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ASSTTFVIVGGGLAGAKAVEALRRSDFGGRIILFGDEEHLPYDRPPLSKEFLAGKKSLSDFTIQTSDWYR DHDVDVRLGVRVSSLDRSAHTVELPDGAAVRYDKLLLATGSAPRRPPIPGSDAAGVHYLRSYNDAVALNS VLVQGSSLAVVGAGWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADLHRDQGVDLRLQTQL EEITAADGKATGLKMRDGSTVAADAVLVAVGAKPNVELAQQAGLAMGEGGVLVDASLRTSDPDIYAVGDI AAAEHPLLGTRVRTEHWANALKQPAVAAAGMLGRPGEYAELPYLFTDQYDLGMEYVGHAPSCDRVVFRGN VAGREFLSFWLDGDSRVLAGMNVNVWDVVDDVKGLIRSGNPVDVDRLVDPQWPLADLTTN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1869c | - | - | 100% (411) | Probable reductase |
| M. tuberculosis H37Rv | Rv0688 | - | 3e-69 | 38.92% (388) | putative ferredoxin reductase |
| M. tuberculosis H37Rv | Rv0252 | nirB | 2e-40 | 36.03% (297) | nitrite reductase large subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1900c | - | 0.0 | 100.00% (411) | reductase |
| M. gilvum PYR-GCK | Mflv_5068 | - | 4e-69 | 38.14% (388) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. leprae Br4923 | MLBr_02387 | lpd | 5e-12 | 28.33% (240) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2047c | - | 1e-64 | 38.59% (355) | ferredoxin reductase |
| M. marinum M | MMAR_1017 | - | 8e-70 | 41.01% (356) | ferredoxin reductase |
| M. avium 104 | MAV_2849 | - | 0.0 | 77.45% (408) | anthranilate dioxygenase reductase |
| M. smegmatis MC2 155 | MSMEG_3594 | - | 1e-174 | 73.33% (405) | anthranilate dioxygenase reductase |
| M. thermoresistible (build 8) | TH_3739 | - | 1e-68 | 39.12% (363) | PUTATIVE Pyridine nucleotide-disulphide oxidoreductase |
| M. ulcerans Agy99 | MUL_0769 | - | 2e-68 | 40.45% (356) | ferredoxin reductase |
| M. vanbaalenii PYR-1 | Mvan_1327 | - | 4e-73 | 40.79% (407) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1869c|M.tuberculosis_H37Rv -----------------MASSTTFVIVGGGLAGAKAVEALRRSDFGGRII
Mb1900c|M.bovis_AF2122/97 -----------------MASSTTFVIVGGGLAGAKAVEALRRSDFGGRII
MAV_2849|M.avium_104 -----------------MASATGFVIIGGGLAAAKAVEALRDNNFDGRII
MSMEG_3594|M.smegmatis_MC2_155 -----------------MTAASTFVIIGGGLAGAKAAEALRDNDFDGQVL
MMAR_1017|M.marinum_M MYEHHVTSSEGVTQDPGATAANGIVIIGGGLAAARTAEQLRRAGYEGQLT
MUL_0769|M.ulcerans_Agy99 MYEHHVTSSEGVTQDPGATAANGIVIIGGGLAAARTAEQLRRAGYEGQLT
TH_3739|M.thermoresistible__bu -----------------VSTTAGIIIVGGGLAAARTAEQLRRSEFGGPIT
Mflv_5068|M.gilvum_PYR-GCK -----------MGTSEVSGGSGGVVIVGGGLAAARTAEQLRRAEYPGAIT
Mvan_1327|M.vanbaalenii_PYR-1 ------------------MSRRTFVTVGAGQTAAVAARNLRRHGFDGRIV
MAB_2047c|M.abscessus_ATCC_199 ------------------MTPERAVIVGASHAGAQLAANLRREGWSGEVV
MLBr_02387|M.leprae_Br4923 ------------------MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVV
: :*.. . . :
