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TLHRAVIVGASHAGAQLAASLRQEGWDGEIVLVGNESALPYHRPPLSKAYLAGKCTVDELAIRNAEFYTK QRIKLMDATVEVLDRSAGHLSLTTGDALPYDKLALCTGARPRRLSIPGADLPGVCYLRTAADVAMIRERT SPGRRAVIVGGGYIGLEAAASLRALGLEVTVLEATERVLERVTAPAVSAFFDRIHREEGVDIQTDALVDA MSGDGRVREVILASGESIPADLVIVGIGVEPNTDLAAAAGLAIDNGVVIDDQARTTDPDIVAAGDCTSHH MARYGRRIRLESVPGAGEQAKVAAATICGKSKKVAALPWFWSDQYDVKLQIAGLNTGYDEVVLSGDPTRD RDFTCFYLRAGELIAADCINRPRDFVFSKRVITQQVPIERAELMLAGPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4591 | - | - | 100% (400) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. gilvum PYR-GCK | Mflv_5068 | - | 1e-63 | 39.67% (363) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0680 | - | 1e-51 | 34.11% (384) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1900c | - | 9e-66 | 38.74% (364) | reductase |
| M. tuberculosis H37Rv | Rv1869c | - | 1e-65 | 38.74% (364) | reductase |
| M. leprae Br4923 | MLBr_02387 | lpd | 8e-11 | 31.06% (161) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2047c | - | 1e-172 | 74.43% (395) | ferredoxin reductase |
| M. marinum M | MMAR_3153 | - | 0.0 | 84.42% (398) | ferredoxin reductase |
| M. avium 104 | MAV_2849 | - | 1e-64 | 37.64% (364) | anthranilate dioxygenase reductase |
| M. smegmatis MC2 155 | MSMEG_3594 | - | 1e-69 | 41.76% (364) | anthranilate dioxygenase reductase |
| M. thermoresistible (build 8) | TH_3739 | - | 1e-62 | 38.76% (387) | PUTATIVE Pyridine nucleotide-disulphide oxidoreductase |
| M. ulcerans Agy99 | MUL_0769 | - | 1e-62 | 37.31% (386) | ferredoxin reductase |
| M. vanbaalenii PYR-1 | Mvan_1290 | - | 4e-64 | 40.06% (362) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4591|M.gilvum_PYR-GCK ------------------MTLHRAVIVGASHAGAQLAASLRQEGWDGEIV
MMAR_3153|M.marinum_M ------------------MTVQRAVIAGASHAGTQLAASLRREGWDGEIV
MAB_2047c|M.abscessus_ATCC_199 ------------------MTPERAVIVGASHAGAQLAANLRREGWSGEVV
Mb1900c|M.bovis_AF2122/97 -----------------MASSTTFVIVGGGLAGAKAVEALRRSDFGGRII
Rv1869c|M.tuberculosis_H37Rv -----------------MASSTTFVIVGGGLAGAKAVEALRRSDFGGRII
MAV_2849|M.avium_104 -----------------MASATGFVIIGGGLAAAKAVEALRDNNFDGRII
MSMEG_3594|M.smegmatis_MC2_155 -----------------MTAASTFVIIGGGLAGAKAAEALRDNDFDGQVL
TH_3739|M.thermoresistible__bu -----------------VSTTAGIIIVGGGLAAARTAEQLRRSEFGGPIT
Mvan_1290|M.vanbaalenii_PYR-1 --------------MTTSEVSGGVVIVGGGLAAARTAEQLRRSEYAGAIT
MUL_0769|M.ulcerans_Agy99 MYEHHVTSSEGVTQDPGATAANGIVIIGGGLAAARTAEQLRRAGYEGQLT
MLBr_02387|M.leprae_Br4923 ------------------MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVV
:: *.. .. . :
Mflv_4591|M.gilvum_PYR-GCK LVGNESALPYHRPPLSKAYLAGKCTVDELAIRNAE---------------
