For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MRVVVAEDEIILREGLCSLLAQEGFDVVAQADTADGLLAAVRDKNPDLALVDIRMPPRHSTEGIDAAKII QQEFPRTAILVLSAHIDAQHAKELLRSGRPVGYLLKSRVASKSVLLDAIRRVADGESVLDSTFVQELVSG ARHNDPLDTLTRREHEVLMLMAEGLSNAGIARRLVVAETTVEKHIGNILAKLNLIDGEDTHRRVAAVLRY LEAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3447 | - | - | 100% (214) | two-component system response regulator |
| M. smegmatis MC2 155 | MSMEG_0983 | - | 1e-67 | 60.75% (214) | two-component system response regulator |
| M. smegmatis MC2 155 | MSMEG_4378 | - | 1e-60 | 56.54% (214) | two-component system response regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3157c | devR | 6e-20 | 30.65% (199) | two component transcriptional regulatory protein DevR |
| M. gilvum PYR-GCK | Mflv_2280 | - | 2e-44 | 44.39% (214) | two component LuxR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3133c | devR | 6e-20 | 30.65% (199) | two component transcriptional regulatory protein DevR |
| M. leprae Br4923 | MLBr_01286 | - | 1e-10 | 33.33% (105) | putative two-component response regulatory protein |
| M. abscessus ATCC 19977 | MAB_4498c | - | 2e-56 | 50.93% (214) | two-component LuxR family response regulator |
| M. marinum M | MMAR_1516 | devR | 6e-21 | 31.98% (197) | two-component transcriptional regulatory protein DevR |
| M. avium 104 | MAV_5280 | - | 1e-20 | 33.33% (201) | two-component system response regulator |
| M. thermoresistible (build 8) | TH_1532 | - | 2e-44 | 44.39% (214) | two-component system response regulator |
| M. ulcerans Agy99 | MUL_2423 | devR | 4e-21 | 31.98% (197) | two component transcriptional regulatory protein DevR |
| M. vanbaalenii PYR-1 | Mvan_2073 | - | 1e-65 | 57.94% (214) | two component LuxR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3157c|M.bovis_AF2122/97 ------------MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAE
Rv3133c|M.tuberculosis_H37Rv ------------MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAE
MMAR_1516|M.marinum_M ------------MVTVFLVDDHEVVRRGLIDLLDADPQLDVVGEAGSVSE
MUL_2423|M.ulcerans_Agy99 ------------MVTVFLVDDHEVVRRGLIDLLDADPQLDVVGEAGSVSE
MAV_5280|M.avium_104 ------MTDPAPEITVLLVDDQDLVRSGLRRILRRKDGFVIVAECADGDE
MAB_4498c|M.abscessus_ATCC_199 ----------MSAIRVLVADDDTLLREGVASVLE-KAGFEVVGRAGDATA
Mvan_2073|M.vanbaalenii_PYR-1 ----------MSALKVVVADDDVLLREGLASLLE-RSGFDVVGQAGDGEK
MSMEG_3447|M.smegmatis_MC2_155 -------------MRVVVAEDEIILREGLCSLLA-QEGFDVVAQADTADG
Mflv_2280|M.gilvum_PYR-GCK -------------MRIVIAEDSALLRAGIERILT-DAGHQVVAGVPDATD
TH_1532|M.thermoresistible__bu -------------MRIVIAEDSALLRAGIERILT-DAGHEVVAGVPDATD
MLBr_01286|M.leprae_Br4923 MTGPTTDADAATPHRVLIAEDEALIRLDLAEMLR-DEGYDIVGEAADGQE
:.:.:* ::* .: :* :*.
Mb3157c|M.bovis_AF2122/97 AMARVPAARPDVAVLDVRLP---DGNGIELCRDLLSRMPDLRCLILTSYT
Rv3133c|M.tuberculosis_H37Rv AMARVPAARPDVAVLDVRLP---DGNGIELCRDLLSRMPDLRCLILTSYT
MMAR_1516|M.marinum_M AMARIPAANPDVAVLDVRLP---DGDGIELCRDLLSRMPNLRCLILTSYT
MUL_2423|M.ulcerans_Agy99 AMARIPAANPDVAVLDVRLP---DGDGIELCRDLLSRMPNLRCLILTSYT
MAV_5280|M.avium_104 VPAAVAAHRPDVVVMDLRMR---RVDGIEATRRLGGRPP---VLALTTFN
MAB_4498c|M.abscessus_ATCC_199 LLELVRTESPNLVVVDIRMPPTHTTEGLEAAQKIRGEHPGIGVLVLSAHV
Mvan_2073|M.vanbaalenii_PYR-1 LLELVRTRQPALVLTDIRMPPTHTSEGLDAAKIIRQESPEVGIVVLSAHV
MSMEG_3447|M.smegmatis_MC2_155 LLAAVRDKNPDLALVDIRMPPRHSTEGIDAAKIIQQEFPRTAILVLSAHI
Mflv_2280|M.gilvum_PYR-GCK LLRLVNDERPDLAILDVRMPPTFTDEGIRAAALLRSQNPESPVLVLSHYV
TH_1532|M.thermoresistible__bu LLRLVNELRPDLAIVDVRMPPTFTDEGIRAAALLRSQNPESPVLVLSHYV
MLBr_01286|M.leprae_Br4923 AVELAERHKPDLVIMDVKMP---RRDGIDAASEIASKRIAP-IVVLTAFS
* :.: *::: :*: : . : *: .
