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MIRSEVDLSGGRVSYLTWSPERPSGTVVLLHGGGVDNAELSWGGIAPGLAAAGYRVVCPDHPGYGHSPLP ALPVTQERLVAYVGDFVDAVVDGRYAIGGLSLGGGMTIGHVLDRPDRVTGAMLLGSYGIMARLSDGPFSA IRQALTWAMVRTGVMGSVMRWTARNRTAMNQSVAAIIRNRVYRTDDLLQAVYAAAAQPGGFIAFEQWQRD QVRWNRQRTDYTDRLRTFPRPALIVHGGRDTGVPVAHARAAARLIPDATLKVVAEAGHWVQRDAPDVVLD AMTTFLARISATA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2517 | - | - | 100% (293) | hydrolase, alpha/beta fold family protein, putative |
| M. smegmatis MC2 155 | MSMEG_6037 | - | 1e-13 | 26.10% (249) | 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase |
| M. smegmatis MC2 155 | MSMEG_6763 | - | 8e-12 | 23.75% (299) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 4e-16 | 27.17% (276) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. gilvum PYR-GCK | Mflv_2367 | - | 2e-15 | 26.58% (301) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3569c | bphD | 4e-16 | 27.17% (276) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | MLBr_02297 | - | 2e-06 | 23.96% (313) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3034 | - | 1e-13 | 27.60% (279) | hydrolase |
| M. marinum M | MMAR_1997 | - | 6e-15 | 28.62% (269) | hydrolase |
| M. avium 104 | MAV_4567 | - | 7e-17 | 27.68% (289) | dihydrolipoyllysine-residue acetyltransferase component of |
| M. thermoresistible (build 8) | TH_1741 | - | 9e-12 | 26.64% (259) | 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE BPHD |
| M. ulcerans Agy99 | MUL_3358 | - | 4e-15 | 28.62% (269) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_2912 | - | 2e-19 | 28.18% (291) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3600c|M.bovis_AF2122/97 MT------------------------ATEELTFESTSRFAEVDV-----D
Rv3569c|M.tuberculosis_H37Rv MT------------------------ATEELTFESTSRFAEVDV-----D
TH_1741|M.thermoresistible__bu MTSYIQEA-----------------ENQVEITFESTSRYAEVKAG----D
Mflv_2367|M.gilvum_PYR-GCK ---------------------------------MTDLRYLDLHG------
MAV_4567|M.avium_104 ---------------------------------MSELKFLELHG------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------MHDDVKYLDLHG------
MMAR_1997|M.marinum_M MTERKRNLRPVR------------------EVTAPSLQFRTIHG------
MUL_3358|M.ulcerans_Agy99 MTERKRNLRPVR------------------EVTAPSLQFRTIHG------
MAB_3034|M.abscessus_ATCC_1997 MNPPPRLLRPVPDTEHIDGVDGGGDTPSAATSTRPRLAFRTIHG------
MSMEG_2517|M.smegmatis_MC2_155 ----------------------------------MIRSEVDLSG------
MLBr_02297|M.leprae_Br4923 ----------------------MAMSNPSVTRIAGPWHHLDVHANGIRFH
:
Mb3600c|M.bovis_AF2122/97 GPLKLHYHEAG------VGNDQTVVLLHGGGPGAASWTNFSRNIAVLARH
Rv3569c|M.tuberculosis_H37Rv GPLKLHYHEAG------VGNDQTVVLLHGGGPGAASWTNFSRNIAVLARH
TH_1741|M.thermoresistible__bu RDMRLHYHEAG------IGHAQKVVLLHGGGPGASSWSNFGRNIAVLARH
Mflv_2367|M.gilvum_PYR-GCK --DRCAYRDEG------DGEE-TLLLLHGMAGSSETWR---AVIPHLAKR
MAV_4567|M.avium_104 --DRVAFRDQG------EGE--VLLLIHGMAGSSETWR---SVIPPLAKK
Mvan_2912|M.vanbaalenii_PYR-1 --DRVAYREAG------QGP--AVLLIHGMGGSSLTWK---ALLPHLATR
MMAR_1997|M.marinum_M --YKRAFRIAG------SGP--AILLIHGIGDNSTTWT---GIHAKLAQR
MUL_3358|M.ulcerans_Agy99 --YKRAFRIAG------SGP--AILLIHGIGDNSTTWT---GIHAKLAQR
MAB_3034|M.abscessus_ATCC_1997 --YRRAYRIAG------SGP--VLLLIHGIGDNSATWD---SVHAQLAEH
MSMEG_2517|M.smegmatis_MC2_155 --GRVSYLTWSP-----ERPSGTVVLLHGGGVDNAELSWGGIAPGLAAAG
MLBr_02297|M.leprae_Br4923 VVEAVPTQPAGQDCAPSATARPLVMLLHGFGSFWWSWR----HQLRGLTE
. ::*:** .
