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MTAASTFVIIGGGLAGAKAAEALRDNDFDGQVLLFAAEEKLPYERPPLSKDYLAGKKTLDEFTVAAPAWY RDHDVTLRLGTEVAAINPADHTVTLPDGSAVGYDKLLLATGSASRRLPIPGADASGVHYLRTVDDAAALD AVLTEGASLAVVGAGWIGLEVAASARTRGVNVTVVEAARLPLLGALGAEVAEVFAQLHREHGVDLRLEQT VEEITTADGRATGLRLGDGSTIAADAVLVAVGAAPNIGLAERAGLATADGGVLVDASLRTSDPDIYAVGD IAAAQHPLFGVRIRTEHWANALKQPAVAVAGMLGRPAEYAELPYFFTDQYDLGMEYAGHAPSYERVVFRG DVPGREFVSFWLDGDNRVLAGMNVNIWDVLDDVKALIRSREPVDPDLLADPGRPLNAPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3594 | - | - | 100% (409) | anthranilate dioxygenase reductase |
| M. smegmatis MC2 155 | MSMEG_1460 | - | 3e-70 | 41.16% (362) | pyridine nucleotide-disulphide oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_1416 | - | 4e-61 | 36.90% (355) | pyridine nucleotide-disulphide oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1900c | - | 1e-174 | 73.33% (405) | reductase |
| M. gilvum PYR-GCK | Mflv_4591 | - | 1e-69 | 41.76% (364) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv1869c | - | 1e-174 | 73.33% (405) | reductase |
| M. leprae Br4923 | MLBr_02387 | lpd | 2e-12 | 30.16% (189) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2047c | - | 1e-68 | 38.68% (393) | ferredoxin reductase |
| M. marinum M | MMAR_3153 | - | 1e-69 | 42.98% (356) | ferredoxin reductase |
| M. avium 104 | MAV_2849 | - | 1e-177 | 76.79% (405) | anthranilate dioxygenase reductase |
| M. thermoresistible (build 8) | TH_3739 | - | 4e-66 | 38.69% (367) | PUTATIVE Pyridine nucleotide-disulphide oxidoreductase |
| M. ulcerans Agy99 | MUL_0769 | - | 2e-68 | 40.17% (361) | ferredoxin reductase |
| M. vanbaalenii PYR-1 | Mvan_1327 | - | 3e-69 | 40.44% (361) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4591|M.gilvum_PYR-GCK ------------------MTLHRAVIVGASHAGAQLAASLRQEGWDGEIV
MMAR_3153|M.marinum_M ------------------MTVQRAVIAGASHAGTQLAASLRREGWDGEIV
MAB_2047c|M.abscessus_ATCC_199 ------------------MTPERAVIVGASHAGAQLAANLRREGWSGEVV
Mb1900c|M.bovis_AF2122/97 -----------------MASSTTFVIVGGGLAGAKAVEALRRSDFGGRII
Rv1869c|M.tuberculosis_H37Rv -----------------MASSTTFVIVGGGLAGAKAVEALRRSDFGGRII
MAV_2849|M.avium_104 -----------------MASATGFVIIGGGLAAAKAVEALRDNNFDGRII
MSMEG_3594|M.smegmatis_MC2_155 -----------------MTAASTFVIIGGGLAGAKAAEALRDNDFDGQVL
