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KPKRRRLSALSGLTWEDGNDGARYGEVYMSSPPPDQWPAPPPPPTGPPQGATQWGPRTTGPTRGGAAAKW VLGGLALLVVVVITVVATILVTQSPQTSGPPVTSTPPRTTASQVAVASADDRDPAGIILDDATCQQWSPI SAAFAHVASNGWNDRDPTIPASDWPPALRSQYEAVATVLNESADRSSELARKTPHRVMRELYEQFIAYSR EYAERIRSYTPEANGFALVTVGLAATLTAVCDAVRSGAAGARSPLVPDAPPPSGSMAKADPDNPQRFLKD LNPVCSQWLNTAKQFGDDTAAWRSVDPNIPGNELDANQRAINASVMSVMEANAMETQLLGKQSSNPIWAD IATLSAQYRRAYVSALTTYQPADNDLQIAASSAIGTVSEACRTVGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0086 | - | - | 100% (397) | hypothetical protein Mvan_0086 |
| M. vanbaalenii PYR-1 | Mvan_0084 | - | 9e-70 | 40.05% (372) | hypothetical protein Mvan_0084 |
| M. vanbaalenii PYR-1 | Mvan_1756 | - | 7e-33 | 26.70% (352) | hypothetical protein Mvan_1756 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1127c | - | 5e-06 | 26.92% (156) | hypothetical protein Mb1127c |
| M. gilvum PYR-GCK | Mflv_0759 | - | 1e-109 | 52.04% (367) | hypothetical protein Mflv_0759 |
| M. tuberculosis H37Rv | Rv1097c | - | 8e-06 | 26.62% (154) | hypothetical protein Rv1097c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_1982 | pknH_2 | 7e-06 | 30.30% (132) | transmembrane serine/threonine-protein kinase H PknH_2 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2820 | - | 6e-82 | 43.23% (384) | hypothetical protein MSMEG_2820 |
| M. thermoresistible (build 8) | TH_2900 | - | 2e-59 | 41.22% (279) | PUTATIVE hypothetical protein MSMEG_2820 |
| M. ulcerans Agy99 | MUL_3375 | pknH_2 | 2e-05 | 28.79% (132) | transmembrane serine/threonine-protein kinase H PknH_2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0086|M.vanbaalenii_PYR-1 MKPKRRRLSALSGLTWEDGNDGARYGEVYMSSPPPDQWPAPPPPPTGPPQ
Mflv_0759|M.gilvum_PYR-GCK -----------------------------MSTPPGDRPPPPPGPPPGYP-
MSMEG_2820|M.smegmatis_MC2_155 --------------MGFQNRAGPALGDAPMTLPPPPNTPPPNGASPPPPF
TH_2900|M.thermoresistible__bu --------------------------------------------------
Mb1127c|M.bovis_AF2122/97 -------------------------MTVPPAGPYGNYPYGPNTYGQDLYW
Rv1097c|M.tuberculosis_H37Rv -------------------------MTVPPAGPYGNYPYGPNTYGQDPYW
