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VSVPESSSGDSQTLRREFSLWSAFAFAFAFISPIVALYGIFGLALSAAGPSFWWGFGLVFAGQFLVALVF AMLVSRWPLEGSIYQWSRRLLGTTYGWFAGWVYMWTLVIAMATVALGAAGFVANIAGLEEPSGGTLALIA LVILLAGTAVNLAGRQALKIFMAASIAAEVIGSVVLGTWLLLFHRENSLSVLFSGGGVDVDMWSYLSGPF LLAVAFIGWSFVGFESAGSIAEEVHEPRKYLPKAVLFSLTFIALVVGYSSLAIILAIPDLDAVAEGAVAD PVYDTLTNALGHGVAKPVEVMFVIGFLASFLALQTSASRVIWAYARDGALPAASALGRLRGPARIPTVAI LVTTVIGACLFLLSIVAGDIYSLMVNFTAGGFYLAFLFPLVGFLVVLLRRTWTPATFSLKGFTLPVALVA VVWASLQFLNIAWPRAAFDQRWLDWSVWIGVAALAVLGTAILASVRSHITGTAVVEEAELRDELADRS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1069 | - | - | 100% (488) | amino acid permease-associated region |
| M. smegmatis MC2 155 | MSMEG_4377 | - | e-150 | 56.65% (466) | amino acid permease family protein, putative |
| M. smegmatis MC2 155 | MSMEG_6735 | - | e-106 | 42.92% (466) | amino acid permease, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3281c | - | 3e-27 | 25.93% (486) | cationic amino acid transport integral membrane protein |
| M. gilvum PYR-GCK | Mflv_0800 | - | 0.0 | 84.47% (470) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv3253c | - | 3e-27 | 25.93% (486) | cationic amino acid transport integral membrane protein |
| M. leprae Br4923 | MLBr_01305 | ansP2 | 6e-16 | 23.08% (442) | putative L-asparagine permease |
| M. abscessus ATCC 19977 | MAB_4090 | - | 1e-49 | 30.25% (486) | putative amino-acid permease |
| M. marinum M | MMAR_2243 | - | 3e-27 | 26.05% (430) | cationic amino acid transport integral membrane protein |
| M. avium 104 | MAV_4216 | - | 8e-29 | 25.90% (498) | cationic amino acid transporter |
| M. thermoresistible (build 8) | TH_0471 | - | 1e-22 | 24.52% (469) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_2597 | - | 3e-24 | 26.08% (464) | cationic amino acid transport integral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_0043 | - | 0.0 | 81.99% (483) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3281c|M.bovis_AF2122/97 -----MAGRRRMKSVEQSIADTD-----EPTTRLRKDLTWWDLVVFGVSV
Rv3253c|M.tuberculosis_H37Rv -----MAGRRRMKSVEQSIADTD-----EPTTRLRKDLTWWDLVVFGVSV
MUL_2597|M.ulcerans_Agy99 -----MAGGLRTKSVEQSIADTD-----EPETRLRKDLTWRDLVVFGVSV
MAV_4216|M.avium_104 -----MASRWRTKSVEQSIADTD-----EPDTRLRKDLTWWDLVVFGVAV
TH_0471|M.thermoresistible__bu -----MTDRLRVKSVEQSIADTD-----EPDSRLRKDLSWWDLTVFGVSV
Mflv_0800|M.gilvum_PYR-GCK ---------------MSSLVSPA-----EQQPQLRREFSLGSAFAFAFAF
Mvan_0043|M.vanbaalenii_PYR-1 ---------------MSISVSPA-----EQPPQLRREFSLGSAFAFAFAF
MSMEG_1069|M.smegmatis_MC2_155 ---------------MSVPESSS-----GDSQTLRREFSLWSAFAFAFAF
MAB_4090|M.abscessus_ATCC_1997 MNASTATGTAAPSAAISAASDSDDLAAFGYKPQLHRSLGKFASFAAGFSF
MMAR_2243|M.marinum_M -----------------MSQPTG-------EPRLRRALGVAGLVAFGLAY
MLBr_01305|M.leprae_Br4923 -----MATLAESPEPKSGASRAG---VLGEEAGYHKGLKPRQLQMIGIGG
. :: : ...
