For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VRVLVTGASGGIGSAVVKELLAAGHHVIGLARSEASAATVSGLGAEPLRGDIADLDVLQKAAVDTDGVAY LAFSHDFSDVGDAIADEARAIDALGAALADTGKPLVLASGTPARPGSVSTEDDPFIADGPLAGRGRTGQA VVELAGRGVRSAVVRLPRAVHDAGGRYGLAGILIQLARQRGVSSFAGDGTQRWPAVHRDDAAALFRLALE QAPAGSVLHAVGDEGVPLRAIAEVIGRRLGVPVESAPADAFGPLGQVFAVDQPSSSALTQRRFGWQPVGP GLLDDLETGVYPE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0588 | - | - | 100% (293) | oxidoreductase |
| M. avium 104 | MAV_2451 | - | 3e-13 | 29.72% (286) | hypothetical protein MAV_2451 |
| M. avium 104 | MAV_0524 | - | 8e-07 | 28.69% (237) | nucleoside-diphosphate-sugar epimerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3752 | - | 2e-09 | 28.24% (262) | putative oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1635 | - | 5e-07 | 34.82% (112) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv3725 | - | 2e-08 | 28.69% (251) | oxidoreductase |
| M. leprae Br4923 | MLBr_00751 | rmlD | 3e-08 | 26.92% (286) | putative dTDP-rhamnose modification protein |
| M. abscessus ATCC 19977 | MAB_0994 | - | 5e-75 | 52.03% (296) | putative NAD-dependent epimerase/dehydratase |
| M. marinum M | MMAR_5252 | - | 4e-11 | 28.24% (262) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_3470 | - | 1e-74 | 52.53% (297) | NAD-dependent epimerase/dehydratase |
| M. thermoresistible (build 8) | TH_0069 | - | 3e-08 | 35.04% (117) | nucleoside-diphosphate-sugar epimerase |
| M. ulcerans Agy99 | MUL_4328 | - | 3e-11 | 28.24% (262) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1926 | - | 3e-72 | 51.35% (296) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3752|M.bovis_AF2122/97 MQNATMRVLVTGGTGFVGGWTAKAIADAGHSVRFLVRNPARLKTSVAKLG
Rv3725|M.tuberculosis_H37Rv MQNATMRVLVTGGTGFVGGWTAKAIADAGHSVRFLVRNPARLKTSVAKLG
MMAR_5252|M.marinum_M MHNRCMHVLVTGGTGFVGGWTAKAIADAGHSVRFLVRNPAKLESSVAKLG
MUL_4328|M.ulcerans_Agy99 MHNRCMHVLVTGGTGFVGGWTAKAIADAGHSVRFLVRNPAKLESSVAKLG
MAB_0994|M.abscessus_ATCC_1997 -----MRVFVTGASGFIGSAVVRELIDSGHTVTGLARS----DSSAAALT
MSMEG_3470|M.smegmatis_MC2_155 -----MRVFVTGASGFIGSAVADELIAAGHTVIGLARS----DASAEALT
Mvan_1926|M.vanbaalenii_PYR-1 -----MKVFVTGASGFIGSAVTAELLGHGHHVLGLARS----DAAAQRIT
MAV_0588|M.avium_104 -----MRVLVTGASGGIGSAVVKELLAAGHHVIGLARS----EASAATVS
Mflv_1635|M.gilvum_PYR-GCK MPGNDVRCVVTGATGYIGGRLVPELLARGLQVRAMARTP---SKLDRTEW
TH_0069|M.thermoresistible__bu MP-DLPRCLVTGATGYIGGRLIPRLLDRGHPVQAMARNP---EKLAGAPW
MLBr_00751|M.leprae_Br4923 MSDRSGRLVITGAGGQLGSALAAQATAAGRDVLALTSSQWDITDAAVAER
: .:**. * :*. * * :. .
Mb3752|M.bovis_AF2122/97 VDVSDFAVADISDRDSVREALNGCDAVVHSAALVATDPRETSRMLSTNMA
Rv3725|M.tuberculosis_H37Rv VDVSDFAVADISDRDSVREALNGCDAVVHSAALVATDPRETSRMLSTNMA
MMAR_5252|M.marinum_M VDVSDFIIGDIKDRDLVREALTGCDAVVHSAALVATDQRQTQDMLSTNME
MUL_4328|M.ulcerans_Agy99 VDVSDFIIGDIKDRDLVREALTGCDAVVHSAALVATDQRQTQDMLSTNME
MAB_0994|M.abscessus_ATCC_1997 AAGADVHRGSLDDLESLRAGAVAADGVAH---LAFVHDFENYAEAVNADK
MSMEG_3470|M.smegmatis_MC2_155 RAGHEVHRGDLTDLDSLRAGAASADGVIH---LAFVHDFENFAGAVQTDS
Mvan_1926|M.vanbaalenii_PYR-1 ATGAEAVRGDLDDLDALEAGASAADAVIH---LAFQHDFTAYDTAARVDR
MAV_0588|M.avium_104 GLGAEPLRGDIADLDVLQKAAVDTDGVAY---LAFSHDFSDVGDAIADEA
Mflv_1635|M.gilvum_PYR-GCK RDRVEVVRGDLTEADSLTAAFNGADVVYY---LVHSMG-TSRDFVAEERR
TH_0069|M.thermoresistible__bu RDRVDVVQGDLTDGDSLTAAFAGVDVVYY---LVHSMG-SADDFAAEEAR
MLBr_00751|M.leprae_Br4923 MGRSALKKNDVVVN---CAAYTNVDGAES----NELAAYAVNATGPEYIA
.: . * .
