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MTRMDAPDWQPSLASHLVAMSSRTTLRPLAQLMPSNAYGLAVMDRVLRTALVASRPRRGVTVRKVDTVFA GGPVRGDWITTPAINPHANPLLYIHGGAYSMCSPETHRGLLGELASASGRPIFAVKYRLAPRYPYPAAAD DALNAYRWLTSGGSPGSCQRTVAVAGDSAGGQLTMATALGARAVGLPLPDAMLLMSPVLDLRCELARARE IRRRDPFASAQSAARALDLYVGGADRGDPRLSVLDADLTSMPPILIQVGGREMLIDDSRRLAERLQSAGS HVEIQVYRGQIHVFQAMFRILPEARDAIHRAGRFLEASEVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2076 | - | - | 100% (321) | putative esterase/acetyl hydrolase |
| M. abscessus ATCC 19977 | MAB_4052c | - | 4e-55 | 39.93% (293) | putative lipase/esterase |
| M. abscessus ATCC 19977 | MAB_1194 | - | 1e-32 | 30.32% (310) | putative lipase LipU |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2406 | mbtJ | 7e-50 | 38.82% (304) | putative acetyl hydrolase MBTJ |
| M. gilvum PYR-GCK | Mflv_4606 | - | 1e-118 | 67.86% (308) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv2385 | mbtJ | 7e-50 | 38.82% (304) | putative acetyl hydrolase MBTJ |
| M. leprae Br4923 | MLBr_00314 | - | 3e-31 | 30.50% (318) | putative esterase |
| M. marinum M | MMAR_3137 | - | 1e-146 | 81.00% (321) | esterase/lipase |
| M. avium 104 | MAV_1798 | - | 4e-49 | 39.73% (292) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3010 | - | 8e-32 | 31.39% (309) | acetyl-hydrolase |
| M. thermoresistible (build 8) | TH_1370 | lipF | 3e-31 | 30.60% (317) | PROBABLE ESTERASE/LIPASE LIPF |
| M. ulcerans Agy99 | MUL_3642 | mbtJ | 7e-48 | 38.98% (313) | acetyl hydrolase MbtJ |
| M. vanbaalenii PYR-1 | Mvan_4675 | - | 8e-31 | 29.19% (322) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
TH_1370|M.thermoresistible__bu MTAPSKVPRTSPLATRAARGHYSRTFPVSDGTPSEYVEDGPSLAGRLTAL
Mvan_4675|M.vanbaalenii_PYR-1 MTAPSKVPATPHAAIAAARAGKIRRFPVSDGAPVEVVEDGPSIAGRLMGL
MLBr_00314|M.leprae_Br4923 -------------------------MAISAGAPVEIVESGPSIAARLASL
MAB_2076|M.abscessus_ATCC_1997 -----------------------MTRMDAPDWQPSLASHLVAMSSRTTLR
MMAR_3137|M.marinum_M -----------------------MTNTDAADRRPSLASHFVAMTSRNTLR
Mflv_4606|M.gilvum_PYR-GCK -----------------------MSSPARPN--PSMASHLVAATARRVLR
MAV_1798|M.avium_104 --------------------------------------------------
MUL_3642|M.ulcerans_Agy99 -------------------------MTDVVPVRGSLRSRTAVAVSSIMMP
Mb2406|M.bovis_AF2122/97 ----------------------------------------------MVLR
Rv2385|M.tuberculosis_H37Rv ----------------------------------------------MVLR
MSMEG_3010|M.smegmatis_MC2_155 -------------------------MIQACVILRHHGNGLVTAHTLAPMS
TH_1370|M.thermoresistible__bu AAYLTVRPTLAIGSFAPRLPWPWGLLDFAARAVRPVPGTVRATIR-LPHC
Mvan_4675|M.vanbaalenii_PYR-1 AAVATVKPFLTVGSYAPKLPWPWGLLDFAARVLKPAPGTVRATIG-LPHC
