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MRVFVTGASGFIGSAVADELIAAGHTVIGLARSDASAEALTRAGHEVHRGDLTDLDSLRAGAASADGVIH LAFVHDFENFAGAVQTDSAAIEALGETLAGSDRPLVVAAGVAGLPRGTTEDDAIPAGFPRLSETTALNQV SKGVRASVVRLPPSVHGRGDYGFVPRLISIARERGVSGYPGDGSNAWSAVHRVDAARVFRLALEDAPAGS RWHAVADEGIAVREIAETIGRGLGLPAVSVPPDQATAHFGWLGGFFAVDANLGSALTRQRLGWEPTGPGL LADLDAGHYFESAAGQGLETVTG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_3470 | - | - | 100% (303) | NAD-dependent epimerase/dehydratase |
M. smegmatis MC2 155 | MSMEG_5228 | - | 7e-09 | 34.78% (115) | 3-beta hydroxysteroid dehydrogenase/isomerase family protein |
M. smegmatis MC2 155 | MSMEG_5799 | - | 1e-08 | 30.92% (152) | nucleoside-diphosphate-sugar epimerase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3658c | galE1 | 1e-08 | 26.06% (307) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
M. gilvum PYR-GCK | Mflv_2075 | - | 1e-07 | 31.06% (132) | 3-beta hydroxysteroid dehydrogenase/isomerase |
M. tuberculosis H37Rv | Rv3634c | galE1 | 1e-08 | 26.06% (307) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
M. leprae Br4923 | MLBr_00204 | rmlB2 | 3e-08 | 26.38% (307) | putative sugar-nucleotide dehydratase |
M. abscessus ATCC 19977 | MAB_0994 | - | 1e-107 | 67.58% (293) | putative NAD-dependent epimerase/dehydratase |
M. marinum M | MMAR_5133 | galE1 | 4e-09 | 25.74% (303) | UDP-glucose 4-epimerase GalE1 |
M. avium 104 | MAV_0588 | - | 9e-75 | 52.53% (297) | oxidoreductase |
M. thermoresistible (build 8) | TH_1114 | - | 8e-08 | 33.85% (130) | PROBABLE CHOLESTEROL DEHYDROGENASE |
M. ulcerans Agy99 | MUL_4210 | galE1 | 3e-09 | 25.74% (303) | UDP-glucose 4-epimerase GalE1 |
M. vanbaalenii PYR-1 | Mvan_1926 | - | 8e-94 | 60.62% (292) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_5133|M.marinum_M ----------MRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGRATN MUL_4210|M.ulcerans_Agy99 ----------MRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGRATN Mb3658c|M.bovis_AF2122/97 ----------MRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATN Rv3634c|M.tuberculosis_H37Rv ----------MRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATN MLBr_00204|M.leprae_Br4923 -----MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAAN Mflv_2075|M.gilvum_PYR-GCK ----MLRTELGRVLVTGGSGFVGANLVTELLDRGLHVRSFDRVAS----- TH_1114|M.thermoresistible__bu MGDPTLRTDLGRVLVTGGSGFVGTNLVTTLLERGHHVRSCDRVGS----- MSMEG_3470|M.smegmatis_MC2_155 ----------MRVFVTGASGFIGSAVADELIAAGHTVIGLARSDAS---- MAB_0994|M.abscessus_ATCC_1997 ----------MRVFVTGASGFIGSAVVRELIDSGHTVTGLARSDSS---- Mvan_1926|M.vanbaalenii_PYR-1 ----------MKVFVTGASGFIGSAVTAELLGHGHHVLGLARSDAA---- MAV_0588|M.avium_104 ----------MRVLVTGASGGIGSAVVKELLAAGHHVIGLARSEAS---- :.:***.:* :*: :. *: * * . . : MMAR_5133|M.marinum_M LEHLVDNLAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQIDVR----HS MUL_4210|M.ulcerans_Agy99 LEHLVDNLAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQIDVR----HS