Mb3600c|M.bovis_AF2122/97 FHVLAVDQPGYGHSDKRAEHGQFNRYAAMALKGLFDQLGLGRVPLVGNSL
Rv3569c|M.tuberculosis_H37Rv FHVLAVDQPGYGHSDKRAEHGQFNRYAAMALKGLFDQLGLGRVPLVGNSL
TH_1741|M.thermoresistible__bu FHVIAVDQPGYGHSDKHTEHEQYNRYSATALLALFDHLGIERADLVGNSL
Mflv_2367|M.gilvum_PYR-GCK YRVIAPDLLGHGSSAKPRGDYSLGAF-AAWLRDLLDELGIRSVTVVGQSL
MAV_4567|M.avium_104 FRVIAPDLLGHGESAKPRTDYSLGAF-AVWLRDFLDELGVSRATVVGHSL
Mvan_2912|M.vanbaalenii_PYR-1 YRVIAPDLLGHGQSDKPRGDYSLGAF-AVWLRDLLDLLGIARVTLVGHSL
MMAR_1997|M.marinum_M FTVIAPDLLGHGRSDKPRADYSIAAY-ANGMRDLLSVLDIERVTIIGHSL
MUL_3358|M.ulcerans_Agy99 FTVIAPDLLGHGRSDKPRADYSIAAY-ANGMRDLLSVLDIERVTIIGHSL
MAB_3034|M.abscessus_ATCC_1997 FTVIAPDLLGHGQSDKPRADYSVAAY-ANGMRDLLAVLDIERVTVVGHSL
MSMEG_2517|M.smegmatis_MC2_155 YRVVCPDHPGYGHSPLPALPVTQERL-VAYVGDFVDAVVDGRYAIGGLSL
MLBr_02297|M.leprae_Br4923 ARLVAVDLRGYGGSDKPPRGYDGWTL-AGDTAGLIRALGHSSATLVGHAE
::. * *:* * . :. : : * :
Mb3600c|M.bovis_AF2122/97 GGGTAVRFALDYPARAGRLVLMGP-------GGLSINL-------FAPDP
Rv3569c|M.tuberculosis_H37Rv GGGTAVRFALDYPARAGRLVLMGP-------GGLSINL-------FAPDP
TH_1741|M.thermoresistible__bu GGGTAVRFALDHPKRAGRLVLMGP-------GGLSVNM-------FAPDP
Mflv_2367|M.gilvum_PYR-GCK GGGVAMQFVYQHPDYCRRLVLISS-------GGLGQDVG----WTLRLLS
MAV_4567|M.avium_104 GGGVAMQFVYQHPDYAQRLILISS-------GGLGPDVG----WVLRLLS
Mvan_2912|M.vanbaalenii_PYR-1 GGGVAMQFVHQHPDYCERLVLISS-------GGLGPELG----RSLRLLS
MMAR_1997|M.marinum_M GGGVAMQFAYQFPQLVDRLILVGA-------GGVTKDVN----VVFRLAS
MUL_3358|M.ulcerans_Agy99 GGGVAMQFAYQFPQLVDRLILVGA-------GGVTKDVN----VVFRLAS
MAB_3034|M.abscessus_ATCC_1997 GGGVAMQFTYQFPHLVERLILVAP-------GGVTKDVN----IVLRCAS
MSMEG_2517|M.smegmatis_MC2_155 GGGMTIGHVLDRPDRVTGAMLLGS-------YGIMARLSDGPFSAIRQAL
