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VDFNQRYGPWALVAGASDGVGAAMAHALARRGLNVVLLARRQPVLDTVAAQIRDTAGVETRTLAIDLAEA GAAQRIIESTAGLDIGFLVYCAGSDTNVTPFLDTPLDVAESMVQRNCMVPVQLCHHYAKPMADRGRGGIV IFGSGAGLAGAPNMVAYSASKAFDMVLAEALWSELHTKGVDVLGLILGKTDTPALRALEFRRGQIASPDT APPGAAPVDDVVAAAFANLTAGPTCLVGEDMQAVAELMASVSRNEAVHIIARAVEHRWVKPALPRPDQPR TSVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6592 | - | - | 100% (284) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_2895 | - | 2e-45 | 43.16% (234) | short chain oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_4722 | - | 9e-19 | 35.52% (183) | short-chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1571 | - | 2e-22 | 31.86% (226) | ketoacyl reductase |
| M. gilvum PYR-GCK | Mflv_2380 | - | 3e-92 | 63.12% (263) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1544 | - | 2e-22 | 31.86% (226) | ketoacyl reductase |
| M. leprae Br4923 | MLBr_00429 | - | 5e-17 | 33.33% (183) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1537c | - | 3e-21 | 36.26% (182) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_3509 | - | 3e-31 | 36.59% (246) | short-chain alcohol dehydrogenase |
| M. avium 104 | MAV_5238 | - | 1e-101 | 69.58% (263) | oxidoreductase, short-chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_2749 | - | 4e-40 | 38.84% (242) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1543 | - | 2e-21 | 30.09% (226) | ketoacyl reductase |
| M. vanbaalenii PYR-1 | Mvan_2633 | - | 6e-40 | 46.56% (189) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6592|M.smegmatis_MC2_155 ------------MDFNQRYGPWALVAGASDGVGAAMAHALARRGLNVVLL
MAV_5238|M.avium_104 ------------MSFAARYGPWALVAGASDGVGAAFAEGLAERGVNVALL
Mflv_2380|M.gilvum_PYR-GCK ------------MSFEDTYGPWALVVGASDGIGSAFAEELAERGLNVVLL
TH_2749|M.thermoresistible__bu ------------VTDLTRYGPTAVIAGGSEGVGAEFARLLADAGIDLVLI
Mvan_2633|M.vanbaalenii_PYR-1 MLPDTRRGDDVTVTDLTGYGPWAVVAGGSEGVGAEFAAQLARAGVNLVLV
MMAR_3509|M.marinum_M -----------------------------------------------MLI
