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MADEAERAAGNSPAVTRSIRILDLLAEARGVPRTLTEIARELGLAKSSVSNLCAALEEGGLVRRSTGGYL LGRRTVELGSAFLSGFNQIREFYRVCEESEVLRHQLVQIAMLDGAHVLYLAVFEGRQRFPLSARVGDRYP ASVTAVGTALLSELTPTQVAELYWDETNFVGLTKKSTATLTTLQEKLQQTRQRGYAVDDGEVHPTVLGLA IPIPGGNGEPTFAIGVSIVHPTGSAEEREAILAAVRDAAESLTRPRLITV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3423 | - | - | 100% (260) | IclR family protein regulator |
| M. smegmatis MC2 155 | MSMEG_2600 | - | 8e-16 | 28.80% (250) | regulatory protein |
| M. smegmatis MC2 155 | MSMEG_6705 | - | 7e-14 | 31.03% (261) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 4e-12 | 26.23% (244) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0686 | - | 5e-16 | 26.34% (243) | regulatory protein, IclR |
| M. tuberculosis H37Rv | Rv1719 | - | 5e-12 | 26.23% (244) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4493 | - | 5e-13 | 27.64% (246) | IclR family transcriptional regulator |
| M. marinum M | MMAR_4423 | - | 1e-11 | 25.10% (243) | transcriptional regulatory protein |
| M. avium 104 | MAV_3513 | - | 4e-16 | 26.97% (241) | transcriptional regulator, IclR family protein |
| M. thermoresistible (build 8) | TH_3251 | - | 2e-14 | 31.22% (221) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_1967 | - | 3e-05 | 26.51% (215) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_2889 | - | 2e-18 | 32.13% (221) | regulatory proteins, IclR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0686|M.gilvum_PYR-GCK -------------MQKPSLAG---MERDSTGKPPQYPIESVDNALRLLLL
MAV_3513|M.avium_104 -----------MPAKRARVAGPAAAAPAADALAPQYPIESVDNALKLLLL
MMAR_4423|M.marinum_M -----------MSSGISSMIMGTGNDGGASESDPAPTVQSVDRALLVLEL
Mb1748|M.bovis_AF2122/97 -------------------------MSAEEQDTRSGGIQVIARAAELLRV
Rv1719|M.tuberculosis_H37Rv -------------------------MSAEEQDTRSGGIQVIARAAELLRV
MAB_4493|M.abscessus_ATCC_1997 -------------------------------------MSVLTRAAQILDA
TH_3251|M.thermoresistible__bu MT--------ATLDQPTPNTTVKR---TGTERTGETPSAVLDRISLVLDA
Mvan_2889|M.vanbaalenii_PYR-1 MTNRHMPIRSMTFRRIPMTVTIESPAAPAAKVATETPSAVIDRVSLVLDA
MUL_1967|M.ulcerans_Agy99 -------------------------------MRQDSGIGVIDKAVGLLRA
MSMEG_3423|M.smegmatis_MC2_155 --------------------------MADEAERAAGNSPAVTRSIRILDL
: . :*
Mflv_0686|M.gilvum_PYR-GCK LGER--SEIRLTDASEYLRVASSTAHRLLSMLQYRGFVRQDPASKAYQPG
