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ITPLVFAGAVSATGPSLPVRTPPVHAAVTPVAAVSPTFPDLTGPAVVAIDRGPTAFHVAEPALSAPPPAA IVNAPGALGIPSIALAAYRNAEQKMAVAAPGCGVSWNLLAGIGRIESGHAGGGAVDARGTAITPIYGPSL DGTLPGNEVIIQSAAGNRVTYARAMGPMQFLPGTWARYASDGKGDGVADPQNLFDSTLAAARYLCSGGLN LRDQSQVLTAILRYNNSMPYAQNVLGWAAAYATGVVPVDLPPMTGPPPPLGDAHLEHPEGLGPNLPMNIN GLPLDDPLARVPLIDLSSPALGSPQPMFPWMTPTPQQAPTQVPGCTVICISSQGSPPAGPPPPFGAPPPF APPPSGPPPFAPPPPDAGPVPAPPAGPAPQAAPAPPAGAAPQAPSPKSAGPTPNAPKKPGPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1369 | - | - | 100% (413) | hypothetical protein MAV_1369 |
| M. avium 104 | MAV_1163 | - | 1e-28 | 42.53% (174) | LpqU protein |
| M. avium 104 | MAV_3468 | secD | 4e-12 | 41.00% (100) | preprotein translocase subunit SecD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1262c | - | 1e-157 | 72.11% (380) | hypothetical protein Mb1262c |
| M. gilvum PYR-GCK | Mflv_2206 | - | 1e-120 | 55.42% (424) | lytic transglycosylase, catalytic |
| M. tuberculosis H37Rv | Rv1230c | - | 1e-158 | 72.37% (380) | hypothetical protein Rv1230c |
| M. leprae Br4923 | MLBr_02395 | Ag36 | 3e-09 | 40.00% (110) | proline rich antigenic protein |
| M. abscessus ATCC 19977 | MAB_1367c | - | 1e-103 | 54.09% (403) | hypothetical protein MAB_1367c |
| M. marinum M | MMAR_4211 | - | 1e-168 | 70.45% (423) | membrane protein |
| M. smegmatis MC2 155 | MSMEG_5067 | - | 1e-135 | 60.89% (427) | secreted protein |
| M. thermoresistible (build 8) | TH_4644 | - | 1e-111 | 67.68% (297) | PUTATIVE secreted protein |
| M. ulcerans Agy99 | MUL_4514 | - | 1e-169 | 70.14% (422) | membrane protein |
| M. vanbaalenii PYR-1 | Mvan_4490 | - | 1e-129 | 56.68% (434) | lytic transglycosylase, catalytic |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1262c|M.bovis_AF2122/97 --MHIGGRWGARPAVAAVRRGACRLTRAPAFG-VAAIAPLVFASAVGGAA
Rv1230c|M.tuberculosis_H37Rv --MHIGGRWGARPAVAAVRRGACRLTRAPAFG-VAAIAPLVFASAVGSAA
MMAR_4211|M.marinum_M --MRIGGRWVAHPAVASVRQRALR-AKTPVFG-IAMITPLVFAGAVGATA
MUL_4514|M.ulcerans_Agy99 --MRIGGRWVAHPAVASVRQRALR-AKTPVFG-IAMITPLVFAGAVGATA
