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MTTELVPEQILPKVMTTFGLTAAYVFIICWITGSSVMAAGGWTAIPMWVLGILTFLVPAGMAVVELGNLW PGQGGVYIWATRTMGETWGFIGGYLSWVPVILNAASSPAVVLQLLLLAFHAEIGLTTSIILQLVILWTVI GLALAKLAANQRIMNIVFIVYGVLTLTIFISGLLFAVENGSATPFSWAEATIPNFAVAGFLYGTVLLYLL GVETPYNMGAEFLSVRKSGPKMILWGSTALVAIYLLTTLGTMMALPGDQIDPVTGVIGMLDVAGFPGLME VGAIVLAFIVVVALMTYQVAYSRLIFVSGLERHLPRIFTHLNPRTRNPVTAVLIQGVISSLILVGLYSQS SMANVTVYLQGGLSTVWLLSGFFFLIPVIVARKKYADRYANEQFWRIPGGMVGVWITVIVGSLATVGGIY YSFVTPWIDVPSATWMTWVGCISLGMFGLGLTVYVFGRRSAHKVSQDDALAHLAVFDLTNQDEAQK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2525 | - | - | 100% (486) | amino acid permease superfamily protein |
| M. smegmatis MC2 155 | MSMEG_6735 | - | 2e-17 | 21.94% (433) | amino acid permease, putative |
| M. smegmatis MC2 155 | MSMEG_1069 | - | 1e-15 | 23.89% (473) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2022c | - | 5e-13 | 24.14% (348) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_4126 | - | 0.0 | 94.62% (483) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv1999c | - | 5e-13 | 24.14% (348) | integral membrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0815 | - | 5e-16 | 20.91% (440) | putative amino acid permease |
| M. marinum M | MMAR_3621 | rocE | 1e-10 | 21.52% (474) | cationic amino acid transport integral membrane protein RocE |
| M. avium 104 | MAV_2087 | - | 4e-10 | 22.29% (489) | amino acid transporter |
| M. thermoresistible (build 8) | TH_4382 | - | 6e-11 | 21.54% (469) | PUTATIVE amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_1244 | rocE | 9e-11 | 21.52% (474) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_2217 | - | 0.0 | 93.03% (488) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4126|M.gilvum_PYR-GCK ----------MTQTEPSPSAGRDKLMTTELVPEQILPKVMTTFGLTAAYV
Mvan_2217|M.vanbaalenii_PYR-1 ----------MTQTEPSPNVERDKLMTTELVPEQILPKVMTTFGLTAAYV
MSMEG_2525|M.smegmatis_MC2_155 -------------------------MTTELVPEQILPKVMTTFGLTAAYV
Mb2022c|M.bovis_AF2122/97 -------------MRRPLD----PRDIPDELRRRLGLLDAVVIGLGSMIG
Rv1999c|M.tuberculosis_H37Rv -------------MRRPLD----PRDIPDELRRRLGLLDAVVIGLGSMIG
MMAR_3621|M.marinum_M MPATSIRLREQMLRRRPVGGAPVAEGAAGSLKRSFGTFELTMFGVGSTVG
MUL_1244|M.ulcerans_Agy99 MPATSIRLREQMLRRRPAGGAPVAEGAAGSLKRSFGTFELTMFGVGSTVG
MAV_2087|M.avium_104 ----------------------MAPGTADHLRRGIGTFQLTMFGVGSTIG
TH_4382|M.thermoresistible__bu ------------------MSGTRTEQAQPELRRVLGPGLLLLFIVGDILG
MAB_0815|M.abscessus_ATCC_1997 -------------------MTTSTNTAPSGSGRALNPTLRRVDVFAVLVC
. : .
