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VTTSAHSAGIVIVGGGLAATRTAEQLRRSEYAGPITIVSDEDHLPYDRPPLSKEVLRAENDDVTLKPAEF YEENNITLRLGSGAQSVDTAAQTVRLADGSELPYDELVIATGLVPKRIGSFPDLQGIRVLRTYDESMALR EDARKASRAVVIGAGFIGCEVAASLRKLGVDVVLVEPQPTPLASVLGEKIGALVTRLHRAEGVDVRCGVG VTEVRGTQNVETVVLADGTELEADLVIVGIGSRPSVDWLKGSGIEVDNGVVCDEVGRTSAPHVWAIGDVA SWRDHVGGQVRVEHWSNVADQARAMVPALLGQEASAVVSVPYFWSDQYDVKIQCLGEPESDDTVHIVEDD GRKFLAYYERDGVLVGVVGGGMPGKVMKTRGKIAAGAPIAEVLGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1416 | - | - | 100% (395) | pyridine nucleotide-disulphide oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_3594 | - | 4e-61 | 36.90% (355) | anthranilate dioxygenase reductase |
| M. smegmatis MC2 155 | MSMEG_1460 | - | 6e-61 | 39.18% (365) | pyridine nucleotide-disulphide oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0707 | - | 1e-172 | 77.92% (385) | putative ferredoxin reductase |
| M. gilvum PYR-GCK | Mflv_5068 | - | 0.0 | 80.56% (391) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv0688 | - | 1e-172 | 77.92% (385) | putative ferredoxin reductase |
| M. leprae Br4923 | MLBr_02387 | lpd | 1e-13 | 27.52% (258) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3838c | - | 1e-151 | 68.29% (391) | putative ferredoxin reductase |
| M. marinum M | MMAR_1017 | - | 1e-172 | 77.66% (385) | ferredoxin reductase |
| M. avium 104 | MAV_4485 | - | 1e-177 | 78.52% (391) | ferredoxin reductase |
| M. thermoresistible (build 8) | TH_3739 | - | 1e-177 | 79.07% (387) | PUTATIVE Pyridine nucleotide-disulphide oxidoreductase |
| M. ulcerans Agy99 | MUL_0769 | - | 1e-172 | 77.40% (385) | ferredoxin reductase |
| M. vanbaalenii PYR-1 | Mvan_1290 | - | 0.0 | 79.44% (394) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5068|M.gilvum_PYR-GCK -----MGTSEVSGGSG-----------GVVIVG----GGLAAARTAEQLR
Mvan_1290|M.vanbaalenii_PYR-1 -----MTTSEVSGG--------------VVIVG----GGLAAARTAEQLR
MSMEG_1416|M.smegmatis_MC2_155 -----MTTSAHSAG--------------IVIVG----GGLAATRTAEQLR
Mb0707|M.bovis_AF2122/97 ------MNAHVTSREGVN-----EFDDGIVIVG----GGLAAARTAEQLR
Rv0688|M.tuberculosis_H37Rv ------MNAHVTSREGVN-----EFDDGIVIVG----GGLAAARTAEQLR
MMAR_1017|M.marinum_M -----MYEHHVTSSEGVTQDPGATAANGIVIIG----GGLAAARTAEQLR