MAV_1369|M.avium_104 -----------------------------------MITPLVFAGAVSATG
Mflv_2206|M.gilvum_PYR-GCK ---------------MAARRRAGQFVRNPAVGVAAVLTPLVLAGAVGASA
Mvan_4490|M.vanbaalenii_PYR-1 --MHIRG----GAALVTARQRTGHFIRMPAFGVAAVLTPLVLAGAVGAAA
MSMEG_5067|M.smegmatis_MC2_155 --MRIGG----GAAIQAARHRAGRFMRTPMVG-AAALAPLILAGAVGASA
TH_4644|M.thermoresistible__bu -------------------------LNRPAFG-LAVITPLVFAGAVGGSG
MAB_1367c|M.abscessus_ATCC_199 MELPHWVATSVNHARGAASRIRGNSASVPWLR-VGGLSALTVVGFAVAAS
MLBr_02395|M.leprae_Br4923 ---------------------------------------------MTDQP
Mb1262c|M.bovis_AF2122/97 PVFPGRTAPVHAVITPVAAVAAS-GIDLSGPVVIAMKRPPTSFRVAVA-T
Rv1230c|M.tuberculosis_H37Rv PVFPGRTAPVHAVITPVAAVAAS-GIDLSGPVVIAMKRPPTSFRVAVA-T
MMAR_4211|M.marinum_M PASYGKTPAVRAAITPVAAVAPSPAIDLSGPSIVAVERPPTNFHIAAG-T
MUL_4514|M.ulcerans_Agy99 PASYGKTPAVRAAITPVAAVAPSPAIDLSGPSIVAVERPPTNFHIAAG-T
MAV_1369|M.avium_104 PSLPVRTPPVHAAVTPVAAVSPT-FPDLTGPAVVAIDRGPTAFHVAEP-A
Mflv_2206|M.gilvum_PYR-GCK P---THTPTRDAAVLPLAAVAPS-ADERAGISVVAVAKAPAPLRTVAGTA
Mvan_4490|M.vanbaalenii_PYR-1 PS--TTTPTRDSAVMPLAAVAPS-ADDRSGPSVVAVAKAPAPLRTVASTA
MSMEG_5067|M.smegmatis_MC2_155 P---PHHGSSDAAVTPLAAVQPQ-ID-HDGPAVVAAAKAPTKFHIATTTA
TH_4644|M.thermoresistible__bu PLQFPHES--DTAVTPLAAVSPE-PVDRSGPTVVALQKKPAPFHFVES-T
MAB_1367c|M.abscessus_ATCC_199 SAQVSGQAVVPVPVPMVSAATPQ--AEVGELNLVTVVRPPTQYRIAPS-A
MLBr_02395|M.leprae_Br4923 PPSGSNPTPAPPPPGSSGGYEPS-----FAPSELGSAYPPPTAPPVGG-S
. .. . : *. . :
Mb1262c|M.bovis_AF2122/97 IPAPPPPMIVNSPGALGIPAMALSAYRNAELKMAAAAPGCGVSWNLLAGI
Rv1230c|M.tuberculosis_H37Rv ISAPPPPMIVNSPGALGIPAMALSAYRNAELKMAAAAPGCGVSWNLLAGI
MMAR_4211|M.marinum_M TAAPPPARVVNAPGALGIPIMALTAYRNAEQKMATAAPACGISWNLLAGI
MUL_4514|M.ulcerans_Agy99 TAAPPPARVVNAPGALGIPIMALTAYRNAEQKMATAAPACGISWNLLAGI
MAV_1369|M.avium_104 LSAPPPAAIVNAPGALGIPSIALAAYRNAEQKMAVAAPGCGVSWNLLAGI
Mflv_2206|M.gilvum_PYR-GCK ASGPTPPTILNAPGTLRIPSVNLAAYRNAETMMAAAYPGCGVSWNLLAGI
Mvan_4490|M.vanbaalenii_PYR-1 TA-PPPPMILNSPGTLRIPSMALAAYRNAETTMAAAQPGCGLSWNLLAGI
MSMEG_5067|M.smegmatis_MC2_155 VSAPPPAVVVNSPGALGIPGMALNAYRNAERMMAAAYPGCGVSWNLLAGI
