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VGFQNRAGPALGDAPMTLPPPPNTPPPNGASPPPPFGGSGPYPQSLHQPWPQQPSPRRSGTWKWVLAIVA LLAVVGVTAAVTVAVTGEPTGGGLPSASTPQAVPSDSEIASAEDSGGVSVITDDPTCAPQRPIVSTLAAK TNAGWDKRDPEVPASDWTPEIRAQYNEVAAAMRDAADQFVQLAKLTPHRVMREIYEQFIAYARAYAASVP NYTPGDDYSARFAVGAAEAISRICAAIDYGSAGARAPLVKVSEPPAEIAPVGDANAPVRFLSEPNAVCRD WNLALMQFQDETAEWRNTDPKIPAGEWTPEQKRLNVEVAPVMRRFATQLRSLGNSSGNPVLADFANLSAQ YRSALEKALPTYVPADDYLAGVSARLNGMVNSACQAVSA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2820 | - | - | 100% (389) | hypothetical protein MSMEG_2820 |
| M. smegmatis MC2 155 | MSMEG_4599 | - | 1e-59 | 40.06% (317) | hypothetical protein MSMEG_4599 |
| M. smegmatis MC2 155 | MSMEG_0070 | - | 2e-20 | 42.73% (110) | hypothetical protein MSMEG_0070 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1127c | - | 6e-06 | 25.99% (304) | hypothetical protein Mb1127c |
| M. gilvum PYR-GCK | Mflv_0759 | - | 1e-82 | 43.05% (374) | hypothetical protein Mflv_0759 |
| M. tuberculosis H37Rv | Rv1097c | - | 5e-06 | 26.22% (286) | hypothetical protein Rv1097c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2581 | pknE | 4e-06 | 28.21% (156) | transmembrane serine/threonine-protein kinase E PknE |
| M. avium 104 | MAV_1369 | - | 2e-05 | 37.68% (69) | hypothetical protein MAV_1369 |
| M. thermoresistible (build 8) | TH_2900 | - | 4e-84 | 52.14% (280) | PUTATIVE hypothetical protein MSMEG_2820 |
| M. ulcerans Agy99 | MUL_3180 | pknE | 3e-06 | 28.21% (156) | transmembrane serine/threonine-protein kinase E PknE |
| M. vanbaalenii PYR-1 | Mvan_0086 | - | 6e-82 | 43.23% (384) | hypothetical protein Mvan_0086 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2820|M.smegmatis_MC2_155 --------------MGFQNRAGPALGDAPMTLPPPPNTPPPNGASPPPPF
TH_2900|M.thermoresistible__bu --------------------------------------------------
Mflv_0759|M.gilvum_PYR-GCK -----------------------------MSTPPGDRPPPPPGPPPGYP-
Mvan_0086|M.vanbaalenii_PYR-1 MKPKRRRLSALSGLTWEDGNDGARYGEVYMSSPPPDQWPAPPPPPTGPPQ
Mb1127c|M.bovis_AF2122/97 -----------MTVPPAGPYGNYPYGPNTYGQDLYWGGQ-----------
Rv1097c|M.tuberculosis_H37Rv -----------MTVPPAGPYGNYPYGPNTYGQDPYWGGQ-----------
MMAR_2581|M.marinum_M -----------MSDATADSREGSQFGPYRLRRIVGRGAMGDVYEAEDTVR
MUL_3180|M.ulcerans_Agy99 -----------MSDATADSREGSQFGPYRLRRIVGRGAMGDVYEAEDTVR
MAV_1369|M.avium_104 ----------MITPLVFAGAVSATGPSLPVRTPPVHAAVTPVAAVSPTFP
MSMEG_2820|M.smegmatis_MC2_155 GGSGPYPQSLHQPWPQQPSPRRSGTWKWVLAIVALLAVVGVT--------
TH_2900|M.thermoresistible__bu --------------------------------------------------
Mflv_0759|M.gilvum_PYR-GCK GGSPWGAAQPNG-------PRGRGAAVWVLGGLAVLVVIVLT--------
