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TPERAVIVGASHAGAQLAANLRREGWSGEVVLIGDEGGLPYHRPPLSKGYLAGKNGLDDLLIRGADFYEK QHIRLLNATVEAIHRSAKRVSLSTGDTLTYTKLALCTGARARRLPTPGVDLPGIHYLRTAADVELIRAAA TPGRRVVIVGGGYIGLETAASLCSLGMNVTVLEATERVLERVTAPEVSAFYTRIHRGEGVEIRTHALVEA FSGNGGVQEVVLADGESIPADLVIVGVGVVPNTELASAAGLSVDNGIVIDDQARTSDPDIVAAGDCTSHT MARYGSRIRLESVSSAGEQAKIAAATICGKHSAIAALPWFWSDQYDLKLQIAGLNAGYDELLLSGDPSRD RDFSCFYFREGELIAADCVNRPRDFMSSKRAISQQLRVDRSELLAGSI*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_2047c | - | - | 100% (399) | ferredoxin reductase |
M. abscessus ATCC 19977 | MAB_0913c | - | 2e-75 | 41.15% (384) | pyridine nucleotide-disulphide oxidoreductase family protein |
M. abscessus ATCC 19977 | MAB_4368c | - | 3e-59 | 36.83% (391) | putative rubredoxin/ferredoxin reductase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1900c | - | 8e-65 | 38.59% (355) | reductase |
M. gilvum PYR-GCK | Mflv_4591 | - | 1e-172 | 74.43% (395) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
M. tuberculosis H37Rv | Rv1869c | - | 8e-65 | 38.59% (355) | reductase |
M. leprae Br4923 | MLBr_02387 | lpd | 3e-13 | 29.22% (219) | dihydrolipoamide dehydrogenase |
M. marinum M | MMAR_3153 | - | 1e-172 | 76.19% (399) | ferredoxin reductase |
M. avium 104 | MAV_2849 | - | 2e-64 | 38.19% (364) | anthranilate dioxygenase reductase |
M. smegmatis MC2 155 | MSMEG_3594 | - | 1e-68 | 38.68% (393) | anthranilate dioxygenase reductase |
M. thermoresistible (build 8) | TH_3739 | - | 4e-63 | 37.11% (380) | PUTATIVE Pyridine nucleotide-disulphide oxidoreductase |
M. ulcerans Agy99 | MUL_0769 | - | 1e-61 | 35.81% (391) | ferredoxin reductase |
M. vanbaalenii PYR-1 | Mvan_1290 | - | 2e-63 | 37.67% (361) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_4591|M.gilvum_PYR-GCK ------------------MTLHRAVIVGASHAGAQLAASLRQEGWDGEIV MMAR_3153|M.marinum_M ------------------MTVQRAVIAGASHAGTQLAASLRREGWDGEIV MAB_2047c|M.abscessus_ATCC_199 ------------------MTPERAVIVGASHAGAQLAANLRREGWSGEVV Mb1900c|M.bovis_AF2122/97 -----------------MASSTTFVIVGGGLAGAKAVEALRRSDFGGRII Rv1869c|M.tuberculosis_H37Rv -----------------MASSTTFVIVGGGLAGAKAVEALRRSDFGGRII MAV_2849|M.avium_104 -----------------MASATGFVIIGGGLAAAKAVEALRDNNFDGRII MSMEG_3594|M.smegmatis_MC2_155 -----------------MTAASTFVIIGGGLAGAKAAEALRDNDFDGQVL TH_3739|M.thermoresistible__bu -----------------VSTTAGIIIVGGGLAAARTAEQLRRSEFGGPIT Mvan_1290|M.vanbaalenii_PYR-1 --------------MTTSEVSGGVVIVGGGLAAARTAEQLRRSEYAGAIT MUL_0769|M.ulcerans_Agy99 MYEHHVTSSEGVTQDPGATAANGIVIIGGGLAAARTAEQLRRAGYEGQLT MLBr_02387|M.leprae_Br4923 ------------------MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVV :: *.. .. . : Mflv_4591|M.gilvum_PYR-GCK LVGNESALPYHRPPLSKAYLAGKCTVDELAIRNAE--------------- MMAR_3153|M.marinum_M LVGDESALPYQRPPLSKSYLADKCELAELAIRNSD--------------- MAB_2047c|M.abscessus_ATCC_199 LIGDEGGLPYHRPPLSKGYLAGKNGLDDLLIRGAD--------------- Mb1900c|M.bovis_AF2122/97 LFGDEEHLPYDRPPLSKEFLAGKKSLSDFTIQTSD--------------- Rv1869c|M.tuberculosis_H37Rv LFGDEEHLPYDRPPLSKEFLAGKKSLSDFTIQTSD--------------- MAV_2849|M.avium_104 VFADEEHLPYERPPLSKEFLAGKKSLTDFTVQNSD--------------- MSMEG_3594|M.smegmatis_MC2_155 LFAAEEKLPYERPPLSKDYLAGKKTLDEFTVAAPA--------------- TH_3739|M.thermoresistible__bu IVSDEDHLPYDRPPLSKDVLSGKT--DDVTLKPAE--------------- Mvan_1290|M.vanbaalenii_PYR-1 IVSDEGHLPYDRPPLSKEVLRAET--DDVTLKPAE--------------- MUL_0769|M.ulcerans_Agy99 IVSDEVHLPYDRPPLSKEVLRSEV--DDVSLKPRE--------------- MLBr_02387|M.leprae_Br4923 EPKYWGGICLNVGCIPSKVLLHNAELAHIFTKEAKTFGISGDASFDYGIA : . :.. * : .. Mflv_4591|M.gilvum_PYR-GCK ----------------FYTKQRIKL-MDATVEVLDRSAGHLSLTTGD--- MMAR_3153|M.marinum_M ----------------FYAKQRIRL-LDATVAAVDRSAGHVVLSTGD--- MAB_2047c|M.abscessus_ATCC_199 ----------------FYEKQHIRL-LNATVEAIHRSAKRVSLSTGD--- Mb1900c|M.bovis_AF2122/97 ----------------WYRDHDVDVRLGVRVSSLDRSAHTVELPDGA--- Rv1869c|M.tuberculosis_H37Rv ----------------WYRDHDVDVRLGVRVSSLDRSAHTVELPDGA--- MAV_2849|M.avium_104 ----------------WYRDNDVDLRLNTRVCALDAAGHTVGLPDGT--- MSMEG_3594|M.smegmatis_MC2_155 ----------------WYRDHDVTLRLGTEVAAINPADHTVTLPDGS--- TH_3739|M.thermoresistible__bu ----------------FYAENDITLLLGTAATALDPQARKLTLADGR--- Mvan_1290|M.vanbaalenii_PYR-1 ----------------FYTENNITVLLGNGAKSVDTDSRTLTLADGT--- MUL_0769|M.ulcerans_Agy99 ----------------WYDEKGITLRLGSAATGLDTAAQTVTLADGT--- MLBr_02387|M.leprae_Br4923 YDRSRKVSEGRVAGVHFLMKKNKITEIHGYGRFTDANTLSVELSEGVPET : .: : . : *. * Mflv_4591|M.gilvum_PYR-GCK --ALPYDKLALCTGARPRRLSIPGADLPGVCYLRTAADVAMIRERTSPGR MMAR_3153|M.marinum_M --ALPYDKLALCTGARPRRLPTPGADLAGVFYLRTAADGEMIREAAGPGR