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TIPSAIRGRRRPGTAEHTVTPDGPAPSNDGGGPAPNPVDEVPSAWKLLVYGLQHLLVMYASTITVPVVVA SALDLSQQDLVYLVTADLLLCGFGTLLQSLGIWRVGVRLPMVIGASYTGIAPMLIIGQGSGLQTMYGAVL VVGLATIAVAPLVGKMMRFFPPVVIGTTILLIGIQLIPAGAKMIVGTDPDASGFGSPAAIGLAAVTALAV LLGYRLLPRLLRSLAVLIGMIAGTVIAAATGFLDLSGIGDTQAISFPDLLHFGAPRFDVLAICSLAIIQI VLVVELAGQVNAVGEVVDQEISDRRLAAAVRADGVVTALGGGVFQSFMYVTFAQNVGILTITRMFSRYVT ATTGVLLMSLAFFPVVGEIVAAIPRPVLGAAAVVMFGTIAVVGIRILGQVDFADTANVIIVAAALGVALL PTTVSGFYSQFPDAARQLLSSGVATGICVAVLLNILFHARRPLEVPVSDRLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2570 | - | - | 100% (473) | xanthine/uracil permease |
| M. smegmatis MC2 155 | MSMEG_1293 | - | 2e-92 | 40.93% (430) | xanthine/uracil permeases family protein |
| M. smegmatis MC2 155 | MSMEG_0810 | - | 1e-36 | 28.74% (421) | putative pyrimidine permease RutG |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3301 | - | 2e-07 | 23.91% (435) | transmembrane carbonic anhydrase |
| M. gilvum PYR-GCK | Mflv_0188 | - | 5e-39 | 29.89% (435) | uracil-xanthine permease |
| M. tuberculosis H37Rv | Rv3273 | - | 2e-07 | 23.91% (435) | transmembrane carbonic anhydrase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2932c | - | 2e-87 | 38.46% (455) | xanthine/uracil permease |
| M. marinum M | MMAR_4949 | - | 9e-94 | 40.93% (430) | xanthine/uracil permease |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_1201 | - | 2e-07 | 22.96% (405) | xanthine/uracil permease |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_5275 | - | 4e-92 | 41.16% (430) | uracil-xanthine permease |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4949|M.marinum_M --------------MSAPPTSP----------VRRVHPVDEVLPIPKLAT
Mvan_5275|M.vanbaalenii_PYR-1 --------------MSAPTKSP----------KKRVHPVDEVLPLPKLAT
MAB_2932c|M.abscessus_ATCC_199 --------------MSADTTRPAAPGAQ----RKKVHPVDEVPSTGRLVT
MSMEG_2570|M.smegmatis_MC2_155 MTIPSAIRGRRRPGTAEHTVTPDGPAPSNDGGGPAPNPVDEVPSAWKLLV
Mb3301|M.bovis_AF2122/97 --------------MTIPRSQHMSTAVN----SCTEAPASRSQWMLANLR
Rv3273|M.tuberculosis_H37Rv --------------MTIPRSQHMSTAVN----SCTEAPASRSQWMLANLR
Mflv_0188|M.gilvum_PYR-GCK --------------MTLTWKRVDSTTDP-----DFVVAPDERLSWPSTLG
TH_1201|M.thermoresistible__bu ----------------VNRLDR------------FFEISARGSTVSTEVR
.
MMAR_4949|M.marinum_M YGFQHVVAFYAGAVVVPIIIANAIDLPHQD-LVKLITADLFTCGVASIIQ
Mvan_5275|M.vanbaalenii_PYR-1 YGFQHVVAFYAGAVLVPILIANAIGLSGEE-LVMLITADLFTCGIASIIQ
MAB_2932c|M.abscessus_ATCC_199 LGIQHVIAFYAGAVLVPLLIARAIDLDAEA-LTMLITADLFTCGVASILQ
MSMEG_2570|M.smegmatis_MC2_155 YGLQHLLVMYASTITVPVVVASALDLSQQD-LVYLVTADLLLCGFGTLLQ
Mb3301|M.bovis_AF2122/97 HDVPASLVVFLVALPLSLGIAIASGAPIIAGVIAAVVGGIVAGAVGGSPV
Rv3273|M.tuberculosis_H37Rv HDVPASLVVFLVALPLSLGIAIASGAPIIAGVIAAVVGGIVAGAVGGSPV
Mflv_0188|M.gilvum_PYR-GCK LGAQHVVAMFGATFLVPVLTG------------FPPATTLLFSGVGTILF
TH_1201|M.thermoresistible__bu GGLVTFIAMAYIIVLNPIILSGSADVDGNR--LGFAQVSAATALTAGVMT
. :.. . .: . .