Mb1571|M.bovis_AF2122/97 -----------MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLV
Rv1544|M.tuberculosis_H37Rv -----------MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLV
MUL_1543|M.ulcerans_Agy99 -----------MTLPKPNKQATVVITGASSGIGVELARGLAGRGFPLMLV
MLBr_00429|M.leprae_Br4923 -----------MPIPAPSPEARAVVTGASQNIGEALATELAAHGHSLIVI
MAB_1537c|M.abscessus_ATCC_199 -----------MPIPAPSPDARAVVTGASQGIGAALAEELAARGHNLIIT
:
MSMEG_6592|M.smegmatis_MC2_155 ARRQPVLDTVAAQIRDTAGVETRTLAIDLAEAGAAQRIIESTAGLDIGFL
MAV_5238|M.avium_104 ARRQDVLDRVAARIRARTSAQTRTLAIDLAHPGAAKAIAAATADVTIGML
Mflv_2380|M.gilvum_PYR-GCK SRRGQVLAALAERIESRFGVTTRVVTADLADESAADAVIEATADLDIGTL
TH_2749|M.thermoresistible__bu ARKPGPLEDTAADCRARG-VEVRTISADLTDPAAVHRVLAECAGLEVGLL
Mvan_2633|M.vanbaalenii_PYR-1 ARTPEPLERTAARCREFG-VQTRTLAVDLVD--ATHEVIAATADLEVGLL
MMAR_3509|M.marinum_M ARAPGPLADTARRCRETG-VHVRTIAVDLVDPEAVALICSETADLEVGLL
Mb1571|M.bovis_AF2122/97 ARRRERLDELADQLRQEHCVGVEVLPLDLADTQARAQLADRLRSDAIAGL
Rv1544|M.tuberculosis_H37Rv ARRRERLDELADQLRQEHCVGVEVLPLDLADTQARAQLADRLRSDAIAGL
MUL_1543|M.ulcerans_Agy99 ARRRERLEELADDLRDKFSIAVEVLPLDLSDAQARTQLADRLRSDSIAGL
MLBr_00429|M.leprae_Br4923 ARREDVLVDLAARLADKYRVAVEVRPADLTDPSERVKLADELTVRPISIL
MAB_1537c|M.abscessus_ATCC_199 ARRGEILNDLANALSEKTGVIVEVRAVDLADPGARDALCTELSERNISIL
:* * * ... . ** . : :. *
MSMEG_6592|M.smegmatis_MC2_155 VYCAGSDTNVTPFLDTPLDVAESMVQRNCMVPVQLCHHYAKPMADRGRGG
MAV_5238|M.avium_104 VYCAGADPDFKPFLANRIEAAEAMVQRNCMVPMQLCHHYAPAMVERGAGG
Mflv_2380|M.gilvum_PYR-GCK VYCAGADPEFKPFLAQPVGAAEAMLRRNCLTLMRLCHHYAGPMVSRGRGA
TH_2749|M.thermoresistible__bu IYNAGANTCSEEFLDGELADFDKVLRLNIDTMLTLVQHFGRPMRERRSGG
Mvan_2633|M.vanbaalenii_PYR-1 IYNAGANTCSEEFLDADLAEFGRVVDLNVTAMMTLVQHYGRPMRERRRGG
MMAR_3509|M.marinum_M IYNAGANTCREQFLDAELTELGRVIDLNVTRMLELVQHFGRPMRARRRGG
Mb1571|M.bovis_AF2122/97 CNSAGFG-TSGRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGA
Rv1544|M.tuberculosis_H37Rv CNSAGFG-TSGRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGA
MUL_1543|M.ulcerans_Agy99 CNSAGFG-TSGRFCELPPERESEQVTLNALALMEFTRAALPGMVERGAGA
MLBr_00429|M.leprae_Br4923 CANAGTA-TFGPVSALDPAGEKAQVQLNAVAVHDLTLAVLPGMIERKAGG
MAB_1537c|M.abscessus_ATCC_199 CNNAGTA-TFGPIRGLDPAGERKQVQLNAVAVHDLTLAVLPGMLARGAGG
** . : * : * * *.
MSMEG_6592|M.smegmatis_MC2_155 IVIFGSGAGLAGAPNMVAYSASKAFDMVLAEALWSELHTKGVDVLGLILG
MAV_5238|M.avium_104 IVLFGSGAGLAGGPNMVAYGASKAFDMVFAEALWAELHDKGVDVLGLILG
Mflv_2380|M.gilvum_PYR-GCK VVVLGSGAGLAGGPNMVAYSATKAFDMVFAEALWTELHGKGVDVLGLILG
TH_2749|M.thermoresistible__bu ILLVGSMAGYLGSARHTVYGGVKAFGRIFAESLWLELRDHGVDVLELVLG
Mvan_2633|M.vanbaalenii_PYR-1 ILLVGSMAGYLGSVRHTVYGGVKAFGRIFAEGLWLELRDHDVHVLELVLG
MMAR_3509|M.marinum_M IVLVGSTAATYGAMRQSAYAGAKAFSRLFAESLWLELRETGVDVLELVLG
Mb1571|M.bovis_AF2122/97 VLNIASIAGFQPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPG
Rv1544|M.tuberculosis_H37Rv VLNIASIAGFQPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPG
MUL_1543|M.ulcerans_Agy99 VLNIASIAGFQPIPFMAVYSASKAFVLTFSEAVQEELHGTGVSVTALCPG
MLBr_00429|M.leprae_Br4923 ILISGSAAGNSPIPYNATYAATKAFANTFSESLRGELHGSGVHVTLLAPG
MAB_1537c|M.abscessus_ATCC_199 ILISGSAAGNSPIPNNATYAATKAFANTFSESLRGELKGTGVHVTLLAPG
:: .* *. .*.. *** ::*.: **: .* * * *
MSMEG_6592|M.smegmatis_MC2_155 KTDTPALRALEFRRGQIASPDTAPPGAAPVDDVVAAAFANLTAGPTCLVG
MAV_5238|M.avium_104 KTDTPALRALEYSRGQIASPDQAPSDAAAVSDVIAEAFENLGNGPTLMVG
Mflv_2380|M.gilvum_PYR-GCK KTDTPALRRLEHARGNLASLDERPKDTATVDDVIAEAFANLTNGPTWIVG
TH_2749|M.thermoresistible__bu VTRTPAMERAGLN------FDVPGLRVADPADVAREGLERLPHGPVHVAG
Mvan_2633|M.vanbaalenii_PYR-1 VTRTPAMERVGLN------FDVPGLRVSEPAEVAAEGLRQLPHGPVHVVN
MMAR_3509|M.marinum_M VTRTPAMQRAGLN------FDAPGISVSDPADVAREGLDNLANGPVVIAG
Mb1571|M.bovis_AF2122/97 PVPTEWAEIASA---ERFSIPLAQVSPHDVAEAAIAGML--SGKRTVVPG
Rv1544|M.tuberculosis_H37Rv PVPTEWAEIASA---ERFSIPLAQVSPHDVAEAAIAGML--SGKRTVVPG
MUL_1543|M.ulcerans_Agy99 PVPTEWAEIASA---ERFSIPLARVSPHDVAEAAIEGML--TGKRTVVPG
MLBr_00429|M.leprae_Br4923 PVRTELPDHDEASLVEKLVPDFLWISTEHTARLSLDALE--RNKMRVVPG
MAB_1537c|M.abscessus_ATCC_199 PVRTVEPDPAEASIVDKVVPDFLWINGEYTARVSLNALE--RNKMRVVPG
. * .: : .
MSMEG_6592|M.smegmatis_MC2_155 EDMQAVAELMASVSRNEAVHIIARAVEHRWVKPALPRPDQPRTSVR
MAV_5238|M.avium_104 DTMRAAAQLLASLSRNQAVELFAQAAA------AAMGPDD------
Mflv_2380|M.gilvum_PYR-GCK QDMRAAAQMMGSVSRSDAVRFIMQASA------AAMGDG-------
TH_2749|M.thermoresistible__bu GNAEDVARRNDPDRAKVVLGAHRFVQKLIGQ-----A---------
Mvan_2633|M.vanbaalenii_PYR-1 GNEDDVARRNDPDRARVVLGAHRFMQKLIGG-----RGHR------
MMAR_3509|M.marinum_M DNAAHVHRGSGADRAAIVLRAHRAMQALIGSPPPPPKGDRA-----
Mb1571|M.bovis_AF2122/97 IVPKFVSTSGRFAPRSLLLPAIRIGNRLRGGPSR------------
Rv1544|M.tuberculosis_H37Rv IVPKFVSTSGRFAPRSLLLPAIRIGNRLRGGPSR------------
MUL_1543|M.ulcerans_Agy99 VVPKFVSTSGRYLPRSVLLPAIRIGNKLRGGPSH------------
MLBr_00429|M.leprae_Br4923 LTSKAMSVASRYAPRAIVASIVGNFYKKLGGG--------------
MAB_1537c|M.abscessus_ATCC_199 ITSKAMSVAAGYAPRAVVAPIVGSFYKKLGD---------------