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MSRRTFVTVGAGQTAAVAARNLRRHGFDGRIVLIGDEPHPPYQRPPLSKEFLAGTENEEGLWILPPKWLQ DNDVEIITDTTVVRVDAAARAVEFSGGAGLQADSVLFATGGAPRRLPVDGPRPDLVHYLRTLDDAARLAP VLTPGRRLAIIGAGFIGLEIAATAAAAGVEVTVLEAVPVPLARVVGPAMGEAVCRLHRDNGVDIRAGVQL AGVRTAADGVVIDIAGAAAPLEADAVVVGIGIIPNTAVAAASGLWVDDGIVVDALGRTAVPGVFAAGDAA RRYSPRAGRHLRLEHFDNASRQGVAVANAMLGREAPSDDPLWFWSDQYGRNIQFVGTASGTPVIRGNRDE FDFTGFYLENDTVCGAFAIDRGEDVTAARELLGRGVDAAALLDEDTDLWDLVYADEDEQVRA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1327 | - | - | 100% (412) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1290 | - | 7e-60 | 36.67% (390) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0467 | - | 2e-58 | 37.89% (388) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1900c | - | 3e-73 | 40.79% (407) | reductase |
| M. gilvum PYR-GCK | Mflv_4591 | - | 5e-64 | 38.62% (391) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv1869c | - | 3e-73 | 40.79% (407) | reductase |
| M. leprae Br4923 | MLBr_02387 | lpd | 7e-10 | 24.90% (245) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4368c | - | 5e-64 | 36.79% (405) | putative rubredoxin/ferredoxin reductase |
| M. marinum M | MMAR_1017 | - | 2e-66 | 38.87% (391) | ferredoxin reductase |
| M. avium 104 | MAV_2849 | - | 2e-69 | 41.99% (362) | anthranilate dioxygenase reductase |
| M. smegmatis MC2 155 | MSMEG_1460 | - | 1e-148 | 64.63% (410) | pyridine nucleotide-disulphide oxidoreductase |
| M. thermoresistible (build 8) | TH_3739 | - | 3e-63 | 37.91% (393) | PUTATIVE Pyridine nucleotide-disulphide oxidoreductase |
| M. ulcerans Agy99 | MUL_0769 | - | 5e-65 | 38.36% (391) | ferredoxin reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1900c|M.bovis_AF2122/97 -----------------MASSTTFVIVGGGLAGAKAVEALRRSDFGGRII
Rv1869c|M.tuberculosis_H37Rv -----------------MASSTTFVIVGGGLAGAKAVEALRRSDFGGRII
MAV_2849|M.avium_104 -----------------MASATGFVIIGGGLAAAKAVEALRDNNFDGRII
MAB_4368c|M.abscessus_ATCC_199 --------------------MKRIVVVGGGIAGVSTVGGLRANGYDGDIT
Mvan_1327|M.vanbaalenii_PYR-1 ------------------MSRRTFVTVGAGQTAAVAARNLRRHGFDGRIV
MSMEG_1460|M.smegmatis_MC2_155 ------------------MTDRTFVTVGAGQTAAVAARTLRRRGFDGRII
