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LADNLGGEFVGRRILVTGGASGVGEACVGYFLGLGATVACIDVKVPARDDAKFVHLSADLRDRDAVSSAV AEIAERFHGLDTLVNNAGVSFVGTVEDGTEDDWNRLWDINVMGAVRSTRAALPLLRRSDSAAIVNVSSLT ATSGIRQRAAYTATKGAIESMTRAMAADLVSEGITVNAVNPGTVDTPFMAELAARAEDPVQRRADFESRQ PIGRMVTPVEVAHAVAYFAHPLSRSTTGSTLMVDGGIFNLHMTRA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2535 | - | - | 100% (255) | dehydrogenase/reductase SDR family protein member 10 |
| M. smegmatis MC2 155 | MSMEG_2566 | - | 6e-32 | 36.59% (246) | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2477 | - | 6e-32 | 35.18% (253) | cyclopentanol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2025 | fabG3 | 3e-32 | 34.00% (250) | 20-beta-hydroxysteroid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4505 | - | 1e-34 | 36.69% (248) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2002 | fabG3 | 3e-32 | 34.00% (250) | 20-beta-hydroxysteroid dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 2e-23 | 29.71% (239) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4680c | - | 5e-26 | 31.17% (247) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_2981 | fabG3_1 | 2e-32 | 34.80% (250) | 20-beta-hydroxysteroid dehydrogenase FabG3_1 |
| M. avium 104 | MAV_0886 | - | 1e-31 | 35.04% (254) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3912 | - | 9e-31 | 36.97% (238) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0336 | - | 3e-31 | 34.51% (255) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0789 | - | 2e-30 | 34.36% (259) | acetoin reductases |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2535|M.smegmatis_MC2_155 ----------MADNLGGEFVGRRILVTGGASGVGEACVGYFLGLGATVAC
TH_3912|M.thermoresistible__bu -------------------------VTGAARGQGSAIVRRLLQDGYRVAA
Mb2025|M.bovis_AF2122/97 ----------MSGR----LIGKVALVSGGARGMGASHVRAMVAEGAKVVF
Rv2002|M.tuberculosis_H37Rv ----------MSGR----LIGKVALVSGGARGMGASHVRAMVAEGAKVVF
MMAR_2981|M.marinum_M ----------MAGR----LTGKVALVSGGARGMGASHVRALVAEGAHVVL
Mflv_4505|M.gilvum_PYR-GCK ----------MTGR----LAGKVALISGAARGMGASHARVMAGHGAKVVC
MAB_4680c|M.abscessus_ATCC_199 ----------MNGNSA-LLQGKNVIVTGGARGLGAAFSRHIVSQGGRVVI
MAV_0886|M.avium_104 ----------MVNE----LAGKVAIVTGGASGIGRGIVERFVAEGARVVI
MUL_0336|M.ulcerans_Agy99 ----------MVDE----LAGKIAIVTGGASGIGRATVARFIAEGARVVI
Mvan_0789|M.vanbaalenii_PYR-1 ----------MTLN------GKVALVTGAARGIGRGIALRLARDGADIAL
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
::*. * * . : * :.