Rv1869c|M.tuberculosis_H37Rv LFGDEEHLPYDRPPLSKEFLAGKKSLSDFTIQTSD---------------
Mb1900c|M.bovis_AF2122/97 LFGDEEHLPYDRPPLSKEFLAGKKSLSDFTIQTSD---------------
MAV_2849|M.avium_104 VFADEEHLPYERPPLSKEFLAGKKSLTDFTVQNSD---------------
MSMEG_3594|M.smegmatis_MC2_155 LFAAEEKLPYERPPLSKDYLAGKKTLDEFTVAAPA---------------
MMAR_1017|M.marinum_M IVSDEVHLPYDRPPLSKEVLRSEVDD--VSLKPRE---------------
MUL_0769|M.ulcerans_Agy99 IVSDEVHLPYDRPPLSKEVLRSEVDD--VSLKPRE---------------
TH_3739|M.thermoresistible__bu IVSDEDHLPYDRPPLSKDVLSGKTDD--VTLKPAE---------------
Mflv_5068|M.gilvum_PYR-GCK IVSDEDHLPYDRPPLSKEVLRAETDD--VTLKPAE---------------
Mvan_1327|M.vanbaalenii_PYR-1 LIGDEPHPPYQRPPLSKEFLAGTENEEGLWILPPK---------------
MAB_2047c|M.abscessus_ATCC_199 LIGDEGGLPYHRPPLSKGYLAGKNGLDDLLIRGAD---------------
MLBr_02387|M.leprae_Br4923 EPKYWGGICLNVGCIPSKVLLHNAELAHIFTKEAKTFGISGDASFDYGIA
. :.. * .
Rv1869c|M.tuberculosis_H37Rv ----------------WYRDHDVDVRLGVRVSSLDRSAHTVELPDGA---
Mb1900c|M.bovis_AF2122/97 ----------------WYRDHDVDVRLGVRVSSLDRSAHTVELPDGA---
MAV_2849|M.avium_104 ----------------WYRDNDVDLRLNTRVCALDAAGHTVGLPDGT---
MSMEG_3594|M.smegmatis_MC2_155 ----------------WYRDHDVTLRLGTEVAAINPADHTVTLPDGS---
MMAR_1017|M.marinum_M ----------------WYDEKDIALRLGSAATGLDTAAQTVTLADGT---
MUL_0769|M.ulcerans_Agy99 ----------------WYDEKGITLRLGSAATGLDTAAQTVTLADGT---
TH_3739|M.thermoresistible__bu ----------------FYAENDITLLLGTAATALDPQARKLTLADGR---
Mflv_5068|M.gilvum_PYR-GCK ----------------FYDENNITVLLGNGAKSVDTAAQTLTLADGS---
Mvan_1327|M.vanbaalenii_PYR-1 ----------------WLQDNDVEIITDTTVVRVDAAARAVEFSGGA---
MAB_2047c|M.abscessus_ATCC_199 ----------------FYEKQHIRLLN-ATVEAIHRSAKRVSLSTGD---
MLBr_02387|M.leprae_Br4923 YDRSRKVSEGRVAGVHFLMKKNKITEIHGYGRFTDANTLSVELSEGVPET
: .: . : :. *
Rv1869c|M.tuberculosis_H37Rv --AVRYDKLLLATGSAPRRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGS
Mb1900c|M.bovis_AF2122/97 --AVRYDKLLLATGSAPRRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGS
MAV_2849|M.avium_104 --TVAYDKLLLATGSAARRPPIPGSDCAGVHYLRTYEVAVALNSFLGEGK
MSMEG_3594|M.smegmatis_MC2_155 --AVGYDKLLLATGSASRRLPIPGADASGVHYLRTVDDAAALDAVLTEGA
MMAR_1017|M.marinum_M --VLGYDELVIATGLVPRRIPA-FPELEGIRVLRSFDECMALRSHASAAK
MUL_0769|M.ulcerans_Agy99 --VLGYDELVIATGLVPRRIPA-FPELEGIRVLRSFDECMALRSHASAAK
TH_3739|M.thermoresistible__bu --ALEYDELIIATGLVPKRIPT-LPDLEGIRVLRTYDESMALRKHAGSAR
Mflv_5068|M.gilvum_PYR-GCK --TLGYDELVIATGLVPKRIPS-FPDLPGIHVLRNFDESLALRREAASAS
Mvan_1327|M.vanbaalenii_PYR-1 --GLQADSVLFATGGAPRRLPVDGPRPDLVHYLRTLDDAARLAPVLTPGR
MAB_2047c|M.abscessus_ATCC_199 --TLTYTKLALCTGARARRLPTPGVDLPGIHYLRTAADVELIRAAATPGR
MLBr_02387|M.leprae_Br4923 PLKVTFNNVIIATGSKTRLVPGTLLSTN----VITYEEQILTRELP---D
: .: :.** .: * : .