MUL_0769|M.ulcerans_Agy99 -----MYEHHVTSSEGVTQDPGATAANGIVIIG----GGLAAARTAEQLR
MAV_4485|M.avium_104 ------MSSDASAS------------NGIVIVG----GGLAAARTAEQLR
TH_3739|M.thermoresistible__bu --------VSTTAG--------------IIIVG----GGLAAARTAEQLR
MAB_3838c|M.abscessus_ATCC_199 -------MTDAERG--------------VLIIG----GGLGAVRTAEQLR
MLBr_02387|M.leprae_Br4923 MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVVEPKYWGGICLNVGCIPSK
:: **: . :
Mflv_5068|M.gilvum_PYR-GCK RAEYPGAITIVSDEDHLPYDRP---PLSKEVLR---AETDDVTLKPAEFY
Mvan_1290|M.vanbaalenii_PYR-1 RSEYAGAITIVSDEGHLPYDRP---PLSKEVLR---AETDDVTLKPAEFY
MSMEG_1416|M.smegmatis_MC2_155 RSEYAGPITIVSDEDHLPYDRP---PLSKEVLR---AENDDVTLKPAEFY
Mb0707|M.bovis_AF2122/97 RAGYSGRLTIVSDEVHLPYDRP---PLSKEVLR---SEVDDVALKPREFY
Rv0688|M.tuberculosis_H37Rv RAGYSGRLTIVSDEVHLPYDRP---PLSKEVLR---SEVDDVALKPREFY
MMAR_1017|M.marinum_M RAGYEGQLTIVSDEVHLPYDRP---PLSKEVLR---SEVDDVSLKPREWY
MUL_0769|M.ulcerans_Agy99 RAGYEGQLTIVSDEVHLPYDRP---PLSKEVLR---SEVDDVSLKPREWY
MAV_4485|M.avium_104 RSEYSGPITIVSDEVHLPYDRP---PLSKEVLR---KEVDDTALKPRQWY
TH_3739|M.thermoresistible__bu RSEFGGPITIVSDEDHLPYDRP---PLSKDVLS---GKTDDVTLKPAEFY
MAB_3838c|M.abscessus_ATCC_199 RAEFTGPITIVSSETHLPYDRP---PLSKDVLRDAEKTIDAVVLKPREFY
MLBr_02387|M.leprae_Br4923 VLLHNAELAHIFTKEAKTFGISGDASFDYGIAYDRSRKVSEGRVAGVHFL
. . :: : : .:. . .:. : . : .:
Mflv_5068|M.gilvum_PYR-GCK DENNITVLLGNGAKSVDTAAQTLTLADGS-----TLGYDELVIATGLVPK
Mvan_1290|M.vanbaalenii_PYR-1 TENNITVLLGNGAKSVDTDSRTLTLADGT-----QLGYDELIIATGLVPK
MSMEG_1416|M.smegmatis_MC2_155 EENNITLRLGSGAQSVDTAAQTVRLADGS-----ELPYDELVIATGLVPK
Mb0707|M.bovis_AF2122/97 DEKDIALRLGSAAVSLDTGEQTVTLADGT-----VLGYDELVIATGLVPR
Rv0688|M.tuberculosis_H37Rv DEKDIALRLGSAAVSLDTGEQTVTLADGT-----VLGYDELVIATGLVPR
MMAR_1017|M.marinum_M DEKDIALRLGSAATGLDTAAQTVTLADGT-----VLGYDELVIATGLVPR
MUL_0769|M.ulcerans_Agy99 DEKGITLRLGSAATGLDTAAQTVTLADGT-----VLGYDELVIATGLVPR
MAV_4485|M.avium_104 DDNDITLRLGSAARSLDTAAQTLTLEDGT-----TLGYDELVIATGLVPR
TH_3739|M.thermoresistible__bu AENDITLLLGTAATALDPQARKLTLADGR-----ALEYDELIIATGLVPK
MAB_3838c|M.abscessus_ATCC_199 DEKQIELRLGSEVTALDPVARTVTLSDGG-----TLEYGEVIIATGLVPR
MLBr_02387|M.leprae_Br4923 MKKNKITEIHGYGRFTDANTLSVELSEGVPETPLKVTFNNVIIATGSKTR
.: : *. .: * :* : :.:::**** .:
Mflv_5068|M.gilvum_PYR-GCK RIP-SFPDLPGIHVLRNFDESLALRREAASASRAVVVGAGFIGCEVAASL
Mvan_1290|M.vanbaalenii_PYR-1 RIP-SFPDLPGIHVLRNFDESLALRQEAGTARRAVVVGAGFIGCEVAASL
MSMEG_1416|M.smegmatis_MC2_155 RIG-SFPDLQGIRVLRTYDESMALREDARKASRAVVIGAGFIGCEVAASL
Mb0707|M.bovis_AF2122/97 RIP-SLPDLDGIRVLRSFDESMALRKHASAARHAVVVGAGFIGCEVAASL
Rv0688|M.tuberculosis_H37Rv RIP-SLPDLDGIRVLRSFDESMALRKHASAARHAVVVGAGFIGCEVAASL
MMAR_1017|M.marinum_M RIP-AFPELEGIRVLRSFDECMALRSHASAAKRAVVIGAGFIGCEVAASL
MUL_0769|M.ulcerans_Agy99 RIP-AFPELEGIRVLRSFDECMALRSHASAAKRAVVIGAGFIGCEVAASL
MAV_4485|M.avium_104 RIP-TIPDLDGIRVLRTFDESLALREHASAAQRAVIIGAGFIGCEVAASL
TH_3739|M.thermoresistible__bu RIP-TLPDLEGIRVLRTYDESMALRKHAGSARNAVVIGAGFIGCEVAASL
MAB_3838c|M.abscessus_ATCC_199 RIP-TFPDLAGVHVLRTADDSFALRGDAENARRAVVVGAGFIGCEVAATL
MLBr_02387|M.leprae_Br4923 LVPGTLLSTN----VITYEEQILTRELP---DSIVIVGAGAIGIEFGYVL
: :: . : . :: : * . *::*** ** *.. *
Mflv_5068|M.gilvum_PYR-GCK RKLGVEVTLVEPQPAPLASILGQQIGDLVTRLHRAEGVDVRCGVGVSEVS
Mvan_1290|M.vanbaalenii_PYR-1 RKLGVEVVLVEPQPAPLASVLGQQIGELVTRLHRAEGVDVRCGVGVSKVS
MSMEG_1416|M.smegmatis_MC2_155 RKLGVDVVLVEPQPTPLASVLGEKIGALVTRLHRAEGVDVRCGVGVTEVR
Mb0707|M.bovis_AF2122/97 RGLGVDVVLVEPQPAPLASVLGEQIGQLVTRLHRDEGVDVRTGVTVAEVR
Rv0688|M.tuberculosis_H37Rv RGLGVDVVLVEPQPAPLASVLGEQIGQLVTRLHRDEGVDVRTGVTVAEVR
MMAR_1017|M.marinum_M RGLGVEVVLVEPQPTPLAAVLGEQIGELVARLHRSEGVDVRTGVGVAEVR
MUL_0769|M.ulcerans_Agy99 RGLGVEVVLVEPQPTPLAAVLGEQIGELVARLHRSEGVDVRTGVGVAEVR
MAV_4485|M.avium_104 RSLGVDVVLVEPQPTPLAAVLGQQIGELVARLHRAEGVDVRLGVGVSEVR
TH_3739|M.thermoresistible__bu RGLGVHVVLVEPQPTPLAGVLGEQIGALVARLHRDEGVDLRCGVGVADVR
MAB_3838c|M.abscessus_ATCC_199 RANGVEVVLVEPQPAPLLAAIGQQLGDLVARLHRNEGVDVRVGVGVDAVE
MLBr_02387|M.leprae_Br4923 KNYGVDVTIVEFLPRAMPNED-AEVSKEIEKQFKKMGIKILTGTKVESIS
: **.*.:** * .: ::. : : .: *:.: *. * :
Mflv_5068|M.gilvum_PYR-GCK GDD-RVRKVTLGDG--TDVEADVVIVGIGSHPATS--WLEGSGLELD---
Mvan_1290|M.vanbaalenii_PYR-1 GDD-RVRKVTLGDG--TELDADIVVVGIGSHPATE--WLADSGLEID---
MSMEG_1416|M.smegmatis_MC2_155 GTQ-NVETVVLADG--TELEADLVIVGIGSRPSVD--WLKGSGIEVD---
Mb0707|M.bovis_AF2122/97 GKG-HVDAVVLTDG--TELPADLVVVGIGSTPATE--WLEGSGVEVD---
Rv0688|M.tuberculosis_H37Rv GKG-HVDAVVLTDG--TELPADLVVVGIGSTPATE--WLEGSGVEVD---
MMAR_1017|M.marinum_M GDG-HVDTVVLADG--TQLDADLVVVGIGSHPATG--WLDGSGIAVD---