Mb3752|M.bovis_AF2122/97 GAQNVLGQAVELGMDPIVHVSSFTALFRPNLATLSADLPVAGGTDGYG-Q
Rv3725|M.tuberculosis_H37Rv GAQNVLGQAVELGMDPIVHVSSFTALFRPNLATLSADLPVAGGTDGYG-Q
MMAR_5252|M.marinum_M GARNVLGQAVALGLDPIVHVSSFTALFHPGLQTLSADLPVVGGSDGYG-T
MUL_4328|M.ulcerans_Agy99 GARNVLGQAVALGLDPIVHVSSFTALFHPGLQTLSADLPVVGGSDGYG-T
MAB_0994|M.abscessus_ATCC_1997 RAIATIGEALAGTERPFVVTSGLAGFGLGRPLTEEDAAAPESPRL----S
MSMEG_3470|M.smegmatis_MC2_155 AAIEALGETLAGSDRPLVVAAGVA--GLPRGTTEDDAIPAGFPRL----S
Mvan_1926|M.vanbaalenii_PYR-1 QAIETLGEALAGSDRALVVASGMAGLGRGRILTEDQAAPPDAPRE----S
MAV_0588|M.avium_104 RAIDALGAALADTGKPLVLASGTP-ARPGSVSTEDDPFIADGPLAGRGRT
Mflv_1635|M.gilvum_PYR-GCK SAHNVVEAAKKAGVRRIVYLSGLHPDRKELSRHLASRVEVGEILMQSGIE
TH_0069|M.thermoresistible__bu SAREVVAAARRTGVRRLVYLGGLHPPGTGLSTHLESRVEVGDILLDSGIE
MLBr_00751|M.leprae_Br4923 RACRCAGAALIHVSTDYVFSGDFGSGANRVAPRPYEPTDETGPLGVYGRS
* : * ..
Mb3752|M.bovis_AF2122/97 SKAQIEIYARGLQDAGAPVNITYPGMVLGPPVGDQFGEAGEGVRSALWMH
Rv3725|M.tuberculosis_H37Rv SKAQIEIYARGLQDAGAPVNITYPGMVLGPPVGDQFGEAGEGVRSALWMH
MMAR_5252|M.marinum_M SKAQVEIYARGLQDAGAPVNITYPGMVLGPPVGNQFGEAGEGVKAALEIR
MUL_4328|M.ulcerans_Agy99 SKAQVEIYARGLQDAGAPVNITYPGMVLGPPVGNQFGEAGEGVKAALEIR
MAB_0994|M.abscessus_ATCC_1997 EE-ALNLADRGVRVS----AVRLAPSVHGEGD-HGFVPRLIEIARAKGVS
MSMEG_3470|M.smegmatis_MC2_155 ETTALNQVSKGVRAS----VVRLPPSVHGRGD-YGFVPRLISIARERGVS
Mvan_1926|M.vanbaalenii_PYR-1 EPAVFAFTDRGVRAA----AVRLAPTVHGEGD-HGFVPTLISIARATGVS
MAV_0588|M.avium_104 GQAVVELAGRGVRSA----VVRLPRAVHDAGGRYGLAGILIQLARQRGVS
Mflv_1635|M.gilvum_PYR-GCK TVVLQAGIVIGSGSASFEMVRHLTDRLPVMTTPKWVHNKIQPISISDVLH
TH_0069|M.thermoresistible__bu TVVLQAGIVIGSGSASFEMIRHLTDRLPVMTTPKWVRNRIQPIAVDDVLH
MLBr_00751|M.leprae_Br4923 KLAGEQAVLAAMPEA----TVVRTAWVYTGGTGKDFVAVMRRLAAGDGPV
. : . : . :
Mb3752|M.bovis_AF2122/97 VIPGRG-AAWLIVDVRDVAALHAALLESG-RGPRRYTAGGH--RIPVPEL
Rv3725|M.tuberculosis_H37Rv VIPGRG-AAWLIVDVRDVAALHAALLESG-RGPRRYTAGGH--RIPVPEL
MMAR_5252|M.marinum_M TIPGRN-AAWLIIDVRDVAAVHAALLEPG-RGPRRYMVGGH--RIPVPEL
MUL_4328|M.ulcerans_Agy99 TIPGRN-AAWLIIDVRDVAAVHAALLEPG-RGPRRYMVGGH--RIPVPEL
MAB_0994|M.abscessus_ATCC_1997 AYPGDGSNRWPAVHRLDAAHLFRLALENAPTGSRLHGVAED--GIPVRDI