MAB_2047c|M.abscessus_ATCC_199 --TLTYTKLALCTGARARRLPTPGVDLPGIHYLRTAADVELIRAAATPGR Mb1900c|M.bovis_AF2122/97 --AVRYDKLLLATGSAPRRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGS Rv1869c|M.tuberculosis_H37Rv --AVRYDKLLLATGSAPRRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGS MAV_2849|M.avium_104 --TVAYDKLLLATGSAARRPPIPGSDCAGVHYLRTYEVAVALNSFLGEGK MSMEG_3594|M.smegmatis_MC2_155 --AVGYDKLLLATGSASRRLPIPGADASGVHYLRTVDDAAALDAVLTEGA TH_3739|M.thermoresistible__bu --ALEYDELIIATGLVPKRIPTLP-DLEGIRVLRTYDESMALRKHAGSAR Mvan_1290|M.vanbaalenii_PYR-1 --QLGYDELIIATGLVPKRIPSFP-DLPGIHVLRNFDESLALRQEAGTAR MUL_0769|M.ulcerans_Agy99 --VLGYDELVIATGLVPRRIPAFP-ELEGIRVLRSFDECMALRSHASAAK MLBr_02387|M.leprae_Br4923 PLKVTFNNVIIATGSKTRLVPGTLLSTN----VITYEEQILTRELP---D : : :: :.** .: . . : . Mflv_4591|M.gilvum_PYR-GCK RAVIVGGGYIGLEAAASLRALGLEVTVLEATERVLERVTAPAVSAFFDRI MMAR_3153|M.marinum_M RAVIVGGGYIGLETAASLRALGLEVTLLEATGRVLERVTAPEVSEFFDRI MAB_2047c|M.abscessus_ATCC_199 RVVIVGGGYIGLETAASLCSLGMNVTVLEATERVLERVTAPEVSAFYTRI Mb1900c|M.bovis_AF2122/97 SLAVVGAGWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADL Rv1869c|M.tuberculosis_H37Rv SLAVVGAGWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADL MAV_2849|M.avium_104 SLAVVGAGWIGLEVAAAARQRGVEVTVVEAARQPLTAALGETVGEVFATL MSMEG_3594|M.smegmatis_MC2_155 SLAVVGAGWIGLEVAASARTRGVNVTVVEAARLPLLGALGAEVAEVFAQL TH_3739|M.thermoresistible__bu NAVVIGAGFIGCEVAASLRGLGVHVVLVEPQPTPLAGVLGEQIGALVARL Mvan_1290|M.vanbaalenii_PYR-1 RAVVVGAGFIGCEVAASLRKLGVEVVLVEPQPAPLASVLGQQIGELVTRL MUL_0769|M.ulcerans_Agy99 RAVVIGAGFIGCEVAASLRGLGVEVVLVEPQPTPLAAVLGEQIGELVARL MLBr_02387|M.leprae_Br4923 SIVIVGAGAIGIEFGYVLKNYGVDVTIVEFLPRAMPNED-AEVSKEIEKQ .::*.* ** * . *:.*.::* : :. Mflv_4591|M.gilvum_PYR-GCK HREEGVDIQTDALVDAMS-GDGRVREVILASG--ESIPADLVIVGIGVEP MMAR_3153|M.marinum_M HREEGVNIRTGTLVEALS-GDGRVREVILAGG--ESIPADLVIVGIGVEP MAB_2047c|M.abscessus_ATCC_199 HRGEGVEIRTHALVEAFS-GNGGVQEVVLADG--ESIPADLVIVGVGVVP Mb1900c|M.bovis_AF2122/97 HRDQGVDLRLQTQLEEITAADGKATGLKMRDG--STVAADAVLVAVGAKP Rv1869c|M.tuberculosis_H37Rv HRDQGVDLRLQTQLEEITAADGKATGLKMRDG--STVAADAVLVAVGAKP MAV_2849|M.avium_104 HREHGVDLRLETQVREITRADGSATGLRTTDG--SAIPADAVLVAVGARP MSMEG_3594|M.smegmatis_MC2_155 HREHGVDLRLEQTVEEITTADGRATGLRLGDG--STIAADAVLVAVGAAP TH_3739|M.thermoresistible__bu HRDEGVDLRCGVGVADVR-GTGAVEKVVLDDG--TELDADLVVVGIGSTP Mvan_1290|M.vanbaalenii_PYR-1 HRAEGVDVRCGVGVSKVS-GDDRVRKVTLGDG--TELDADIVVVGIGSHP MUL_0769|M.ulcerans_Agy99 HRSEGVDVRTGVGVAEVR-GDGHVDTVVLADG--TQLDADLVVVGIGSHP MLBr_02387|M.leprae_Br4923 FKKMGIKILTGTKVESISDNGSHVLVAVSKDGQFQELKADKVLQAIGFAP .: *:.: : . . . .