Mflv_4126|M.gilvum_PYR-GCK FIICWITGSSVMAGGGWTAIPMWVLGILTFLVPAGMAVVELGNLWPGQGG
Mvan_2217|M.vanbaalenii_PYR-1 FIICWITGSSVMAGGGWTAIPMWVLGILTFLIPAGMAVVELGNLWPGQGG
MSMEG_2525|M.smegmatis_MC2_155 FIICWITGSSVMAAGGWTAIPMWVLGILTFLVPAGMAVVELGNLWPGQGG
Mb2022c|M.bovis_AF2122/97 AGIFAALAPAAYAAGSGLLLGLAVAAVVAYCN--AISSARLAARYPASGG
Rv1999c|M.tuberculosis_H37Rv AGIFAALAPAAYAAGSGLLLGLAVAAVVAYCN--AISSARLAARYPASGG
MMAR_3621|M.marinum_M TGIFFVLAEAVPEAGPAVIVSFIIAGVAAGLA--AICYAELASAVPVSGS
MUL_1244|M.ulcerans_Agy99 TGIFFVLAEAVPEAGPAVIVSFIIAGVAAGLA--AICCAELASAVPVSGS
MAV_2087|M.avium_104 TGIFFVMSQAVPEAGPAVIVSFLLAGVAAGLA--AVCYAELASAVPVSGS
TH_4382|M.thermoresistible__bu TGIYALVGDVAGEVGGAAWLPFLIAFLIATVT--AFSYLELVTKYPQAAG
MAB_0815|M.abscessus_ATCC_1997 ALVGVDTLGAVSAYGPQGLLWMALVAVIFFLP-YGLLTAELGSAFPQEGG
: . * : : : : .. .* * ..
Mflv_4126|M.gilvum_PYR-GCK VYIWATRTMG-ETWGFIGGYLSWVPVILNAASSPAVVLQLLLLAFHAELG
Mvan_2217|M.vanbaalenii_PYR-1 VYIWATRTMG-ETWGFIGGYLSWVPVILNAASSPAVVLQFLLLAFHAELG
MSMEG_2525|M.smegmatis_MC2_155 VYIWATRTMG-ETWGFIGGYLSWVPVILNAASSPAVVLQLLLLAFHAEIG
Mb2022c|M.bovis_AF2122/97 TYVYGRMRLG-DFWGYLAGWGFVVGKTASCAAMALTVGFYVWPAQAHAVA
Rv1999c|M.tuberculosis_H37Rv TYVYGRMRLG-DFWGYLAGWGFVVGKTASCAAMALTVGFYVWPAQAHAVA
MMAR_3621|M.marinum_M SYSYAYATLG-EAVAMGVASCLLLEYGVATAAVAVGWSGYVNKLLHNVFG
MUL_1244|M.ulcerans_Agy99 SYSYAYATLG-EAVAMGVASCLLLEYGVATAAVAVGLSGYVNKLLHNVFG
MAV_2087|M.avium_104 SYSYAYTTLG-EVVAMGVAACLLLEYGVATAAVSVNWSGYLNKLLSNVVG
TH_4382|M.thermoresistible__bu AALYVHKAFGIQFVTFLVAFIVMCSGITSASTASRFFAANLEVGLGQEWG
MAB_0815|M.abscessus_ATCC_1997 PYVWTKLAFGKFAAGINQFFYWISNPVWIGGTLCIVAVVTFEEFFFPLPG
: :* .: . .
