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VGENLVVAAVQPRVLDGDVEANVASHVEAIVSADARLVVFPELSLSGYRADAQPVDLAGDGLAQLVRACA ATHSVALVGAAVETSGGRFIAMVQVDGTGVDVAYRKTFLSGDESRHFTAGDGPSVIEVDGWRVGMGICRD TGIDDHVRGTAALGVDVYACGVVHHATELAEQQRRGRNISAVCDAPVVMASFAGATGGGFTKTAGRSAIW AKDGSVLAEADACPGGMAHTTLQRTVIAARRARRASR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2902 | - | - | 100% (247) | hydrolase, putative |
| M. smegmatis MC2 155 | MSMEG_6733 | - | 8e-20 | 36.89% (225) | hydrolase, carbon-nitrogen family protein |
| M. smegmatis MC2 155 | MSMEG_2988 | - | 9e-09 | 32.74% (168) | carbon-nitrogen hydrolase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2464c | nadE | 2e-07 | 29.57% (257) | NAD synthetase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv2438c | nadE | 2e-07 | 29.57% (257) | NAD synthetase |
| M. leprae Br4923 | MLBr_02449 | - | 2e-06 | 32.81% (128) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4348c | - | 2e-13 | 35.19% (162) | putative hydrolase |
| M. marinum M | MMAR_4512 | - | 1e-73 | 58.97% (234) | amidohydrolase |
| M. avium 104 | MAV_4670 | - | 8e-07 | 26.52% (230) | carbon-nitrogen hydrolase |
| M. thermoresistible (build 8) | TH_0873 | - | 3e-08 | 28.39% (236) | POSSIBLE AMIDOHYDROLASE |
| M. ulcerans Agy99 | MUL_4683 | - | 6e-62 | 60.31% (194) | amidohydrolase |
| M. vanbaalenii PYR-1 | Mvan_1219 | - | 4e-09 | 29.30% (256) | Nitrilase/cyanide hydratase and apolipoprotein |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_02449|M.leprae_Br4923 -----------MRIALAQILSGT-DPVANLRLVREYTGQATDAGATLVVF
MAV_4670|M.avium_104 -----------MRIALAQILSGT-DPAANLALVGEYTRRAAGAGARLVVF
TH_0873|M.thermoresistible__bu -----------MRIALAQIRSGT-DPSANLNLVEEYTRRAAATGAGLVLF
MMAR_4512|M.marinum_M ----MHQVETELVVAVAQPRTEMGAVAANVDAHAALIRRANAR---LVVF
MUL_4683|M.ulcerans_Agy99 ----MHQVKTELVVAVAQPRTVMGAVAANVDAHAALIQRANAR---LVVF
MSMEG_2902|M.smegmatis_MC2_155 -------MGENLVVAAVQPRVLDGDVEANVASHVEAIVSADAR---LVVF
Mb2464c|M.bovis_AF2122/97 MNFYSAYQHGFVRVAACTHHTTIGDPAANAASVLDMARACHDDGAALAVF
Rv2438c|M.tuberculosis_H37Rv MNFYSAYQHGFVRVAACTHHTTIGDPAANAASVLDMARACHDDGAALAVF
MAB_4348c|M.abscessus_ATCC_199 ----MTLSTGRLKVAGLQTSGTPGDIAANLDELASAACAAAGEGAQLLIT
Mvan_1219|M.vanbaalenii_PYR-1 -----------MKVGAVAAHFGR-DVDRGVAKVVGIVEAAARDGVQLLVF
: :. . . * :
MLBr_02449|M.leprae_Br4923 PEATMCRFG-----VPLGPVAEPIDGPWANGVRQIATEAGITIIAGIFTP