Mb3157c|M.bovis_AF2122/97 SDEAMLDAILAG--ASGYVVKD--IKGMELARAVKDVGAGRSLLDNRAAA
Rv3133c|M.tuberculosis_H37Rv SDEAMLDAILAG--ASGYVVKD--IKGMELARAVKDVGAGRSLLDNRAAA
MMAR_1516|M.marinum_M SDEAMLDAILAG--ASGYVVKD--IKGMELARAIKEVGAGRSLLDNRAAA
MUL_2423|M.ulcerans_Agy99 SDEAMLDAILAG--ASGYVVKD--IKGMELARAIKEVGAGRSLLDNRAAA
MAV_5280|M.avium_104 EDELLSGALRAG--AAGFVLKD--SSAEELIRAVRAVARGEGYLDPAVTS
MAB_4498c|M.abscessus_ATCC_199 EVEYAAELITSG-DGVGYLLKSRIGDVGEFADACTRVAGGGSIVDPELVR
Mvan_2073|M.vanbaalenii_PYR-1 DVDHAMELLAGG-HAIGYLLKTRVTDVADFVDTLQRIANGASVVDPALVA
MSMEG_3447|M.smegmatis_MC2_155 DAQHAKELLRSG-RPVGYLLKSRVASKSVLLDAIRRVADGESVLDSTFVQ
Mflv_2280|M.gilvum_PYR-GCK EERYAADLIASDTRGFGYLLKDRVADVPAFLDAVEVVGAGGTVLDPEVVS
TH_1532|M.thermoresistible__bu EERYAADLIASDTKGFGYLLKDRVADVPAFLDAVEVVGGGGTVLDPEVVS
MLBr_01286|M.leprae_Br4923 QRDLVERARDAG--AMAYLVKP-----FTISDLIPAIALAMSRFS-----
. .. .:::* : :. . ..
Mb3157c|M.bovis_AF2122/97 ALMAKLRGAAEKQD--PLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEK
Rv3133c|M.tuberculosis_H37Rv ALMAKLRGAAEKQD--PLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEK
MMAR_1516|M.marinum_M ALMSRLRGVVERPD--PLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEK
MUL_2423|M.ulcerans_Agy99 ALMSRLRGVVERPD--PLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEK
MAV_5280|M.avium_104 RVLTTYRKAAPGPHGAAIAELTTRERDVLTLIGKGLSNSEIADELCISGV
MAB_4498c|M.abscessus_ATCC_199 ELLSARRKDD------PLSALSQRELEVLELMAQGLSNSGIAGRLWITES
Mvan_2073|M.vanbaalenii_PYR-1 ELVSARKRDD------PLAALSAREHEVLTLMAEGLSNGGIGRRLWVTEG
MSMEG_3447|M.smegmatis_MC2_155 ELVSGARHND------PLDTLTRREHEVLMLMAEGLSNAGIARRLVVAET
Mflv_2280|M.gilvum_PYR-GCK QILARSHRRN------VLDALTPRENEVLQLMAEGKTNSAIASGLHMSVG
TH_1532|M.thermoresistible__bu QILVRSHRRS------ALDELTAREHDVLRLMAEGKTNSAIAGALHISIG
MLBr_01286|M.leprae_Br4923 ----------------ELTALEREVATLADRLETRKLVERAKGLLQVKQG
: * . : : : :
Mb3157c|M.bovis_AF2122/97 TVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
Rv3133c|M.tuberculosis_H37Rv TVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
MMAR_1516|M.marinum_M TVKNYVSRLLAKLGMERRTQAAVFAAELKRARSAGHR-
MUL_2423|M.ulcerans_Agy99 TVKNYVSRLLAKLGMERRTQAAVFAAELKRARSAGHR-
MAV_5280|M.avium_104 TVKSHIGRIFGKLDLRDRAAAIVYAYDNGIVAPR----
MAB_4498c|M.abscessus_ATCC_199 TVEKHVHSVMRRLDLGHADEYHRRVLAVLAFLTHR---
Mvan_2073|M.vanbaalenii_PYR-1 TVEKHVRSILTKLNLPETGDDHRRVRAVIMYLETR---
MSMEG_3447|M.smegmatis_MC2_155 TVEKHIGNILAKLNLIDGEDTHRRVAAVLRYLEAR---
Mflv_2280|M.gilvum_PYR-GCK SAEKHIASIFTKLGLAPDDTENRRVLAVLRYLES----
TH_1532|M.thermoresistible__bu SAEKHIASIFTKLGLEPDESENRRVLAVLRYLES----
MLBr_01286|M.leprae_Br4923 MTEPEAFKWIQRAAMDRRTTMKRVAEVVLETLDTPKDT
.: : : : .