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VTKYGPWAVIAGGSEGVGAEFAKALAEDGANLVLIARKPQPLDETAQECRRLGAQVRTIALDLLDADSTS RIVDATSDVEVGLLIYNAGASTCNERFLDAELSEFGKVIDLNTTRMLELTQHFGRRMAAMSRGGIVLVGS LSGYMGAERHSVYAGAKAFSRVFAESLWLELREHGVDVLELVLGVTRTPAMERAGLNFDAPGIIVNDPAD VAREGLRHIADGPVFIAGGNAERAARSSAPDRAAVVLGSHEMIKRLRGMRP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4545 | - | - | 100% (261) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2380 | - | 6e-39 | 36.67% (240) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_0138 | - | 2e-20 | 30.45% (220) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1571 | - | 7e-19 | 28.52% (256) | ketoacyl reductase |
| M. tuberculosis H37Rv | Rv1544 | - | 7e-19 | 28.52% (256) | ketoacyl reductase |
| M. leprae Br4923 | MLBr_00429 | - | 1e-14 | 31.32% (182) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4261c | - | 2e-19 | 32.48% (234) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_3509 | - | 9e-84 | 68.56% (229) | short-chain alcohol dehydrogenase |
| M. avium 104 | MAV_5238 | - | 4e-42 | 39.83% (241) | oxidoreductase, short-chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_2895 | - | 1e-105 | 72.73% (253) | short chain oxidoreductase |
| M. thermoresistible (build 8) | TH_2749 | - | 6e-95 | 65.12% (258) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0124 | - | 4e-22 | 32.27% (220) | ketoacyl reductase |
| M. vanbaalenii PYR-1 | Mvan_2633 | - | 8e-95 | 63.08% (260) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4545|M.gilvum_PYR-GCK ---------------MTKYGPWAVIAGGSEGVGAEFAKALAEDGANLVLI
MMAR_3509|M.marinum_M -----------------------------------------------MLI
MSMEG_2895|M.smegmatis_MC2_155 ------------MPDLATYGPWAVIAGGSEGVGAEFARLLAEAGVNLVLI
TH_2749|M.thermoresistible__bu ------------VTDLTRYGPTAVIAGGSEGVGAEFARLLADAGIDLVLI
Mvan_2633|M.vanbaalenii_PYR-1 MLPDTRRGDDVTVTDLTGYGPWAVVAGGSEGVGAEFAAQLARAGVNLVLV
MAV_5238|M.avium_104 ------------MSFAARYGPWALVAGASDGVGAAFAEGLAERGVNVALL
Mb1571|M.bovis_AF2122/97 -----------MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLV
Rv1544|M.tuberculosis_H37Rv -----------MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLV
MLBr_00429|M.leprae_Br4923 -----------MPIPAPSPEARAVVTGASQNIGEALATELAAHGHSLIVI