TH_3739|M.thermoresistible__bu -----------------VSTTAGIIIVGGGLAAARTAEQLRRSEFGGPIT
MUL_0769|M.ulcerans_Agy99 MYEHHVTSSEGVTQDPGATAANGIVIIGGGLAAARTAEQLRRAGYEGQLT
Mvan_1327|M.vanbaalenii_PYR-1 ------------------MSRRTFVTVGAGQTAAVAARNLRRHGFDGRIV
MLBr_02387|M.leprae_Br4923 ------------------MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVV
: : *.. . . :
Mflv_4591|M.gilvum_PYR-GCK LVGNESALPYHRPPLSKAYLAGKCTVDELAIRNAE---------------
MMAR_3153|M.marinum_M LVGDESALPYQRPPLSKSYLADKCELAELAIRNSD---------------
MAB_2047c|M.abscessus_ATCC_199 LIGDEGGLPYHRPPLSKGYLAGKNGLDDLLIRGAD---------------
Mb1900c|M.bovis_AF2122/97 LFGDEEHLPYDRPPLSKEFLAGKKSLSDFTIQTSD---------------
Rv1869c|M.tuberculosis_H37Rv LFGDEEHLPYDRPPLSKEFLAGKKSLSDFTIQTSD---------------
MAV_2849|M.avium_104 VFADEEHLPYERPPLSKEFLAGKKSLTDFTVQNSD---------------
MSMEG_3594|M.smegmatis_MC2_155 LFAAEEKLPYERPPLSKDYLAGKKTLDEFTVAAPA---------------
TH_3739|M.thermoresistible__bu IVSDEDHLPYDRPPLSKDVLSGKTDD--VTLKPAE---------------
MUL_0769|M.ulcerans_Agy99 IVSDEVHLPYDRPPLSKEVLRSEVDD--VSLKPRE---------------
Mvan_1327|M.vanbaalenii_PYR-1 LIGDEPHPPYQRPPLSKEFLAGTENEEGLWILPPK---------------
MLBr_02387|M.leprae_Br4923 EPKYWGGICLNVGCIPSKVLLHNAELAHIFTKEAKTFGISGDASFDYGIA
. :.. * .
Mflv_4591|M.gilvum_PYR-GCK ----------------FYTKQRIKL-MDATVEVLDRSAGHLSLTTGD---
MMAR_3153|M.marinum_M ----------------FYAKQRIRL-LDATVAAVDRSAGHVVLSTGD---
MAB_2047c|M.abscessus_ATCC_199 ----------------FYEKQHIRL-LNATVEAIHRSAKRVSLSTGD---
Mb1900c|M.bovis_AF2122/97 ----------------WYRDHDVDVRLGVRVSSLDRSAHTVELPDGA---
Rv1869c|M.tuberculosis_H37Rv ----------------WYRDHDVDVRLGVRVSSLDRSAHTVELPDGA---
MAV_2849|M.avium_104 ----------------WYRDNDVDLRLNTRVCALDAAGHTVGLPDGT---
MSMEG_3594|M.smegmatis_MC2_155 ----------------WYRDHDVTLRLGTEVAAINPADHTVTLPDGS---
TH_3739|M.thermoresistible__bu ----------------FYAENDITLLLGTAATALDPQARKLTLADGR---
MUL_0769|M.ulcerans_Agy99 ----------------WYDEKGITLRLGSAATGLDTAAQTVTLADGT---
Mvan_1327|M.vanbaalenii_PYR-1 ----------------WLQDNDVEIITDTTVVRVDAAARAVEFSGGA---
MLBr_02387|M.leprae_Br4923 YDRSRKVSEGRVAGVHFLMKKNKITEIHGYGRFTDANTLSVELSEGVPET
: .: . : :. *
Mflv_4591|M.gilvum_PYR-GCK --ALPYDKLALCTGARPRRLSIPGADLPGVCYLRTAADVAMIRERTSPGR
MMAR_3153|M.marinum_M --ALPYDKLALCTGARPRRLPTPGADLAGVFYLRTAADGEMIREAAGPGR