MMAR_1017|M.marinum_M MYEHHVTSSEGVTQDPGATAANGIVIIGGGLAAARTAEQLRRAGYEGQLT
MUL_0769|M.ulcerans_Agy99 MYEHHVTSSEGVTQDPGATAANGIVIIGGGLAAARTAEQLRRAGYEGQLT
TH_3739|M.thermoresistible__bu -----------------VSTTAGIIIVGGGLAAARTAEQLRRSEFGGPIT
Mflv_4591|M.gilvum_PYR-GCK ------------------MTLHRAVIVGASHAGAQLAASLRQEGWDGEIV
MLBr_02387|M.leprae_Br4923 ------------------MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVV
: :*.. . . :
Mb1900c|M.bovis_AF2122/97 LFGDEEHLPYDRPPLSKEFLAGKKSLSDFTIQTSDWYRDH-DVDVRLGVR
Rv1869c|M.tuberculosis_H37Rv LFGDEEHLPYDRPPLSKEFLAGKKSLSDFTIQTSDWYRDH-DVDVRLGVR
MAV_2849|M.avium_104 VFADEEHLPYERPPLSKEFLAGKKSLTDFTVQNSDWYRDN-DVDLRLNTR
MAB_4368c|M.abscessus_ATCC_199 MI-DAGGSPYDRPPLSKDYLSGKVKLADIELRPEQWYRDQ-QVRLISEST
Mvan_1327|M.vanbaalenii_PYR-1 LIGDEPHPPYQRPPLSKEFLAGTENEEGLWILPPKWLQDN-DVEIITDTT
MSMEG_1460|M.smegmatis_MC2_155 LVGDEPHAPYQRPPLSKEFLCDTAASDDLWILPEKWCADN-GVEIRTGAE
MMAR_1017|M.marinum_M IVSDEVHLPYDRPPLSKEVLRS--EVDDVSLKPREWYDEK-DIALRLGSA
MUL_0769|M.ulcerans_Agy99 IVSDEVHLPYDRPPLSKEVLRS--EVDDVSLKPREWYDEK-GITLRLGSA
TH_3739|M.thermoresistible__bu IVSDEDHLPYDRPPLSKDVLSG--KTDDVTLKPAEFYAEN-DITLLLGTA
Mflv_4591|M.gilvum_PYR-GCK LVGNESALPYHRPPLSKAYLAGKCTVDELAIRNAEFYTKQ-RIKLMD-AT
MLBr_02387|M.leprae_Br4923 EPKYWGGICLNVGCIPSKVLLHNAELAHIFTKEAKTFGISGDASFDYGIA
. :.. * . . .
Mb1900c|M.bovis_AF2122/97 VSSLDRSAHTVELPDGAAVRYDKLLLATGS--------APRRPPIPGSDA
Rv1869c|M.tuberculosis_H37Rv VSSLDRSAHTVELPDGAAVRYDKLLLATGS--------APRRPPIPGSDA
MAV_2849|M.avium_104 VCALDAAGHTVGLPDGTTVAYDKLLLATGS--------AARRPPIPGSDC
MAB_4368c|M.abscessus_ATCC_199 VAVLRPALGAVETADGTLLAADRVVLATGG--------GAARPPIPGSEN
Mvan_1327|M.vanbaalenii_PYR-1 VVRVDAAARAVEFSGGAGLQADSVLFATGG--------APRRLPVDGPRP
MSMEG_1460|M.smegmatis_MC2_155 VTRVDAATGTVEIAGQAPVRADAVLFATGG--------RPRRLPVPGPRP
MMAR_1017|M.marinum_M ATGLDTAAQTVTLADGTVLGYDELVIATGL--------VPRRIPA-FPEL
MUL_0769|M.ulcerans_Agy99 ATGLDTAAQTVTLADGTVLGYDELVIATGL--------VPRRIPA-FPEL
TH_3739|M.thermoresistible__bu ATALDPQARKLTLADGRALEYDELIIATGL--------VPKRIPT-LPDL
Mflv_4591|M.gilvum_PYR-GCK VEVLDRSAGHLSLTTGDALPYDKLALCTGA--------RPRRLSIPGADL
MLBr_02387|M.leprae_Br4923 YDRSRKVSEGRVAGVHFLMKKNKITEIHGYGRFTDANTLSVELSEGVPET
: : : * . . . .