MAB_4261c|M.abscessus_ATCC_199 ------------MAATNSARPVALITGPTSGLGGGFARKYASQGYDVVLV
MUL_0124|M.ulcerans_Agy99 -----------------MPRPVALITGPTSGIGAGYARRYAQDGYDLILV
::
Mflv_4545|M.gilvum_PYR-GCK ARKPQPLDETAQECRRLG-AQVRTIALDLLDADSTSRIVDATSDVEVGLL
MMAR_3509|M.marinum_M ARAPGPLADTARRCRETG-VHVRTIAVDLVDPEAVALICSETADLEVGLL
MSMEG_2895|M.smegmatis_MC2_155 ARKPGPLQDTAQRCREIG-VDVRTVATDLLDPTAVEQITGATAGLDVGLL
TH_2749|M.thermoresistible__bu ARKPGPLEDTAADCRARG-VEVRTISADLTDPAAVHRVLAECAGLEVGLL
Mvan_2633|M.vanbaalenii_PYR-1 ARTPEPLERTAARCREFG-VQTRTLAVDLVD--ATHEVIAATADLEVGLL
MAV_5238|M.avium_104 ARRQDVLDRVAARIRARTSAQTRTLAIDLAHPGAAKAIAAATADVTIGML
Mb1571|M.bovis_AF2122/97 ARRRERLDELADQLRQEHCVGVEVLPLDLADTQARAQLADRLRSDAIAGL
Rv1544|M.tuberculosis_H37Rv ARRRERLDELADQLRQEHCVGVEVLPLDLADTQARAQLADRLRSDAIAGL
MLBr_00429|M.leprae_Br4923 ARREDVLVDLAARLADKYRVAVEVRPADLTDPSERVKLADELTVRPISIL
MAB_4261c|M.abscessus_ATCC_199 ARDEQRLGALADELTCRFGVYAEALPADLADAADRARVADRLAAG-VSVL
MUL_0124|M.ulcerans_Agy99 ARDVDRLTQSAVELEDDAGN-VEILPADLADAAGRDKVAERLSRG-VRVL
** * * .. . ** . : : *
Mflv_4545|M.gilvum_PYR-GCK IYNAGASTCNERFLDAELSEFGKVIDLNTTRMLELTQHFGRRMAAMSRGG
MMAR_3509|M.marinum_M IYNAGANTCREQFLDAELTELGRVIDLNVTRMLELVQHFGRPMRARRRGG
MSMEG_2895|M.smegmatis_MC2_155 IYNAGASTCNEPFLDAPLDDFRKVLDLNVTRMMELVQHYARPMVARQRGG
TH_2749|M.thermoresistible__bu IYNAGANTCSEEFLDGELADFDKVLRLNIDTMLTLVQHFGRPMRERRSGG
Mvan_2633|M.vanbaalenii_PYR-1 IYNAGANTCSEEFLDADLAEFGRVVDLNVTAMMTLVQHYGRPMRERRRGG
MAV_5238|M.avium_104 VYCAGADPDFKPFLANRIEAAEAMVQRNCMVPMQLCHHYAPAMVERGAGG
Mb1571|M.bovis_AF2122/97 CNSAGFGTS-GRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGA
Rv1544|M.tuberculosis_H37Rv CNSAGFGTS-GRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGA
MLBr_00429|M.leprae_Br4923 CANAGTATF-GPVSALDPAGEKAQVQLNAVAVHDLTLAVLPGMIERKAGG
MAB_4261c|M.abscessus_ATCC_199 VNNAGFATA-GEFWTAAPELLHSQLDVNVTAVMELTRAALPSMIEAGAGT
MUL_0124|M.ulcerans_Agy99 VNNAGFATS-GEFWETEPAALQAQLDVNVTAVMQLTRAALPPMLAAGAGT
** . . : * * * *
Mflv_4545|M.gilvum_PYR-GCK IVLVGSLSGYMGAERHSVYAGAKAFSRVFAESLWLELREHGVDVLELVLG
MMAR_3509|M.marinum_M IVLVGSTAATYGAMRQSAYAGAKAFSRLFAESLWLELRETGVDVLELVLG
MSMEG_2895|M.smegmatis_MC2_155 VLIVGSLSGYMGADRHSVYGGAKAFSRIFAESLWLELREHNVDVVELVLG
TH_2749|M.thermoresistible__bu ILLVGSMAGYLGSARHTVYGGVKAFGRIFAESLWLELRDHGVDVLELVLG