Mflv_4126|M.gilvum_PYR-GCK LTTSIILQLVILWTVIG---------------LALAKLAANQKIMNVVFV
Mvan_2217|M.vanbaalenii_PYR-1 LTTSIILQLVILWTVIG---------------LALAKLAANQKIMNIVFV
MSMEG_2525|M.smegmatis_MC2_155 LTTSIILQLVILWTVIG---------------LALAKLAANQRIMNIVFI
Mb2022c|M.bovis_AF2122/97 VAVVVALTAVNY---------------------------AGIQKSAWLTR
Rv1999c|M.tuberculosis_H37Rv VAVVVALTAVNY---------------------------AGIQKSAWLTR
MMAR_3621|M.marinum_M FQLPQALSEAPWDERPGEAAGYLNLPAIILIGLCALLLIRGVSESAKVNA
MUL_1244|M.ulcerans_Agy99 FQLPQALSEAPWDERPGEAAGYLNLPAIILIGLCALLLIRGVSESAKVNA
MAV_2087|M.avium_104 FQLPHALSAAPWDAQPG----YVNLPAVMLIGMCALLLIRGASESAKVNA
TH_4382|M.thermoresistible__bu RLGVAGVALLFMALLAMVN-------------------LRGVGESVRLNV
MAB_0815|M.abscessus_ATCC_1997 LWKWVAAAVFVWGSACVIG--------------------ASVRFGRWIFL
. :
Mflv_4126|M.gilvum_PYR-GCK VYGVLTLT---IFISGLMFAVENGSATPFSWAEATIPN------FAVAGF
Mvan_2217|M.vanbaalenii_PYR-1 VYGILTLT---IFVSGLLFAVNNGSATPFSWAEATIPN------FAVAGF
MSMEG_2525|M.smegmatis_MC2_155 VYGVLTLT---IFISGLLFAVENGSATPFSWAEATIPN------FAVAGF
Mb2022c|M.bovis_AF2122/97 SIVAVVLV---VLTAVVVAAYGSGAADPARLDIGVDAH------VWGMLQ
Rv1999c|M.tuberculosis_H37Rv SIVAVVLV---VLTAVVVAAYGSGAADPARLDIGVDAH------VWGMLQ
MMAR_3621|M.marinum_M IMVLIKLG---VLGMFVILALT--AYDTNHLKDFAPFG------VAGVGA
MUL_1244|M.ulcerans_Agy99 IMVLIKLG---VLGMFVILALT--AYDTNHLKDFAPFG------VAGVGA
MAV_2087|M.avium_104 IMVMVKLG---VLVVFGILAFT--AFDMHHLDDFAPFG------VAGVGT
TH_4382|M.thermoresistible__bu LLTIVEISGLLLVIFVGLWAFTGGGADVDFTRVVAFETTTDKSVFLAVSA
MAB_0815|M.abscessus_ATCC_1997 VGAAARIALLGLFIASVIVYAYKNGLQPMHTSDFSWTY-------AGFVA
: :. : .
Mflv_4126|M.gilvum_PYR-GCK LYGTVLLYLLGVETPYNMGAEFLSVRKSGPKMILWGSAALVAIYLLTTLG
Mvan_2217|M.vanbaalenii_PYR-1 LYGTVLLYLLGVETPYNMGAEFLSVRKSGPKMILWGSAALVAIYLLTTLG
MSMEG_2525|M.smegmatis_MC2_155 LYGTVLLYLLGVETPYNMGAEFLSVRKSGPKMILWGSTALVAIYLLTTLG
Mb2022c|M.bovis_AF2122/97 AAGLLFFAFAGYARIATLGEEVRDPARTIPRAIPLALGITLAVYALVAVA
Rv1999c|M.tuberculosis_H37Rv AAGLLFFAFAGYARIATLGEEVRDPARTIPRAIPLALGITLAVYALVAVA
MMAR_3621|M.marinum_M AAGTIFFSFIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFA
MUL_1244|M.ulcerans_Agy99 AAGTIFFSFIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFA
MAV_2087|M.avium_104 AAGTIFFSYIGLDAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVALA
TH_4382|M.thermoresistible__bu ATSLAFFAMVGFEDSVNMAEETRDPVVIFPRALLTGLGIAGAVYVVVAIV
MAB_0815|M.abscessus_ATCC_1997 VIPVIVFNFLGFEVPSNAAEEMVNPQKDVPLTVLRGGLTATLLYGIPVLG
.: * . . * . * : . :* . ..