MLBr_00314|M.leprae_Br4923 TSRLTIRPILAVGSYVPQLPWPFGLIDHAARVLLPVTNAARAEVN-LSNT
MAB_2076|M.abscessus_ATCC_1997 PLAQLMPSN-AYGLAVMDRVLRTALVASRPRRG-VTVRKVDTVFA-GGPV
MMAR_3137|M.marinum_M PLSQLIPSS-AHGLAVMDRVLRMALVGSRPRRS-VAVRTIDTEFA-GNQI
Mflv_4606|M.gilvum_PYR-GCK PLTQVIPAN-DHGFAVMDRVLRGTLVVSRPRRA-ISVEKVDTPFA-GERV
MAV_1798|M.avium_104 ----MIPPERAWGLWLSRQIVARIMGTFGPSLSGTRVQSVDTRLPDGRRV
MUL_3642|M.ulcerans_Agy99 PIIAAIPPERAWGIWMTRQVIARLMGTLGPSLSGTHVKPVNSVLPDGRRV
Mb2406|M.bovis_AF2122/97 PITGAIPPDGPWGIWASRRIIAGLMGTFGPSLAGTRVEQVNSVLPDGRRV
Rv2385|M.tuberculosis_H37Rv PITGAIPPDGPWGIWASRRIIAGLMGTFGPSLAGTRVEQVNSVLPDGRRV
MSMEG_3010|M.smegmatis_MC2_155 INQPNDPLGVIYAEWTEEFVANPDMSLRLMRWVFEDWQRVTSEPEDVTYA
. : :
TH_1370|M.thermoresistible__bu TAQLVRAPGVLPADGRRS-----VVLYLHGGAFLTCGAHTHGRLVTALSE
Mvan_4675|M.vanbaalenii_PYR-1 NAQLVRAAGVLPADGHRS-----VILYLHGGAFLTCGVNTHGRLVTALSK
MLBr_00314|M.leprae_Br4923 SAQLVRAAGVRPADGSGR-----IVLYLHGGAFLGCGANSHRRLVETLSK
MAB_2076|M.abscessus_ATCC_1997 RGDWITTPAINPHAN--------PLLYIHGGAYSMCSPETHRGLLGELAS
MMAR_3137|M.marinum_M RGDWITSPAVDPHAV--------PLLYIHGGAYSMCSPATHRGLLGELAS
Mflv_4606|M.gilvum_PYR-GCK RGDWVKAANVASDAP--------PILYIHGGAFSMCSPETHRGLISELSA
MAV_1798|M.avium_104 KGEWVFGPRTPTSEHSRPSSIAEAIYYIHGSGYAVCSPKTHRRLTSWLSS
MUL_3642|M.ulcerans_Agy99 VGEWVHGPHLPTGPAPNRS---GAIYFVHGSGYTMCSPRTHRRLTAWLSS
Mb2406|M.bovis_AF2122/97 VGEWVYGPHNNAINAGPGG---GAIYYVHGSGYTMCSPRTHRRLTSWLSS
Rv2385|M.tuberculosis_H37Rv VGEWVYGPHNNAINAGPGG---GAIYYVHGSGYTMCSPRTHRRLTSWLSS
MSMEG_3010|M.smegmatis_MC2_155 STRIGGVPGILVKPLDADP--GQMLVVLHGGGFALGSSASHRKLAGHLAR
. : :**..: . :* * *:
TH_1370|M.thermoresistible__bu FADSPVLVVNYRMIPKHSVGTAIDDCYDGYQWLRAKGYEPD---QIVLAG
Mvan_4675|M.vanbaalenii_PYR-1 CADAPVLVVNYRMIPKHSVGTALDDCFDGYKWLRELGYEPD---QIVLAG
MLBr_00314|M.leprae_Br4923 LADSPILVVNYRLLPKHSIGMALDDCHDGYQWLRRLGYDPE---QIVLAG
MAB_2076|M.abscessus_ATCC_1997 ASGRPIFAVKYRLAPRYPYPAAADDALNAYRWLTSGGSPGSCQRTVAVAG
MMAR_3137|M.marinum_M ASGRPIFAVRYRLAPRYPFPAAADDALNAYRWLVTGQPSASGERGVAVAG
Mflv_4606|M.gilvum_PYR-GCK AARRPVFAVRYRLVPRYPFPAAADDALIAYRWLTEGSAITASSGTVALAG
MAV_1798|M.avium_104 LTGLPVFCVDYRLAPRHRFPTAADDVRAGWDWLINTCGVPP--EQMVIAG
MUL_3642|M.ulcerans_Agy99 LTGLPVFSVDYRLAPRHRFPTAADDVRAGWDWLPGACGLSP--ERMVVVA
Mb2406|M.bovis_AF2122/97 LTGLPVFSVDYRLAPRYRFPTAATDVRAAWDWLAHVCGLAA--EHMVIAA
Rv2385|M.tuberculosis_H37Rv LTGLPVFSVDYRLAPRYRFPTAATDVRAAWDWLAHVCGLAA--EHMVIAA
MSMEG_3010|M.smegmatis_MC2_155 AFGAHAFVADFRLAPEHPYPAQIDDATAVFTSLLDNGIDAS---SITFVG
: . :*: *.: * : * :....
TH_1370|M.thermoresistible__bu DSAGGYLALSLAQRLLDE------GEEPAALVALSPLFEIDNESRAQHPN
