::.*: .*:::
MSMEG_6174|M.smegmatis_MC2_155 TRPYMPAARMRGLVPVVRRS-------------AARISSAMGYREAQAQ-
Mflv_0531|M.gilvum_PYR-GCK PTLKRDRQRLLGALQVAARG-------------IGRLL------------
MAB_0077|M.abscessus_ATCC_1997 PMTRMTFDQRLAAPVRMTAMGIWRNVENGPSRVAPTLQPIRPLRCGPAAS
MAV_3024|M.avium_104 PLQRMALDQRLAAPVRMTAMGVWRNVEGGPQRVAPTLQRLRPLP--PMRP
TH_3251|M.thermoresistible__bu PMNQMAFDHRLVAPVRMAALGIWRAMEGARQRVVPTLQQVRPLRPGPTAQ
Mvan_4411|M.vanbaalenii_PYR-1 PTSR--FNRRRFTVQLLKAT------------EALSLGSLRSA-------
Mb3013|M.bovis_AF2122/97 PIDRMGRRPGVRWAADLLSA-------------ADALTRRL---------
Rv2989|M.tuberculosis_H37Rv PIDRMGRRPGVRWAADLLSA-------------ADALTRRL---------
MMAR_1725|M.marinum_M PIDRIGRRPGARWAADLLAA-------------ADELARRL---------
MUL_1967|M.ulcerans_Agy99 PIDRIGRRPGARWAADLLAA-------------ADELARRL---------
. :
MSMEG_6174|M.smegmatis_MC2_155 ---------------------------
Mflv_0531|M.gilvum_PYR-GCK ---------------------------
MAB_0077|M.abscessus_ATCC_1997 STG-REMNSPALQYA------------
MAV_3024|M.avium_104 QHP-VPKPRPALQYA------------
TH_3251|M.thermoresistible__bu SLSHSALSHPAQSHPARSHRADTRRFA
Mvan_4411|M.vanbaalenii_PYR-1 ---------------------------
Mb3013|M.bovis_AF2122/97 ---------------------------
Rv2989|M.tuberculosis_H37Rv ---------------------------
MMAR_1725|M.marinum_M ---------------------------
MUL_1967|M.ulcerans_Agy99 ---------------------------