TH_4644|M.thermoresistible__bu VAAPPPAAVVNTPGTLGIPAMALRAYRNAERMMAHAQPECGVSWNLLAGI
MAB_1367c|M.abscessus_ATCC_199 AIAPPPPGIVMAPGGLGIPKIALEAYQNAEKMMAKAAPGCGVSWNLLAGI
MLBr_02395|M.leprae_Br4923 YPPPPPPGGSYPP---------------------PPPPGG----------
*.*. .* . *
Mb1262c|M.bovis_AF2122/97 GRIESMHANGGATDARGTAIQPIYGPTLDGTLPGNEIIIQ---SSVGNRV
Rv1230c|M.tuberculosis_H37Rv GRIESMHANGGATDARGTAIQPIYGPTLDGTLPGNEIIIQ---SSVGNRV
MMAR_4211|M.marinum_M GRIESMHANGGAVDERGTAVNPIYGPALDGTLPGNEVIIQ---SKVGNRV
MUL_4514|M.ulcerans_Agy99 GRIESMHANGGAVDERGTAVNPIYGPALDGTLPGNEVIIQ---SKVGNRV
MAV_1369|M.avium_104 GRIESGHAGGGAVDARGTAITPIYGPSLDGTLPGNEVIIQ---SAAGNRV
Mflv_2206|M.gilvum_PYR-GCK GRIESMHSYGGATDSRGTAVRPIYGPTLDGTLPGNEVIVE---SRSADRV
Mvan_4490|M.vanbaalenii_PYR-1 GRIESMHAYGGATDSRGTAVRPIYGPALDGTLPGNEVIVQ---SRAADRV
MSMEG_5067|M.smegmatis_MC2_155 GRIESMHANGGQTDARGTAVRPIYGPALDGTLPGNEIIVQ---SAQAGRV
TH_4644|M.thermoresistible__bu GRIESMHAYGGATDANGTAIRPILGPLLDGSLPGNEIIVQ---SRTADRV
MAB_1367c|M.abscessus_ATCC_199 GRIESGHANNGATDVKGRVVRPIYGPSLDGTLPGNEVIVDHEQSRTQGAQ
MLBr_02395|M.leprae_Br4923 -------SYPPPPPSTGAYAPPPPGPAIR-SLPKEAYTFW-----VTRVL
: * * ** : :** : .
Mb1262c|M.bovis_AF2122/97 TYARAMGPMQFLPGTWARYATDGDDDGVADPQNLFDSTLAAARYLCSGGL
Rv1230c|M.tuberculosis_H37Rv TYARAMGPMQFLPGTWARYATDGDDDGVADPQNLFDSTLAAARYLCSGGL
MMAR_4211|M.marinum_M TYARAMGPMQFLPGTWARYASDGDSDGVPDPQNIFDSTLAAARYLCSGGL
MUL_4514|M.ulcerans_Agy99 TYARAMGPMQFLPGTWARYASDGDSDGVPDPQNIFDSTLAAARYLCSGGL
MAV_1369|M.avium_104 TYARAMGPMQFLPGTWARYASDGKGDGVADPQNLFDSTLAAARYLCSGGL
Mflv_2206|M.gilvum_PYR-GCK VYARAMGPMQFLPGTWSRYAADGDGDGKADVQNIYDAALGAARYLCSGGL
Mvan_4490|M.vanbaalenii_PYR-1 VYARAMGPMQFLPGTWSRYASDGDGDGKADVQNLFDATLAAARYLCSGGM
MSMEG_5067|M.smegmatis_MC2_155 TYARAMGPMQFLPGTWARYASDGDGDGKADVQNLFDASLAAARYLCSGGL
TH_4644|M.thermoresistible__bu TYARALGPMQFLPGTWARFASDGDGDGKADVQNLFDSTLAAARYLCSGGM
MAB_1367c|M.abscessus_ATCC_199 VYVRAMGPMQFLPSTWNHYASDGDGDGKADPQNVFDASLAAARYLCSGGL
MLBr_02395|M.leprae_Br4923 AYVIDNIPATVLLGIGMLIQTLTKQEACVTDITQYNVNQYCATQPTG---
.*. * .* . : . :. . :: .* .