Rv1869c|M.tuberculosis_H37Rv SLAVVGAGWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADL
Mb1900c|M.bovis_AF2122/97 SLAVVGAGWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADL
MAV_2849|M.avium_104 SLAVVGAGWIGLEVAAAARQRGVEVTVVEAARQPLTAALGETVGEVFATL
MSMEG_3594|M.smegmatis_MC2_155 SLAVVGAGWIGLEVAASARTRGVNVTVVEAARLPLLGALGAEVAEVFAQL
MMAR_1017|M.marinum_M RAVVIGAGFIGCEVAASLRGLGVEVVLVEPQPTPLAAVLGEQIGELVARL
MUL_0769|M.ulcerans_Agy99 RAVVIGAGFIGCEVAASLRGLGVEVVLVEPQPTPLAAVLGEQIGELVARL
TH_3739|M.thermoresistible__bu NAVVIGAGFIGCEVAASLRGLGVHVVLVEPQPTPLAGVLGEQIGALVARL
Mflv_5068|M.gilvum_PYR-GCK RAVVVGAGFIGCEVAASLRKLGVEVTLVEPQPAPLASILGQQIGDLVTRL
Mvan_1327|M.vanbaalenii_PYR-1 RLAIIGAGFIGLEIAATAAAAGVEVTVLEAVPVPLARVVGPAMGEAVCRL
MAB_2047c|M.abscessus_ATCC_199 RVVIVGGGYIGLETAASLCSLGMNVTVLEATERVLERVTAPEVSAFYTRI
MLBr_02387|M.leprae_Br4923 SIVIVGAGAIGIEFGYVLKNYGVDVTIVEFLPRAMPNED-AEVSKEIEKQ
.::*.* ** * . *:.*.::* : :.
Rv1869c|M.tuberculosis_H37Rv HRDQGVDLRLQTQLEEITAADGKATGLKMRDG--STVAADAVLVAVGAKP
Mb1900c|M.bovis_AF2122/97 HRDQGVDLRLQTQLEEITAADGKATGLKMRDG--STVAADAVLVAVGAKP
MAV_2849|M.avium_104 HREHGVDLRLETQVREITRADGSATGLRTTDG--SAIPADAVLVAVGARP
MSMEG_3594|M.smegmatis_MC2_155 HREHGVDLRLEQTVEEITTADGRATGLRLGDG--STIAADAVLVAVGAAP
MMAR_1017|M.marinum_M HRSEGVDVRTGVGVAEVR-GDGHVDTVVLADG--TQLDADLVVVGIGSHP
MUL_0769|M.ulcerans_Agy99 HRSEGVDVRTGVGVAEVR-GDGHVDTVVLADG--TQLDADLVVVGIGSHP
TH_3739|M.thermoresistible__bu HRDEGVDLRCGVGVADVR-GTGAVEKVVLDDG--TELDADLVVVGIGSTP
Mflv_5068|M.gilvum_PYR-GCK HRAEGVDVRCGVGVSEVS-GDDRVRKVTLGDG--TDVEADVVIVGIGSHP
Mvan_1327|M.vanbaalenii_PYR-1 HRDNGVDIRAGVQLAGVRTAADGVVIDIAGAA--APLEADAVVVGIGIIP
MAB_2047c|M.abscessus_ATCC_199 HRGEGVEIRTHALVEAFS-GNGGVQEVVLADG--ESIPADLVIVGVGVVP
MLBr_02387|M.leprae_Br4923 FKKMGIKILTGTKVESISDNGSHVLVAVSKDGQFQELKADKVLQAIGFAP
.: *:.: : . . . . : ** *: .:* *
Rv1869c|M.tuberculosis_H37Rv NVE---LAQQAGLAMGEGGVLVDASLRTSDPDIYAVGDIAAAEHPLLGTR
Mb1900c|M.bovis_AF2122/97 NVE---LAQQAGLAMGEGGVLVDASLRTSDPDIYAVGDIAAAEHPLLGTR
MAV_2849|M.avium_104 NIE---LAEAAGLSLADGGVLVDASLRTSDPDIYAVGDIAAAEHPLLRTR