Mvan_2633|M.vanbaalenii_PYR-1 ILLVGSMAGYLGSVRHTVYGGVKAFGRIFAEGLWLELRDHDVHVLELVLG
MAV_5238|M.avium_104 IVLFGSGAGLAGGPNMVAYGASKAFDMVFAEALWAELHDKGVDVLGLILG
Mb1571|M.bovis_AF2122/97 VLNIASIAGFQPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPG
Rv1544|M.tuberculosis_H37Rv VLNIASIAGFQPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPG
MLBr_00429|M.leprae_Br4923 ILISGSAAGNSPIPYNATYAATKAFANTFSESLRGELHGSGVHVTLLAPG
MAB_4261c|M.abscessus_ATCC_199 VINVASVAG-LVSGRGSTYSASKAWVVSFTEGLANGLLGTGVGMHVLCPG
MUL_0124|M.ulcerans_Agy99 VINIASVAG-LLSGRGSTYSASKAWVISFSEGLSTGLEGTGVGVHAVCPG
:: .* :. .*.. **: *:*.: * .* : : *
Mflv_4545|M.gilvum_PYR-GCK VTRTPAMERAGLN---FDAPGIIVNDPA---DVAREGLRHIADGPVFIAG
MMAR_3509|M.marinum_M VTRTPAMQRAGLN---FDAPGISVSDPA---DVAREGLDNLANGPVVIAG
MSMEG_2895|M.smegmatis_MC2_155 VTRTPAMERVGLN---FDVPGMIVNDPA---DVAAEGLANLANGPVHIAG
TH_2749|M.thermoresistible__bu VTRTPAMERAGLN---FDVPGLRVADPA---DVAREGLERLPHGPVHVAG
Mvan_2633|M.vanbaalenii_PYR-1 VTRTPAMERVGLN---FDVPGLRVSEPA---EVAAEGLRQLPHGPVHVVN
MAV_5238|M.avium_104 KTDTPALRALEYSRGQIASPDQAPSDAAAVSDVIAEAFENLGNGPTLMVG
Mb1571|M.bovis_AF2122/97 PVPTEWAEIASA---ERFSIPLAQVSPH---DVAEAAIAGMLSGKRTVVP
Rv1544|M.tuberculosis_H37Rv PVPTEWAEIASA---ERFSIPLAQVSPH---DVAEAAIAGMLSGKRTVVP
MLBr_00429|M.leprae_Br4923 PVRTELPDHDEASLVEKLVPDFLWISTE---HTARLSLDALERNKMRVVP
MAB_4261c|M.abscessus_ATCC_199 FIHTEFHERAGIE--MGTIPEFMWLQVD---DVVNACLHDIAAGKVLIVP
MUL_0124|M.ulcerans_Agy99 YVHTEFHARAGID--MTKLPSFMWLDVD---DVIQESLADIADGKVIGIP
* . .. : : .
Mflv_4545|M.gilvum_PYR-GCK GNAERAARSSA-PDRAAVVLGSHEMIKRLRGMRP--------
MMAR_3509|M.marinum_M DNAAHVHRGSG-ADRAAIVLRAHRAMQALIGSPPPPPKGDRA
MSMEG_2895|M.smegmatis_MC2_155 GNAAIAAANNA-PDRAKVVLQAHERMRRLINRGA--------
TH_2749|M.thermoresistible__bu GNAEDVARRND-PDRAKVVLGAHRFVQKLIGQA---------
Mvan_2633|M.vanbaalenii_PYR-1 GNEDDVARRND-PDRARVVLGAHRFMQKLIGGRGHR------
MAV_5238|M.avium_104 DTMRAAAQLLASLSRNQAVELFAQAAAAAMGPDD--------
Mb1571|M.bovis_AF2122/97 GIVPKFVSTSGRFAPRSLLLPAIR-IGNRLRGGPSR------
Rv1544|M.tuberculosis_H37Rv GIVPKFVSTSGRFAPRSLLLPAIR-IGNRLRGGPSR------
MLBr_00429|M.leprae_Br4923 GLTSKAMSVASRYAPRAIVASIVGNFYKKLGGG---------
MAB_4261c|M.abscessus_ATCC_199 GVQYKAITSVTRLIPRGLVRKYNSVVGRGRGRT---------
MUL_0124|M.ulcerans_Agy99 GVQYKALVGAGRMIPRGLLRAVMKRVGGGRGRT---------
. :