Mvan_4675|M.vanbaalenii_PYR-1 DSAGGYLALSLAERLQAEGINGFVGETPAAIVTMSPLFEIDNEARADHPN
MLBr_00314|M.leprae_Br4923 DSAGGYLALALAQRLQDV------GEEPAALVAISPLLQLAKKGKQAHPN
MAB_2076|M.abscessus_ATCC_1997 DSAGGQLTMATALGARAVGLP-----LPDAMLLMSPVLDLRCELARAREI
MMAR_3137|M.marinum_M DSAGGQLTMATALGARSDGLP-----LPDSMLLMSPVLDLTCELARAREL
Mflv_4606|M.gilvum_PYR-GCK DSAGGQLAAATALGAREHRLP-----TPDAMLLMSPVLDLTCQLAMDRDL
MAV_1798|M.avium_104 DSAGGHLSVDLLLQP-GVEH-------PAAMVLFSPLYDLTFELAKARER
MUL_3642|M.ulcerans_Agy99 DSAGGHLSVDLLLQP-DVAAR-----PPASLVLFSPLIDLTFGLSAARER
Mb2406|M.bovis_AF2122/97 DSAGGHLTVDMLLQP-EVAAR-----PPAAVVLFSPLIDLTFRLGASREL
Rv2385|M.tuberculosis_H37Rv DSAGGHLTVDMLLQP-EVAAR-----PPAAVVLFSPLIDLTFRLGASREL
MSMEG_3010|M.smegmatis_MC2_155 DSAGASIAVATTLRLLRDGAP-----VPGRVITISPWLDMENSGSTIESN
****. :: * :: :** :: .
TH_1370|M.thermoresistible__bu IRTDAMFPPRAFSALIELVEEAAERRTTNGRPEEVYEPLDNIEPGLPRTL
Mvan_4675|M.vanbaalenii_PYR-1 VRTDAMFPPKAFHALVELIEAAAERRMVDGKPEEVYEPLDHIEPGLPRTL
MLBr_00314|M.leprae_Br4923 AKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELYEPLDHIAPGLPRTL
MAB_2076|M.abscessus_ATCC_1997 RRRDPFASAQSAARALDLYVGGADR------GDPRLSVLDADLTSMPPIL
MMAR_3137|M.marinum_M RRRDPFASARSAARALDLYVAGADH------RNERISVLDADLRSMPPIL
Mflv_4606|M.gilvum_PYR-GCK RRRDPFASAISASRTIGLYVAGADP------ADPRISVLDADLTDMPPTL
MAV_1798|M.avium_104 IRPDPATRAANAIRLVGLYHSGVDL------THERLTLDVARGPVLPPTL
MUL_3642|M.ulcerans_Agy99 TKPDPAVRAATAARVVGLYHAGIDP------THHRLSLDVAGGSPLPSTL
Mb2406|M.bovis_AF2122/97 QRPDPVVRADRAARSVALYYTGVDP------AHHRLALDVAGGPPLPPTL
Rv2385|M.tuberculosis_H37Rv QRPDPVVRADRAARSVALYYTGVDP------AHHRLALDVAGGPPLPPTL