MAV_4670|M.avium_104 PEATMCRFG-----VPLAPIAEPVDGPWADGVRRIATEANVTVIAGMFTP
TH_0873|M.thermoresistible__bu PEATMCRFG-----VSLKPVAEPLDGPWATAVREIAAGAGVVVVAGMFTP
MMAR_4512|M.marinum_M PELSLTGY-------QLKVAPVDVAGPVVDRLVLACAATGCSVLVGAPVE
MUL_4683|M.ulcerans_Agy99 PELSLTGY-------QLEVAPVDVAGPVVDRLVLACAATGCSALVGAPVE
MSMEG_2902|M.smegmatis_MC2_155 PELSLSGY-------RADAQPVDLAGDGLAQLVRACAATHSVALVGAAVE
Mb2464c|M.bovis_AF2122/97 PELTLSGYSIED--VLLQDSLLDAVEDALLDLVTESADLLPVLVVGAPLR
Rv2438c|M.tuberculosis_H37Rv PELTLSGYSIED--VLLQDSLLDAVEDALLDLVTESADLLPVLVVGAPLR
MAB_4348c|M.abscessus_ATCC_199 PELFVTGYD------IGDVIYELAAQDLLSPLKRIAEEHGIALVVGIPEA
Mvan_1219|M.vanbaalenii_PYR-1 PDACLGGYIGDLRRPDPSDPPPALDPDGPEIAAVIAAAGPMTVCVGYAEA
*: : : . .*
MLBr_02449|M.leprae_Br4923 A-DDGRVMNTLIAAGPGTPNQPDTHYHKIHLYDAFGFTESRTVTAGHEPV
MAV_4670|M.avium_104 S-GDGRVKNTLLVAN--SDDQAVTHYDKIHLYDAFGFTESRTVAPGREPV
TH_0873|M.thermoresistible__bu S-GDGRVTNTLLATG----PGVAAHYHKIHLYDAYGFTESRTVAPGSEPV
MMAR_4512|M.marinum_M D-RGRRYIAMVLVDS----SGAEVVYRKTHLGAA----EKARFRPGPGPR
MUL_4683|M.ulcerans_Agy99 D-RGRRYIAMVLVDS----SGAEVVYRKTHLDAA----EKARFRPGPGPR
MSMEG_2902|M.smegmatis_MC2_155 T-SGGRFIAMVQVDG----TGVDVAYRKTFLSGD----ESRHFTAGDGPS
Mb2464c|M.bovis_AF2122/97 H-RHRIYNTAVVIHR----GAVLGVVPKSYLPTYREFYERRQMAPGDGER
Rv2438c|M.tuberculosis_H37Rv H-RHRIYNTAVVIHR----GAVLGVVPKSYLPTYREFYERRQMAPGDGER
MAB_4348c|M.abscessus_ATCC_199 V-GEKLYNSAVFVDQ---QGQVRATHRKTHLFGP---LDRQYFTAGSDAV
Mvan_1219|M.vanbaalenii_PYR-1 APGGSRYNSAICVSG----DGVLGTHRKVHQPAG----ESLAYLAGDTFA
: * . : .*
MLBr_02449|M.leprae_Br4923 -------------------VITVDDVQVGLTICYDIRFPALYTELARRGA
MAV_4670|M.avium_104 -------------------VVGVDGVRVGLSVCYDIRFPELYTELARRGA
TH_0873|M.thermoresistible__bu -------------------TIDVGGVRVGLTTCYDIRFPELYVELARRGA
MMAR_4512|M.marinum_M -------------------TIDLDGWRIGLGICRDTGVPEHVRGTARLGV
MUL_4683|M.ulcerans_Agy99 -------------------TIDLDGWRIGLGICRDTGVPEHVRGTARLGV
MSMEG_2902|M.smegmatis_MC2_155 -------------------VIEVDGWRVGMGICRDTGIDDHVRGTAALGV
Mb2464c|M.bovis_AF2122/97 GTIRIGGADVAFGTDLLFAASDLPGFVLHVEICEDMFVPMPPSAEAALAG
Rv2438c|M.tuberculosis_H37Rv GTIRIGGADVAFGTDLLFAASDLPGFVLHVEICEDMFVPMPPSAEAALAG
MAB_4348c|M.abscessus_ATCC_199 T------------------VVDYLGLKVGMMICYDVEFPENPRMAALEGV
Mvan_1219|M.vanbaalenii_PYR-1 -------------------AFDTPVGRLGMLIDYDKTFPESARALALDGA
. : : * . * .