MMAR_3153|M.marinum_M LVGDESALPYQRPPLSKSYLADKCELAELAIRNSD---------------
MAB_2047c|M.abscessus_ATCC_199 LIGDEGGLPYHRPPLSKGYLAGKNGLDDLLIRGAD---------------
Mb1900c|M.bovis_AF2122/97 LFGDEEHLPYDRPPLSKEFLAGKKSLSDFTIQTSD---------------
Rv1869c|M.tuberculosis_H37Rv LFGDEEHLPYDRPPLSKEFLAGKKSLSDFTIQTSD---------------
MAV_2849|M.avium_104 VFADEEHLPYERPPLSKEFLAGKKSLTDFTVQNSD---------------
MSMEG_3594|M.smegmatis_MC2_155 LFAAEEKLPYERPPLSKDYLAGKKTLDEFTVAAPA---------------
TH_3739|M.thermoresistible__bu IVSDEDHLPYDRPPLSKDVLSGKT--DDVTLKPAE---------------
Mvan_1290|M.vanbaalenii_PYR-1 IVSDEGHLPYDRPPLSKEVLRAET--DDVTLKPAE---------------
MUL_0769|M.ulcerans_Agy99 IVSDEVHLPYDRPPLSKEVLRSEV--DDVSLKPRE---------------
MLBr_02387|M.leprae_Br4923 EPKYWGGICLNVGCIPSKVLLHNAELAHIFTKEAKTFGISGDASFDYGIA
: . :.. * : ..
Mflv_4591|M.gilvum_PYR-GCK ----------------FYTKQRIKL-MDATVEVLDRSAGHLSLTTGD---
MMAR_3153|M.marinum_M ----------------FYAKQRIRL-LDATVAAVDRSAGHVVLSTGD---
MAB_2047c|M.abscessus_ATCC_199 ----------------FYEKQHIRL-LNATVEAIHRSAKRVSLSTGD---
Mb1900c|M.bovis_AF2122/97 ----------------WYRDHDVDVRLGVRVSSLDRSAHTVELPDGA---
Rv1869c|M.tuberculosis_H37Rv ----------------WYRDHDVDVRLGVRVSSLDRSAHTVELPDGA---
MAV_2849|M.avium_104 ----------------WYRDNDVDLRLNTRVCALDAAGHTVGLPDGT---
MSMEG_3594|M.smegmatis_MC2_155 ----------------WYRDHDVTLRLGTEVAAINPADHTVTLPDGS---
TH_3739|M.thermoresistible__bu ----------------FYAENDITLLLGTAATALDPQARKLTLADGR---
Mvan_1290|M.vanbaalenii_PYR-1 ----------------FYTENNITVLLGNGAKSVDTDSRTLTLADGT---
MUL_0769|M.ulcerans_Agy99 ----------------WYDEKGITLRLGSAATGLDTAAQTVTLADGT---
MLBr_02387|M.leprae_Br4923 YDRSRKVSEGRVAGVHFLMKKNKITEIHGYGRFTDANTLSVELSEGVPET
: .: : . : *. *
Mflv_4591|M.gilvum_PYR-GCK --ALPYDKLALCTGARPRRLSIPGADLPGVCYLRTAADVAMIRERTSPGR
MMAR_3153|M.marinum_M --ALPYDKLALCTGARPRRLPTPGADLAGVFYLRTAADGEMIREAAGPGR
MAB_2047c|M.abscessus_ATCC_199 --TLTYTKLALCTGARARRLPTPGVDLPGIHYLRTAADVELIRAAATPGR
Mb1900c|M.bovis_AF2122/97 --AVRYDKLLLATGSAPRRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGS
Rv1869c|M.tuberculosis_H37Rv --AVRYDKLLLATGSAPRRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGS
MAV_2849|M.avium_104 --TVAYDKLLLATGSAARRPPIPGSDCAGVHYLRTYEVAVALNSFLGEGK
MSMEG_3594|M.smegmatis_MC2_155 --AVGYDKLLLATGSASRRLPIPGADASGVHYLRTVDDAAALDAVLTEGA
TH_3739|M.thermoresistible__bu --ALEYDELIIATGLVPKRIPTLP-DLEGIRVLRTYDESMALRKHAGSAR
Mvan_1290|M.vanbaalenii_PYR-1 --QLGYDELIIATGLVPKRIPSFP-DLPGIHVLRNFDESLALRQEAGTAR
MUL_0769|M.ulcerans_Agy99 --VLGYDELVIATGLVPRRIPAFP-ELEGIRVLRSFDECMALRSHASAAK
MLBr_02387|M.leprae_Br4923 PLKVTFNNVIIATGSKTRLVPGTLLSTN----VITYEEQILTRELP---D
: : :: :.** .: . . : .
