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TQTEPSPSAGRDKLMTTELVPEQILPKVMTTFGLTAAYVFIICWITGSSVMAGGGWTAIPMWVLGILTFL VPAGMAVVELGNLWPGQGGVYIWATRTMGETWGFIGGYLSWVPVILNAASSPAVVLQLLLLAFHAELGLT TSIILQLVILWTVIGLALAKLAANQKIMNVVFVVYGVLTLTIFISGLMFAVENGSATPFSWAEATIPNFA VAGFLYGTVLLYLLGVETPYNMGAEFLSVRKSGPKMILWGSAALVAIYLLTTLGTMMALPGDQIDPVTGV IGMLDVAGFPGLMEIGAVVLAFIVIVALMTYQVAYSRLIFVSGLERHLPRIFTHLNPRTRNPVTAILIQG VISSLILVGLYSQSSMANVTVYLQGGLSTVWLLSGFFFLIPVVVARKKYADRYESEQFWRIPGGMAGVWT TVVVGSLATAGGIYYSFVTPWIDVPSSTWMTWVGSISLGMFALGLTVYIFGRRSAHKVSQEDSLAHLAVF DLTNKEEEPTK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4126 | - | - | 100% (502) | amino acid permease-associated region |
| M. gilvum PYR-GCK | Mflv_0800 | - | 9e-18 | 22.75% (501) | amino acid permease-associated region |
| M. gilvum PYR-GCK | Mflv_4427 | - | 1e-13 | 24.78% (460) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2022c | - | 9e-13 | 23.93% (351) | integral membrane protein |
| M. tuberculosis H37Rv | Rv1999c | - | 9e-13 | 23.93% (351) | integral membrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0815 | - | 1e-14 | 21.35% (431) | putative amino acid permease |
| M. marinum M | MMAR_0665 | - | 4e-10 | 22.93% (410) | ethanolamine transporter |
| M. avium 104 | MAV_2087 | - | 7e-10 | 21.87% (471) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_2525 | - | 0.0 | 94.62% (483) | amino acid permease superfamily protein |
| M. thermoresistible (build 8) | TH_4382 | - | 5e-12 | 22.01% (468) | PUTATIVE amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_4508 | gabP_1 | 3e-10 | 23.02% (378) | GabA permease GabP_1 |
| M. vanbaalenii PYR-1 | Mvan_2217 | - | 0.0 | 94.19% (499) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4126|M.gilvum_PYR-GCK MTQTEPSPSAGRDKLMTTELVPEQILPKVMT------TFGLTAAYVFIIC
MSMEG_2525|M.smegmatis_MC2_155 ---------------MTTELVPEQILPKVMT------TFGLTAAYVFIIC
Mvan_2217|M.vanbaalenii_PYR-1 MTQTEPSPNVERDKLMTTELVPEQILPKVMT------TFGLTAAYVFIIC
Mb2022c|M.bovis_AF2122/97 ---------------MRRPLDPRDIPDELRR------RLGLLDAVVIGLG
Rv1999c|M.tuberculosis_H37Rv ---------------MRRPLDPRDIPDELRR------RLGLLDAVVIGLG
TH_4382|M.thermoresistible__bu ----------------MSGTRTEQAQPELRR------VLGPGLLLLFIVG
MAV_2087|M.avium_104 --------------------MAPGTADHLRR------GIGTFQLTMFGVG
MUL_4508|M.ulcerans_Agy99 -----------------MAGADTEHEIALGK------GLRQRHLSLIALG
MMAR_0665|M.marinum_M -MAGDHEVAHLAGGHLAGTDSHLESPTYLQKRQLRTGSAGWLLLAGLGVS