Mb1262c|M.bovis_AF2122/97 NLRDPAQVMAALLRYNNSMPYAQNVLGWAAGYATGVFPVDLPPITGPPPP
Rv1230c|M.tuberculosis_H37Rv NLRDPAQVMAALLRYNNSMPYAQNVLGWAAGYATGVFPVDLPPITGPPPP
MMAR_4211|M.marinum_M NLRDPGQVMAAILRYNNSMPYAQNVLGWAAAYATGVLPVDLPPITGPPPP
MUL_4514|M.ulcerans_Agy99 NLRDPGQVMAAILRYNNSMPYAQNVLGWAAAYATGVLPVDLPPITGPPPP
MAV_1369|M.avium_104 NLRDQSQVLTAILRYNNSMPYAQNVLGWAAAYATGVVPVDLPPMTGPPPP
Mflv_2206|M.gilvum_PYR-GCK NLRNQADVMAAILRYNNSMSYAQNVLSWAAAYATGVVPLELPPITGSVPE
Mvan_4490|M.vanbaalenii_PYR-1 NLRNQPDVIAAILRYNNSMAYTQNVLSWAAAYATGVVPVDLPPITGEVPA
MSMEG_5067|M.smegmatis_MC2_155 NLRDQSQVMTAILRYNNSIAYARNVLGWAAAYATGVVPVDLPPITGEIPA
TH_4644|M.thermoresistible__bu NLRDPSHVMQALLRYNNSVAYAHNVMGWAAAYATGVHPVDLPPLTGPVPS
MAB_1367c|M.abscessus_ATCC_199 NLRDRSQTMSAILRYNNSVAYAQNVLAWAAGYATGVLPLNLPPLTAADVA
MLBr_02395|M.leprae_Br4923 ---------IGMLAFWFAWLMATAYLVWNYGYRQGATGSSIGKTVMKFKV
.:* : : : : * .* *. .: .
Mb1262c|M.bovis_AF2122/97 LG-------DAHLENPE--GLGPGLPINVNGLTADGPMAHLPLIDLTP--
Rv1230c|M.tuberculosis_H37Rv LG-------DAHLENPE--GLGPGLPINVNGLTADGPMAHLPLIDLTP--
MMAR_4211|M.marinum_M IG-------DAHLEHPE--GLGPNLPLNANGLGPADPLSHMPLIDFAP--
MUL_4514|M.ulcerans_Agy99 IG-------DAHLEHPE--GLGPNLPLNANGLEPADPLSHMPLIDFAP--
MAV_1369|M.avium_104 LG-------DAHLEHPE--GLGPNLPMNINGLPLDDPLARVPLIDLSS--
Mflv_2206|M.gilvum_PYR-GCK LEAATTATLTAHLDRRA--GLGPGLPLNATGLPANDPLALIPLMERT---
Mvan_4490|M.vanbaalenii_PYR-1 LGTIG----DSHLDRPE--GIGPGLPLNATGLPANDPLSLIPLMTRT---
MSMEG_5067|M.smegmatis_MC2_155 LG-------DSHLERKE--GLGPGLPVNALGLPPDDPLALIPVLDSN---
TH_4644|M.thermoresistible__bu LN--------SHVSGYD--GLGPGSPLNAMGLSPGDPLAVLPLIDGXXXL
MAB_1367c|M.abscessus_ATCC_199 PER------KAHLGGGESRGLGPGSVTDVAGLSPNDPLAQLPIVNPLT--
MLBr_02395|M.leprae_Br4923 IS-------------------------EATGQPIGFGMSVVRQLAHFVD-
: * :: : :
Mb1262c|M.bovis_AF2122/97 -------------RQAALNPPPMFPWMAPDPS---APMPGCTLICIGSHG
Rv1230c|M.tuberculosis_H37Rv -------------RQAALNPPPMFPWMAPDPS---APMPGCTLICIGSHG
MMAR_4211|M.marinum_M -------------PQMPAPPPPMFPWMQPTPQPL-APQPGCTLICVTNPP
MUL_4514|M.ulcerans_Agy99 -------------PQMPAPPPPMFPWMQPTPQPL-APQPGCTLICVTNPP
MAV_1369|M.avium_104 -------------PALGS-PQPMFPWMTPTPQQAPTQVPGCTVICISSQG
Mflv_2206|M.gilvum_PYR-GCK --------------DVASQINTGLPGFGAGQTLG--PLPGPMPA--AAPQ
Mvan_4490|M.vanbaalenii_PYR-1 --------------DVASQINTNLPGFVPGQTLG--PLPGPAPAPLAVPE
MSMEG_5067|M.smegmatis_MC2_155 --------------VTATRVPAANLGFAPNQVLG--PLPGPAEAVPTAPA
TH_4644|M.thermoresistible__bu DLLDRSALHDLRLDIDILVNNAGVQHVDPVTEFPPDQFRDMLTLMVEAPF
MAB_1367c|M.abscessus_ATCC_199 --------------PDRAVIAALPGAVPPAPEAP----QAPCMLFCAPPP
MLBr_02395|M.leprae_Br4923 --------------AVICCIGFLFPLWDSKRQ----TLADKIMTTVCLPI
.