MAV_3513|M.avium_104 LGEQ--PEIRLSEATRYLGVASSTAHRLLAMLAYRGFVRQDPVSKAYLPG
MMAR_4423|M.marinum_M LADL--GKAGVTEVADELGVHKSTASRLITALEARGYVEQLSDRGKYQLG
Mb1748|M.bovis_AF2122/97 LQAHP-GGLSQAEIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLG
Rv1719|M.tuberculosis_H37Rv LQAHP-GGLSQAEIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLG
MAB_4493|M.abscessus_ATCC_1997 LAESN-SGLSVRELAEATGLPKSSVHRIVQELTVSQYVMAGGRGGSYQLG
TH_3251|M.thermoresistible__bu FDGP--GRLTLAQVVRRTGLPRSSAHRMLERLVQLRWLRRDGR--DYELG
Mvan_2889|M.vanbaalenii_PYR-1 FDGP--GRLTLAQIVRRTGLPRSSAHRMLERLVQLRWLRRSGR--DYELG
MUL_1967|M.ulcerans_Agy99 TAKS---PCGLAELCERTGLPRATAYRLAAALEVHRLLGRDED-GRWGLG
MSMEG_3423|M.smegmatis_MC2_155 LAEARGVPRTLTEIARELGLAKSSVSNLCAALEEGGLVRRSTG--GYLLG
: : ::. .: * : : *
Mflv_0686|M.gilvum_PYR-GCK PSLTNVAFAVHSRMDIPRTAAPILRQLVDTLQETVHVGTLDGRLVRFIAA
MAV_3513|M.avium_104 PSLTGVAFAIFGRLDIARSAAPIMRALSEQLRETVHVGMLDGASVRFVAA
MMAR_4423|M.marinum_M IGVSRLARARSGHSDLVKLSQDACDKLAADLGETANLAILDENRAVNIVE
Mb1748|M.bovis_AF2122/97 PEITRMATTV--RLGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQ
Rv1719|M.tuberculosis_H37Rv PEITRMATTV--RLGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQ
MAB_4493|M.abscessus_ATCC_1997 PGLLKLGLNN--RRQFVAPMRKAIATVAREVNENIDLAMLSGGELVIIEQ
TH_3251|M.thermoresistible__bu MRLVELGSLAVHQDRLHRAAIPRLHELHAATGLVVHLAVLDGSDVVYLEK
Mvan_2889|M.vanbaalenii_PYR-1 MRLVELGSLAVHQDRLHKAAIPMLHELHAATGLVVHLAVLDGSDVVYMEK
MUL_1967|M.ulcerans_Agy99 PAITELAAHVD--DPLLTAGATVLPRLCETTGESVQLYRREGTSRVCVAA
MSMEG_3423|M.smegmatis_MC2_155 RRTVELGSAFLSGFNQIREFYRVCEESEVLRHQLVQIAMLDGAHVLYLAV
:. .: . :
Mflv_0686|M.gilvum_PYR-GCK LESPSAVRVISRLGSTRPAHCTSTGKVLLAGLSVDELDQLY-PDPHLEPL
MAV_3513|M.avium_104 VEGPAAVRVASRLGRALPAHCTSTGKVMLAQLSAAELRALL-PRERLKRI
MMAR_4423|M.marinum_M AVSTAEIALQTWVGQSCPVHATSSGKVLLAGLDADEVRQRV-G-ATLDSF
Mb1748|M.bovis_AF2122/97 VVPPQRLRAVSAVGESFPLYCCANGKALLAALPPERQARAL-P-SRLAPL
Rv1719|M.tuberculosis_H37Rv VVPPQRLRAVSAVGESFPLYCCANGKALLAALPPERQARAL-P-SRLAPL
MAB_4493|M.abscessus_ATCC_1997 IATVRNLPTVTVVGRTFALHASSIGKALLSQLPPDQVRNML-P-ADLEVF
TH_3251|M.thermoresistible__bu VGSRLAAAIPTRVGGRRPANCAAVGKAILAYAEDDG-VLS--GTGPLPRN
Mvan_2889|M.vanbaalenii_PYR-1 VGNRMTAAIPTRVGGRQPAHCAAVGKAMLAFAAAED-IQAY-DSAQLPRR
MUL_1967|M.ulcerans_Agy99 LEPPAGLRDTVPVGARLPMTAGSGAKVLLAHSDPATQQAVL-PTAKFT--