MAB_0815|M.abscessus_ATCC_1997 -------------MTTSTNTAPSGSGRALNP------TLRRVDVFAVLVC
: . :
Mflv_4126|M.gilvum_PYR-GCK WITGS---SVMAGGGWTAIPMWVLGILTFLVPAG---MAVVELGNLWPGQ
MSMEG_2525|M.smegmatis_MC2_155 WITGS---SVMAAGGWTAIPMWVLGILTFLVPAG---MAVVELGNLWPGQ
Mvan_2217|M.vanbaalenii_PYR-1 WITGS---SVMAGGGWTAIPMWVLGILTFLIPAG---MAVVELGNLWPGQ
Mb2022c|M.bovis_AF2122/97 SMIGAGIFAALAPAAYAAGSGLLLGLAVAAVVAYCNAISSARLAARYPAS
Rv1999c|M.tuberculosis_H37Rv SMIGAGIFAALAPAAYAAGSGLLLGLAVAAVVAYCNAISSARLAARYPAS
TH_4382|M.thermoresistible__bu DILGTGIYALVGDVAGEVGGAAWLPFLIAFLIATVTAFSYLELVTKYPQA
MAV_2087|M.avium_104 STIGTGIFFVMSQAVPEAGPAVIVSFLLAGVAAGLAAVCYAELASAVPVS
MUL_4508|M.ulcerans_Agy99 GVIGAGLFVGSGVVIAGTGPAAVISFLIAGLITMLIMRMLAEMAASQPVV
MMAR_0665|M.marinum_M YVISGDYSGWNFGLARGGFGGLAIAAVVIAAMYLALVLSMAELSSALPAA
MAB_0815|M.abscessus_ATCC_1997 ALVGVDTLGAVSAYGPQGLLWMALVAVIFFLPYG---LLTAELGSAFPQE
. : .: *
Mflv_4126|M.gilvum_PYR-GCK GGVYIWATRTMG-ETWGFIGGYLSWVPVILNAASSPAVV-----LQLLLL
MSMEG_2525|M.smegmatis_MC2_155 GGVYIWATRTMG-ETWGFIGGYLSWVPVILNAASSPAVV-----LQLLLL
Mvan_2217|M.vanbaalenii_PYR-1 GGVYIWATRTMG-ETWGFIGGYLSWVPVILNAASSPAVV-----LQFLLL
Mb2022c|M.bovis_AF2122/97 GGTYVYGRMRLG-DFWGYLAG---WGFVVGKTASCAAMA-----LTVGFY
Rv1999c|M.tuberculosis_H37Rv GGTYVYGRMRLG-DFWGYLAG---WGFVVGKTASCAAMA-----LTVGFY
TH_4382|M.thermoresistible__bu AGAALYVHKAFGIQFVTFLVAFIVMCSGITSASTASRFF-----AANLEV
MAV_2087|M.avium_104 GSSYSYAYTTLGEVVAMGVAACLLLEYGVATAAVSVNWSGYLNKLLSNVV
MUL_4508|M.ulcerans_Agy99 GSFYVYARQALG-PRGGFVTGWMYWYFFVVVVAVETVAGG---RILQLWV
MMAR_0665|M.marinum_M GGGYTFARRALG-PWGGFATGTAVLIEYSIAPAAIATFIG-------AYV
MAB_0815|M.abscessus_ATCC_1997 GGPYVWTKLAFG----KFAAGINQFFYWISNPVWIGGTLC------IVAV
.. : :* .
Mflv_4126|M.gilvum_PYR-GCK AFHAELGLTTSIILQLVILWTVIGLALAKLAANQKIMNVVFVVYGVLTLT
MSMEG_2525|M.smegmatis_MC2_155 AFHAEIGLTTSIILQLVILWTVIGLALAKLAANQRIMNIVFIVYGVLTLT
Mvan_2217|M.vanbaalenii_PYR-1 AFHAELGLTTSIILQLVILWTVIGLALAKLAANQKIMNIVFVVYGILTLT
Mb2022c|M.bovis_AF2122/97 VWPAQAHAVAVAVVVALTAVNYAGIQKSAWLT-RSIVAVVLVVLTAVVVA
Rv1999c|M.tuberculosis_H37Rv VWPAQAHAVAVAVVVALTAVNYAGIQKSAWLT-RSIVAVVLVVLTAVVVA
TH_4382|M.thermoresistible__bu GLGQEWGRLGVAGVALLFMALLAMVNLRGVGESVRLNVLLTIVEISGLLL
MAV_2087|M.avium_104 GFQLPHALSAAPWDAQPGYVNLPAVMLIGMCALLLIRGASESAKVNAIMV
MUL_4508|M.ulcerans_Agy99 PQIPLWVLSLGLLLALTATNLVSARSFGEFEYWFSSIKVIAVVVFLGLGL
MMAR_0665|M.marinum_M QSLGLFGIRNGWWVYLTIYALFIGIHLSGVGEALKVMFIITGVALVGLVV
MAB_0815|M.abscessus_ATCC_1997 VTFEEFFFPLPGLWKWVAAAVFVWGSACVIGASVRFGRWIFLVGAAARIA
.