Mvan_0086|M.vanbaalenii_PYR-1 GATQWGPRTTGP-------TRGGAAAKWVLGGLALLVVVVIT--------
Mb1127c|M.bovis_AF2122/97 ---------PQGGSYPPAYPPQQYPPGWPAG-------------------
Rv1097c|M.tuberculosis_H37Rv ---------PQGGSYPPAYPPQQYPPGWPAG-------------------
MMAR_2581|M.marinum_M ERVVALKLMSQTLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYGEIDGQ
MUL_3180|M.ulcerans_Agy99 ERVVALKLMSQTLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYGEIDGQ
MAV_1369|M.avium_104 DLTGPAVVAIDRGPTAFHVAEPALSAPPPAAIVNAPGALGIP--------
MSMEG_2820|M.smegmatis_MC2_155 --AAVTVAVTGEPTG--GGLPSASTPQAVPSDSEIASAED----------
TH_2900|M.thermoresistible__bu ----------------------------------VASAND----------
Mflv_0759|M.gilvum_PYR-GCK --VAATLFVTGRQSEEAGPDPAKPSPTTAVDTSEIASADD----------
Mvan_0086|M.vanbaalenii_PYR-1 --VVATILVT-QSPQTSGPPVTSTPPRTTASQVAVASADD----------
Mb1127c|M.bovis_AF2122/97 ------------------PYPPGPPPPGPGSK------------------
Rv1097c|M.tuberculosis_H37Rv ------------------PYPPGPPPPGPGSK------------------
MMAR_2581|M.marinum_M LYVDMRLIDGKDLAAMLKRYGPLPPPRAVAITRQIGSALDAAHAAGVTHR
MUL_3180|M.ulcerans_Agy99 LYVDMRLIDGKDLAAMLKRYGPLPPPRAVAITRQIGSALDAAHAAGVTHR
MAV_1369|M.avium_104 -SIALAAYRNAEQKMAVAAPGCGVSWNLLAGIGRIESGHAGGG-------
MSMEG_2820|M.smegmatis_MC2_155 -----------SGGVSVITDDPTCAP------------------------
TH_2900|M.thermoresistible__bu -----------TGPVAIITEEPTCAP------------------------
Mflv_0759|M.gilvum_PYR-GCK -----------DGPVEIITEDPTCSS------------------------
Mvan_0086|M.vanbaalenii_PYR-1 -----------RDPAGIILDDATCQQ------------------------
Mb1127c|M.bovis_AF2122/97 -------------TPWLILAGLAVLG------------------------
Rv1097c|M.tuberculosis_H37Rv -------------TPWLILAGLAVLG------------------------
MMAR_2581|M.marinum_M DVKPENILVSHDDFAYLVDFGIASATSDEKLTQLGSTVGTLYYMAPERFS
MUL_3180|M.ulcerans_Agy99 DVKPENILVSHDDFAYLVDFGIASATSDEKLTQLGSTVGTLYYMAPERFS
MAV_1369|M.avium_104 -------AVDARGTAITPIYGPSLDG------------------------
:
MSMEG_2820|M.smegmatis_MC2_155 ---------QRPIVSTLAAKTNAGWDKRDPEVPASDWTPEIRAQYNEVA-
TH_2900|M.thermoresistible__bu ---------VRPILIVFSDAQQNGWDRRDASIPASGWTHEVRVQYEEVG-
Mflv_0759|M.gilvum_PYR-GCK ---------WTTIVTAFVDASRNGWDARDPTSPAASWTPEQSRQYEAMG-
Mvan_0086|M.vanbaalenii_PYR-1 ---------WSPISAAFAHVASNGWNDRDPTIPASDWPPALRSQYEAVA-
Mb1127c|M.bovis_AF2122/97 ---------VILLVVILVIGLRGDNKSTTATSPATSAPTSQPFSQQTAT-
Rv1097c|M.tuberculosis_H37Rv ---------VILLVVILVIGLRGDNKSTTATSPATSAPTSQPFSQQTAT-
MMAR_2581|M.marinum_M SGDVTYRADIYALACVLYECLTGSPPYRGDQLSVMGAHLSQPIPRPSAAR
MUL_3180|M.ulcerans_Agy99 SGDVTYRADIYALACVLYECLTGSPPYRGDQLSVIGAHLSQPIPRPSAAR
MAV_1369|M.avium_104 ---------TLPGNEVIIQSAAGNRVTYARAMGPMQFLPGTWARYASDG-
: .