MSMEG_3423|M.smegmatis_MC2_155 FEGRQRFPLSARVGDRYPASVTAVGTALLSELTPTQVAELYWDETNFVGL
:* . : ...:*: :
Mflv_0686|M.gilvum_PYR-GCK TEHSVRTLTELRTQLAEVRKSGFAISRQESEEGVASVAVAVPQGGSGIRL
MAV_3513|M.avium_104 TAHSIGSRAALETELAAIRERGYATNREESEEGVASVAVPIPTRAPGLRL
MMAR_4423|M.marinum_M TENTIVTIDALEAQLAATRAAGWASAREELEIGLNAVAAPVYDSTGRVAA
Mb1748|M.bovis_AF2122/97 TANTITDRAALRDELNRIRVDGVAYDREEQTEGICAVGAVLR-GVSVELV
Rv1719|M.tuberculosis_H37Rv TANTITDRAALRDELNRIRVDGVAYDREEQTEGICAVGAVLR-GVSVELV
MAB_4493|M.abscessus_ATCC_1997 TTNTITDVTALLRELDDVRSTGVAFDHEEHDVGISSVAVPLP-HPAAIPQ
TH_3251|M.thermoresistible__bu TKYSISDPARLRAELAKVRAHGVAFDREESLPGIGCVAAPIG-DPGEAVA
Mvan_2889|M.vanbaalenii_PYR-1 TKYSISTHAQLRTELQKVRSHGIAFDREESVPGFGCVAAPIG-DPGEAAA
MUL_1967|M.ulcerans_Agy99 -----------DRVLAEVRRRGWAQSVAEREPGVASVSAPVRDGRGVVVA
MSMEG_3423|M.smegmatis_MC2_155 TKKSTATLTTLQEKLQQTRQRGYAVDDGEVHPTVLGLAIPIPGGNGEPTF
* * * * * . :. :
Mflv_0686|M.gilvum_PYR-GCK ALNASAPSYRFRPSDVRKACSALKDAAAELARNLG---------------
MAV_3513|M.avium_104 ALNAAAPQNRLDAARYPAVAAALVAAAKEIGDQLG---------------
MMAR_4423|M.marinum_M ALSVSGPAYRLPAADFEEVAQQTIAAADAVSRGLGWTDRIS---------
Mb1748|M.bovis_AF2122/97 AVSVPVPAQRFYGREAELAGALLAWVSKVDAWFNGTEDRK----------
Rv1719|M.tuberculosis_H37Rv AVSVPVPAQRFYGREAELAGALLAWVSKVDAWFNGTEDRK----------
MAB_4493|M.abscessus_ATCC_1997 AMAIVAPTPRFAQRKTKYVAALDSLTKRANST------------------
TH_3251|M.thermoresistible__bu AISVCGPMNQMA-FDHRLVAPVRMAALGIWRAMEGARQRVVPTLQQVRPL
Mvan_2889|M.vanbaalenii_PYR-1 AVSVCGPMNAMK-FDQRLVAPVRMAAMRIWRAVEGGPMRVAPTLQQVRPL
MUL_1967|M.ulcerans_Agy99 AISVSGPIDRIGRRPGARWAADLLAAADELARRL----------------
MSMEG_3423|M.smegmatis_MC2_155 AIGVSIVHPTGSAEEREAILAAVRDAAESLTRPRLITV------------
*: .
Mflv_0686|M.gilvum_PYR-GCK ----------------------------------
MAV_3513|M.avium_104 ----------------------------------
MMAR_4423|M.marinum_M ----------------------------------
Mb1748|M.bovis_AF2122/97 ----------------------------------
Rv1719|M.tuberculosis_H37Rv ----------------------------------
MAB_4493|M.abscessus_ATCC_1997 ----------------------------------
TH_3251|M.thermoresistible__bu RPGPTAQSLSHSALSHPAQSHPARSHRADTRRFA
Mvan_2889|M.vanbaalenii_PYR-1 RGG---MQLA------------------------
MUL_1967|M.ulcerans_Agy99 ----------------------------------
MSMEG_3423|M.smegmatis_MC2_155 ----------------------------------