MAB_2047c|M.abscessus_ATCC_199 --TLTYTKLALCTGARARRLPTPGVDLPGIHYLRTAADVELIRAAATPGR
Mb1900c|M.bovis_AF2122/97 --AVRYDKLLLATGSAPRRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGS
Rv1869c|M.tuberculosis_H37Rv --AVRYDKLLLATGSAPRRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGS
MAV_2849|M.avium_104 --TVAYDKLLLATGSAARRPPIPGSDCAGVHYLRTYEVAVALNSFLGEGK
MSMEG_3594|M.smegmatis_MC2_155 --AVGYDKLLLATGSASRRLPIPGADASGVHYLRTVDDAAALDAVLTEGA
TH_3739|M.thermoresistible__bu --ALEYDELIIATGLVPKRIPT-LPDLEGIRVLRTYDESMALRKHAGSAR
MUL_0769|M.ulcerans_Agy99 --VLGYDELVIATGLVPRRIPA-FPELEGIRVLRSFDECMALRSHASAAK
Mvan_1327|M.vanbaalenii_PYR-1 --GLQADSVLFATGGAPRRLPVDGPRPDLVHYLRTLDDAARLAPVLTPGR
MLBr_02387|M.leprae_Br4923 PLKVTFNNVIIATGSKTRLVPGTLLSTN----VITYEEQILTRELP---D
: .: :.** .: . : :
Mflv_4591|M.gilvum_PYR-GCK RAVIVGGGYIGLEAAASLRALGLEVTVLEATERVLERVTAPAVSAFFDRI
MMAR_3153|M.marinum_M RAVIVGGGYIGLETAASLRALGLEVTLLEATGRVLERVTAPEVSEFFDRI
MAB_2047c|M.abscessus_ATCC_199 RVVIVGGGYIGLETAASLCSLGMNVTVLEATERVLERVTAPEVSAFYTRI
Mb1900c|M.bovis_AF2122/97 SLAVVGAGWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADL
Rv1869c|M.tuberculosis_H37Rv SLAVVGAGWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADL
MAV_2849|M.avium_104 SLAVVGAGWIGLEVAAAARQRGVEVTVVEAARQPLTAALGETVGEVFATL
MSMEG_3594|M.smegmatis_MC2_155 SLAVVGAGWIGLEVAASARTRGVNVTVVEAARLPLLGALGAEVAEVFAQL
TH_3739|M.thermoresistible__bu NAVVIGAGFIGCEVAASLRGLGVHVVLVEPQPTPLAGVLGEQIGALVARL
MUL_0769|M.ulcerans_Agy99 RAVVIGAGFIGCEVAASLRGLGVEVVLVEPQPTPLAAVLGEQIGELVARL
Mvan_1327|M.vanbaalenii_PYR-1 RLAIIGAGFIGLEIAATAAAAGVEVTVLEAVPVPLARVVGPAMGEAVCRL
MLBr_02387|M.leprae_Br4923 SIVIVGAGAIGIEFGYVLKNYGVDVTIVEFLPRAMPNED-AEVSKEIEKQ
.::*.* ** * . *:.*.::* : :.
Mflv_4591|M.gilvum_PYR-GCK HREEGVDIQTDALVDAMS-GDGRVREVILASG--ESIPADLVIVGIGVEP
MMAR_3153|M.marinum_M HREEGVNIRTGTLVEALS-GDGRVREVILAGG--ESIPADLVIVGIGVEP
MAB_2047c|M.abscessus_ATCC_199 HRGEGVEIRTHALVEAFS-GNGGVQEVVLADG--ESIPADLVIVGVGVVP
Mb1900c|M.bovis_AF2122/97 HRDQGVDLRLQTQLEEITAADGKATGLKMRDG--STVAADAVLVAVGAKP
Rv1869c|M.tuberculosis_H37Rv HRDQGVDLRLQTQLEEITAADGKATGLKMRDG--STVAADAVLVAVGAKP
MAV_2849|M.avium_104 HREHGVDLRLETQVREITRADGSATGLRTTDG--SAIPADAVLVAVGARP
MSMEG_3594|M.smegmatis_MC2_155 HREHGVDLRLEQTVEEITTADGRATGLRLGDG--STIAADAVLVAVGAAP