Mflv_4126|M.gilvum_PYR-GCK IFISGLMFAVENGSATPFSWAEATIPN-----FAVAGFLYGTVLLYLLGV
MSMEG_2525|M.smegmatis_MC2_155 IFISGLLFAVENGSATPFSWAEATIPN-----FAVAGFLYGTVLLYLLGV
Mvan_2217|M.vanbaalenii_PYR-1 IFVSGLLFAVNNGSATPFSWAEATIPN-----FAVAGFLYGTVLLYLLGV
Mb2022c|M.bovis_AF2122/97 AYGS--------GAADPARLDIGVDAH-----VWGMLQAAGLLFFAFAGY
Rv1999c|M.tuberculosis_H37Rv AYGS--------GAADPARLDIGVDAH-----VWGMLQAAGLLFFAFAGY
TH_4382|M.thermoresistible__bu VIFVGLWAFTGGGADVDFTRVVAFETTTDKSVFLAVSAATSLAFFAMVGF
MAV_2087|M.avium_104 MVKLGVLVVFGILAFTAFDMHHLDDFAPFG--VAGVGTAAGTIFFSYIGL
MUL_4508|M.ulcerans_Agy99 LWTMGLWPSATPGLGKLVDFGGFAPLG-----WGAVLAAVVPCVAFYTGA
MMAR_0665|M.marinum_M FAIAAVGHFRLANLVDITPSDAVGASAFLPHGYLGVWSALPFAIWFFLAV
MAB_0815|M.abscessus_ATCC_1997 LLGLFIASVIVYAYKNGLQPMHTSDFS---WTYAGFVAVIPVIVFNFLGF
. .
Mflv_4126|M.gilvum_PYR-GCK ETPYNMGAEFLSVRKSGPKMILWGSAALVAIYLLTTLGTMMALPGDQIDP
MSMEG_2525|M.smegmatis_MC2_155 ETPYNMGAEFLSVRKSGPKMILWGSTALVAIYLLTTLGTMMALPGDQIDP
Mvan_2217|M.vanbaalenii_PYR-1 ETPYNMGAEFLSVRKSGPKMILWGSAALVAIYLLTTLGTMMALPGDEIDP
Mb2022c|M.bovis_AF2122/97 ARIATLGEEVRDPARTIPRAIPLALGITLAVYALVAVAVIAVLGPQRLAR
Rv1999c|M.tuberculosis_H37Rv ARIATLGEEVRDPARTIPRAIPLALGITLAVYALVAVAVIAVLGPQRLAR
TH_4382|M.thermoresistible__bu EDSVNMAEETRDPVVIFPRALLTGLGIAGAVYVVVAIVAVALVPVGTLQA
MAV_2087|M.avium_104 DAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALGTQPWQDFGG
MUL_4508|M.ulcerans_Agy99 EIVTVAAAESAEPEGSVSRAMKSIVARIIAFYVGSILVVVAVVPWNTKSV
MMAR_0665|M.marinum_M EGVPLAAEETADPARNVPRGITAAFSVLVLTCAAVLLLATGAGGAAAMSS
MAB_0815|M.abscessus_ATCC_1997 EVPSNAAEEMVNPQKDVPLTVLRGGLTATLLYGIPVLGILLVLPKNQLGT
. * . . : :
Mflv_4126|M.gilvum_PYR-GCK ----------------VTG-VIGMLDVAGFPG-LMEIGAVVLAFIVIVAL
MSMEG_2525|M.smegmatis_MC2_155 ----------------VTG-VIGMLDVAGFPG-LMEVGAIVLAFIVVVAL
Mvan_2217|M.vanbaalenii_PYR-1 ----------------VTG-VIGMLDVAGFPG-LMEVCAIVLAFIIIVAL
Mb2022c|M.bovis_AF2122/97 ----------------AAAPLSEAMRVAGVNW-LIPVVQIGAAVAALGSL
Rv1999c|M.tuberculosis_H37Rv ----------------AAAPLSEAMRVAGVNW-LIPVVQIGAAVAALGSL