* : ** *: .:* * Mflv_4591|M.gilvum_PYR-GCK NTD---LAAAAGLAIDNG-VVIDDQARTTDPDIVAAGDCTSHHMARYGRR MMAR_3153|M.marinum_M NTE---LAATAGLVVDNG-VVIDDQARTSDPDIVAAGDCASHDMARYGRR MAB_2047c|M.abscessus_ATCC_199 NTE---LASAAGLSVDNG-IVIDDQARTSDPDIVAAGDCTSHTMARYGSR Mb1900c|M.bovis_AF2122/97 NVE---LAQQAGLAMGEGGVLVDASLRTSDPDIYAVGDIAAAEHPLLGTR Rv1869c|M.tuberculosis_H37Rv NVE---LAQQAGLAMGEGGVLVDASLRTSDPDIYAVGDIAAAEHPLLGTR MAV_2849|M.avium_104 NIE---LAEAAGLSLADGGVLVDASLRTSDPDIYAVGDIAAAEHPLLRTR MSMEG_3594|M.smegmatis_MC2_155 NIG---LAERAGLATADGGVLVDASLRTSDPDIYAVGDIAAAQHPLFGVR TH_3739|M.thermoresistible__bu ATD---WLQGSGVEVDNG-VVCDAVGRTNVEHVWAIGDVASWRN-TVGKQ Mvan_1290|M.vanbaalenii_PYR-1 ATE---WLADSGLEIDNG-VVCDEAGRASAPHVWAIGDVASWRD-NVGGQ MUL_0769|M.ulcerans_Agy99 ATG---WLDGSGIAVDNG-VVCDAAGRTSAPNVWAFGDVASWRD-QMGHQ MLBr_02387|M.leprae_Br4923 NVDGYGLDKVGVALTADKAVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAE . : : * ::. .: * ** :. . Mflv_4591|M.gilvum_PYR-GCK IRLESVPGAGEQAKVAAATICGK-------SKKVAALPWFWSDQYDVKLQ MMAR_3153|M.marinum_M IRLESVPSAAEQAKVAAATVCGK-------SKKIAALPWFWSDQYDLKLQ MAB_2047c|M.abscessus_ATCC_199 IRLESVSSAGEQAKIAAATICGK-------HSAIAALPWFWSDQYDLKLQ Mb1900c|M.bovis_AF2122/97 VRTEHWANALKQPAVAAAGMLGR-------PGEYAELPYLFTDQYDLGME Rv1869c|M.tuberculosis_H37Rv VRTEHWANALKQPAVAAAGMLGR-------PGEYAELPYLFTDQYDLGME MAV_2849|M.avium_104 IRTEHWANALKQPAIAVAGMLGR-------PGEYDELPYFFTDQYDLGME MSMEG_3594|M.smegmatis_MC2_155 IRTEHWANALKQPAVAVAGMLGR-------PAEYAELPYFFTDQYDLGME TH_3739|M.thermoresistible__bu VRVEHWSNVADQARVLVPALLGQE------VPVAATVPYFWSDQYDVKIQ Mvan_1290|M.vanbaalenii_PYR-1 VRVEHWSNVADQARVLVPTMLGQQ------PPAAVSVPYFWSDQYDVKIQ MUL_0769|M.ulcerans_Agy99 VRVEHWSNVADQARVVVPAMLGRE------VSSNVVVPYFWSDQYDVKIQ MLBr_02387|M.leprae_Br4923 AQGVVAAEAIAGAETLALSDYRMMPRATFCQPNVASFGLTEQQARDGGYD : . . . . . : * : Mflv_4591|M.gilvum_PYR-GCK IAGLNTGYDEVVLSGDPTRDRDFTCFYL--RAGELIAADCINRPRDFVFS MMAR_3153|M.marinum_M IAGLNTGYDEVVLSGDPTRERDFTCFYL--RAGELLAADCINRPRDFMFS