MSMEG_2820|M.smegmatis_MC2_155 -----------------------------------------------AAM
TH_2900|M.thermoresistible__bu -----------------------------------------------DAM
Mflv_0759|M.gilvum_PYR-GCK -----------------------------------------------AAM
Mvan_0086|M.vanbaalenii_PYR-1 -----------------------------------------------TVL
Mb1127c|M.bovis_AF2122/97 --------------------------------------------------
Rv1097c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2581|M.marinum_M PGIPAGFDNVIARGMAKDPADRYATCGDLSAAAYSALATPDQDRATDILQ
MUL_3180|M.ulcerans_Agy99 PGIPAGFDNVIARGMAKDPADRYATCGDLSAAAYSALATPDQDRATDILQ
MAV_1369|M.avium_104 -------------------------------------------------K
MSMEG_2820|M.smegmatis_MC2_155 RDAADQFVQLAKLTPHRVMREIYEQFIAYARAYAASVPNYTPGDDYSARF
TH_2900|M.thermoresistible__bu RETADRLVPMVKLTPHRVVRELYEQMIAYLRAYAQAIPRYRPADDFLARS
Mflv_0759|M.gilvum_PYR-GCK QSIADRTVELAKRTPHRVMRILYEQFVAYSRAYVGKLSTYTEQDDRFVRV
Mvan_0086|M.vanbaalenii_PYR-1 NESADRSSELARKTPHRVMRELYEQFIAYSREYAERIRSYTPEANGFALV
Mb1127c|M.bovis_AF2122/97 ---------GCTPNVSGGVQPIGDSISAG----KLSFPTSAAPGWSAFSD
Rv1097c|M.tuberculosis_H37Rv ---------GCTPNVSGGVQPIGDSISAG----KLSFPTSAAPGWSAFSD
MMAR_2581|M.marinum_M RSQVAQLPAGFASTPPGGFAPSSPAVPVPGSAPSTGWPAPSVPGAPVAPS
MUL_3180|M.ulcerans_Agy99 RSQVAQLPAGFASTSPGGFAPSSPAVPVPGSAPSTGWPAPSVPGAPVAPS
MAV_1369|M.avium_104 GDGVADPQNLFDSTLAAARYLCSGGLNLRDQSQVLTAILRYNNSMPYAQN
. .
MSMEG_2820|M.smegmatis_MC2_155 AVGAAEAISRICAAIDYGSAGARAPLV--KVSEPPAEIAPVGDANAPVRF
TH_2900|M.thermoresistible__bu GNAAADAISNICKSIEYGAAAARARMV--TPLAAPEVLAPVGDIANPQRL
Mflv_0759|M.gilvum_PYR-GCK AISFSGTLNAICDSIAFGAAGARAPLV--PGSAPPRDLERELDPDNAKPF
Mvan_0086|M.vanbaalenii_PYR-1 TVGLAATLTAVCDAVRSGAAGARSPLV--PDAPPPSGSMAKADPDNPQRF
Mb1127c|M.bovis_AF2122/97 DQNPN---LIDAVGVGHEVAGADQWMM--QAEVAITNFVTTMDVAAQASK
Rv1097c|M.tuberculosis_H37Rv DQNPN---LIDAVGVGHEVAGADQWMM--QAEVAITNFVTTMDVAAQASK
MMAR_2581|M.marinum_M APVPTPWAGVPGWGVGHTGTTGAPPWG--QPPPQPTVAAKTWPWIAAAVA
MUL_3180|M.ulcerans_Agy99 APVPTPWAGVPGWGVGHTGTTGAPPWG--QPPPEPTVAAKTWPWIAAAVA
MAV_1369|M.avium_104 VLGWAAAYATGVVPVDLPPMTGPPPPLGDAHLEHPEGLGPNLPMNINGLP
: .
MSMEG_2820|M.smegmatis_MC2_155 LSEPNAVCRDWNLALMQFQDETAEWRNTDPKIPAGEWTPEQKR-------
TH_2900|M.thermoresistible__bu LTEIDPVCAEWADAVSEFQRDAAAWGTTSPDIPASQWSSEQRA-------
Mflv_0759|M.gilvum_PYR-GCK MTSPSSSCGQWLYATEKFTNDTAAWRGIDPNIPASELTADQRA-------
Mvan_0086|M.vanbaalenii_PYR-1 LKDLNPVCSQWLNTAKQFGDDTAAWRSVDPNIPGNELDANQRA-------
Mb1127c|M.bovis_AF2122/97 LMQCVA-------------DGPGYAGSSPTLGPTKTSSITVDG-------
Rv1097c|M.tuberculosis_H37Rv LMQCVA-------------DGPGYAGSSPTLGPTKTSSITVDG-------
MMAR_2581|M.marinum_M VVVVIAGVLGVVIAHPWRSPGPPTASAPPPPPPDAVQLRVLNDGVFIGSS
MUL_3180|M.ulcerans_Agy99 VVVVIAGVLGVVIAHPWRSPGPPTASAPPPPPPDAVQLRVLNDGVFIGSS
MAV_1369|M.avium_104 LDDPLARVPLIDLSSPALGSPQPMFPWMTPTPQQAPTQVPGCT-------
: . .