MLBr_02449|M.leprae_Br4923 QLIVVCASWG-SGAGKLEQWTLLARARALDSMSYVAAVGQADPGGALTDS
MAV_4670|M.avium_104 QLIAVCASWG-AGPGKLDQWTLLARARALDSMSYIAAAGQADPGGSLSAS
TH_0873|M.thermoresistible__bu ELLTVHASWG-SGPGKLEQWTLLARARALDTTCVVAAVGQAYPGDEIAAQ
MMAR_4512|M.marinum_M DLYACGVVHHDWELGEQRHR---ARTIAATCDAPVAMASFAGPTGGGYLH
MUL_4683|M.ulcerans_Agy99 DLYACGVVHHDGELGEQRHR---ARTIAATCTAPVAMASFAGP-------
MSMEG_2902|M.smegmatis_MC2_155 DVYACGVVHHATELAEQQRR---GRNISAVCDAPVVMASFAGATGGGFTK
Mb2464c|M.bovis_AF2122/97 ATVLANLSGSPITIGRAEDRRLLARSASARCLAAYVYAAAGEGESTTDLA
Rv2438c|M.tuberculosis_H37Rv ATVLANLSGSPITIGRAEDRRLLARSASARCLAAYVYAAAGEGESTTDLA
MAB_4348c|M.abscessus_ATCC_199 DLLAVPTAQMKPFEFVADSV---IRTRAWENQMYVAYINHAGRERQTAYV
Mvan_1219|M.vanbaalenii_PYR-1 HIIAALSAWPASVTDRASRLPADRQSRLFDLYDCARAAENQVVVVSANQT
:
MLBr_02449|M.leprae_Br4923 GPSSAAPTGVGGSLVASPLGEVVASAGTESKLVVADIDVDNVTTARENIA
MAV_4670|M.avium_104 G----APTGVGGSLVASPLGEVVASAGAQPQLVLADIDVDRVAQARKTIA
TH_0873|M.thermoresistible__bu G-----PTGVGGSLVASATGEVLAAAGPEPELLVADLDLDAARRARDTIA
MMAR_4512|M.marinum_M TAGHSAIWSATSTLVAEAGAGPDQIAHTTIGRPPPGRAGDDHTPKTA---
MUL_4683|M.ulcerans_Agy99 ---------------------PEVATYTQRAIRLSGRRRRRW--------
MSMEG_2902|M.smegmatis_MC2_155 TAGRSAIWAKDGSVLAEADACPGGMAHTTLQRTVIAARRARRASR-----
Mb2464c|M.bovis_AF2122/97 WDGQTMIWEN-GALLAESERFPKGVRRSVADVDTELLRSERLRMGTFDDN
Rv2438c|M.tuberculosis_H37Rv WDGQTMIWEN-GALLAESERFPKGVRRSVADVDTELLRSERLRMGTFDDN
MAB_4348c|M.abscessus_ATCC_199 G--RSSIVAPDATVLGRILSATGIIYGIVDGHAVRSARKRNPYLSDTRPE
Mvan_1219|M.vanbaalenii_PYR-1 G-IMGSLRFLGQAKVVGPGGDVLATTRSKGGLARVDIDVEAEIARARRVL
MLBr_02449|M.leprae_Br4923 VLRNRSHFA-----------------------------------------
MAV_4670|M.avium_104 ALSNRSDFAQVGRAESVG--------------------------------
TH_0873|M.thermoresistible__bu VLRNRSDVAQWGKAESVG--------------------------------
MMAR_4512|M.marinum_M --------------------------------------------------
MUL_4683|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2902|M.smegmatis_MC2_155 --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 RRHHRELTESFRRIDFALDPPAGDIGLLREVERFPFVPADPQRLQQDCYE
Rv2438c|M.tuberculosis_H37Rv RRHHRELTESFRRIDFALDPPAGDIGLLREVERFPFVPADPQRLQQDCYE
MAB_4348c|M.abscessus_ATCC_199 LNQRLIRRHEPGD-------------------------------------
Mvan_1219|M.vanbaalenii_PYR-1 DHLAERRVDTYSTTARS---------------------------------
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
MMAR_4512|M.marinum_M --------------------------------------------------
MUL_4683|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2902|M.smegmatis_MC2_155 --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 AYNIQVSGLEQRLRALDYPKVVIGVSGGLDSTHALIVATHAMDREGRPRS
Rv2438c|M.tuberculosis_H37Rv AYNIQVSGLEQRLRALDYPKVVIGVSGGLDSTHALIVATHAMDREGRPRS
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1219|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
MMAR_4512|M.marinum_M --------------------------------------------------
MUL_4683|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2902|M.smegmatis_MC2_155 --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 DILAFALPGFATGEHTKNNAIKLARALGVTFSEIDIGDTARLMLHTIGHP