Mb3658c|M.bovis_AF2122/97 LEHLADNSAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVR----RS Rv3634c|M.tuberculosis_H37Rv LEHLADNSAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVR----RS MLBr_00204|M.leprae_Br4923 LEHLASTPALAFVEADIVTADLQTILDEHRPEVVFHLAAQIDVR----HS Mflv_2075|M.gilvum_PYR-GCK --ALPAHARLEIVEGDITDADDVAAAVEG-VDTVFHTAAIIDLMGGASVS TH_1114|M.thermoresistible__bu --PLPDHPRLEVIDGDICDADAVAAAVDG-IDTVFHTAAVIDLMGGAGVT MSMEG_3470|M.smegmatis_MC2_155 -AEALTRAGHEVHRGDLTDLDSLRAGAAS-ADGVIHLAFVHDFE------ MAB_0994|M.abscessus_ATCC_1997 -AAALTAAGADVHRGSLDDLESLRAGAVA-ADGVAHLAFVHDFE------ Mvan_1926|M.vanbaalenii_PYR-1 -AQRITATGAEAVRGDLDDLDALEAGASA-ADAVIHLAFQHDFT------ MAV_0588|M.avium_104 -AATVSGLGAEPLRGDIADLDVLQKAAVD-TDGVAYLAFSHDFS------ ..: : : : : * *. MMAR_5133|M.marinum_M VADPQFDASVNVIGTLRLAEAARLTGVRKVVHTSSGGSIYGTPPQYPTSE MUL_4210|M.ulcerans_Agy99 VADPQFDASVNVIGTLRLAEAARLTGVRKVVHTSSGGSIYGTPPQYPTSE Mb3658c|M.bovis_AF2122/97 VADPQFDAAVNVIGTVRLAEAARQTGVRKIVHTSSGGSIYGTPPEYPTPE Rv3634c|M.tuberculosis_H37Rv VADPQFDAAVNVIGTVRLAEAARQTGVRKIVHTSSGGSIYGTPPEYPTPE MLBr_00204|M.leprae_Br4923 VVDPQFDASVNVIGTVRLAEAARHTGVRKIVHTSSGGSIYGTPSQYPTPE Mflv_2075|M.gilvum_PYR-GCK EEYRQRSFAVNVTGTQNLVHAAQKAGVTRFVYTASNSVVMGGQRIAGGDE TH_1114|M.thermoresistible__bu DEYRERSFAVNVHGTERLVRAAQQAGVRRFVYTASNSVVMGGQPIADGDE MSMEG_3470|M.smegmatis_MC2_155 ----NFAGAVQTDSAAIEALGETLAGSDRPLVVAAGVA--GLPRGTTEDD MAB_0994|M.abscessus_ATCC_1997 ----NYAEAVNADKRAIATIGEALAGTERPFVVTSGLAGFGLGRPLTEED Mvan_1926|M.vanbaalenii_PYR-1 ----AYDTAARVDRQAIETLGEALAGSDRALVVASGMAGLGRGRILTEDQ MAV_0588|M.avium_104 ----DVGDAIADEARAIDALGAALADTGKPLVLASGTP-ARPGSVSTEDD : . . :. : . ::. : MMAR_5133|M.marinum_M RVPTDP--ASPYAAGKVAGEIYLNTFRHLYGLECSHIAPANVYGPRQDPH MUL_4210|M.ulcerans_Agy99 RVPTDP--ASPYAAGKVAGEIYLNTFRHLYGLECSHIAPANVYGPRQDPH Mb3658c|M.bovis_AF2122/97 TAPTDP--ASPYAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPH Rv3634c|M.tuberculosis_H37Rv TAPTDP--ASPYAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPH MLBr_00204|M.leprae_Br4923 TVPTDP--TSPYAAGKVAGEIYLNTFRHLCGLDCSHIAPANVYGPRQDPY Mflv_2075|M.gilvum_PYR-GCK TLPYTERFNDLYTETKVVAEKFVLSQNGVSGLLTCSIRPSGIWGR----- TH_1114|M.thermoresistible__bu TLPYTDRFNDLYTETKVIAERFVLGQNGIEGMLTCSIRPSGIWGP----- MSMEG_3470|M.smegmatis_MC2_155 AIPAGF---PRL----SETTALNQVSKGVRASVVRLPPSVHGRGD----- MAB_0994|M.abscessus_ATCC_1997 AAAPES---PRL----SEE-ALNLADRGVRVSAVRLAPSVHGEGD----- Mvan_1926|M.vanbaalenii_PYR-1 AAPPDA---PRE----SEPAVFAFTDRGVRAAAVRLAPTVHGEGD----- MAV_0588|M.avium_104 PFIADG---PLAGRGRTGQAVVELAGRGVRSAVVRLPRAVHDAGGR---- . : . * MMAR_5133|M.marinum_M GEAGVVAIFAQALLSGKPTKVFGDGTNTRDYVFVDDVVDAFVRAGSDVG- MUL_4210|M.ulcerans_Agy99 GEAGVVAIFAQALLSGKPTKVFGDGTNTRDYVFVDDVVDAFVKAGSDVG- Mb3658c|M.bovis_AF2122/97 GEAGVVAIFAQALLSGKPTRVFGDGTNTRDYVFVDDVVDAFVRVSADVG- Rv3634c|M.tuberculosis_H37Rv GEAGVVAIFAQALLSGKPTRVFGDGTNTRDYVFVDDVVDAFVRVSADVG- MLBr_00204|M.leprae_Br4923 GEAGVVAIFVQALLSDRPTKVFGDGTHTRDYVFVDDVVDAFIKASGDAG- Mflv_2075|M.gilvum_PYR-GCK