TH_4382|M.thermoresistible__bu ----------------SDVPLVEVVKAGAPGLPIEELLPWISMFAVSNTA
MAV_2087|M.avium_104 Q---------------QEAGLATILDHVTHGSWASTILAAGAVISIFSVT
MUL_4508|M.ulcerans_Agy99 ----------------GVSPYASALAVIGIPG-VTTVMNAIVLTAVLSCL
MMAR_0665|M.marinum_M ----------------SGNPLVAALGPTVAAT----VVNYIGLAGLVASF
MAB_0815|M.abscessus_ATCC_1997 VTGFVDACRAVFTVYGGSVAPDGTAELHGLGQAAAQVAAAGLIIGLFTSG
:
Mflv_4126|M.gilvum_PYR-GCK MTYQVAYSRLIFVSGLERHLPRIFTHLNPRTRNPVTAILIQGVISSLILV
MSMEG_2525|M.smegmatis_MC2_155 MTYQVAYSRLIFVSGLERHLPRIFTHLNPRTRNPVTAVLIQGVISSLILV
Mvan_2217|M.vanbaalenii_PYR-1 MTYQVAYSRLIFVSGLERHLPRIFTHLNPRTRNPVTAILIQGVISSLILV
Mb2022c|M.bovis_AF2122/97 LALILGVSRTTLAMARDRHLPRWLAAVHPRFKVPFRAELVVGAVVAALAA
Rv1999c|M.tuberculosis_H37Rv LALILGVSRTTLAMARDRHLPRWLAAVHPRFKVPFRAELVVGAVVAALAA
TH_4382|M.thermoresistible__bu LINMLMASRLIYGMARQRVLPPVLGSVHPRRRTPWVAIIFTTLIAFGLIF
MAV_2087|M.avium_104 LVTMYGITRILFAMGRDGLLPPRFARVNPRTMTPVNNTVIVAVAAATLAA
MUL_4508|M.ulcerans_Agy99 NSALYTTSRMAFALTIHGDGPRFFTKLS-RSGVPRRAIILGTTVGYASVV
MMAR_0665|M.marinum_M FSIIYAYSRQLFALSRAGYLPTALSITN-SRKAPTLALIVPGVIGFALSV
MAB_0815|M.abscessus_ATCC_1997 TAWAMGVSRAQAVAFTDGAGPAWLGKFS-GNGSPARVNIMSAVVSTIVMA
:* * : * :.
Mflv_4126|M.gilvum_PYR-GCK GLY---SQSSMANVTVYLQGGLSTVWLLSGFFFLIPVVVARKKYADRYES
MSMEG_2525|M.smegmatis_MC2_155 GLY---SQSSMANVTVYLQGGLSTVWLLSGFFFLIPVIVARKKYADRYAN
Mvan_2217|M.vanbaalenii_PYR-1 GLY---SQSSMANVTIYLQGGLSTVWLLSGFFFLIPVVVARKKYADRYAS
Mb2022c|M.bovis_AF2122/97 TAD---IRGAIG---------------FSSFGVLVYYAIANAS-------
Rv1999c|M.tuberculosis_H37Rv TAD---IRGAIG---------------FSSFGVLVYYAIANAS-------
TH_4382|M.thermoresistible__bu YVT---AFADSTAIAVLGG--------TTSLLLLAVFAMVNVAVLVLRRD
MAV_2087|M.avium_104 FIP---LQNLAD---------------MVSIGTLTAFVVVSVG-------
MUL_4508|M.ulcerans_Agy99 ATY---VWGDVVFEFL-----------VNSYGAVALFVYLIIAISQVILR
MMAR_0665|M.marinum_M TGEGDLLLN------------------MAVFGATLSYVLMMIS-------
MAB_0815|M.abscessus_ATCC_1997 AAMIFAHGNAEKYFSAAIG--------LVVSATAISYILTFSSFIRLRHK
Mflv_4126|M.gilvum_PYR-GCK EQFWRIPGGMAGVWTTVVVGSLATAGGIYYSFVTPWID------------