MSMEG_3470|M.smegmatis_MC2_155 GYPGDGSNAWSAVHRVDAARVFRLALEDAPAGSRWHAVADE--GIAVREI
Mvan_1926|M.vanbaalenii_PYR-1 TYPGDGSNRWPAVHRLDAAALFRIAAEDAPAGTLLHAVADE--GIPVRQI
MAV_0588|M.avium_104 SFAGDGTQRWPAVHRDDAAALFRLALEQAPAGSVLHAVGDE--GVPLRAI
Mflv_1635|M.gilvum_PYR-GCK YLAEAATAEFGESRTWDIGGPDVMEYGDAMQGYADVAGLRRRVMVVLPFL
TH_0069|M.thermoresistible__bu YLAEAATAAVPGSRAWDVGGPDVLEYGEAIQVYAEEAGRRRRVIVPLPWL
MLBr_00751|M.leprae_Br4923 YVVDDQIGSPT--YVVDLAAALLQVADGSVHGSVLHAANEGE-VSRFGQA
* . . .
Mb3752|M.bovis_AF2122/97 AKILGEVAGTTMLAVPVPDSALRV--AGSVLDQAGPYLPFNTPFTAAGMQ
Rv3725|M.tuberculosis_H37Rv AKILGGSPAPRCWPSRCPIPRCVS--RDRCWIKPGP-------------I
MMAR_5252|M.marinum_M AKMLGQVAETPIVSVPIPDSVLRV--AGSLLDLAGPYLPFDNPFTAAGMQ
MUL_4328|M.ulcerans_Agy99 AKMLGQVAETPIVSVPIPDSVLRV--AGSLLDLAGPYLPFDNPFTAAGMQ
MAB_0994|M.abscessus_ATCC_1997 AEVIGRHLNLPVESVPLAQAFDHFGWLGGFFAMDLP------ATSVLTQE
MSMEG_3470|M.smegmatis_MC2_155 AETIGRGLGLPAVSVPPDQATAHFGWLGGFFAVDAN------LGSALTRQ
Mvan_1926|M.vanbaalenii_PYR-1 AEAIGHGLDVSVEATTAQASIDRAGFIGAVFAMDLP------ASSALTRT
MAV_0588|M.avium_104 AEVIGRRLGVPVESAP----ADAFGPLGQVFAVDQP------SSSALTQR
Mflv_1635|M.gilvum_PYR-GCK TPTIASWWVGLVTPIPSGLARPLVESLECDAICHEH-----DIDAVIPPP
TH_0069|M.thermoresistible__bu TPRIASWWVGLVTPLPPGLAPPX---PRCSATCRS------------PPS
MLBr_00751|M.leprae_Br4923 RAVFEECGADPLQVQPVSTAQNPRSAARPAYSALSG-------RQSVAAG
:
Mb3752|M.bovis_AF2122/97 YYTQMPEPDDSPSEKELGITYRDPRDTVADTVTALRGLGS
Rv3725|M.tuberculosis_H37Rv CLSILRSPRQVCS-----TTHRCRSPTIRRAKKN------
MMAR_5252|M.marinum_M YYTQMPDSDDSPSELELGVTYRDPRTTLADTVAALTA---
MUL_4328|M.ulcerans_Agy99 YYTQMPDSDDSPSELELGVTYRDPRTTLADTVAALTA---
MAB_0994|M.abscessus_ATCC_1997 RLGWRPVQPGLIADLEKGHYFDE-----------------
MSMEG_3470|M.smegmatis_MC2_155 RLGWEPTGPGLLADLDAGHYFESAAGQGLETVTG------
Mvan_1926|M.vanbaalenii_PYR-1 QFGWQPTHPGLLADLSQAHYFATPEA--------------
MAV_0588|M.avium_104 RFGWQPVGPGLLDDLETGVYPE------------------
Mflv_1635|M.gilvum_PYR-GCK KGGLIGYREAVAKELRSEGGSSAGRRHLLRFSPAASD---
TH_0069|M.thermoresistible__bu --------SSAPAWSRSGSGCSS----------AAS----
MLBr_00751|M.leprae_Br4923 LTPLRPWRSALVEALAVSRSLPVDRPLPSTRD--------