MMAR_4949|M.marinum_M SVGFWKIGVRLPLLQGVAFAGVSPVIAIGLSHGGGTPSLLYVYGAVIVAG
Mvan_5275|M.vanbaalenii_PYR-1 AVGFKNIGVRLPLLQGVTFAGVAPIIAIGLAHGGGTESLLYVYGAVIVAG
MAB_2932c|M.abscessus_ATCC_199 AVGFWKIGVRLPLLQGVTFATLAPVIKIANDHGGGRVGLLTVYGAVIAAG
MSMEG_2570|M.smegmatis_MC2_155 SLGIWRVGVRLPMVIGASYTGIAPMLIIGQGSG-----LQTMYGAVLVVG
Mb3301|M.bovis_AF2122/97 QVSGPAAGLTVVVAELIDELGWPMLCLMTIAAG----ALQIVFGLSRMAR
Rv3273|M.tuberculosis_H37Rv QVSGPAAGLTVVVAELIDELGWPMLCLMTIAAG----ALQIVFGLSRMAR
Mflv_0188|M.gilvum_PYR-GCK LL---ITGNRLPSYLGSSFSVIAPVTAATASHG-----TGSALGGIIAVG
TH_1201|M.thermoresistible__bu ILFGVVARLPFAFAAGLGINSFLATSVVGSVSWAEAMGLVVINGLIIVLL
: . *
MMAR_4949|M.marinum_M LFTILIAPIF----TKLLR-FFPPVVTGTLITIIGLCLVPVGAGDAVTNP
Mvan_5275|M.vanbaalenii_PYR-1 VFTFLIAPMF----VRLLK-FFPPVVTGTLITIIGLCLVPIGALDAVTNP
MAB_2932c|M.abscessus_ATCC_199 AFTFLIAPFF----ARLIR-FFPPVVTGSVITIIGVSLLPVGIGDATRNP
MSMEG_2570|M.smegmatis_MC2_155 LATIAVAPLV----GKMMR-FFPPVVIGTTILLIGIQLIPAGAKMIVGTD
Mb3301|M.bovis_AF2122/97 AALAIAPVVV----HAMLAGIGITIALQQIHVLLGGTSHSSAWRNIVALP
Rv3273|M.tuberculosis_H37Rv AALAIAPVVV----HAMLAGIGITIALQQIHVLLGGTSHSSAWRNIVALP
Mflv_0188|M.gilvum_PYR-GCK VLLIIIGAVVHVAGTRWIDITLPPVVTGAIVALIGFNLAPAAKNNFEQGP
TH_1201|M.thermoresistible__bu SSTGLRRMIF----DAVPMQLKLSITAGIGLFILFIGLVNAGFIGSTGLP
.. .:. :: .
