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VSTPPGDRPPPPPGPPPGYPGGSPWGAAQPNGPRGRGAAVWVLGGLAVLVVIVLTVAATLFVTGRQSEEA GPDPAKPSPTTAVDTSEIASADDDGPVEIITEDPTCSSWTTIVTAFVDASRNGWDARDPTSPAASWTPEQ SRQYEAMGAAMQSIADRTVELAKRTPHRVMRILYEQFVAYSRAYVGKLSTYTEQDDRFVRVAISFSGTLN AICDSIAFGAAGARAPLVPGSAPPRDLERELDPDNAKPFMTSPSSSCGQWLYATEKFTNDTAAWRGIDPN IPASELTADQRAVNAAVAPVMEAFATESQQLGRRSNNPIWADLAALSAQYRRAYVSALVTYSPSDNDLQV AAGSTAGAISEACRIVMD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0759 | - | - | 100% (368) | hypothetical protein Mflv_0759 |
| M. gilvum PYR-GCK | Mflv_0761 | - | 4e-62 | 41.23% (325) | hypothetical protein Mflv_0761 |
| M. gilvum PYR-GCK | Mflv_2547 | - | 7e-06 | 30.59% (85) | hypothetical protein Mflv_2547 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1127c | - | 8e-06 | 34.48% (87) | hypothetical protein Mb1127c |
| M. tuberculosis H37Rv | Rv1097c | - | 8e-06 | 34.48% (87) | hypothetical protein Rv1097c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_1982 | pknH_2 | 3e-05 | 32.35% (102) | transmembrane serine/threonine-protein kinase H PknH_2 |
| M. avium 104 | MAV_1219 | - | 2e-06 | 29.41% (136) | hypothetical protein MAV_1219 |
| M. smegmatis MC2 155 | MSMEG_2820 | - | 1e-82 | 43.05% (374) | hypothetical protein MSMEG_2820 |
| M. thermoresistible (build 8) | TH_2900 | - | 2e-63 | 44.77% (277) | PUTATIVE hypothetical protein MSMEG_2820 |
| M. ulcerans Agy99 | MUL_0182 | - | 3e-05 | 30.66% (137) | membrane glycine and proline rich protein |
| M. vanbaalenii PYR-1 | Mvan_0086 | - | 1e-109 | 52.04% (367) | hypothetical protein Mvan_0086 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0759|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0086|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2820|M.smegmatis_MC2_155 --------------------------------------------------
TH_2900|M.thermoresistible__bu --------------------------------------------------
Mb1127c|M.bovis_AF2122/97 --------------------------------------------------
Rv1097c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0182|M.ulcerans_Agy99 --------------------------------------------------
MAV_1219|M.avium_104 --------------------------------------------------
MMAR_1982|M.marinum_M MSASARRSRVGTRFGPYYLKRQLGTGGMGEVYEAVDTVRQRVVALKLMSE
Mflv_0759|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0086|M.vanbaalenii_PYR-1 -------------------------------MKPKRRRLSALSGLTWEDG
MSMEG_2820|M.smegmatis_MC2_155 ---------------------------------------------MGFQN
TH_2900|M.thermoresistible__bu --------------------------------------------------
Mb1127c|M.bovis_AF2122/97 --------------------------------------------------
Rv1097c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0182|M.ulcerans_Agy99 --------------------------------------------------
MAV_1219|M.avium_104 --------------------------------------------------