Mflv_4126|M.gilvum_PYR-GCK TMMALPGDQIDP-----------------VTGVIGMLD-VAGFPGLMEIG
Mvan_2217|M.vanbaalenii_PYR-1 TMMALPGDEIDP-----------------VTGVIGMLD-VAGFPGLMEVC
MSMEG_2525|M.smegmatis_MC2_155 TMMALPGDQIDP-----------------VTGVIGMLD-VAGFPGLMEVG
Mb2022c|M.bovis_AF2122/97 VIAVLGPQRLAR----------------AAAPLSEAMR-VAGVNWLIPVV
Rv1999c|M.tuberculosis_H37Rv VIAVLGPQRLAR----------------AAAPLSEAMR-VAGVNWLIPVV
MMAR_3621|M.marinum_M ALGTQPWQMFAGQ---------------EEAGLATILDNVTHSAWASTVL
MUL_1244|M.ulcerans_Agy99 ALGTQPWQMFAGQ---------------EEAGLATILDNVTHSAWASTVL
MAV_2087|M.avium_104 ALGTQPWQDFGGQ---------------QEAGLATILDHVTHGSWASTIL
TH_4382|M.thermoresistible__bu AVALVPVGTLQA----------------SDVPLVEVVKAGAPGLPIEELL
MAB_0815|M.abscessus_ATCC_1997 ILLVLPKNQLGTVTGFVDACRAVFTVYGGSVAPDGTAELHGLGQAAAQVA
: : . :
Mflv_4126|M.gilvum_PYR-GCK AVVLAFIVIVALMTYQVAYSRLIFVSGLERHLPRIFTHLN----PRTRNP
Mvan_2217|M.vanbaalenii_PYR-1 AIVLAFIIIVALMTYQVAYSRLIFVSGLERHLPRIFTHLN----PRTRNP
MSMEG_2525|M.smegmatis_MC2_155 AIVLAFIVVVALMTYQVAYSRLIFVSGLERHLPRIFTHLN----PRTRNP
Mb2022c|M.bovis_AF2122/97 QIGAAVAALGSLLALILGVSRTTLAMARDRHLPRWLAAVH----PRFKVP
Rv1999c|M.tuberculosis_H37Rv QIGAAVAALGSLLALILGVSRTTLAMARDRHLPRWLAAVH----PRFKVP
MMAR_3621|M.marinum_M AMGAVISIFTVTLVTMYGQTRILFAMGRDGLLPARFAAVH----PRFQTP
MUL_1244|M.ulcerans_Agy99 AMGAVISIFTVTLVTMYGQTRILFAMGRDGLLPARFAAVH----PRFQTP
MAV_2087|M.avium_104 AAGAVISIFSVTLVTMYGITRILFAMGRDGLLPPRFARVN----PRTMTP
TH_4382|M.thermoresistible__bu PWISMFAVSNTALINMLMASRLIYGMARQRVLPPVLGSVH----PRRRTP
MAB_0815|M.abscessus_ATCC_1997 AAGLIIGLFTSGTAWAMGVSRAQAVAFTDGAGPAWLGKFSGNGSPARVNI
. :* : * : . *
Mflv_4126|M.gilvum_PYR-GCK VTAILIQGVISSLILVGLYSQSSMANVTVYLQGGLSTVWLLSGFFFLIPV
Mvan_2217|M.vanbaalenii_PYR-1 VTAILIQGVISSLILVGLYSQSSMANVTIYLQGGLSTVWLLSGFFFLIPV
MSMEG_2525|M.smegmatis_MC2_155 VTAVLIQGVISSLILVGLYSQSSMANVTVYLQGGLSTVWLLSGFFFLIPV
Mb2022c|M.bovis_AF2122/97 FRAELVVGAVVAALAA-----------TADIRGAIGFSSFGVLVYYAIAN
Rv1999c|M.tuberculosis_H37Rv FRAELVVGAVVAALAA-----------TADIRGAIGFSSFGVLVYYAIAN
MMAR_3621|M.marinum_M VSNTVVVAIAAAVLAA-----------LVPLNRLADMVSIGTLTAFIVVS
MUL_1244|M.ulcerans_Agy99 VSNTVVVAIAAAVLAA-----------LVPLNRLADMVSIGTLTAFIVVS
MAV_2087|M.avium_104 VNNTVIVAVAAATLAA-----------FIPLQNLADMVSIGTLTAFVVVS
TH_4382|M.thermoresistible__bu WVAIIFTTLIAFGLIFYVT----AFADSTAIAVLGGTTSLLLLAVFAMVN