Mb1900c|M.bovis_AF2122/97 AGVHYLRSYNDAVALNSVLVQG--------------------SSLAVVGA
Rv1869c|M.tuberculosis_H37Rv AGVHYLRSYNDAVALNSVLVQG--------------------SSLAVVGA
MAV_2849|M.avium_104 AGVHYLRTYEVAVALNSFLGEG--------------------KSLAVVGA
MAB_4368c|M.abscessus_ATCC_199 AAIHVLRDVADAQRLRDGLRSG--------------------VRVLIVGA
Mvan_1327|M.vanbaalenii_PYR-1 DLVHYLRTLDDAARLAPVLTPG--------------------RRLAIIGA
MSMEG_1460|M.smegmatis_MC2_155 ELVHYLRTLDDARRLHDALASG--------------------CRLGVIGA
MMAR_1017|M.marinum_M EGIRVLRSFDECMALRSHASAA--------------------KRAVVIGA
MUL_0769|M.ulcerans_Agy99 EGIRVLRSFDECMALRSHASAA--------------------KRAVVIGA
TH_3739|M.thermoresistible__bu EGIRVLRTYDESMALRKHAGSA--------------------RNAVVIGA
Mflv_4591|M.gilvum_PYR-GCK PGVCYLRTAADVAMIRERTSPG--------------------RRAVIVGG
MLBr_02387|M.leprae_Br4923 PLKVTFNNVIIATGSKTRLVPGTLLSTNVITYEEQILTRELPDSIVIVGA
:. . ::*.
Mb1900c|M.bovis_AF2122/97 GWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADLHRDQGVD
Rv1869c|M.tuberculosis_H37Rv GWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADLHRDQGVD
MAV_2849|M.avium_104 GWIGLEVAAAARQRGVEVTVVEAARQPLTAALGETVGEVFATLHREHGVD
MAB_4368c|M.abscessus_ATCC_199 GLVGAEIASTAVDLGCSVVLVDPVRPPLVAAVGADMADWLHHKHRERGV-
Mvan_1327|M.vanbaalenii_PYR-1 GFIGLEIAATAAAAGVEVTVLEAVPVPLARVVGPAMGEAVCRLHRDNGVD
MSMEG_1460|M.smegmatis_MC2_155 GFVGLEIAATAVGLGASVTVLEAAPMPLGTVVGSRVAAEIVRLHRGNGVE
MMAR_1017|M.marinum_M GFIGCEVAASLRGLGVEVVLVEPQPTPLAAVLGEQIGELVARLHRSEGVD
MUL_0769|M.ulcerans_Agy99 GFIGCEVAASLRGLGVEVVLVEPQPTPLAAVLGEQIGELVARLHRSEGVD
TH_3739|M.thermoresistible__bu GFIGCEVAASLRGLGVHVVLVEPQPTPLAGVLGEQIGALVARLHRDEGVD
Mflv_4591|M.gilvum_PYR-GCK GYIGLEAAASLRALGLEVTVLEATERVLERVTAPAVSAFFDRIHREEGVD
MLBr_02387|M.leprae_Br4923 GAIGIEFGYVLKNYGVDVTIVEFLPRAMPNED-AEVSKEIEKQFKKMGIK
* :* * . * *.::: : :. . .: *:
Mb1900c|M.bovis_AF2122/97 LRLQTQLEEITAADGKATGLKMRD--GSTVAADAVLVAVGAKPNVE---L
Rv1869c|M.tuberculosis_H37Rv LRLQTQLEEITAADGKATGLKMRD--GSTVAADAVLVAVGAKPNVE---L
MAV_2849|M.avium_104 LRLETQVREITRADGSATGLRTTD--GSAIPADAVLVAVGARPNIE---L
MAB_4368c|M.abscessus_ATCC_199 VTLQAGVEAFHQRIGEIEVSLQGE--YRPQVADVVVLAVGMVPRTS---L
Mvan_1327|M.vanbaalenii_PYR-1 IRAGVQLAGVR--TAADGVVIDIAGAAAPLEADAVVVGIGIIPNTA---V
MSMEG_1460|M.smegmatis_MC2_155 LLTGVAVNGVR--TDADGVVVSTG--AQDLRFDAVVIGIGITPNTA---V