Mb3281c|M.bovis_AF2122/97 VIGAGIFTVTASTAGDITGPAIWISFLIAAATCALAALCYAEFASTLPVA
Rv3253c|M.tuberculosis_H37Rv VIGAGIFTVTASTAGDITGPAIWISFLIAAATCALAALCYAEFASTLPVA
MUL_2597|M.ulcerans_Agy99 VIGAGIFTVTASTAGDITGPAIWISFLIAAGTCALAALCYAEFASTLPVA
MAV_4216|M.avium_104 VIGAGIFTVTASTTGDITGPAIWVSFVIAAGTCALAALCYAEFASTLPVA
TH_0471|M.thermoresistible__bu VIGAGIFTVTASTAGNITGPAISVSFIIAAIACGLAALCYAEFASTVPVA
Mflv_0800|M.gilvum_PYR-GCK ISPIVALYGIFGLALSAAGPSFWWGFGLVFAGQFLVALVFATLVSRWPLE
Mvan_0043|M.vanbaalenii_PYR-1 ISPIVALYGIFGLALSAAGPSFWWGFALVFAGQFLVALVFAALVSRWPLE
MSMEG_1069|M.smegmatis_MC2_155 ISPIVALYGIFGLALSAAGPSFWWGFGLVFAGQFLVALVFAMLVSRWPLE
MAB_4090|M.abscessus_ATCC_1997 VSILTTIFQLFAFGFSFGGPAFFWTWPIVFLGQYMVALNFAELAARYPIS
MMAR_2243|M.marinum_M IDPLAMFDTFGVVSQTTHG-HVPTAYVVTFVAMLFTAASYAVLVHAYPSA
MLBr_01305|M.leprae_Br4923 AIGTGLFLGAGG-RLAKAGPGLFLVYAVCGVFVFLILRALGELVLHRPSS
: * . : : : . :. *
Mb3281c|M.bovis_AF2122/97 GSAYTFSYATFGEFLAWVIGWNLVLELAMGAAVVAKGWSSYLG--TVFG-
Rv3253c|M.tuberculosis_H37Rv GSAYTFSYATFGEFLAWVIGWNLVLELAMGAAVVAKGWSSYLG--TVFG-
MUL_2597|M.ulcerans_Agy99 GSAYTFSYATFGEFLAWVIGWNLVLELAIGAAVVAKGWSSYLG--TVFG-
MAV_4216|M.avium_104 GSAYTFSYATFGEFLAWIIGWNLLLELAIGAAVVAKGWSSYLG--TVFG-
TH_0471|M.thermoresistible__bu GSAYTFSYATFGEFVAWIIGWDLILEFSVAAAVVAKGWSSYLG--EVFE-
Mflv_0800|M.gilvum_PYR-GCK GSIYQWSRRLLGTAYGWFAGWVYMWTLVIAMATVALGAAGFTA--NIVG-
Mvan_0043|M.vanbaalenii_PYR-1 GSIYQWSRRLLGSTYGWFAGWVYMWTLVIAMATVALGAAGFVA--HIVG-
MSMEG_1069|M.smegmatis_MC2_155 GSIYQWSRRLLGTTYGWFAGWVYMWTLVIAMATVALGAAGFVA--NIAG-
MAB_4090|M.abscessus_ATCC_1997 GAIYQWARRLGGAAVGWFAGWFMIIAQIVTASAAAIALQVVLP--TVWSG
MMAR_2243|M.marinum_M GSAYTFARRSFGGNVGFLTGWALMLDYLLLPLVNYLLIGIYLN--AQFP-
MLBr_01305|M.leprae_Br4923 GSFVSYAREFFGEKAAYVVGWLYFLDWAMTAIVDTTAIATYLHRWTIFT-
*: :: * .:. ** . : .
Mb3281c|M.bovis_AF2122/97 -FGNGTGHLGSLQLDWGALVIVTLVATLIALGTKLSSRFSAVVTAIK--V
Rv3253c|M.tuberculosis_H37Rv -FGNGTGHLGSLQLDWGALVIVTLVATLIALGTKLSSRFSAVVTAIK--V
MUL_2597|M.ulcerans_Agy99 -FSGGTADFGSIRLDWGALLSVSIVSLLVAYGTKLSSRFSAVVTTIK--V
MAV_4216|M.avium_104 -FSGGTVKFGAAQLDWGALVIVGGVATLIALGTKLSSRFSAVITGIK--V
TH_0471|M.thermoresistible__bu -FAGATTRLGPITLDWGALLIIGFVTVLLATGTKLSANVSLAITVIK--V
Mflv_0800|M.gilvum_PYR-GCK -IEEPSG---------GTLALIALVILLAGTAVNLIGRQALKIFMIGSII
Mvan_0043|M.vanbaalenii_PYR-1 -IEEASG---------GTLAWIALLILLAGTAVNLVGRQALKIFMIGSII
MSMEG_1069|M.smegmatis_MC2_155 -LEEPSG---------GTLALIALVILLAGTAVNLAGRQALKIFMAASIA
MAB_4090|M.abscessus_ATCC_1997 FQLIGTDSSLTSVSGASNAVLLGSLLLVATTAINAVGVNWMSRINSIGVT
MMAR_2243|M.marinum_M ---------------AVPAPVFCLAAIALVTTVNIVGVVIMNRLNFALVG
MLBr_01305|M.leprae_Br4923 ------------ALPQWTLALLALAVVLVMNLISVEWFGELEFWAALIKV
. .