MSMEG_3594|M.smegmatis_MC2_155 NIG---LAERAGLATADGGVLVDASLRTSDPDIYAVGDIAAAQHPLFGVR
MMAR_1017|M.marinum_M ATG---WLDGSGIAVDNG-VVCDAAGRTSAPNVWALGDVAS-WRDQMGHQ
MUL_0769|M.ulcerans_Agy99 ATG---WLDGSGIAVDNG-VVCDAAGRTSAPNVWAFGDVAS-WRDQMGHQ
TH_3739|M.thermoresistible__bu ATD---WLQGSGVEVDNG-VVCDAVGRTNVEHVWAIGDVAS-WRNTVGKQ
Mflv_5068|M.gilvum_PYR-GCK ATS---WLEGSGLELDNG-VVCDEAGRASAPHVWAIGDVAS-WRDTVGGQ
Mvan_1327|M.vanbaalenii_PYR-1 NTA---VAAASGLWVDDG-IVVDALGRTAVPGVFAAGDAARRYSPRAGRH
MAB_2047c|M.abscessus_ATCC_199 NTE---LASAAGLSVDNG-IVIDDQARTSDPDIVAAGDCTSHTMARYGSR
MLBr_02387|M.leprae_Br4923 NVDGYGLDKVGVALTADKAVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAE
. : : * :: : * ** : .
Rv1869c|M.tuberculosis_H37Rv VRTEHWANALKQPAVAAAGMLGR-------PGEYAELPYLFTDQYDLGME
Mb1900c|M.bovis_AF2122/97 VRTEHWANALKQPAVAAAGMLGR-------PGEYAELPYLFTDQYDLGME
MAV_2849|M.avium_104 IRTEHWANALKQPAIAVAGMLGR-------PGEYDELPYFFTDQYDLGME
MSMEG_3594|M.smegmatis_MC2_155 IRTEHWANALKQPAVAVAGMLGR-------PAEYAELPYFFTDQYDLGME
MMAR_1017|M.marinum_M VRVEHWSNVADQARVVVPAMLGRE------VSSNVVVPYFWSDQYDVKIQ
MUL_0769|M.ulcerans_Agy99 VRVEHWSNVADQARVVVPAMLGRE------VSSNVVVPYFWSDQYDVKIQ
TH_3739|M.thermoresistible__bu VRVEHWSNVADQARVLVPALLGQE------VPVAATVPYFWSDQYDVKIQ
Mflv_5068|M.gilvum_PYR-GCK VRVEHWSNVADQARVLVPTMLGQE------PPAAVSVPYFWSDQYDVKIQ
Mvan_1327|M.vanbaalenii_PYR-1 LRLEHFDNASRQGVAVANAMLGRE------APSDDPL-WFWSDQYGRNIQ
MAB_2047c|M.abscessus_ATCC_199 IRLESVSSAGEQAKIAAATICGK-------HSAIAALPWFWSDQYDLKLQ
MLBr_02387|M.leprae_Br4923 AQGVVAAEAIAGAETLALSDYRMMPRATFCQPNVASFGLTEQQARDGGYD
: .. . . : . :
Rv1869c|M.tuberculosis_H37Rv YVGHAPSCDRVVFRG-NVAGREFLSFWLDG-DSRVLAGMNVNVWDVVDDV
Mb1900c|M.bovis_AF2122/97 YVGHAPSCDRVVFRG-NVAGREFLSFWLDG-DSRVLAGMNVNVWDVVDDV
MAV_2849|M.avium_104 YVGHAPRFERVVFRG-DVAAREFVAFWLDA-DDRVLAGMNVNIWDVLDDV
MSMEG_3594|M.smegmatis_MC2_155 YAGHAPSYERVVFRG-DVPGREFVSFWLDG-DNRVLAGMNVNIWDVLDDV
MMAR_1017|M.marinum_M CLGEPHSTD-VVHLV-EDDGRKFLAYYER--DGVLVGVVGGGVPGKVMKV
MUL_0769|M.ulcerans_Agy99 CLGEPHSTD-VVHLV-EDDGRKLLAYYQR--DGVLVGVVGGGVPGKVMKV