MMAR_1982|M.marinum_M -------------------------MSASARRSRVGTRFGPYYLKRQLGT
MUL_3375|M.ulcerans_Agy99 -------------------------MSASARRSRVGTRFGPYYLKRQLGT
Mvan_0086|M.vanbaalenii_PYR-1 GATQWGPRTTGP-------TRGGAAAKWVLGGLALLVVVVITVVATILVT
Mflv_0759|M.gilvum_PYR-GCK GGSPWGAAQPNG-------PRGRGAAVWVLGGLAVLVVIVLTVAATLFVT
MSMEG_2820|M.smegmatis_MC2_155 GGSGPYPQSLHQPWPQQPSPRRSGTWKWVLAIVALLAVVGVTAAVTVAVT
TH_2900|M.thermoresistible__bu --------------------------------------------------
Mb1127c|M.bovis_AF2122/97 GGQ--------------------PQGGSYPPAYPPQQYPPGWPAG--PYP
Rv1097c|M.tuberculosis_H37Rv GGQ--------------------PQGGSYPPAYPPQQYPPGWPAG--PYP
MMAR_1982|M.marinum_M GGMGEVYEAVDTVRQRVVALKLMSESLSHDPVFRMRMQREARNAGRLQEP
MUL_3375|M.ulcerans_Agy99 GGMGEVYEAVDTVRQRVVALKLMSESLSHDPVFRMRMQREARNAGRLQEP
Mvan_0086|M.vanbaalenii_PYR-1 -QSPQTSGPPVTSTPPRTTASQVAVASADDRDPAGIILDDATCQQWSPIS
Mflv_0759|M.gilvum_PYR-GCK GRQSEEAGPDPAKPSPTTAVDTSEIASADDDGPVEIITEDPTCSSWTTIV
MSMEG_2820|M.smegmatis_MC2_155 --GEPTGGGLPSASTPQAVPSDSEIASAEDSGGVSVITDDPTCAPQRPIV
TH_2900|M.thermoresistible__bu ------------------------VASANDTGPVAIITEEPTCAPVRPIL
Mb1127c|M.bovis_AF2122/97 PGPPPPGPGSKTPWLILAGLAVLGVILLVVILVIGLRGDNKSTTATSPAT
Rv1097c|M.tuberculosis_H37Rv PGPPPPGPGSKTPWLILAGLAVLGVILLVVILVIGLRGDNKSTTATSPAT
MMAR_1982|M.marinum_M HVVPIHDYGEIDGQLYLDMRLIEGTHLALLLERFGPVTPPWAVALVHQVA
MUL_3375|M.ulcerans_Agy99 HVVPIHDYGEIDGQLYLDMRLIERTHLALLLERFGPVTPPWAVALVHQVA
:
Mvan_0086|M.vanbaalenii_PYR-1 AAFAHVASNGWNDRDPTIPASDWPPA-------LRSQYEAVATVLNESAD
Mflv_0759|M.gilvum_PYR-GCK TAFVDASRNGWDARDPTSPAASWTPE-------QSRQYEAMGAAMQSIAD
MSMEG_2820|M.smegmatis_MC2_155 STLAAKTNAGWDKRDPEVPASDWTPE-------IRAQYNEVAAAMRDAAD
TH_2900|M.thermoresistible__bu IVFSDAQQNGWDRRDASIPASGWTHE-------VRVQYEEVGDAMRETAD
Mb1127c|M.bovis_AF2122/97 SAPTSQPFSQQTATGCTPN---------------------VSGGVQPIGD
Rv1097c|M.tuberculosis_H37Rv SAPTSQPFSQQTATGCTPN---------------------VSGGVQPIGD
MMAR_1982|M.marinum_M SALDAAHAAGVMHRDVKPENILVTQDDFVYLVDFGIASAATDEKLTQIGS
MUL_3375|M.ulcerans_Agy99 SALDAAHAAGVMHRDVKPENILVTQDDFVYLVDFGIASAATDEKLTQIGS
. . : ..