Mflv_4591|M.gilvum_PYR-GCK RAVIVGGGYIGLEAAASLRALGLEVTVLEATERVLERVTAPAVSAFFDRI
MMAR_3153|M.marinum_M RAVIVGGGYIGLETAASLRALGLEVTLLEATGRVLERVTAPEVSEFFDRI
MAB_2047c|M.abscessus_ATCC_199 RVVIVGGGYIGLETAASLCSLGMNVTVLEATERVLERVTAPEVSAFYTRI
Mb1900c|M.bovis_AF2122/97 SLAVVGAGWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADL
Rv1869c|M.tuberculosis_H37Rv SLAVVGAGWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADL
MAV_2849|M.avium_104 SLAVVGAGWIGLEVAAAARQRGVEVTVVEAARQPLTAALGETVGEVFATL
MSMEG_3594|M.smegmatis_MC2_155 SLAVVGAGWIGLEVAASARTRGVNVTVVEAARLPLLGALGAEVAEVFAQL
TH_3739|M.thermoresistible__bu NAVVIGAGFIGCEVAASLRGLGVHVVLVEPQPTPLAGVLGEQIGALVARL
Mvan_1290|M.vanbaalenii_PYR-1 RAVVVGAGFIGCEVAASLRKLGVEVVLVEPQPAPLASVLGQQIGELVTRL
MUL_0769|M.ulcerans_Agy99 RAVVIGAGFIGCEVAASLRGLGVEVVLVEPQPTPLAAVLGEQIGELVARL
MLBr_02387|M.leprae_Br4923 SIVIVGAGAIGIEFGYVLKNYGVDVTIVEFLPRAMPNED-AEVSKEIEKQ
.::*.* ** * . *:.*.::* : :.
Mflv_4591|M.gilvum_PYR-GCK HREEGVDIQTDALVDAMS-GDGRVREVILASG--ESIPADLVIVGIGVEP
MMAR_3153|M.marinum_M HREEGVNIRTGTLVEALS-GDGRVREVILAGG--ESIPADLVIVGIGVEP
MAB_2047c|M.abscessus_ATCC_199 HRGEGVEIRTHALVEAFS-GNGGVQEVVLADG--ESIPADLVIVGVGVVP
Mb1900c|M.bovis_AF2122/97 HRDQGVDLRLQTQLEEITAADGKATGLKMRDG--STVAADAVLVAVGAKP
Rv1869c|M.tuberculosis_H37Rv HRDQGVDLRLQTQLEEITAADGKATGLKMRDG--STVAADAVLVAVGAKP
MAV_2849|M.avium_104 HREHGVDLRLETQVREITRADGSATGLRTTDG--SAIPADAVLVAVGARP
MSMEG_3594|M.smegmatis_MC2_155 HREHGVDLRLEQTVEEITTADGRATGLRLGDG--STIAADAVLVAVGAAP
TH_3739|M.thermoresistible__bu HRDEGVDLRCGVGVADVR-GTGAVEKVVLDDG--TELDADLVVVGIGSTP
Mvan_1290|M.vanbaalenii_PYR-1 HRAEGVDVRCGVGVSKVS-GDDRVRKVTLGDG--TELDADIVVVGIGSHP
MUL_0769|M.ulcerans_Agy99 HRSEGVDVRTGVGVAEVR-GDGHVDTVVLADG--TQLDADLVVVGIGSHP
MLBr_02387|M.leprae_Br4923 FKKMGIKILTGTKVESISDNGSHVLVAVSKDGQFQELKADKVLQAIGFAP
.: *:.: : . . . .* : ** *: .:* *
Mflv_4591|M.gilvum_PYR-GCK NTD---LAAAAGLAIDNG-VVIDDQARTTDPDIVAAGDCTSHHMARYGRR
MMAR_3153|M.marinum_M NTE---LAATAGLVVDNG-VVIDDQARTSDPDIVAAGDCASHDMARYGRR
MAB_2047c|M.abscessus_ATCC_199 NTE---LASAAGLSVDNG-IVIDDQARTSDPDIVAAGDCTSHTMARYGSR