MMAR_4949|M.marinum_M RT--GEHDPTNIRWLLYALGTIAIIVAIQRVFSGFMATIAVLIGLVVGCV
Mvan_5275|M.vanbaalenii_PYR-1 AT--HEPDPTNLRWVLYALGTIAVIVAIQRLFRGFMSTIAVLLGLVAGCT
MAB_2932c|M.abscessus_ATCC_199 HSPVAAHDPGNGRWLMYALGTIGAIVLMQRFFRGFWSTIAVLLGLVAGTV
MSMEG_2570|M.smegmatis_MC2_155 PD---ASGFGSPAAIGLAAVTALAVLLGYRLLPRLLRSLAVLIGMIAGTV
Mb3301|M.bovis_AF2122/97 DG-----ILHHELHEVIVGGTVIAILLMWSKLPAKVRIIPGPLVAIAGAT
Rv3273|M.tuberculosis_H37Rv DG-----ILHHELHEVIVGGTVIAILLMWSKLPAKVRIIPGPLVAIAGAT
Mflv_0188|M.gilvum_PYR-GCK LLG---------------FVTLVLLVVVLAAFRGLLGRLAIFVAVAAGYL
TH_1201|M.thermoresistible__bu SPPTGLGVDGGGSITTVPTVLFVATLLVTGILIARRVRGAILIGLIGGTV
: : . : *
MMAR_4949|M.marinum_M VAYGLGDMSFAKVDEAS----VIGFTEPFVFG---MPKFDFVACLTMIIV
Mvan_5275|M.vanbaalenii_PYR-1 VAFTLGDMNFDRVAEAS----MFGFTPPFAFG---MPRFDIVAIITMIIV
MAB_2932c|M.abscessus_ATCC_199 VAWLAGDTDFGRVGEAD----WIGFTSPFAFG---APRFDVIAVVSLIVV
MSMEG_2570|M.smegmatis_MC2_155 IAAATGFLDLSGIGDTQ----AISFPDLLHFG---APRFDVLAICSLAII
Mb3301|M.bovis_AF2122/97 VLALLPVLQTERIDLQGNFFDAIGLPKLAEMSPGGQPWSHEISAIALGVL
Rv3273|M.tuberculosis_H37Rv VLALLPVLQTERIDLQGNFFDAIGLPKLAEMSPGGQPWSHEISAIALGVL
Mflv_0188|M.gilvum_PYR-GCK LAVFLGEVDTSGIAAAA----WIGLPDFQAPT------FTLSVLPLFLPA
TH_1201|M.thermoresistible__bu VAAVIEAVWHLGPAAERPGGWGLSVPALDGSP---FALPDLSLIGEFSFA
: :... :
MMAR_4949|M.marinum_M LMITSVESTGSTLATGEIVGKRIKAAQIGNVLRADGLATVIGG-IFNSFP
Mvan_5275|M.vanbaalenii_PYR-1 MMIIAVESTGSTIATGEIVGKRVRPSDIGNVLRADGVATTIGG-IFNSFP
MAB_2932c|M.abscessus_ATCC_199 LMVTAVESTGAVFATAEIVGKRVRGADIAATVRADGIATVIGG-TFNSFP
MSMEG_2570|M.smegmatis_MC2_155 QIVLVVELAGQVNAVGEVVDQEISDRRLAAAVRADGVVTALGGGVFQSFM
Mb3301|M.bovis_AF2122/97 TIALIASVESLLSAVGVDKLHHGPRTDFNREMVGQGSANVVSG-LLGGLP
Rv3273|M.tuberculosis_H37Rv TIALIASVESLLSAVGVDKLHHGPRTDFNREMVGQGSANVVSG-LLGGLP
Mflv_0188|M.gilvum_PYR-GCK VVALVAENIGHVKSVGQMTKRDMDP-LTGRALAADGVATTLAG-FGGGSA
TH_1201|M.thermoresistible__bu GFSRIGVLAATVFVFTLVFANFFDAMGTFTGLSREAGLAGPDG-TFPRLR
. . . : :. *
MMAR_4949|M.marinum_M YTAFSENVGLVRLTRVKSRWVVAAAGVVMIVLG-FLPKVAAVVSAVPSP-
Mvan_5275|M.vanbaalenii_PYR-1 YTAFSENVGLVRLTGVKSRWVVAAAGVIMILLG-FLPKVAAIVASIPNP-
MAB_2932c|M.abscessus_ATCC_199 YTAFSENVGLVRLTGVKSRWVVAAAGVIMMVLG-VLPKTAKIVESIPAP-
MSMEG_2570|M.smegmatis_MC2_155 YVTFAQNVGILTITRMFSRYVTATTGVLLMSLA-FFPVVGEIVAAIPRP-
Mb3301|M.bovis_AF2122/97 ITGVIVRSSANVAAGARTRMSTILHGVWILLFASLFTNLVELIPKAALAG
Rv3273|M.tuberculosis_H37Rv ITGVIVRSSANVAAGARTRMSTILHGVWILLFASLFTNLVELIPKAALAG
Mflv_0188|M.gilvum_PYR-GCK TTTYAENIGVMAATRVYSTAPYWIAALVAILLS-LCPKVGAVIAAIPAG-
TH_1201|M.thermoresistible__bu SALVVEGVGAVAGGAASASSNTVFVESGAGIGEGARTGLANLVTGALFLA