MAB_0815|M.abscessus_ATCC_1997 MSAVVSTIVMAAAMIFAHG------NAEKYFSAAIGLVVSATAISYILTF
: : : . : :
Mflv_4126|M.gilvum_PYR-GCK VVARKKYADRYESEQFWRIPGGMAGVWTTVVVGSLATAGGIYYSFVTPWI
Mvan_2217|M.vanbaalenii_PYR-1 VVARKKYADRYASEQFWRIPGGMAGVWTAVIVGSLGTVGGIYYSFVTPWI
MSMEG_2525|M.smegmatis_MC2_155 IVARKKYADRYANEQFWRIPGGMVGVWITVIVGSLATVGGIYYSFVTPWI
Mb2022c|M.bovis_AF2122/97 ASALTLGLDEGRPRR---------------LIPLVGLIGCVVLAFALPLS
Rv1999c|M.tuberculosis_H37Rv ASALTLGLDEGRPRR---------------LIPLVGLIGCVVLAFALPLS
MMAR_3621|M.marinum_M VGVIILRVREPALPRGFWVPG-------YPVTPILSILACGYLLYSLHWY
MUL_1244|M.ulcerans_Agy99 VGVIILRVREPALPRGFWVPG-------YPVTPILSILACGYLLYSLHWY
MAV_2087|M.avium_104 VGVIVLRVREPDLPRGFRVPG-------YPVTPVLSIMACGYILASLHWY
TH_4382|M.thermoresistible__bu VAVLVLRRDESRDPVVARRHFR-----TPTFLPVVGFVASLYLVTPLSGR
MAB_0815|M.abscessus_ATCC_1997 SSFIRLRHKYPHTRRPFQVFGGRIG---GWIVTVLTVGTMLFTVVSLFWP
. :
Mflv_4126|M.gilvum_PYR-GCK DV--------------------------PSSTWMTWVGSISLGMFALGLT
Mvan_2217|M.vanbaalenii_PYR-1 DV--------------------------PTATWMTWVGGISLGMFALGLT
MSMEG_2525|M.smegmatis_MC2_155 DV--------------------------PSATWMTWVGCISLGMFGLGLT
Mb2022c|M.bovis_AF2122/97 -------------------------------SVAAGAAVLGVGVAAYGVR
Rv1999c|M.tuberculosis_H37Rv -------------------------------SVAAGAAVLGVGVAAYGVR
MMAR_3621|M.marinum_M -------------------------------TWIAFGGWVGIALIFYLFW
MUL_1244|M.ulcerans_Agy99 -------------------------------TWIAFGGWVGIALIFYLFW
MAV_2087|M.avium_104 -------------------------------TWIAFSGWVLLALIFYFVW
TH_4382|M.thermoresistible__bu ----------------------------PAQQYLLSVVLIVIGVLLFGVT
MAB_0815|M.abscessus_ATCC_1997 GVGVGWTGSGDDADALLPKGFEGHRLEYTLSQLVPMAAVLGMASCLYLLG
: :. .
Mflv_4126|M.gilvum_PYR-GCK VYIFGRRSAHKVSQEDSLAHLAVFDLTNKE-EEPTK
Mvan_2217|M.vanbaalenii_PYR-1 VYVFGRRSAHKVSQEDSLAHLAVFDLNKTETEESAK
MSMEG_2525|M.smegmatis_MC2_155 VYVFGRRSAHKVSQDDALAHLAVFDLTNQD--EAQK
Mb2022c|M.bovis_AF2122/97 RIITRRARQTDSGDTQRSGHPSAT------------
Rv1999c|M.tuberculosis_H37Rv RIITRRARQTDSGDTQRSGHPSAT------------
MMAR_3621|M.marinum_M GRHHSRLNAPALHDNPTGEER---------------
MUL_1244|M.ulcerans_Agy99 GRHHSRLNAPALHDNPTGEER---------------
MAV_2087|M.avium_104 GRHHSALNDAAVD--PSGQER---------------
TH_4382|M.thermoresistible__bu MAINRQLGIPTRAVGDPAKMVLPPD-----------
MAB_0815|M.abscessus_ATCC_1997 VFGKRPTAARRDMSSPQDGVPGITNEKESIGA----