MSMEG_3010|M.smegmatis_MC2_155 DATDFLITREGLQGNIDRYLSGGASP-----TDPLVNPLYADFTGFPRLY
* . . :*
TH_1370|M.thermoresistible__bu IHVSGSEALISDARKAARRLAAAGVPVEIRVWPGQMHVFQIAAPFVPEAK
Mvan_4675|M.vanbaalenii_PYR-1 IHVSGSEVLLSDARKAARLLAAAGVPVEVRVWPGQMHVFQLGAPAVSEAN
MLBr_00314|M.leprae_Br4923 IHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQAAAPMVPEAT
MAB_2076|M.abscessus_ATCC_1997 IQVGGREMLIDDSRRLAERLQSAGSHVEIQVYRGQIHVFQAMFRILPEAR
MMAR_3137|M.marinum_M IQVGGREMLIDDSRHLADRLRSAGSSVEIQVYRGQIHVFQAMFRILPEAR
Mflv_4606|M.gilvum_PYR-GCK IQVGGREMLLDDSRVFAKRLQTAGVSSQLQVFRGQIHVFQAMFRLLPEAR
MAV_1798|M.avium_104 IQAGGAEMLQADAHQLAADIRTAGGRCELQIWPHQVHVFQALPRMTPEAA
MUL_3642|M.ulcerans_Agy99 IQAGAAEMLEADARQLAADIRTAGGRCELQVWPDQMHVFQALPRMTPEAA
Mb2406|M.bovis_AF2122/97 IQVGGAEILEADARQLDADIRAAGGICELQVWPDQMHVFQALPRMTPEAA
Rv2385|M.tuberculosis_H37Rv IQVGGAEILEADARQLDADIRAAGGICELQVWPDQMHVFQALPRMTPEAA
MSMEG_3010|M.smegmatis_MC2_155 ITVSDTESLYADATRLAEKARAAGVDVTFEVASGQQHVFPLQAGVLPEAD
* .. * * *: :.* ..: * *** .**
TH_1370|M.thermoresistible__bu RSLRQIGEYIREATW----------
Mvan_4675|M.vanbaalenii_PYR-1 RSIKQIGEYIREATW----------
MLBr_00314|M.leprae_Br4923 LSLRQISQYIREATASKASRDRQSL
MAB_2076|M.abscessus_ATCC_1997 DAIHRAGRFLEASEVR---------
MMAR_3137|M.marinum_M EAIHRAGNFLKASAHR---------
Mflv_4606|M.gilvum_PYR-GCK EALRLGGEFLATSATVR--------
MAV_1798|M.avium_104 KAMAYVARFITHALQDARALTQEVH
MUL_3642|M.ulcerans_Agy99 KAMAYASAFIAGSLQDN-ATAEAV-
Mb2406|M.bovis_AF2122/97 KAMTYVAQFIRSTTARGDL------
Rv2385|M.tuberculosis_H37Rv KAMTYVAQFIRSTTARGDL------
MSMEG_3010|M.smegmatis_MC2_155 AAIESMAAWYRSAKPLAV-------
:: . : :