. . : . ::
MMAR_4949|M.marinum_M -------------------VLGGAALTLFATVAVVGIQTLGK--VDFTDH
Mvan_5275|M.vanbaalenii_PYR-1 -------------------VLGGAALTLFATVAVVGIQTLGK--VDFTDH
MAB_2932c|M.abscessus_ATCC_199 -------------------VLGGAAMTLFATVAVVGIQTLGK--VDFNDH
MSMEG_2570|M.smegmatis_MC2_155 -------------------VLGAAAVVMFGTIAVVGIRILGQ--VDFADT
Mb3301|M.bovis_AF2122/97 LLIVIGAQLVKLAHIKLAWRTGNFVIYAITIVCVVFLNLLEG--VAIGLV
Rv3273|M.tuberculosis_H37Rv LLIVIGAQLVKLAHIKLAWRTGNFVIYAITIVCVVFLNLLEG--VAIGLV
Mflv_0188|M.gilvum_PYR-GCK -------------------VLGGATVVLYGLVGIIGIRIWLTNHVDFSKP
TH_1201|M.thermoresistible__bu -----------------AMFVSPLASVVPTEVAAAALVVVGAMMVSHLRH
. . : : *
MMAR_4949|M.marinum_M RNLIIVTTSLALALWVTS-------------------------YPDVAES
Mvan_5275|M.vanbaalenii_PYR-1 RNVIIVTTSLALALLVTS-------------------------YPDISSQ
MAB_2932c|M.abscessus_ATCC_199 RNLIIASTSLAMGMYVQFSQSSGPATVLDHGRG-----IAVPALPGIDQA
MSMEG_2570|M.smegmatis_MC2_155 ANVIIVAAALGVALLPTT-------------------------VSGFYSQ
Mb3301|M.bovis_AF2122/97 VAIVFLLVRVVRAPVEVKPVGGEQSKRWRVDIDGTLSFLLLPRLTTVLSK
Rv3273|M.tuberculosis_H37Rv VAIVFLLVRVVRAPVEVKPVGGEQSKRWRVDIDGTLSFLLLPRLTTVLSK
Mflv_0188|M.gilvum_PYR-GCK VNQMTAAIPLIIGIADFT--------------------------------
TH_1201|M.thermoresistible__bu VDITEFSVALPVVLTVVS--------------------------------
:
MMAR_4949|M.marinum_M MPSGVDLIFGS-GISIGAVAAIVLNIVFFHTGSHGPRVAGGGSITLHEVN
Mvan_5275|M.vanbaalenii_PYR-1 LPAGLDILFGS-GISTGAITAIVLNIVFFHIVKKGPRVAGSGSITLDEVN
MAB_2932c|M.abscessus_ATCC_199 VPGLLQIPFST-GITMGAITAIVLNLLFFHTGSRGVAVAGGGAIRLAQVN
MSMEG_2570|M.smegmatis_MC2_155 FPDAARQLLSS-GVATGICVAVLLNILFHARRPLEVPVSDRLS-------
Mb3301|M.bovis_AF2122/97 LPEGSEVTLNLNADYIDDSVSEAISDWRRAHETRGGVVAIVETSPAKLHH
Rv3273|M.tuberculosis_H37Rv LPEGSEVTLNLNADYIDDSVSEAISDWRRAHETRGGVVAIVETSPAKLHH
Mflv_0188|M.gilvum_PYR-GCK ---WSAGSLTFTGIALGSIAALLIYHGMRLLG-FRPGRERPSTVYADPAG
TH_1201|M.thermoresistible__bu --MPFSYSIAN-GIGIGFISWVVMRSAVGRAREVSPLLWVVAAGFLLYFA
: . . : :
MMAR_4949|M.marinum_M AMTRERFTEVFGHVVQDVPWVIDRAYEHRPFADTAALREAFQD-------
Mvan_5275|M.vanbaalenii_PYR-1 AMTRERFTEVFGHVVQGVSWAADRAFDQRPFADTAALREAFQD-------
MAB_2932c|M.abscessus_ATCC_199 EMTLEQFRRTFGGLVQDVHWVVDRAYRQRPFADAHDLRSAFQE-------
MSMEG_2570|M.smegmatis_MC2_155 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 AHARPPKRHFASDPIGLVPWRSARGKDRGSASVLDRIDEYHRNGAAVLHP
Rv3273|M.tuberculosis_H37Rv AHARPPKRHFASDPIGLVPWRSARGKDRGSASVLDRIDEYHRNGAAVLHP
Mflv_0188|M.gilvum_PYR-GCK PAPEPR--------------------------------------------