MAB_2047c|M.abscessus_ATCC_199 IAGLNAGYDELLLSGDPSRDRDFSCFYF--REGELIAADCVNRPRDFMSS Mb1900c|M.bovis_AF2122/97 YVGHAPSCDRVVFRGNVA-GREFLSFWLD-GDSRVLAGMNVNVWDVVDDV Rv1869c|M.tuberculosis_H37Rv YVGHAPSCDRVVFRGNVA-GREFLSFWLD-GDSRVLAGMNVNVWDVVDDV MAV_2849|M.avium_104 YVGHAPRFERVVFRGDVA-AREFVAFWLD-ADDRVLAGMNVNIWDVLDDV MSMEG_3594|M.smegmatis_MC2_155 YAGHAPSYERVVFRGDVP-GREFVSFWLD-GDNRVLAGMNVNIWDVLDDV TH_3739|M.thermoresistible__bu CLGEPEAGDTVHVVSDD--GRKFLAYYE--RDGVLTGVVGGGMPGKVMKA Mvan_1290|M.vanbaalenii_PYR-1 ALGEPEATDTVHIVEDD--GRKFLAYYE--RDGVVVGVVGGGFPGKVMKV MUL_0769|M.ulcerans_Agy99 CLGEPHSTDVVHLVEDD--GRKLLAYYQ--RDGVLVGVVGGGVPGKVMKV MLBr_02387|M.leprae_Br4923 VVVAKFPFTANAKAHGMGDPSGFVKLVADAKYGELLGGHMIGHNVSELLP . : . : . . Mflv_4591|M.gilvum_PYR-GCK KRVITQQVPIERAELMLAGPA----------------------------- MMAR_3153|M.marinum_M KRVITQQVAVERAELVLAGSD----------------------------- MAB_2047c|M.abscessus_ATCC_199 KRAISQQLRVDRSE-LLAGSI----------------------------- Mb1900c|M.bovis_AF2122/97 KGLIRSGNPVDVDRLVDPQWPLADLTTN---------------------- Rv1869c|M.tuberculosis_H37Rv KGLIRSGNPVDVDRLVDPQWPLADLTTN---------------------- MAV_2849|M.avium_104 KALIRSRAPIDADRLGDPGAPLGELLG----------------------- MSMEG_3594|M.smegmatis_MC2_155 KALIRSREPVDPDLLADPGRPLNAPG------------------------ TH_3739|M.thermoresistible__bu RAKIAAGAPISEVLE----------------------------------- Mvan_1290|M.vanbaalenii_PYR-1 RAKIAAGAPISELLG----------------------------------- MUL_0769|M.ulcerans_Agy99 RAKIAAAVPISEMLDESQGQTSARIPARGAGPGGPLVRWPTLTKSGRWRA MLBr_02387|M.leprae_Br4923 ELTLAQKWDLTATELVRNVHTHPTLSEALQECFHGLIGHMINF------- . : : Mflv_4591|M.gilvum_PYR-GCK --------------------------------- MMAR_3153|M.marinum_M --------------------------------- MAB_2047c|M.abscessus_ATCC_199 --------------------------------- Mb1900c|M.bovis_AF2122/97 --------------------------------- Rv1869c|M.tuberculosis_H37Rv --------------------------------- MAV_2849|M.avium_104 --------------------------------- MSMEG_3594|M.smegmatis_MC2_155 --------------------------------- TH_3739|M.thermoresistible__bu --------------------------------- Mvan_1290|M.vanbaalenii_PYR-1 --------------------------------- MUL_0769|M.ulcerans_Agy99 EKATASSPVARVDGIGLEPGPRRTASWPDVPGT MLBr_02387|M.leprae_Br4923 ---------------------------------