Mvan_0086|M.vanbaalenii_PYR-1 RSSELARKTPHR------VMRELYEQFIAYSREYAERIRSYTPEANGFAL
Mflv_0759|M.gilvum_PYR-GCK RTVELAKRTPHR------VMRILYEQFVAYSRAYVGKLSTYTEQDDRFVR
MSMEG_2820|M.smegmatis_MC2_155 QFVQLAKLTPHR------VMREIYEQFIAYARAYAASVPNYTPGDDYSAR
TH_2900|M.thermoresistible__bu RLVPMVKLTPHR------VVRELYEQMIAYLRAYAQAIPRYRPADDFLAR
Mb1127c|M.bovis_AF2122/97 SISAGKLSFPT---------------------SAAPGWSAFSDDQN----
Rv1097c|M.tuberculosis_H37Rv SISAGKLSFPT---------------------SAAPGWSAFSDDQN----
MMAR_1982|M.marinum_M AVGTWRYMAPERFSDAEVNQRADIYSLTCVLHECLTGTPPYRADSAGMLI
MUL_3375|M.ulcerans_Agy99 AVGTWRYMAPERFSDAEVNQRADIYSLTCVLHECLTGTPPYRADSAGMLI
* :
Mvan_0086|M.vanbaalenii_PYR-1 VT---------VGLAATLTAVCDAVRSGAAGARSPLVPDAPPPSGSMAKA
Mflv_0759|M.gilvum_PYR-GCK VA---------ISFSGTLNAICDSIAFGAAGARAPLVPGSAPPRDLEREL
MSMEG_2820|M.smegmatis_MC2_155 FA---------VGAAEAISRICAAIDYGSAGARAPLVKVSEPPAEIAPVG
TH_2900|M.thermoresistible__bu SG---------NAAADAISNICKSIEYGAAAARARMVTPLAAPEVLAPVG
Mb1127c|M.bovis_AF2122/97 ------------------PNLIDAVGVG-------HEVAGADQWMMQAEV
Rv1097c|M.tuberculosis_H37Rv ------------------PNLIDAVGVG-------HEVAGADQWMMQAEV
MMAR_1982|M.marinum_M TAHLMAPIPRPSQLRPGIPATFDAVIARGMAKRPEDRFASAGELAAAAHQ
MUL_3375|M.ulcerans_Agy99 TAHLMAPIPRPSQLRPDIPATFDAVIARGMAKRPEDRFASAGELAAAAHQ
::
Mvan_0086|M.vanbaalenii_PYR-1 DPDNP-----QRFLKDLNPVCSQWLNTAKQFGDDTAAWRSVDPNIPGNEL
Mflv_0759|M.gilvum_PYR-GCK DPDNA-----KPFMTSPSSSCGQWLYATEKFTNDTAAWRGIDPNIPASEL
MSMEG_2820|M.smegmatis_MC2_155 DANAP-----VRFLSEPNAVCRDWNLALMQFQDETAEWRNTDPKIPAGEW
TH_2900|M.thermoresistible__bu DIANP-----QRLLTEIDPVCAEWADAVSEFQRDAAAWGTTSPDIPASQW
Mb1127c|M.bovis_AF2122/97 AITN-----FVTTMDVAAQASKLMQCVADGPGYAGSSPTLG----PTKTS
Rv1097c|M.tuberculosis_H37Rv AITN-----FVTTMDVAAQASKLMQCVADGPGYAGSSPTLG----PTKTS
MMAR_1982|M.marinum_M ALSAPHQAQEFRILKRSEEAGGLHTDAAAEAGITFASPSTASPSAPTPVA
MUL_3375|M.ulcerans_Agy99 ALSAPHQAQEFRILKRGEEAGGLHTDAAAEAGITFASPSTASPSAPTPVA
: . : *
Mvan_0086|M.vanbaalenii_PYR-1 DANQRAINASVMSVMEANAMETQLLGKQSSNPIWADIATLSAQYRRAYVS
Mflv_0759|M.gilvum_PYR-GCK TADQRAVNAAVAPVMEAFATESQQLGRRSNNPIWADLAALSAQYRRAYVS
MSMEG_2820|M.smegmatis_MC2_155 TPEQKRLNVEVAPVMRRFATQLRSLGNSSGNPVLADFANLSAQYRSALEK
TH_2900|M.thermoresistible__bu SSEQRALNDQVMPVMQTFADRLVALGQRTSNPTLRDFAELSALYRSAYIE
Mb1127c|M.bovis_AF2122/97 SITVDGVRAAR---------VDADITIADSSRNVKGDSVTIIAVDTKPVT
Rv1097c|M.tuberculosis_H37Rv SITVDGVRAAR---------VDADITIADSSRNVKGDSVTIIAVDTKPVT
MMAR_1982|M.marinum_M STSQPDLRISGPLSIPSFPTSEANVPLFDASTSSWGDLTAAPPPQAPPAP
MUL_3375|M.ulcerans_Agy99 STSQPDLRISGPLSIPSFPTSEANVPLFDASTSSWGDLTAAPPPQAPPAP
:. : . .