TH_1201|M.thermoresistible__bu RGWIEALAGV----------------------------------------
MMAR_4949|M.marinum_M -------------------------AVLTGSSEQQMELLNAFHDLGAED-
Mvan_5275|M.vanbaalenii_PYR-1 -------------------------AVLTGNAEQQQELLDAFHDLGAED-
MAB_2932c|M.abscessus_ATCC_199 -------------------------AMLTGSDEEQLELIGSFPDLGAED-
MSMEG_2570|M.smegmatis_MC2_155 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 HIAGLTDSQDPYELFLTCADSRILPNVITASGPGDLYTVRNLGNLVPTDP
Rv3273|M.tuberculosis_H37Rv HIAGLTDSQDPYELFLTCADSRILPNVITASGPGDLYTVRNLGNLVPTDP
Mflv_0188|M.gilvum_PYR-GCK --------------------------------------------------
TH_1201|M.thermoresistible__bu --------------------------------------------------
MMAR_4949|M.marinum_M -----ETGRALAVDHVSLSNLDERDHNVVVELASAYREHFG------FPL
Mvan_5275|M.vanbaalenii_PYR-1 -----ETGQVLAVDHVALSNLDEEDHQDVVTLAAAYREHFG------FPL
MAB_2932c|M.abscessus_ATCC_199 -----EAGEMVAVDHTILQTLDEAELNNVVSLATAYREHFG------FPL
MSMEG_2570|M.smegmatis_MC2_155 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 DDRSVDAALDFAVNQLGVSSVVVCGHSSCAAMTALLEDDPANTTTPMMRW
Rv3273|M.tuberculosis_H37Rv DDRSVDAALDFAVNQLGVSSVVVCGHSSCAAMTALLEDDPANTTTPMMRW
Mflv_0188|M.gilvum_PYR-GCK --------------------------------------------------
TH_1201|M.thermoresistible__bu --------------------------------------------------
MMAR_4949|M.marinum_M IICARETERFDRVLKNGWSRMDNSPATERAYALIEAAKIANYRFSDLVAD
Mvan_5275|M.vanbaalenii_PYR-1 IICARETERFDRVLRNGWSRMDNSPATEKAYALIEVAKIANYRFTDLVAD
MAB_2932c|M.abscessus_ATCC_199 VVCARETERYERLLRSGWSRMENSATSERSFALIEIAKIANYRFDDLVAD
MSMEG_2570|M.smegmatis_MC2_155 --------------------------------------------------
Mb3301|M.bovis_AF2122/97 LENAHDSLVVFRNHHPARRSAESAGYPEADQLSIVNVAVQVERLTRHPIL
Rv3273|M.tuberculosis_H37Rv LENAHDSLVVFRNHHPARRSAESAGYPEADQLSIVNVAVQVERLTRHPIL
Mflv_0188|M.gilvum_PYR-GCK --------------------------------------------------
TH_1201|M.thermoresistible__bu --------------------------------------------------
MMAR_4949|M.marinum_M ANPIASARLSRLNELH--------------------------------
Mvan_5275|M.vanbaalenii_PYR-1 ANPIAAARFGRLNELS--------------------------------
MAB_2932c|M.abscessus_ATCC_199 ANPITAARFGRFEDFHATR-----------------------------
MSMEG_2570|M.smegmatis_MC2_155 ------------------------------------------------
Mb3301|M.bovis_AF2122/97 ATAVAAADLQVIGIFFDISTARVYEVGPNGIICPDEPADRPVDHESAQ
Rv3273|M.tuberculosis_H37Rv ATAVAAADLQVIGIFFDISTARVYEVGPNGIICPDEPADRPVDHESAQ
Mflv_0188|M.gilvum_PYR-GCK ------------------------------------------------
TH_1201|M.thermoresistible__bu ------------------------------------------------