MSMEG_2525|M.smegmatis_MC2_155 EQFWRIPGGMVGVWITVIVGSLATVGGIYYSFVTPWID------------
Mvan_2217|M.vanbaalenii_PYR-1 EQFWRIPGGMAGVWTAVIVGSLGTVGGIYYSFVTPWID------------
Mb2022c|M.bovis_AF2122/97 ----ALTLGLDEGRPRRLIPLVGLIGCVVLAFALPLSS------------
Rv1999c|M.tuberculosis_H37Rv ----ALTLGLDEGRPRRLIPLVGLIGCVVLAFALPLSS------------
TH_4382|M.thermoresistible__bu ES-RDPVVARRHFRTPTFLPVVGFVASLYL--VTPLSG------------
MAV_2087|M.avium_104 ----VIVLRVREPDLPRGFRVPGYPVTPVLSIMACGYI------------
MUL_4508|M.ulcerans_Agy99 RRAEREDPGGLRLKMWLFPWLSYATIALMASVILAMAA------------
MMAR_0665|M.marinum_M ----HIVLRRRAADMARPYRTPGGIATSGFALLVAATA------------
MAB_0815|M.abscessus_ATCC_1997 YPHTRRPFQVFGGRIGGWIVTVLTVGTMLFTVVSLFWPGVGVGWTGSGDD
Mflv_4126|M.gilvum_PYR-GCK ---------------VPSSTWMTWVGSISLGMFALGLTVYIFGRRSAHKV
MSMEG_2525|M.smegmatis_MC2_155 ---------------VPSATWMTWVGCISLGMFGLGLTVYVFGRRSAHKV
Mvan_2217|M.vanbaalenii_PYR-1 ---------------VPTATWMTWVGGISLGMFALGLTVYVFGRRSAHKV
Mb2022c|M.bovis_AF2122/97 ---------------VAAG-----AAVLGVGVAAYGVRRIITRRARQTDS
Rv1999c|M.tuberculosis_H37Rv ---------------VAAG-----AAVLGVGVAAYGVRRIITRRARQTDS
TH_4382|M.thermoresistible__bu ---------------RPAQQYLLSVVLIVIGVLLFGVTMAINRQLGIPTR
MAV_2087|M.avium_104 ---------------LASLHWYTWIAFSGWVLLALIFYFVWGRHHSALND
MUL_4508|M.ulcerans_Agy99 ---------------LSATRSRFLMSGVTLVLILATYEVRRRRRVAVARN
MMAR_0665|M.marinum_M ---------------LIATFLVDTVAALCCLGVFCAFILYFALYSRHQLV
MAB_0815|M.abscessus_ATCC_1997 ADALLPKGFEGHRLEYTLSQLVPMAAVLGMASCLYLLGVFGKRPTAARRD
Mflv_4126|M.gilvum_PYR-GCK SQEDSLAHLAVFDLTNKEEEPTK-
MSMEG_2525|M.smegmatis_MC2_155 SQDDALAHLAVFDLTNQDEAQK--
Mvan_2217|M.vanbaalenii_PYR-1 SQEDSLAHLAVFDLNKTETEESAK
Mb2022c|M.bovis_AF2122/97 GDTQRSGHPSAT------------
Rv1999c|M.tuberculosis_H37Rv GDTQRSGHPSAT------------
TH_4382|M.thermoresistible__bu AVGDPAKMVLPPD-----------
MAV_2087|M.avium_104 AAVDPSGQER--------------
MUL_4508|M.ulcerans_Agy99 ATVAARAFQPGVPMPACAQRCG--
MMAR_0665|M.marinum_M ANSPDEELAGSQDFESELQ-----
MAB_0815|M.abscessus_ATCC_1997 MSSPQDGVPGITNEKESIGA----