MUL_0769|M.ulcerans_Agy99 GDG-HVDTVVLADG--TQLDADLVVVGIGSHPATG--WLDGSGIAVD---
MAV_4485|M.avium_104 GDR-HVEAVVLTDG--TELAADVVVIGIGSRPATD--WLEGSGVAIDSVD
TH_3739|M.thermoresistible__bu GTG-AVEKVVLDDG--TELDADLVVVGIGSTPATD--WLQGSGVEVD---
MAB_3838c|M.abscessus_ATCC_199 GQD-RVQSVTLSDG--TRLDTDLVVLGIGSRPAID--WLDGSGVAVD---
MLBr_02387|M.leprae_Br4923 DNGSHVLVAVSKDGQFQELKADKVLQAIGFAPNVDGYGLDKVGVALT-AD
. * .. ** : :* *: .** * * *: :
Mflv_5068|M.gilvum_PYR-GCK NGVVCDEAGRASAPHVWAIGDVA-----SWRDTVGGQVRVEHWS-----N
Mvan_1290|M.vanbaalenii_PYR-1 NGVVCDEAGRASAPHVWAIGDVA-----SWRDNVGGQVRVEHWS-----N
MSMEG_1416|M.smegmatis_MC2_155 NGVVCDEVGRTSAPHVWAIGDVA-----SWRDHVGGQVRVEHWS-----N
Mb0707|M.bovis_AF2122/97 NGVICDKAGRTSAPNVWALGDVA-----SWRDPMGHQARVEHWS-----N
Rv0688|M.tuberculosis_H37Rv NGVICDKAGRTSAPNVWALGDVA-----SWRDPMGHQARVEHWS-----N
MMAR_1017|M.marinum_M NGVVCDAAGRTSAPNVWALGDVA-----SWRDQMGHQVRVEHWS-----N
MUL_0769|M.ulcerans_Agy99 NGVVCDAAGRTSAPNVWAFGDVA-----SWRDQMGHQVRVEHWS-----N
MAV_4485|M.avium_104 RGVLCDEAGRTSAPNVWALGDVA-----SWRDATGHQGRVEHWS-----N
TH_3739|M.thermoresistible__bu NGVVCDAVGRTNVEHVWAIGDVA-----SWRNTVGKQVRVEHWS-----N
MAB_3838c|M.abscessus_ATCC_199 NGVVCDAVGATGTPHVWALGDVA-----AWAGADGRPNRVEHWS-----N
MLBr_02387|M.leprae_Br4923 KAVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAEAQGVVAAEAIAGAETLA
..* * :.. :::*:***: : .* :
Mflv_5068|M.gilvum_PYR-GCK VADQARVLVPTMLGQEPPA-AVSVPYFWSDQYDVKIQALGEPEATDTVHI
Mvan_1290|M.vanbaalenii_PYR-1 VADQARVLVPTMLGQQPPA-AVSVPYFWSDQYDVKIQALGEPEATDTVHI
MSMEG_1416|M.smegmatis_MC2_155 VADQARAMVPALLGQEASA-VVSVPYFWSDQYDVKIQCLGEPESDDTVHI
Mb0707|M.bovis_AF2122/97 VADQARVVVPAMLGTDVPT-GVVVPYFWSDQYDVKIQCLGEPHATDVVHL
Rv0688|M.tuberculosis_H37Rv VADQARVVVPAMLGTDVPT-GVVVPYFWSDQYDVKIQCLGEPHATDVVHL
MMAR_1017|M.marinum_M VADQARVVVPAMLGREVSS-NVVVPYFWSDQYDVKIQCLGEPHSTDVVHL
MUL_0769|M.ulcerans_Agy99 VADQARVVVPAMLGREVSS-NVVVPYFWSDQYDVKIQCLGEPHSTDVVHL
MAV_4485|M.avium_104 VADQARVVVPAMLGKEVPP-VVVVPYFWSDQYDVKIQCLGEPEADDIVHI
TH_3739|M.thermoresistible__bu VADQARVLVPALLGQEVPV-AATVPYFWSDQYDVKIQCLGEPEAGDTVHV
MAB_3838c|M.abscessus_ATCC_199 VADQVRALVPALLGQETSANTVAVPYFWSDQYDVKIQSLGHLGSSDTVHL
MLBr_02387|M.leprae_Br4923 LSDYRMMPRATFCQPNVASFGLTEQQARDGGYDVVVAKFPFTANAKAHGM
::* .:: : . .. *** : : . :