TH_3739|M.thermoresistible__bu HRDEGVDLRCGVGVADVR-GTGAVEKVVLDDG--TELDADLVVVGIGSTP
MUL_0769|M.ulcerans_Agy99 HRSEGVDVRTGVGVAEVR-GDGHVDTVVLADG--TQLDADLVVVGIGSHP
Mvan_1327|M.vanbaalenii_PYR-1 HRDNGVDIRAGVQLAGVRTAADGVVIDIAGAA--APLEADAVVVGIGIIP
MLBr_02387|M.leprae_Br4923 FKKMGIKILTGTKVESISDNGSHVLVAVSKDGQFQELKADKVLQAIGFAP
.: *:.: : . . . . : ** *: .:* *
Mflv_4591|M.gilvum_PYR-GCK NTD---LAAAAGLAIDNG-VVIDDQARTTDPDIVAAGDCTSHHMARYGRR
MMAR_3153|M.marinum_M NTE---LAATAGLVVDNG-VVIDDQARTSDPDIVAAGDCASHDMARYGRR
MAB_2047c|M.abscessus_ATCC_199 NTE---LASAAGLSVDNG-IVIDDQARTSDPDIVAAGDCTSHTMARYGSR
Mb1900c|M.bovis_AF2122/97 NVE---LAQQAGLAMGEGGVLVDASLRTSDPDIYAVGDIAAAEHPLLGTR
Rv1869c|M.tuberculosis_H37Rv NVE---LAQQAGLAMGEGGVLVDASLRTSDPDIYAVGDIAAAEHPLLGTR
MAV_2849|M.avium_104 NIE---LAEAAGLSLADGGVLVDASLRTSDPDIYAVGDIAAAEHPLLRTR
MSMEG_3594|M.smegmatis_MC2_155 NIG---LAERAGLATADGGVLVDASLRTSDPDIYAVGDIAAAQHPLFGVR
TH_3739|M.thermoresistible__bu ATD---WLQGSGVEVDNG-VVCDAVGRTNVEHVWAIGDVAS-WRNTVGKQ
MUL_0769|M.ulcerans_Agy99 ATG---WLDGSGIAVDNG-VVCDAAGRTSAPNVWAFGDVAS-WRDQMGHQ
Mvan_1327|M.vanbaalenii_PYR-1 NTA---VAAASGLWVDDG-IVVDALGRTAVPGVFAAGDAARRYSPRAGRH
MLBr_02387|M.leprae_Br4923 NVDGYGLDKVGVALTADKAVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAE
. : : * :* : * ** : .
Mflv_4591|M.gilvum_PYR-GCK IR----LESVPGAGEQAKVAAATICGKSK-KVAALPWFWSDQYDVK--LQ
MMAR_3153|M.marinum_M IR----LESVPSAAEQAKVAAATVCGKSK-KIAALPWFWSDQYDLK--LQ
MAB_2047c|M.abscessus_ATCC_199 IR----LESVSSAGEQAKIAAATICGKHS-AIAALPWFWSDQYDLK--LQ
Mb1900c|M.bovis_AF2122/97 VR----TEHWANALKQPAVAAAGMLGRPG-EYAELPYLFTDQYDLG--ME
Rv1869c|M.tuberculosis_H37Rv VR----TEHWANALKQPAVAAAGMLGRPG-EYAELPYLFTDQYDLG--ME
MAV_2849|M.avium_104 IR----TEHWANALKQPAIAVAGMLGRPG-EYDELPYFFTDQYDLG--ME
MSMEG_3594|M.smegmatis_MC2_155 IR----TEHWANALKQPAVAVAGMLGRPA-EYAELPYFFTDQYDLG--ME
TH_3739|M.thermoresistible__bu VR----VEHWSNVADQARVLVPALLGQEVPVAATVPYFWSDQYDVK--IQ
MUL_0769|M.ulcerans_Agy99 VR----VEHWSNVADQARVVVPAMLGREVSSNVVVPYFWSDQYDVK--IQ
Mvan_1327|M.vanbaalenii_PYR-1 LR----LEHFDNASRQGVAVANAMLGREAPSDDPL-WFWSDQYGRN--IQ
MLBr_02387|M.leprae_Br4923 AQGVVAAEAIAGAETLALSDYRMMPRATFCQPNVASFGLTEQQARDGGYD
: * .. : : ::* :
Mflv_4591|M.gilvum_PYR-GCK IAGLNTGYDEVVLSGDPTRDRDFTCFYLR--AGELIAADCINRPRDFVFS
MMAR_3153|M.marinum_M IAGLNTGYDEVVLSGDPTRERDFTCFYLR--AGELLAADCINRPRDFMFS