Mb1262c|M.bovis_AF2122/97 PPVGAP-PFPPT------------APPPPFLPAAPPPPDPLA--------
Rv1230c|M.tuberculosis_H37Rv PPVGAP-PFPPT------------APPPPFLPAAPPPPDPLA--------
MMAR_4211|M.marinum_M EAVPPPAPMPFG------------LMPPPPAPAAPPPPDPLAPLGAPPVG
MUL_4514|M.ulcerans_Agy99 EAVPPPAPMPFG------------LMPPPPAPAAPPPPDPLAPLGVPPVG
MAV_1369|M.avium_104 SPPAGP-PPPFG------------APPPFAPPPSGPPPFAPPPPDAGPVP
Mflv_2206|M.gilvum_PYR-GCK PVAPPP-TWVPP------------WVQQP-APQKPAQCAVFCIQDLPAAP
Mvan_4490|M.vanbaalenii_PYR-1 PVAPPPPAWVPP------------WMQQ---PQQQPECAVFCIKDLPPA-
MSMEG_5067|M.smegmatis_MC2_155 APPEPP-RWIPP------------WEQP----PRQPECVVFCLGEQAPP-
TH_4644|M.thermoresistible__bu LLIRAALPYMFERGFGRIVNISSVHGLRASEYKAAYVTAKHALEGLSKVT
MAB_1367c|M.abscessus_ATCC_199 PPAEPFNPFAPQ--------------------PPAEPFNPFAPNQAPQPF
MLBr_02395|M.leprae_Br4923 --------------------------------------------------
Mb1262c|M.bovis_AF2122/97 GPPGD-----------------------AGLAPP----------------
Rv1230c|M.tuberculosis_H37Rv GPPGD-----------------------AGLAPP----------------
MMAR_4211|M.marinum_M GPPAAPAPAPAG-----------PAPAPAGPAPAP---------------
MUL_4514|M.ulcerans_Agy99 GPPAAPAPAPAGPPVPGGPAPAGPAPAPAGPAPAP---------------
MAV_1369|M.avium_104 APPAGPAPQAAP-------------APPAGAAPQA---------------
Mflv_2206|M.gilvum_PYR-GCK APAPGPVPAGPL---------GLQPAAPLPVAPPA---------------
Mvan_4490|M.vanbaalenii_PYR-1 APAPAPAPAGPL---------GLTPAPGPAPLLPA---------------
MSMEG_5067|M.smegmatis_MC2_155 APAPGPPPAAP------------TPGPAPGPAPGP---------------
TH_4644|M.thermoresistible__bu ALEGGPHGVTSNCVNPGYVRTPLVTRQIADQARAHGISEGEVLEQILLKE
MAB_1367c|M.abscessus_ATCC_199 NPFAPPPP-----------------PVELGPAPGP---------------
MLBr_02395|M.leprae_Br4923 --------------------------------------------------
Mb1262c|M.bovis_AF2122/97 --------APAPAG---------------------------
Rv1230c|M.tuberculosis_H37Rv --------APAPAG---------------------------
MMAR_4211|M.marinum_M -------GAPVPAGPAPTPTPSGPAPGEPVLTPVH------
MUL_4514|M.ulcerans_Agy99 -------GAPAPAGPAPTPTPSGPAPGEPVLTPVH------
MAV_1369|M.avium_104 -------PSPKSAGPTPN-APKKPGPA--------------
Mflv_2206|M.gilvum_PYR-GCK -------TPGPQPGPAPG---PAPGPAPGPVA---------
Mvan_4490|M.vanbaalenii_PYR-1 -------GPPPPPAPALPGMPPAPGPAPGPVG---------
MSMEG_5067|M.smegmatis_MC2_155 -------APAPAPAPVLG---PAPGPAPESP----------
TH_4644|M.thermoresistible__bu SAIKRLIEPDEVASLVGWLASPDAGMVTGASYTMDGGWSAR
MAB_1367c|M.abscessus_ATCC_199 --------APAPAAPRP------------------------
MLBr_02395|M.leprae_Br4923 -----------------------------------------