MMAR_1017|M.marinum_M VRTGVGVAEVRGDGHVDTVVLADG---TQLDADLVVVGIGSHPATG---W
MUL_0769|M.ulcerans_Agy99 VRTGVGVAEVRGDGHVDTVVLADG---TQLDADLVVVGIGSHPATG---W
TH_3739|M.thermoresistible__bu LRCGVGVADVRGTGAVEKVVLDDG---TELDADLVVVGIGSTPATD---W
Mflv_4591|M.gilvum_PYR-GCK IQTDALVDAMSGDGRVREVILASG---ESIPADLVIVGIGVEPNTD---L
MLBr_02387|M.leprae_Br4923 ILTGTKVESISDNGSHVLVAVSKDGQFQELKADKVLQAIGFAPNVDGYGL
: . : . * *: .:* *
Mb1900c|M.bovis_AF2122/97 AQQAGLAMGEGGVLVDASLRTSDPDIYAVGDIAAA----EHPLLGTRVRT
Rv1869c|M.tuberculosis_H37Rv AQQAGLAMGEGGVLVDASLRTSDPDIYAVGDIAAA----EHPLLGTRVRT
MAV_2849|M.avium_104 AEAAGLSLADGGVLVDASLRTSDPDIYAVGDIAAA----EHPLLRTRIRT
MAB_4368c|M.abscessus_ATCC_199 ATAAGLEV-DGAVVVDVRQLTSNPAILAVGDVARI----RKDGR-LLARS
Mvan_1327|M.vanbaalenii_PYR-1 AAASGLWVDDG-IVVDALGRTAVPGVFAAGDAARR----YSPRAGRHLRL
MSMEG_1460|M.smegmatis_MC2_155 AEVSGLAVDDG-IVVDAQGRASVPNIYAAGDVARR----YSERAGKHVRI
MMAR_1017|M.marinum_M LDGSGIAVDNG-VVCDAAGRTSAPNVWALGDVAS-----WRDQMGHQVRV
MUL_0769|M.ulcerans_Agy99 LDGSGIAVDNG-VVCDAAGRTSAPNVWAFGDVAS-----WRDQMGHQVRV
TH_3739|M.thermoresistible__bu LQGSGVEVDNG-VVCDAVGRTNVEHVWAIGDVAS-----WRNTVGKQVRV
Mflv_4591|M.gilvum_PYR-GCK AAAAGLAIDNG-VVIDDQARTTDPDIVAAGDCTSH----HMARYGRRIRL
MLBr_02387|M.leprae_Br4923 DKVGVALTADKAVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAEAQGVVAA
. : : * : : * ** :
Mb1900c|M.bovis_AF2122/97 EHWANALKQPAVAAAGMLGRPGEYAE-LPYLFTDQYDLG----MEYVGHA
Rv1869c|M.tuberculosis_H37Rv EHWANALKQPAVAAAGMLGRPGEYAE-LPYLFTDQYDLG----MEYVGHA
MAV_2849|M.avium_104 EHWANALKQPAIAVAGMLGRPGEYDE-LPYFFTDQYDLG----MEYVGHA
MAB_4368c|M.abscessus_ATCC_199 EHWDGAGASGGRAAATLMGADPPPAS-APWFWTDRHGDH----VEAVGQM
Mvan_1327|M.vanbaalenii_PYR-1 EHFDNASRQGVAVANAMLGREAPSDD-PLWFWSDQYGRN----IQFVGTA
MSMEG_1460|M.smegmatis_MC2_155 EHFDNANRQGAAVANAMLGRDAVNDD-APWFWSDQYEHN----LQLLGEA
MMAR_1017|M.marinum_M EHWSNVADQARVVVPAMLGREVSSNVVVPYFWSDQYDVK----IQCLGEP
MUL_0769|M.ulcerans_Agy99 EHWSNVADQARVVVPAMLGREVSSNVVVPYFWSDQYDVK----IQCLGEP
TH_3739|M.thermoresistible__bu EHWSNVADQARVLVPALLGQEVPVAATVPYFWSDQYDVK----IQCLGEP
Mflv_4591|M.gilvum_PYR-GCK ESVPGAGEQAKVAAATICGKSKKVAA-LPWFWSDQYDVK----LQIAGLN
MLBr_02387|M.leprae_Br4923 EAIAGAETLALSDYRMMPRATFCQPNVASFGLTEQQARDGGYDVVVAKFP
* .. : : ::: :
Mb1900c|M.bovis_AF2122/97 PSCDRVVFRGNVAGREFLSFWLDGDSRVLAGMNVNVWDVVDDVKGLIRSG