MAB_2047c|M.abscessus_ATCC_199 IAGLNAGYDELLLSGDPSRDRDFSCFYFR--EGELIAADCVNRPRDFMSS
Mb1900c|M.bovis_AF2122/97 YVGHAPSCDRVVFRG-NVAGREFLSFWLDG-DSRVLAGMNVNVWDVVDDV
Rv1869c|M.tuberculosis_H37Rv YVGHAPSCDRVVFRG-NVAGREFLSFWLDG-DSRVLAGMNVNVWDVVDDV
MAV_2849|M.avium_104 YVGHAPRFERVVFRG-DVAAREFVAFWLDA-DDRVLAGMNVNIWDVLDDV
MSMEG_3594|M.smegmatis_MC2_155 YAGHAPSYERVVFRG-DVPGREFVSFWLDG-DNRVLAGMNVNIWDVLDDV
TH_3739|M.thermoresistible__bu CLGEPEAGD-TVHVV-SDDGRKFLAYYER--DGVLTGVVGGGMPGKVMKA
MUL_0769|M.ulcerans_Agy99 CLGEPHSTD-VVHLV-EDDGRKLLAYYQR--DGVLVGVVGGGVPGKVMKV
Mvan_1327|M.vanbaalenii_PYR-1 FVGTASGTP-VIRGN-RDE-FDFTGFYLE--NDTVCGAFAIDRGEDVTAA
MLBr_02387|M.leprae_Br4923 VVVAKFPFTANAKAHGMGDPSGFVKLVADAKYGELLGGHMIGHNVSELLP
: . : . .
Mflv_4591|M.gilvum_PYR-GCK KRVITQQVPIERAELMLAGPA-----------------------------
MMAR_3153|M.marinum_M KRVITQQVAVERAELVLAGSD-----------------------------
MAB_2047c|M.abscessus_ATCC_199 KRAISQQLRVDRSE-LLAGSI-----------------------------
Mb1900c|M.bovis_AF2122/97 KGLIRSGNPVDVDRLVDPQWPLADLTTN----------------------
Rv1869c|M.tuberculosis_H37Rv KGLIRSGNPVDVDRLVDPQWPLADLTTN----------------------
MAV_2849|M.avium_104 KALIRSRAPIDADRLGDPGAPLGELLG-----------------------
MSMEG_3594|M.smegmatis_MC2_155 KALIRSREPVDPDLLADPGRPLNAPG------------------------
TH_3739|M.thermoresistible__bu RAKIAAG--APISEVLE---------------------------------
MUL_0769|M.ulcerans_Agy99 RAKIAAA--VPISEMLDESQGQTSARIPARGAGPGGPLVRWPTLTKSGRW
Mvan_1327|M.vanbaalenii_PYR-1 RELLGRG--VDAAALLDEDTDLWDLVYADEDEQVRA--------------
MLBr_02387|M.leprae_Br4923 ELTLAQKWDLTATELVRNVHTHPTLSEALQECFHGLIGHMINF-------
. :
Mflv_4591|M.gilvum_PYR-GCK -----------------------------------
MMAR_3153|M.marinum_M -----------------------------------
MAB_2047c|M.abscessus_ATCC_199 -----------------------------------
Mb1900c|M.bovis_AF2122/97 -----------------------------------
Rv1869c|M.tuberculosis_H37Rv -----------------------------------
MAV_2849|M.avium_104 -----------------------------------
MSMEG_3594|M.smegmatis_MC2_155 -----------------------------------
TH_3739|M.thermoresistible__bu -----------------------------------
MUL_0769|M.ulcerans_Agy99 RAEKATASSPVARVDGIGLEPGPRRTASWPDVPGT
Mvan_1327|M.vanbaalenii_PYR-1 -----------------------------------
MLBr_02387|M.leprae_Br4923 -----------------------------------