MSMEG_2535|M.smegmatis_MC2_155 IDVKVPAR-------DDAKFVH--LSADLRDRDAVSSAVAEIAERFHGLD
TH_3912|M.thermoresistible__bu CDVLVDELHGSVADLDGDTVLP--LALDVTSAPQWADAVAATVGRFGALS
Mb2025|M.bovis_AF2122/97 GDILDEEGKAVAAELADAARY---VHLDVTQPAQWTAAVDTAVTAFGGLH
Rv2002|M.tuberculosis_H37Rv GDILDEEGKAVAAELADAARY---VHLDVTQPAQWTAAVDTAVTAFGGLH
MMAR_2981|M.marinum_M GDILDDEGRAVAAELGDAARY---VHLDVTQPEQWTAAVDTAVNEFGGLH
Mflv_4505|M.gilvum_PYR-GCK GDILDSDGEAVAAELGDAARY---VHLDVTSPDDWDRAVAAAVADFGGLD
MAB_4680c|M.abscessus_ATCC_199 ADVLDGDGRQLAAELGDAARF---THLDVTDAEQWRELIDTTLAGFGTIT
MAV_0886|M.avium_104 ADIETERGERLAAELGGEAVF---RRTDVSDIEQVGALVAAAVEKFGGLH
MUL_0336|M.ulcerans_Agy99 ADVEEERGESLAAALGADAMF---CRTDVSQPEQVAAVVAAAVDNFGGLH
Mvan_0789|M.vanbaalenii_PYR-1 VDVLPEGLDGVADKIAGIGGKTTMFVADVSDREQVFAAVDHAAAALGGFD
MLBr_01807|M.leprae_Br4923 THR---------ASVVPDWFFG--VECDVTDNDAIGAAFKAVEEHQGPVE
. *: . . .
MSMEG_2535|M.smegmatis_MC2_155 TLVNNAGVSF--VGTVEDGTEDDWNRLWDINVMGAVRSTRAALPLLRRSD
TH_3912|M.thermoresistible__bu ALINNAGVLH--RAALPDETAEGFERSWRVNCLGPFLGIRAALDPLRHAH
Mb2025|M.bovis_AF2122/97 VLVNNAGILN--IGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAG
Rv2002|M.tuberculosis_H37Rv VLVNNAGILN--IGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAG
MMAR_2981|M.marinum_M VLVNNAGILN--IGTIEDYALSEWQRILDINVTGVFLGIRAAVKPMKEAG
Mflv_4505|M.gilvum_PYR-GCK VLVNNAGILN--IGTVEDYELSEWHRILDVNLTGVFLGIRAATPTMKAAG
MAB_4680c|M.abscessus_ATCC_199 GLVNNAGISS--AAMVADEPLEHFRKVIEINLVGVFIGMQAVIPAMRAHG
MAV_0886|M.avium_104 VMVNNAGISSPLRR-LLDDDLADFHRVMGVNVLGVMAGTRDAARHMADNG
MUL_0336|M.ulcerans_Agy99 VMVNNAGVSGAMHRRFLDDDLADFHRVMAVNVLGVMAGTRDAARHMAAHG
Mvan_0789|M.vanbaalenii_PYR-1 IMVNNAGIAL--VGPISDVTPEQIEKLWAINVNGVLWGTQAAVAKFKELK
MLBr_01807|M.leprae_Br4923 VLVANAGITS--DMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQR
:: ***: . .: :* * . : . :
MSMEG_2535|M.smegmatis_MC2_155 S------AAIVNVSSLTATSGIRQRAAYTATKGAIESMTRAMAADLVSEG
TH_3912|M.thermoresistible__bu N------ASVVNTCSTGALRAFPNHAAYGSSKWALRGLTQIAAAELAAAG
Mb2025|M.bovis_AF2122/97 R------GSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSG
Rv2002|M.tuberculosis_H37Rv R------GSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSG
MMAR_2981|M.marinum_M R------GSIINISSIEGLAGTIASHGYTVSKFAVRGLTKSTALELGPSG
Mflv_4505|M.gilvum_PYR-GCK R------GSIINIASIEGMAGTVGCHGYTATKFAVRGLTKSTALELGPFG
MAB_4680c|M.abscessus_ATCC_199 C------GSIVNISSAAGLVGLALTSGYGASKWGVRGLSKVAAIELGRER
MAV_0886|M.avium_104 G------GAIINLTSIGGIQAGGGVMTYRASKAAVIQFTKAAAIELARYD