Mb3281c|M.bovis_AF2122/97 SVVVLVVVVGAFYIRAANYSPFIPEPEVQHHG-GGLDQSVFSLLTGAQGS
Rv3253c|M.tuberculosis_H37Rv SVVVLVVVVGAFYIRAANYSPFIPEPEVQHHG-GGLDQSVFSLLTGAQGS
MUL_2597|M.ulcerans_Agy99 AVVILVVVVGAFYVKAANYSPFIPEPEAGPEG-RGADQSLLSLLTGAPGS
MAV_4216|M.avium_104 SVVVFVVVVGVFYIKRANYSPFIPKPEAGGQA-KGIDQSVLSLLTGAHTS
TH_0471|M.thermoresistible__bu GVVLLVVIVGAFFIKAANYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGS
Mflv_0800|M.gilvum_PYR-GCK AEVIGSVVLGTWLLIFHRQNSISVLFEG-----GGADVDLGAYLGGP---
Mvan_0043|M.vanbaalenii_PYR-1 AEVVGSVVLGTWLLLFHRQNSLSVLFEG-----GGTDVDLWSYLGGP---
MSMEG_1069|M.smegmatis_MC2_155 AEVIGSVVLGTWLLLFHRENSLSVLFSG-----GGVDVDMWSYLSGP---
MAB_4090|M.abscessus_ATCC_1997 CEIVGVVAVVGMLFGHAERGPSVVLHTG-----DAGSGYPWAFLAAG---
MMAR_2243|M.marinum_M LQLAFVLVFITVSLLYLRDHPDASLLQP---------LYSAGFRGGD---
MLBr_01305|M.leprae_Br4923 CALMAFLVVGTIFLGGR--YPVDGHNTG---------LSLWTSHGGLFPT
: : . . . .
Mb3281c|M.bovis_AF2122/97 HYGWYGVLAGASIVFFAFIGFDIVATMAEETKRPQRDVPRGILASLGVVT
Rv3253c|M.tuberculosis_H37Rv HYGWYGVLAGASIVFFAFIGFDIVATMAEETKRPQRDVPRGILASLGVVT
MUL_2597|M.ulcerans_Agy99 HYGWYGVLAGASIVFFAFIGFDIVATMAEETKHPQRDVPRGILVSLGVVT
MAV_4216|M.avium_104 HYGWYGVLAGASIVFFAFIGFDIVATMAEETKHPQRDVPRGILASLGIVT
TH_0471|M.thermoresistible__bu SYGWYGLLAGASIVFFAFIGFDIIATTAEETKNPQRDVARGIMATLGIVT
Mflv_0800|M.gilvum_PYR-GCK ------FLLAVAFIGWSFVGFESAGSIAEEVHNPRRDLPKAVLFSIAFIA
Mvan_0043|M.vanbaalenii_PYR-1 ------FLLAVAFIGWSFVGFESAGSIAEEVHNPGRDLPKAVLFSLAFIA
MSMEG_1069|M.smegmatis_MC2_155 ------FLLAVAFIGWSFVGFESAGSIAEEVHEPRKYLPKAVLFSLTFIA
MAB_4090|M.abscessus_ATCC_1997 -----------LMAAYVLVGFGSASELAEETRNPRRVAPRTILSAIVVSA
MMAR_2243|M.marinum_M ------ILGGAAVVALSFVGFDAVSTMAEEARNPRRTVPLAIILTVLIGG
MLBr_01305|M.leprae_Br4923 G--VAPLIVVSSGVMFAYAAVELVGTAAGETVEPKKIMPRAINSVIARIA
.. . * *. .* : . : :
Mb3281c|M.bovis_AF2122/97 LLYVAVSVVLSGMVPYTQLRTVPGRGPANLATAFQANGVYWASGIISVGA
Rv3253c|M.tuberculosis_H37Rv LLYVAVSVVLSGMVPYTQLRTVPGRGPANLATAFQANGVYWASGIISVGA
MUL_2597|M.ulcerans_Agy99 LLYVAVSIVLSGMVSYTQLRTVSGGGHANLATAFKANGVYWASGIISVGA
MAV_4216|M.avium_104 LLYVAVAVVLSGMVSYTQLKTMPGRGQANLATAFTANGIHWASKIISIGA
TH_0471|M.thermoresistible__bu VLYVAVSLVLTGMVHYTELRAAG--ENANLATAFAANGIDWAAKVISIGA