Mvan_0086|M.vanbaalenii_PYR-1 ALTTYQPAD-----------------------------------------
Mflv_0759|M.gilvum_PYR-GCK ALVTYSPSD-----------------------------------------
MSMEG_2820|M.smegmatis_MC2_155 ALPTYVPAD-----------------------------------------
TH_2900|M.thermoresistible__bu AIPTYMPAD-----------------------------------------
Mb1127c|M.bovis_AF2122/97 VFLGATPIG-----------------------------------------
Rv1097c|M.tuberculosis_H37Rv VFLGATPIG-----------------------------------------
MMAR_1982|M.marinum_M PTPPTPPVPPTPPQPPKQTSDTSPSGPGPHSLAARLRNPWMLLGAAALVA
MUL_3375|M.ulcerans_Agy99 LTPPTPPVPPTPPQPPKQTSDTSPSGPGPHFLAASLRNPWMLLGAAALVA
*
Mvan_0086|M.vanbaalenii_PYR-1 -----------------------------NDLQIAASSAIGTVSEACRTV
Mflv_0759|M.gilvum_PYR-GCK -----------------------------NDLQVAAGSTAGAISEACRIV
MSMEG_2820|M.smegmatis_MC2_155 -----------------------------DYLAGVSARLNGMVNSACQAV
TH_2900|M.thermoresistible__bu -----------------------------QYLTAASIRIAGVVNAACKAL
Mb1127c|M.bovis_AF2122/97 --------------------------------DATSRATVERVIEALKVN
Rv1097c|M.tuberculosis_H37Rv --------------------------------DATSRATVERVIEALKVN
MMAR_1982|M.marinum_M LIVFAAQGIWLSFRPKSESASTSPSTASPSAPSPASADALARLLSTLPLG
MUL_3375|M.ulcerans_Agy99 LIVFAAQGIWLSFRPKSESASTSPSTASPSAPSPASADALARLLSTLPLG
.: : :
Mvan_0086|M.vanbaalenii_PYR-1 GA------------------------------------------------
Mflv_0759|M.gilvum_PYR-GCK MD------------------------------------------------
MSMEG_2820|M.smegmatis_MC2_155 SA------------------------------------------------
TH_2900|M.thermoresistible__bu TNN-----------------------------------------------
Mb1127c|M.bovis_AF2122/97 KS------------------------------------------------
Rv1097c|M.tuberculosis_H37Rv KS------------------------------------------------
MMAR_1982|M.marinum_M YAPGTCRAFLPAKDSLARVTCDKNVDPGGPSRGVYTLFGETATLRQYFDG
MUL_3375|M.ulcerans_Agy99 YAPGTCRAFLPAKDSLARVTCDKNVDPGGPSRGVYTLFGETATLRQYFDG
Mvan_0086|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0759|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2820|M.smegmatis_MC2_155 --------------------------------------------------
TH_2900|M.thermoresistible__bu --------------------------------------------------
Mb1127c|M.bovis_AF2122/97 --------------------------------------------------
Rv1097c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1982|M.marinum_M LLRTDIMVDCPGEKKSPTAWHHPDSPQVGGMIFCAIQEGSPSVVWTNEAQ
MUL_3375|M.ulcerans_Agy99 LLRTDIMVDCPGEKKSPTAWHHPDSPQVGGMIFCAIQEGSPSVVWTNEAQ
Mvan_0086|M.vanbaalenii_PYR-1 --------------------------
Mflv_0759|M.gilvum_PYR-GCK --------------------------
MSMEG_2820|M.smegmatis_MC2_155 --------------------------
TH_2900|M.thermoresistible__bu --------------------------
Mb1127c|M.bovis_AF2122/97 --------------------------
Rv1097c|M.tuberculosis_H37Rv --------------------------
MMAR_1982|M.marinum_M LMISVVQGDPRGPNLEELYSWWKKHS
MUL_3375|M.ulcerans_Agy99 LMISVVPGDPRGPNLEELYSWWKKHS