Mb1900c|M.bovis_AF2122/97 NVE---LAQQAGLAMGEGGVLVDASLRTSDPDIYAVGDIAAAEHPLLGTR
Rv1869c|M.tuberculosis_H37Rv NVE---LAQQAGLAMGEGGVLVDASLRTSDPDIYAVGDIAAAEHPLLGTR
MAV_2849|M.avium_104 NIE---LAEAAGLSLADGGVLVDASLRTSDPDIYAVGDIAAAEHPLLRTR
MSMEG_3594|M.smegmatis_MC2_155 NIG---LAERAGLATADGGVLVDASLRTSDPDIYAVGDIAAAQHPLFGVR
TH_3739|M.thermoresistible__bu ATD---WLQGSGVEVDNG-VVCDAVGRTNVEHVWAIGDVASWRN-TVGKQ
Mvan_1290|M.vanbaalenii_PYR-1 ATE---WLADSGLEIDNG-VVCDEAGRASAPHVWAIGDVASWRD-NVGGQ
MUL_0769|M.ulcerans_Agy99 ATG---WLDGSGIAVDNG-VVCDAAGRTSAPNVWAFGDVASWRD-QMGHQ
MLBr_02387|M.leprae_Br4923 NVDGYGLDKVGVALTADKAVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAE
. : : * ::. .: * ** :. .
Mflv_4591|M.gilvum_PYR-GCK IRLESVPGAGEQAKVAAATICGK-------SKKVAALPWFWSDQYDVKLQ
MMAR_3153|M.marinum_M IRLESVPSAAEQAKVAAATVCGK-------SKKIAALPWFWSDQYDLKLQ
MAB_2047c|M.abscessus_ATCC_199 IRLESVSSAGEQAKIAAATICGK-------HSAIAALPWFWSDQYDLKLQ
Mb1900c|M.bovis_AF2122/97 VRTEHWANALKQPAVAAAGMLGR-------PGEYAELPYLFTDQYDLGME
Rv1869c|M.tuberculosis_H37Rv VRTEHWANALKQPAVAAAGMLGR-------PGEYAELPYLFTDQYDLGME
MAV_2849|M.avium_104 IRTEHWANALKQPAIAVAGMLGR-------PGEYDELPYFFTDQYDLGME
MSMEG_3594|M.smegmatis_MC2_155 IRTEHWANALKQPAVAVAGMLGR-------PAEYAELPYFFTDQYDLGME
TH_3739|M.thermoresistible__bu VRVEHWSNVADQARVLVPALLGQE------VPVAATVPYFWSDQYDVKIQ
Mvan_1290|M.vanbaalenii_PYR-1 VRVEHWSNVADQARVLVPTMLGQQ------PPAAVSVPYFWSDQYDVKIQ
MUL_0769|M.ulcerans_Agy99 VRVEHWSNVADQARVVVPAMLGRE------VSSNVVVPYFWSDQYDVKIQ
MLBr_02387|M.leprae_Br4923 AQGVVAAEAIAGAETLALSDYRMMPRATFCQPNVASFGLTEQQARDGGYD
: . . . . . : * :
Mflv_4591|M.gilvum_PYR-GCK IAGLNTGYDEVVLSGDPTRDRDFTCFYL--RAGELIAADCINRPRDFVFS
MMAR_3153|M.marinum_M IAGLNTGYDEVVLSGDPTRERDFTCFYL--RAGELLAADCINRPRDFMFS
MAB_2047c|M.abscessus_ATCC_199 IAGLNAGYDELLLSGDPSRDRDFSCFYF--REGELIAADCVNRPRDFMSS
Mb1900c|M.bovis_AF2122/97 YVGHAPSCDRVVFRGNVA-GREFLSFWLD-GDSRVLAGMNVNVWDVVDDV
Rv1869c|M.tuberculosis_H37Rv YVGHAPSCDRVVFRGNVA-GREFLSFWLD-GDSRVLAGMNVNVWDVVDDV