Mflv_0800|M.gilvum_PYR-GCK LVVGYSALAIILAIPDLDAVAEGAVADPVYDTLTTALGAG-IAKPVQVMF
Mvan_0043|M.vanbaalenii_PYR-1 LVVGYSSLAIILAIPDLDAVAEGAVSDPVYETLTTALGAG-IAKPVQVLF
MSMEG_1069|M.smegmatis_MC2_155 LVVGYSSLAIILAIPDLDAVAEGAVADPVYDTLTNALGHG-VAKPVEVMF
MAB_4090|M.abscessus_ATCC_1997 IG---GALMILGALMAAPSLTDGQLATGGLPYVLDSKLASPFGTLLLIDV
MMAR_2243|M.marinum_M ATFLSVSYCATLVEPDYRAITTPN--SAALQIVVSAGGHS-LQTFFIIAY
MLBr_01305|M.leprae_Br4923 IFYVGSVILLALLLPYSAFKASE----SPFVTFFSKVGFYGAGDLMNIVV
: . :
Mb3281c|M.bovis_AF2122/97 LAGLTTVVMVLMLGQCRVLFAMARDGLVPRQLAKTGSRGTP--VRVTVLV
Rv3253c|M.tuberculosis_H37Rv LAGLTTVVMVLMLGQCRVLFAMARDGLVPRQLAKTGSRGTP--VRVTVLV
MUL_2597|M.ulcerans_Agy99 LAGLTTVVMVLMLGQCRVLFAMARDGLLPRQLAKTGARGTP--VRITVLV
MAV_4216|M.avium_104 LAGLTTVVMVLMLGQCRVLFAMARDGLLPRALAKTGSRGTP--VRITVLV
TH_0471|M.thermoresistible__bu LAGLTTVVIVLVLGQTRVLFAMSRDGLLPRPLSKTGPRGTP--VRITVLV
Mflv_0800|M.gilvum_PYR-GCK VIGFLASFLALQTSASRVIWAYSRDGALPAAGTLVQLRGKARIPVAAILV
Mvan_0043|M.vanbaalenii_PYR-1 VIGFLASFLALQTSASRVIWAYARDGALPAAGTLVQLRGRARIPVVAILV
MSMEG_1069|M.smegmatis_MC2_155 VIGFLASFLALQTSASRVIWAYARDGALPAASALGRLRGPARIPTVAILV
MAB_4090|M.abscessus_ATCC_1997 AIAVFVCTLAIQTAASRLMFSMARDGKLPFSAVLSHVNPRTGTPIAPAVV
MMAR_2243|M.marinum_M MCACSAAALSSQVSVTRILYAMGRDGVLPR-AVFGRISRRFRTPIGAALV
MLBr_01305|M.leprae_Br4923 LTAALSSLNAGLYATGRVMHSIAINGSGPKFTARMSKNGVPYGGILLAAV
. . *:: : . :* * *
Mb3281c|M.bovis_AF2122/97 AVLVATTASVFP-------ITK---LEEMVNVGT-----LFAFILVSAGV
Rv3253c|M.tuberculosis_H37Rv AVLVATTASVFP-------ITK---LEEMVNVGT-----LFAFILVSAGV
MUL_2597|M.ulcerans_Agy99 AVVVGATASVFP-------ITK---LEEMVNVGT-----LFAFVLVSAGV
MAV_4216|M.avium_104 ALVVAVTASVFP-------ITK---LEEMVNVGT-----LFAFVLVSAGV
TH_0471|M.thermoresistible__bu GALVAIAASVFP-------VGN---LEEMVNIGT-----LFAFALVSAGV
Mflv_0800|M.gilvum_PYR-GCK TTVIGAALFLLS-------IVAGDIYSLMVNFTAGGFYLAFLFPLIGFLV
Mvan_0043|M.vanbaalenii_PYR-1 TTVIGAGLFLLS-------IVAGDIYSLMVNFTAGGFYLAFLFPLIGFLV
MSMEG_1069|M.smegmatis_MC2_155 TTVIGACLFLLS-------IVAGDIYSLMVNFTAGGFYLAFLFPLVGFLV
MAB_4090|M.abscessus_ATCC_1997 VGVCCVLILAVN-------FGNAALFTSLCSVCIALIYLAYLMVTTPLLL
MMAR_2243|M.marinum_M VSAVSTLALIAD-------LET---MASIVSFGALAAFTLVHLAVTKHFL