MMAR_1982|M.marinum_M SLSHDPVFRMRMQREARNAGRLQEPHVVPIHDYGEIDGQLYLDMRLIEGT
Mflv_0759|M.gilvum_PYR-GCK ----------MSTPPGDRPPPPPGPPPGYP-GGSPWGAAQPNG-------
Mvan_0086|M.vanbaalenii_PYR-1 NDGARYGEVYMSSPPPDQWPAPPPPPTGPPQGATQWGPRTTGP-------
MSMEG_2820|M.smegmatis_MC2_155 RAGPALGDAPMTLPPPPNTPPPNGASPPPPFGGSGPYPQSLHQPWPQQPS
TH_2900|M.thermoresistible__bu --------------------------------------------------
Mb1127c|M.bovis_AF2122/97 ----------MTVPPAG--PYGNYPYGPNTYGQDLYWGGQPQGG------
Rv1097c|M.tuberculosis_H37Rv ----------MTVPPAG--PYGNYPYGPNTYGQDPYWGGQPQGG------
MUL_0182|M.ulcerans_Agy99 ----------MTTPPGG--PYGQDPAGYNPYGQAPYGYGQPQAGGQY---
MAV_1219|M.avium_104 ----------MTAPPGG--PYGPGSYGSNPYGQEPNWSGQPPGGQPQGGQ
MMAR_1982|M.marinum_M HLALLLERFGPVTPPWAVALVHQVASALDAAHAAGVMHRDVKPENILVTQ
Mflv_0759|M.gilvum_PYR-GCK PRGRGAAVWVLGGLAVLVVIVLTVAATLFVTGRQSEEAGPDPAKPSPTTA
Mvan_0086|M.vanbaalenii_PYR-1 TRGGAAAKWVLGGLALLVVVVITVVATILVT-QSPQTSGPPVTSTPPRTT
MSMEG_2820|M.smegmatis_MC2_155 PRRSGTWKWVLAIVALLAVVGVTAAVTVAVT--GEPTGGGLPSASTPQAV
TH_2900|M.thermoresistible__bu --------------------------------------------------
Mb1127c|M.bovis_AF2122/97 ---------------------------------SYPP-------------
Rv1097c|M.tuberculosis_H37Rv ---------------------------------SYPP-------------
MUL_0182|M.ulcerans_Agy99 ---------------------------------PYPPTGPYTN-------
MAV_1219|M.avium_104 PQGG-----------------------------PYPQPGQYPAGGPYPYP
MMAR_1982|M.marinum_M DDFVYLVDFGIASAATDEKLTQIGSAVGTWRYMAPERFSDAEVNQRADIY
Mflv_0759|M.gilvum_PYR-GCK VDTSEIASADDDGPVE------------IITEDPTCSSWTTIVTAFVDAS
Mvan_0086|M.vanbaalenii_PYR-1 ASQVAVASADDRDPAG------------IILDDATCQQWSPISAAFAHVA
MSMEG_2820|M.smegmatis_MC2_155 PSDSEIASAEDSGGVS------------VITDDPTCAPQRPIVSTLAAKT
TH_2900|M.thermoresistible__bu -----VASANDTGPVA------------IITEEPTCAPVRPILIVFSDAQ
Mb1127c|M.bovis_AF2122/97 -----------AYPPQ------------QYP---------PGWPAGPYPP
Rv1097c|M.tuberculosis_H37Rv -----------AYPPQ------------QYP---------PGWPAGPYPP
MUL_0182|M.ulcerans_Agy99 PQGGAPSYGPGTYPPQ------------QFPQAGQPYGTGPGWPTGPYSP
MAV_1219|M.avium_104 PPGGGYPYPGGPYPGG------------PYPGAPYPGPGQPFGPGGPYSP
MMAR_1982|M.marinum_M SLTCVLHECLTGTPPYRADSAGMLITAHLMAPIPRPSQLRPGIPATFDAV
.
Mflv_0759|M.gilvum_PYR-GCK RNGWDARDPTSPAASWTPEQSRQYEAMGAAMQSIADRTVELAKRTPHRVM
Mvan_0086|M.vanbaalenii_PYR-1 SNGWNDRDPTIPASDWPPALRSQYEAVATVLNESADRSSELARKTPHRVM
MSMEG_2820|M.smegmatis_MC2_155 NAGWDKRDPEVPASDWTPEIRAQYNEVAAAMRDAADQFVQLAKLTPHRVM
TH_2900|M.thermoresistible__bu QNGWDRRDASIPASGWTHEVRVQYEEVGDAMRETADRLVPMVKLTPHRVV
Mb1127c|M.bovis_AF2122/97 GP-----PPPGPGSKTPWLILAGLAVLGVILLVVILVIGLRGD--NKSTT
Rv1097c|M.tuberculosis_H37Rv GP-----PPPGPGSKTPWLILAGLAVLGVILLVVILVIGLRGD--NKSTT
MUL_0182|M.ulcerans_Agy99 GP-----PPKGPGSKAPWLIIAGVAVLGVLALVVVLVFTLGGNKSNNAGP
MAV_1219|M.avium_104 GP-----PPGGPGSKLPWLIVAGLVVLAVIALVATLVVMKGGH--GSKPS
MMAR_1982|M.marinum_M IARGMAKRPEDRFASAGELAAAAHQALSAPHQAQEFRILKRSEEAGGLHT
. : :.