Rv1869c|M.tuberculosis_H37Rv PSCDRVVFRGNVAGREFLSFWLDGDSRVLAGMNVNVWDVVDDVKGLIRSG
MAV_2849|M.avium_104 PRFERVVFRGDVAAREFVAFWLDADDRVLAGMNVNIWDVLDDVKALIRSR
MAB_4368c|M.abscessus_ATCC_199 SGADHTVLRGDVGDPGFAVFGLR-DGALVGAASVNQPNIVRAARRLIDRG
Mvan_1327|M.vanbaalenii_PYR-1 SGTP--VIRGNRDEFDFTGFYLEN-DTVCGAFAIDRGEDVTAARELLGRG
MSMEG_1460|M.smegmatis_MC2_155 TGNL--VIRGDVGEFEFTAFYVDTDDTLRGVFTVDRGEDVMVGRELLGRR
MMAR_1017|M.marinum_M HSTD--VVHLVEDDGRKFLAYYERDGVLVGVVGGGVPGKVMKVRAKIAAA
MUL_0769|M.ulcerans_Agy99 HSTD--VVHLVEDDGRKLLAYYQRDGVLVGVVGGGVPGKVMKVRAKIAAA
TH_3739|M.thermoresistible__bu EAGD--TVHVVSDDGRKFLAYYERDGVLTGVVGGGMPGKVMKARAKIAAG
Mflv_4591|M.gilvum_PYR-GCK TGYDEVVLSGDPTRDRDFTCFYLRAGELIAADCINRPRDFVFSKRVITQQ
MLBr_02387|M.leprae_Br4923 FTANAKAHGMGDPSGFVKLVADAKYGELLGGHMIGHNVSELLPELTLAQK
. . : . . . :
Mb1900c|M.bovis_AF2122/97 NPVDVDRLVDPQWPLADLTTN-----------------------------
Rv1869c|M.tuberculosis_H37Rv NPVDVDRLVDPQWPLADLTTN-----------------------------
MAV_2849|M.avium_104 APIDADRLGDPGAPLGELLG------------------------------
MAB_4368c|M.abscessus_ATCC_199 VQLTAEVLGDPHSDLRELLKQQRSVRISGRGED-----------------
Mvan_1327|M.vanbaalenii_PYR-1 --VDAAALLDEDTDLWDLVYADEDEQVRA---------------------
MSMEG_1460|M.smegmatis_MC2_155 --IPRAVLEDDDADLWELVDTEEVAQ------------------------
MMAR_1017|M.marinum_M --VPISEMLDESQG------------------------------------
MUL_0769|M.ulcerans_Agy99 --VPISEMLDESQGQTSARIPARGAGPGGPLVRWPTLTKSGRWRAEKATA
TH_3739|M.thermoresistible__bu --APISEVLE----------------------------------------
Mflv_4591|M.gilvum_PYR-GCK VPIERAELMLAGPA------------------------------------
MLBr_02387|M.leprae_Br4923 WDLTATELVRNVHTHPTLSEALQECFHGLIGHMINF--------------
:
Mb1900c|M.bovis_AF2122/97 ----------------------------
Rv1869c|M.tuberculosis_H37Rv ----------------------------
MAV_2849|M.avium_104 ----------------------------
MAB_4368c|M.abscessus_ATCC_199 ----------------------------
Mvan_1327|M.vanbaalenii_PYR-1 ----------------------------
MSMEG_1460|M.smegmatis_MC2_155 ----------------------------
MMAR_1017|M.marinum_M ----------------------------
MUL_0769|M.ulcerans_Agy99 SSPVARVDGIGLEPGPRRTASWPDVPGT
TH_3739|M.thermoresistible__bu ----------------------------
Mflv_4591|M.gilvum_PYR-GCK ----------------------------
MLBr_02387|M.leprae_Br4923 ----------------------------