MLBr_01305|M.leprae_Br4923 ICLCGVALNAFNPGQAFEIVLSVAALGIIAGWGTIVLCQLRLHKMAKAGI
. : . :
Mb3281c|M.bovis_AF2122/97 VVLRR---TRPDLQ----------RGFTAPWVPLLPIAAVCACLWLMLNL
Rv3253c|M.tuberculosis_H37Rv VVLRR---TRPDLQ----------RGFTAPWVPLLPIAAVCACLWLMLNL
MUL_2597|M.ulcerans_Agy99 IVLRK---KRPDLE----------RGFRAPWVPVLPIASLCACLWLMLNL
MAV_4216|M.avium_104 MVLRR---TRPDLE----------RGFKAPWVPVLPIASIGACVWLMLNL
TH_0471|M.thermoresistible__bu IVLRR---TRPDLK----------RGFRVPFVPWLPLAAIAACLWLMLNL
Mflv_0800|M.gilvum_PYR-GCK VLLRK---TWKPGS----------FSLRAATMPVAAVAVVWAVLQFLNIA
Mvan_0043|M.vanbaalenii_PYR-1 VVLRK---VWKPAS----------FSLRGWTLPVAVVAVVWAVLQFLNIA
MSMEG_1069|M.smegmatis_MC2_155 VLLRR---TWTPAT----------FSLKGFTLPVALVAVVWASLQFLNIA
MAB_4090|M.abscessus_ATCC_1997 RRLGIGGSTWDANLGQTDADGRKLFSLGRCGLPINILAVGYGAFMILNLS
MMAR_2243|M.marinum_M IDQRR-------------------RGWRSWALYAAMPAVGVVLTGWLWTS
MLBr_01305|M.leprae_Br4923 MRRPRFRMPLAPYSG--------YLTLAFLFAVLVVMAFDKPIGTWTVAS
*
Mb3281c|M.bovis_AF2122/97 T-----ALTWIRFGIWLVAGTAIYVGYGRRHSAQGLRQARESATRRC---
Rv3253c|M.tuberculosis_H37Rv T-----ALTWIRFGIWLVAGTAIYVGYGRRHSAQGLRQARESATRRC---
MUL_2597|M.ulcerans_Agy99 T-----ALTWIRFGVWLLVGTVIYVGYGRKHSMVGRRQLAEAAMDK----
MAV_4216|M.avium_104 T-----ALTWVRFGIWLVVGTAIYAGYGYWHSVQGRRDAGEPDRSDALAA
TH_0471|M.thermoresistible__bu T-----GLTWVRFLGWMALGLVLYFFYGRHHSMLGRGMTDISARRTG---
Mflv_0800|M.gilvum_PYR-GCK WPRVAFEQRYLDWSVWIGVVVLGIIGAALYASVKSRIVAPRDHDEPALAD
Mvan_0043|M.vanbaalenii_PYR-1 WPRVAFEQRYLDWSVWIGVVVLGMIGAVLFATVKSRIAAPQDQDDRALVD
MSMEG_1069|M.smegmatis_MC2_155 WPRAAFDQRWLDWSVWIGVAALAVLGTAILASVRSHITGTAVVEEAELRD
MAB_4090|M.abscessus_ATCC_1997 WPRPAVFDPTGEHPYLVWMAPICIIAVLLAGLVAYPRHTASTTEETVR--
MMAR_2243|M.marinum_M LSVGAFAIGFAWLGIGTSYLAVLTRGFRKPAPAVDFDADAAPIQTEIDLT
MLBr_01305|M.leprae_Br4923 LIVIVPALIAGWYSIRKRVMTIARERMGYTGPFPAIANPPVQPSERSHSQ
Mb3281c|M.bovis_AF2122/97 -------
Rv3253c|M.tuberculosis_H37Rv -------
MUL_2597|M.ulcerans_Agy99 -------
MAV_4216|M.avium_104 DPNSPVP
TH_0471|M.thermoresistible__bu -------
Mflv_0800|M.gilvum_PYR-GCK D------
Mvan_0043|M.vanbaalenii_PYR-1 D------
MSMEG_1069|M.smegmatis_MC2_155 ELADRS-
MAB_4090|M.abscessus_ATCC_1997 -------
MMAR_2243|M.marinum_M KEGTLQ-
MLBr_01305|M.leprae_Br4923 NP-----