MUL_0336|M.ulcerans_Agy99 G------GSIVNLTSIGGIQAGGGVMTYRASKGAVIQFTKSAAIELAHYE
Mvan_0789|M.vanbaalenii_PYR-1 NKDKGRVSRIINASSIAGHDGFAMLGPYSATKFAVRALTQAAAKEHAADG
MLBr_01807|M.leprae_Br4923 F------GRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRS
. : * . . * :* .: ::: * :
MSMEG_2535|M.smegmatis_MC2_155 ITVNAVNPGTVDTPFMAELAARAEDPVQRRAD------FESRQPIGRMVT
TH_3912|M.thermoresistible__bu IRVNAVLPGPVATPML-------DDATQRR--------LAATMAAGRLGR
Mb2025|M.bovis_AF2122/97 IRVNSIHPGLVKTPMTDWV-----PEDIF------------QTALGRAAE
Rv2002|M.tuberculosis_H37Rv IRVNSIHPGLVKTPMTDWV-----PEDIF------------QTALGRAAE
MMAR_2981|M.marinum_M IRVNSIHPGLVKTPMTEWV-----PEDLF------------QTALGRAAE
Mflv_4505|M.gilvum_PYR-GCK IRVNSVHPGLVKTPMADWV-----PEDIF------------QSALGRIAQ
MAB_4680c|M.abscessus_ATCC_199 IRVNSVHPGVIYTPMTAKEGFREGEGNMP------------IAAMGRVGN
MAV_0886|M.avium_104 IRVNAIAPGNIPTPILGKSAGDMDPEQRERFEARIREGMREDRPLKREGT
MUL_0336|M.ulcerans_Agy99 IRVNAIAPGNIPTPLLASSAAGLDQEQVERFTAQIRQTMREDRPLKREGT
Mvan_0789|M.vanbaalenii_PYR-1 ITVNAYCPGVVGTDMWVEIDKRFAELTGAAEG-ETYDKFVGGIALGRAET
MLBr_01807|M.leprae_Br4923 ITANVVAPGFIDTEMTRAMDSKYQEAALQ------------AIPLGRIGA
* .* ** : * : . *
MSMEG_2535|M.smegmatis_MC2_155 PVEVAHAVAYFAHPLSRSTTGSTLMVDGGIFNLHMTRA------------
TH_3912|M.thermoresistible__bu PTEVADAVAFLVSEQASFITGSELVVDGGQS---LTIG------------
Mb2025|M.bovis_AF2122/97 PVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEW
Rv2002|M.tuberculosis_H37Rv PVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEW
MMAR_2981|M.marinum_M PMEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHKDFSAVDVAAQPEW
Mflv_4505|M.gilvum_PYR-GCK PHEVSNLVVYLASDESSYSTGAEFVVDGGTLAGLAHKDFSAVDVDQQPEW
MAB_4680c|M.abscessus_ATCC_199 ADEVAGAVAYLLSDAASYVTGAELAVDGGWTAGPTLTTITGQ--------
MAV_0886|M.avium_104 PDDVAEAALYFATERSRYVTGTVLPVDGGTSAGKAMRSKRQG--------
MUL_0336|M.ulcerans_Agy99 PEDIAEAALYFAGERSRYVTGTVLPVDGGTVAGKVIRRSR----------
Mvan_0789|M.vanbaalenii_PYR-1 PDDVAGFVSYLAGPDADYMTGQSGLIDGGLVYR-----------------
MLBr_01807|M.leprae_Br4923 VEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH----------------
::: . :: : :* :***
MSMEG_2535|M.smegmatis_MC2_155 --
TH_3912|M.thermoresistible__bu --
Mb2025|M.bovis_AF2122/97 VT
Rv2002|M.tuberculosis_H37Rv VT
MMAR_2981|M.marinum_M VT
Mflv_4505|M.gilvum_PYR-GCK IT
MAB_4680c|M.abscessus_ATCC_199 --
MAV_0886|M.avium_104 --
MUL_0336|M.ulcerans_Agy99 --
Mvan_0789|M.vanbaalenii_PYR-1 --
MLBr_01807|M.leprae_Br4923 --