GDQTMFRKVFESVLAGHVKVLVGNKETKLDNSYVHNLVHGFILAAEHLVE TH_1114|M.thermoresistible__bu GDQTMFRKLFESVHAGHVKVLIGSRHARLDNSYVHNLVHGFILAAEHLVP MSMEG_3470|M.smegmatis_MC2_155 --YGFVPRLISIARERGVSGYPGDGSNAWSAVHRVDAARVFRLALEDAP- MAB_0994|M.abscessus_ATCC_1997 --HGFVPRLIEIARAKGVSAYPGDGSNRWPAVHRLDAAHLFRLALENAP- Mvan_1926|M.vanbaalenii_PYR-1 --HGFVPTLISIARATGVSTYPGDGSNRWPAVHRLDAAALFRIAAEDAP- MAV_0588|M.avium_104 --YGLAGILIQLARQRGVSSFAGDGTQRWPAVHRDDAAALFRLALEQAP- . . . . *. . : . * . . MMAR_5133|M.marinum_M ----GGQRFNIGTGVETSDRQLHSAVAAAVG------------------- MUL_4210|M.ulcerans_Agy99 ----GGQRFNIGTGVETSDRQLHSAVAAAVG------------------- Mb3658c|M.bovis_AF2122/97 ----GGLRFNIGTGKETSDRQLHSAVAAAVG------------------- Rv3634c|M.tuberculosis_H37Rv ----GGLRFNIGTGKETSDRQLHSAVAAAVG------------------- MLBr_00204|M.leprae_Br4923 ----GGQRFNIGTGIETSDRQLHTAVSAAVG------------------- Mflv_2075|M.gilvum_PYR-GCK GGSAPGQAYFINDGEPINMFEFARPVVQACGEPFPKFRVPGRLVWFAMTI TH_1114|M.thermoresistible__bu GGTAPGQAYFINDGEPINMFEFARPVVTACGQRWPTLRVSGPLVRAVMSL MSMEG_3470|M.smegmatis_MC2_155 ----AGSRWHAVADEGIAVREIAETIGRGLGLP----------------- MAB_0994|M.abscessus_ATCC_1997 ----TGSRLHGVAEDGIPVRDIAEVIGRHLNLP----------------- Mvan_1926|M.vanbaalenii_PYR-1 ----AGTLLHAVADEGIPVRQIAEAIGHGLDVS----------------- MAV_0588|M.avium_104 ----AGSVLHAVGDEGVPLRAIAEVIGRRLGVP----------------- * : : . MMAR_5133|M.marinum_M --------GPDDPEFHPPRLGDLKRS-CLDISRAEEVLGWRPQVELADGV MUL_4210|M.ulcerans_Agy99 --------GPDDPEFHPPRLGDLKRS-CLDISRAEEVLGWRPQVELADGV Mb3658c|M.bovis_AF2122/97 --------GPDDPEFHPPRLGDLKRS-CLDIGLAERVLGWRPQIELADGV Rv3634c|M.tuberculosis_H37Rv --------GPDDPEFHPPRLGDLKRS-CLDIGLAERVLGWRPQIELADGV MLBr_00204|M.leprae_Br4923 --------GPDDPEFHPPRLGDLKRS-CLDIGLATTVLGWSPQVQLDDGV Mflv_2075|M.gilvum_PYR-GCK WQFLHFKFGLPKPLLEPLAVERLYLDNYFSIAKAQRDLGYQPLFTTEQAL TH_1114|M.thermoresistible__bu WQRLHFRFGLPKPPLEPLAVERLYLDNYFSIDKARRELGYRPRYTTEQAL MSMEG_3470|M.smegmatis_MC2_155 ---AVSVPPDQATAHFGWLGGFFAVDANLGSALTRQRLGWEPTGPGLLAD MAB_0994|M.abscessus_ATCC_1997 ---VESVPLAQAFDHFGWLGGFFAMDLPATSVLTQERLGWRPVQPGLIAD Mvan_1926|M.vanbaalenii_PYR-1 ---VEATTAQASIDRAGFIGAVFAMDLPASSALTRTQFGWQPTHPGLLAD MAV_0588|M.avium_104 ---VESAP----ADAFGPLGQVFAVDQPSSSALTQRRFGWQPVGPGLLDD : . : :*: * MMAR_5133|M.marinum_M RRTVDYFRRTHGS-------------------- MUL_4210|M.ulcerans_Agy99 RRTVDYFRRTHGS-------------------- Mb3658c|M.bovis_AF2122/97 RRTVEYFRHKHTD-------------------- Rv3634c|M.tuberculosis_H37Rv RRTVEYFRHKHTD-------------------- MLBr_00204|M.leprae_Br4923 RRTVEYFRAAQRS-------------------- Mflv_2075|M.gilvum_PYR-GCK AQCIPYYVELFDRMKREAGNPVVQAAAPAPPKG TH_1114|M.thermoresistible__bu QECLPYYVDLFHRMKAEPATV------------ MSMEG_3470|M.smegmatis_MC2_155 LDAGHYFESAAGQGLETVTG------------- MAB_0994|M.abscessus_ATCC_1997 LEKGHYFDE------------------------ Mvan_1926|M.vanbaalenii_PYR-1 LSQAHYFATPEA--------------------- MAV_0588|M.avium_104 LETGVYPE------------------------- *