Mflv_0759|M.gilvum_PYR-GCK RILYEQFVAYSRAYVGKLSTYTEQDDR-----------------------
Mvan_0086|M.vanbaalenii_PYR-1 RELYEQFIAYSREYAERIRSYTPEANG-----------------------
MSMEG_2820|M.smegmatis_MC2_155 REIYEQFIAYARAYAASVPNYTPGDDY-----------------------
TH_2900|M.thermoresistible__bu RELYEQMIAYLRAYAQAIPRYRPADDF-----------------------
Mb1127c|M.bovis_AF2122/97 ATSPATS-APTSQP-FSQQTATGCTPN-----------------------
Rv1097c|M.tuberculosis_H37Rv ATSPATS-APTSQP-FSQQTATGCTPN-----------------------
MUL_0182|M.ulcerans_Agy99 SGTPATSGASTSEPDNSEQNATGCTPN-----------------------
MAV_1219|M.avium_104 GATPSSTSTSVSQPKNSAQNATDCTPN-----------------------
MMAR_1982|M.marinum_M DAAAEAGITFASPSTASPSAPTPVASTSQPDLRISGPLSIPSFPTSEANV
:
Mflv_0759|M.gilvum_PYR-GCK --FVRVAISFSGTLNAICDSIAFGAAGARAPLVPGSAPP---RDLERELD
Mvan_0086|M.vanbaalenii_PYR-1 --FALVTVGLAATLTAVCDAVRSGAAGARSPLVPDAPPP---SGSMAKAD
MSMEG_2820|M.smegmatis_MC2_155 --SARFAVGAAEAISRICAAIDYGSAGARAPLVKVSEPP---AEIAPVGD
TH_2900|M.thermoresistible__bu --LARSGNAAADAISNICKSIEYGAAAARARMVTPLAAP---EVLAPVGD
Mb1127c|M.bovis_AF2122/97 --VSGGVQPIGDSISAGKLSFPTSAAP-GWSAFSDDQNPNLIDAVGVGHE
Rv1097c|M.tuberculosis_H37Rv --VSGGVQPIGDSISAGKLSFPTSAAP-GWSAFSDDQNPNLIDAVGVGHE
MUL_0182|M.ulcerans_Agy99 --VSAGERPLGEIISAGKLSFPISAAP-GWSVFGDDQSPNLIGALGVGQE
MAV_1219|M.avium_104 --VSGGDMPRSDSIAAGKLSFPANAAPSGWTVFSDDQGPNLIGALGVAQD
MMAR_1982|M.marinum_M PLFDASTSSWGDLTAAPPPQAPPAPPTPPTPPVPPTPPQPPKQTSDTSPS
. .. . .