MSMEG_2820|M.smegmatis_MC2_155 --------------------LNVEVAPVMRRFATQ---------------
TH_2900|M.thermoresistible__bu --------------------LNDQVMPVMQTFADR---------------
Mflv_0759|M.gilvum_PYR-GCK --------------------VNAAVAPVMEAFATE---------------
Mvan_0086|M.vanbaalenii_PYR-1 --------------------INASVMSVMEANAME---------------
Mb1127c|M.bovis_AF2122/97 --------------------VRAARVDADITIAD----------------
Rv1097c|M.tuberculosis_H37Rv --------------------VRAARVDADITIAD----------------
MMAR_2581|M.marinum_M AATTTIDIFNEPICPPCGAFIRSYASDIDAAVANKKLAVRYHLLNFLDEQ
MUL_3180|M.ulcerans_Agy99 AATTTIDIFNEPICPPCGAFIRSYASDIDAAVANKKLAVRYHLLNFLDEQ
MAV_1369|M.avium_104 -----------------VICISSQGSPPAGPPPPFG--------------
: .
MSMEG_2820|M.smegmatis_MC2_155 -------LRSLGNSSGNPVLADFANLSAQYRSALEKALPTYVPADDYLAG
TH_2900|M.thermoresistible__bu -------LVALGQRTSNPTLRDFAELSALYRSAYIEAIPTYMPADQYLTA
Mflv_0759|M.gilvum_PYR-GCK -------SQQLGRRSNNPIWADLAALSAQYRRAYVSALVTYSPSDNDLQV
Mvan_0086|M.vanbaalenii_PYR-1 -------TQLLGKQSSNPIWADIATLSAQYRRAYVSALTTYQPADNDLQI
Mb1127c|M.bovis_AF2122/97 ------SSRNVKGDSVTIIAVDTKPVTVFLGATPIGDATSR---------
Rv1097c|M.tuberculosis_H37Rv ------SSRNVKGDSVTIIAVDTKPVTVFLGATPIGDATSR---------
MMAR_2581|M.marinum_M SHTKTYSTRAVAASYCVAAQDDPKVYTDFYAALFASDFQPQEAAASDRTD
MUL_3180|M.ulcerans_Agy99 SHTKTYSTRAVAASYCVAAQDDPKVYTDFYAALFASDFQPQEAAASDRTD
MAV_1369|M.avium_104 ------APPPFAPPPSGPPPFAPPPPDAGPVPAPPAGPAPQAAPAPPAGA
. .
MSMEG_2820|M.smegmatis_MC2_155 VSARLNGMVNSACQAVSA--------------------------------
TH_2900|M.thermoresistible__bu ASIRIAGVVNAACKALTNN-------------------------------
Mflv_0759|M.gilvum_PYR-GCK AAGSTAGAISEACRIVMD--------------------------------
Mvan_0086|M.vanbaalenii_PYR-1 AASSAIGTVSEACRTVGA--------------------------------
Mb1127c|M.bovis_AF2122/97 ATVERVIEALKVNKS-----------------------------------
Rv1097c|M.tuberculosis_H37Rv ATVERVIEALKVNKS-----------------------------------
MMAR_2581|M.marinum_M AELAHLAQTVGANGTATSCIKAGNDMGTARTKAAAADATLSELNASGTPF
MUL_3180|M.ulcerans_Agy99 AELAHLAQTVGANGTATSCIKAGNDMGTARTKAAAADATLSELNAG----
MAV_1369|M.avium_104 APQAPSPKSAGPTPNAPKKPGPA---------------------------
.
MSMEG_2820|M.smegmatis_MC2_155 ---------------------
TH_2900|M.thermoresistible__bu ---------------------
Mflv_0759|M.gilvum_PYR-GCK ---------------------
Mvan_0086|M.vanbaalenii_PYR-1 ---------------------
Mb1127c|M.bovis_AF2122/97 ---------------------
Rv1097c|M.tuberculosis_H37Rv ---------------------
MMAR_2581|M.marinum_M VWDGSKSIDLQNPSWLTKLIG
MUL_3180|M.ulcerans_Agy99 ---------------LRRC--
MAV_1369|M.avium_104 ---------------------