TH_3739|M.thermoresistible__bu CLGEPEAGD-TVHVV-SDDGRKFLAYYER--DGVLTGVVGGGMPGKVMKA
Mflv_5068|M.gilvum_PYR-GCK ALGEPEATD-TVHIV-EDDGRKFLAYYER--DGAVVAVVGGGFPGKVMKT
Mvan_1327|M.vanbaalenii_PYR-1 FVGTASGTP-VIRGN-RDE-FDFTGFYLE--NDTVCGAFAIDRGEDVTAA
MAB_2047c|M.abscessus_ATCC_199 IAGLNAGYDELLLSGDPSRDRDFSCFYFR--EGELIAADCVNRPRDFMSS
MLBr_02387|M.leprae_Br4923 VVVAKFPFTANAKAHGMGDPSGFVKLVADAKYGELLGGHMIGHNVSELLP
: . : . .
Rv1869c|M.tuberculosis_H37Rv KGLIRSGNPVDVDRLVDPQWPLADLTTN----------------------
Mb1900c|M.bovis_AF2122/97 KGLIRSGNPVDVDRLVDPQWPLADLTTN----------------------
MAV_2849|M.avium_104 KALIRSRAPIDADRLGDPGAPLGELLG-----------------------
MSMEG_3594|M.smegmatis_MC2_155 KALIRSREPVDPDLLADPGRPLNAPG------------------------
MMAR_1017|M.marinum_M RAKIAAA--VPISEMLDESQG-----------------------------
MUL_0769|M.ulcerans_Agy99 RAKIAAA--VPISEMLDESQGQTSARIPARGAGPGGPLVRWPTLTKSGRW
TH_3739|M.thermoresistible__bu RAKIAAG--APISEVLE---------------------------------
Mflv_5068|M.gilvum_PYR-GCK RAKIAAG--APISDLLG---------------------------------
Mvan_1327|M.vanbaalenii_PYR-1 RELLGRG--VDAAALLDEDTDLWDLVYADEDEQVRA--------------
MAB_2047c|M.abscessus_ATCC_199 KRAISQQLRVDRSELLAGSI------------------------------
MLBr_02387|M.leprae_Br4923 ELTLAQKWDLTATELVRNVHTHPTLSEALQECFHGLIGHMINF-------
. : :
Rv1869c|M.tuberculosis_H37Rv -----------------------------------
Mb1900c|M.bovis_AF2122/97 -----------------------------------
MAV_2849|M.avium_104 -----------------------------------
MSMEG_3594|M.smegmatis_MC2_155 -----------------------------------
MMAR_1017|M.marinum_M -----------------------------------
MUL_0769|M.ulcerans_Agy99 RAEKATASSPVARVDGIGLEPGPRRTASWPDVPGT
TH_3739|M.thermoresistible__bu -----------------------------------
Mflv_5068|M.gilvum_PYR-GCK -----------------------------------
Mvan_1327|M.vanbaalenii_PYR-1 -----------------------------------
MAB_2047c|M.abscessus_ATCC_199 -----------------------------------
MLBr_02387|M.leprae_Br4923 -----------------------------------