Rv2438c|M.tuberculosis_H37Rv DILAFALPGFATGEHTKNNAIKLARALGVTFSEIDIGDTARLMLHTIGHP
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1219|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
MMAR_4512|M.marinum_M --------------------------------------------------
MUL_4683|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2902|M.smegmatis_MC2_155 --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 YSVGEKVYDVTFENVQAGLRTDYLFRIANQRGGIVLGTGDLSELALGWST
Rv2438c|M.tuberculosis_H37Rv YSVGEKVYDVTFENVQAGLRTDYLFRIANQRGGIVLGTGDLSELALGWST
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1219|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
MMAR_4512|M.marinum_M --------------------------------------------------
MUL_4683|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2902|M.smegmatis_MC2_155 --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 YGVGDQMSHYNVNAGVPKTLIQHLIRWVISAGEFGEKVGEVLQSVLDTEI
Rv2438c|M.tuberculosis_H37Rv YGVGDQMSHYNVNAGVPKTLIQHLIRWVISAGEFGEKVGEVLQSVLDTEI
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1219|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
MMAR_4512|M.marinum_M --------------------------------------------------
MUL_4683|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2902|M.smegmatis_MC2_155 --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 TPELIPTGEEELQSSEAKVGPFALQDFSLFQVLRYGFRPSKIAFLAWHAW
Rv2438c|M.tuberculosis_H37Rv TPELIPTGEEELQSSEAKVGPFALQDFSLFQVLRYGFRPSKIAFLAWHAW
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1219|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_02449|M.leprae_Br4923 --------------------------------------------------
MAV_4670|M.avium_104 --------------------------------------------------
TH_0873|M.thermoresistible__bu --------------------------------------------------
MMAR_4512|M.marinum_M --------------------------------------------------
MUL_4683|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2902|M.smegmatis_MC2_155 --------------------------------------------------
Mb2464c|M.bovis_AF2122/97 NDAERGNWPPGFPKSERPSYSLAEIRHWLQIFVQRFYSFSQFKRSALPNG
Rv2438c|M.tuberculosis_H37Rv NDAERGNWPPGFPKSERPSYSLAEIRHWLQIFVQRFYSFSQFKRSALPNG
MAB_4348c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1219|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_02449|M.leprae_Br4923 -------------------------------------
MAV_4670|M.avium_104 -------------------------------------
TH_0873|M.thermoresistible__bu -------------------------------------
MMAR_4512|M.marinum_M -------------------------------------
MUL_4683|M.ulcerans_Agy99 -------------------------------------
MSMEG_2902|M.smegmatis_MC2_155 -------------------------------------
Mb2464c|M.bovis_AF2122/97 PKVSHGGALSPRGDWRAPSDMSARIWLDQIDREVPKG
Rv2438c|M.tuberculosis_H37Rv PKVSHGGALSPRGDWRAPSDMSARIWLDQIDREVPKG
MAB_4348c|M.abscessus_ATCC_199 -------------------------------------
Mvan_1219|M.vanbaalenii_PYR-1 -------------------------------------