MAV_2849|M.avium_104 YVGHAPRFERVVFRGDVA-AREFVAFWLD-ADDRVLAGMNVNIWDVLDDV
MSMEG_3594|M.smegmatis_MC2_155 YAGHAPSYERVVFRGDVP-GREFVSFWLD-GDNRVLAGMNVNIWDVLDDV
TH_3739|M.thermoresistible__bu CLGEPEAGDTVHVVSDD--GRKFLAYYE--RDGVLTGVVGGGMPGKVMKA
Mvan_1290|M.vanbaalenii_PYR-1 ALGEPEATDTVHIVEDD--GRKFLAYYE--RDGVVVGVVGGGFPGKVMKV
MUL_0769|M.ulcerans_Agy99 CLGEPHSTDVVHLVEDD--GRKLLAYYQ--RDGVLVGVVGGGVPGKVMKV
MLBr_02387|M.leprae_Br4923 VVVAKFPFTANAKAHGMGDPSGFVKLVADAKYGELLGGHMIGHNVSELLP
. : . : . .
Mflv_4591|M.gilvum_PYR-GCK KRVITQQVPIERAELMLAGPA-----------------------------
MMAR_3153|M.marinum_M KRVITQQVAVERAELVLAGSD-----------------------------
MAB_2047c|M.abscessus_ATCC_199 KRAISQQLRVDRSE-LLAGSI-----------------------------
Mb1900c|M.bovis_AF2122/97 KGLIRSGNPVDVDRLVDPQWPLADLTTN----------------------
Rv1869c|M.tuberculosis_H37Rv KGLIRSGNPVDVDRLVDPQWPLADLTTN----------------------
MAV_2849|M.avium_104 KALIRSRAPIDADRLGDPGAPLGELLG-----------------------
MSMEG_3594|M.smegmatis_MC2_155 KALIRSREPVDPDLLADPGRPLNAPG------------------------
TH_3739|M.thermoresistible__bu RAKIAAGAPISEVLE-----------------------------------
Mvan_1290|M.vanbaalenii_PYR-1 RAKIAAGAPISELLG-----------------------------------
MUL_0769|M.ulcerans_Agy99 RAKIAAAVPISEMLDESQGQTSARIPARGAGPGGPLVRWPTLTKSGRWRA
MLBr_02387|M.leprae_Br4923 ELTLAQKWDLTATELVRNVHTHPTLSEALQECFHGLIGHMINF-------
. : :
Mflv_4591|M.gilvum_PYR-GCK ---------------------------------
MMAR_3153|M.marinum_M ---------------------------------
MAB_2047c|M.abscessus_ATCC_199 ---------------------------------
Mb1900c|M.bovis_AF2122/97 ---------------------------------
Rv1869c|M.tuberculosis_H37Rv ---------------------------------
MAV_2849|M.avium_104 ---------------------------------
MSMEG_3594|M.smegmatis_MC2_155 ---------------------------------
TH_3739|M.thermoresistible__bu ---------------------------------
Mvan_1290|M.vanbaalenii_PYR-1 ---------------------------------
MUL_0769|M.ulcerans_Agy99 EKATASSPVARVDGIGLEPGPRRTASWPDVPGT
MLBr_02387|M.leprae_Br4923 ---------------------------------