Mflv_0759|M.gilvum_PYR-GCK PDNAKPFMTSPS-----------------SSCGQWLYATEKFTNDTAAWR
Mvan_0086|M.vanbaalenii_PYR-1 PDNPQRFLKDLN-----------------PVCSQWLNTAKQFGDDTAAWR
MSMEG_2820|M.smegmatis_MC2_155 ANAPVRFLSEPN-----------------AVCRDWNLALMQFQDETAEWR
TH_2900|M.thermoresistible__bu IANPQRLLTEID-----------------PVCAEWADAVSEFQRDAAAWG
Mb1127c|M.bovis_AF2122/97 VAGADQWMMQAE-----------------VAITNFVTTMDVAAQASKLMQ
Rv1097c|M.tuberculosis_H37Rv VAGADQWMMQAE-----------------VAITNFVTTMDVAAQASKLMQ
MUL_0182|M.ulcerans_Agy99 VPDASQWMMQAE-----------------VAVTNFVASMDVSEQASKLMQ
MAV_1219|M.avium_104 VPGANQWMMTAE-----------------VGVTNFVPSMDLTAQATKLMQ
MMAR_1982|M.marinum_M GPGPHSLAARLRNPWMLLGAAALVALIVFAAQGIWLSFRPKSESASTSPS
. : :
Mflv_0759|M.gilvum_PYR-GCK GIDPNIPASELTADQRAVNAAVAPVMEAFATESQQLGRRSNNPIWADLAA
Mvan_0086|M.vanbaalenii_PYR-1 SVDPNIPGNELDANQRAINASVMSVMEANAMETQLLGKQSSNPIWADIAT
MSMEG_2820|M.smegmatis_MC2_155 NTDPKIPAGEWTPEQKRLNVEVAPVMRRFATQLRSLGNSSGNPVLADFAN
TH_2900|M.thermoresistible__bu TTSPDIPASQWSSEQRALNDQVMPVMQTFADRLVALGQRTSNPTLRDFAE
Mb1127c|M.bovis_AF2122/97 CVADGPGYAGSSPTLGPTKTSSITVDGVRAARVD--ADITIADSSRNVKG
Rv1097c|M.tuberculosis_H37Rv CVADGPGYAGSSPTLGPTKTSSITVDGVRAARVD--ADITIADSSRNVKG
MUL_0182|M.ulcerans_Agy99 CVVDGPGYVQSSPTLGPTKKSSTTVDGVKAARVD--ADITIADTSRNVKG
MAV_1219|M.avium_104 CLANGPGYANAMPTLGPIKTSPITVDGTKAVRAD--ADVTIADPTRNVKG
MMAR_1982|M.marinum_M TASPSAPSPASADALARLLSTLPLGYAPGTCRAFLPAKDSLARVTCDKNV
: . . : :
Mflv_0759|M.gilvum_PYR-GCK LS------AQYRRAYVSALVTYSP-----------------SDNDLQVAA
Mvan_0086|M.vanbaalenii_PYR-1 LS------AQYRRAYVSALTTYQP-----------------ADNDLQIAA
MSMEG_2820|M.smegmatis_MC2_155 LS------AQYRSALEKALPTYVP-----------------ADDYLAGVS
TH_2900|M.thermoresistible__bu LS------ALYRSAYIEAIPTYMP-----------------ADQYLTAAS
Mb1127c|M.bovis_AF2122/97 DS------VTIIAVDTKPVTVFLG-----------------ATPIGDATS
Rv1097c|M.tuberculosis_H37Rv DS------VTIIAVDTKPVTVFLG-----------------ATPIGDATS
MUL_0182|M.ulcerans_Agy99 DS------VVIIAVDTKPVTIFLG-----------------ATPIGDAAS
MAV_1219|M.avium_104 DS------VTIIAVDTKPVSVFIG-----------------STPIGDSAS
MMAR_1982|M.marinum_M DPGGPSRGVYTLFGETATLRQYFDGLLRTDIMVDCPGEKKSPTAWHHPDS
. . .: : . :
Mflv_0759|M.gilvum_PYR-GCK GSTAGAISEACRIVMD----------------------------------
Mvan_0086|M.vanbaalenii_PYR-1 SSAIGTVSEACRTVGA----------------------------------
MSMEG_2820|M.smegmatis_MC2_155 ARLNGMVNSACQAVSA----------------------------------
TH_2900|M.thermoresistible__bu IRIAGVVNAACKALTNN---------------------------------
Mb1127c|M.bovis_AF2122/97 RATVERVIEALKVNKS----------------------------------
Rv1097c|M.tuberculosis_H37Rv RATVERVIEALKVNKS----------------------------------
MUL_0182|M.ulcerans_Agy99 AATISKVIAALKVDKS----------------------------------
MAV_1219|M.avium_104 AGLIGKIIAALKVAKS----------------------------------
MMAR_1982|M.marinum_M PQVGGMIFCAIQEGSPSVVWTNEAQLMISVVQGDPRGPNLEELYSWWKKH
: * :
Mflv_0759|M.gilvum_PYR-GCK -
Mvan_0086|M.vanbaalenii_PYR-1 -
MSMEG_2820|M.smegmatis_MC2_155 -
TH_2900|M.thermoresistible__bu -
Mb1127c|M.bovis_AF2122/97 -
Rv1097c|M.tuberculosis_H37Rv -
MUL_0182|M.ulcerans_Agy99 -
MAV_1219|M.avium_104 -
MMAR_1982|M.marinum_M S