Mflv_5068|M.gilvum_PYR-GCK VEDDGRKFLAYYERDGAVVA--VVGGGFPGKVMKTRAKIAAGAPISDLLG
Mvan_1290|M.vanbaalenii_PYR-1 VEDDGRKFLAYYERDGVVVG--VVGGGFPGKVMKVRAKIAAGAPISELLG
MSMEG_1416|M.smegmatis_MC2_155 VEDDGRKFLAYYERDGVLVG--VVGGGMPGKVMKTRGKIAAGAPIAEVLG
Mb0707|M.bovis_AF2122/97 VEDDGRKFLAYYERDGVLVG--VVGGGMAGKVMKVRGKIAAGAPIAEVLD
Rv0688|M.tuberculosis_H37Rv VEDDGRKFLAYYERDGVLVG--VVGGGMAGKVMKVRGKIAAGAPIAEVLD
MMAR_1017|M.marinum_M VEDDGRKFLAYYERDGVLVG--VVGGGVPGKVMKVRAKIAAAVPISEMLD
MUL_0769|M.ulcerans_Agy99 VEDDGRKLLAYYQRDGVLVG--VVGGGVPGKVMKVRAKIAAAVPISEMLD
MAV_4485|M.avium_104 VEDDGRKFLAYYERDGALVG--VVGGGMPGKVMKTRAKIAAAVPIAEMLG
TH_3739|M.thermoresistible__bu VSDDGRKFLAYYERDGVLTG--VVGGGMPGKVMKARAKIAAGAPISEVLE
MAB_3838c|M.abscessus_ATCC_199 ISDDGRKFLAYLERDGVLTG--VVGCGMAGPVMKMRAKIAAGTPIAEVLA
MLBr_02387|M.leprae_Br4923 GDPSGFVKLVADAKYGELLGGHMIGHNVSELLPELTLAQKWDLTATELVR
. .* *. : * : . ::* ... : : . ::::
Mflv_5068|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1290|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1416|M.smegmatis_MC2_155 G-------------------------------------------------
Mb0707|M.bovis_AF2122/97 QTQA----------------------------------------------
Rv0688|M.tuberculosis_H37Rv QTQA----------------------------------------------
MMAR_1017|M.marinum_M ESQG----------------------------------------------
MUL_0769|M.ulcerans_Agy99 ESQGQTSARIPARGAGPGGPLVRWPTLTKSGRWRAEKATASSPVARVDGI
MAV_4485|M.avium_104 --------------------------------------------------
TH_3739|M.thermoresistible__bu --------------------------------------------------
MAB_3838c|M.abscessus_ATCC_199 GS------------------------------------------------
MLBr_02387|M.leprae_Br4923 NVHTHPTLSEALQECFHGLIGHMINF------------------------
Mflv_5068|M.gilvum_PYR-GCK ------------------
Mvan_1290|M.vanbaalenii_PYR-1 ------------------
MSMEG_1416|M.smegmatis_MC2_155 ------------------
Mb0707|M.bovis_AF2122/97 ------------------
Rv0688|M.tuberculosis_H37Rv ------------------
MMAR_1017|M.marinum_M ------------------
MUL_0769|M.ulcerans_Agy99 GLEPGPRRTASWPDVPGT
MAV_4485|M.avium_104 ------------------
TH_3739|M.thermoresistible__bu ------------------
MAB_3838c|M.abscessus_ATCC_199 ------------------
MLBr_02387|M.leprae_Br4923 ------------------