MLBr_02297|M.leprae_Br4923 GGLACWATALLHPRLVRAIALINSPHPAALRRSMLTHRNQGYALLPTLLR
** . * *: . .:
Mb3600c|M.bovis_AF2122/97 TEG---VKRLSKFSVAPTRENLEAFLRVMVYDKNLITPELVDQRFALAST
Rv3569c|M.tuberculosis_H37Rv TEG---VKRLSKFSVAPTRENLEAFLRVMVYDKNLITPELVDQRFALAST
TH_1741|M.thermoresistible__bu TEG---VKLLARFNAEPTRENLEAFLRIMVYDQSLITEELIDERFAIAAT
Mflv_2367|M.gilvum_PYR-GCK APG---SELLLPLIAPSPVVRAGDRVRAWFSARNIQSPRGAEMWSAYASL
MAV_4567|M.avium_104 APG---AELVLPVIAPTPVLSVGNKLRSWLRGAGIQSPRGAELWNAYSSL
Mvan_2912|M.vanbaalenii_PYR-1 TPG---IELLLPVAAAPSVVAVGERVRSWLGARGLASPEVGETWNAYASL
MMAR_1997|M.marinum_M LPMGAEALALLRLPMVLPTVQLAGKVLGMALGSTALGQDLPNVLRILDDL
MUL_3358|M.ulcerans_Agy99 LPMGAEALALLRLPMVLPTVQLAGKVLGMALGSTALGQDLPNVLRILDDL
MAB_3034|M.abscessus_ATCC_1997 LPFIGDALGLLRLPMAMPMLRLGGAVARATFGRASMARDIPDVLRVLADL
MSMEG_2517|M.smegmatis_MC2_155 TWAMVRTGVMGSVMRWTARNRTAMNQSVAAIIRNRVYRTDDLLQAVYAAA
MLBr_02297|M.leprae_Br4923 YQLPIWPERLLTRNNAAEIERLVRSRSSAKWQACEDFAVTIDHLRIAIQI
:
Mb3600c|M.bovis_AF2122/97 PES---LTATRAMGKSFAGADFEAGMMWREVYRLRQPVLLIWGREDRVNP
Rv3569c|M.tuberculosis_H37Rv PES---LTATRAMGKSFAGADFEAGMMWREVYRLRQPVLLIWGREDRVNP
TH_1741|M.thermoresistible__bu PES---LAATRAMGKSFMGPDFELGMMWRDAYKLRQRVLLIWGREDRVNP
Mflv_2367|M.gilvum_PYR-GCK SDAHTRHAFLRTLRSVVDYRGQAVSALNKLHLTTELPLMVIWGDQDRIIP
MAV_4567|M.avium_104 SDGETRQSFLKTLRSVVDYRGQAVSALNRLRLREELPVMAIWGERDGIIP
Mvan_2912|M.vanbaalenii_PYR-1 SDPQTRTAFLRTLRSVVDAQGQAVSALNRLHFTLGLPTLLIWGDQDRLIP
MMAR_1997|M.marinum_M PEPTASSAFTRTLRAVVDWRGQIVTMLDRCYLTQAIPVQIIWGSRDAVVP
MUL_3358|M.ulcerans_Agy99 PEPTASSAFTRTLRAVVDWRGQIVTMLDRCYLTQAIPVQIIWGSRDAVVP
MAB_3034|M.abscessus_ATCC_1997 PEPRASAAFTRTLRAVVDWRGQVVTMLDRCYLTESVPVQLIWGSDDLVIP
MSMEG_2517|M.smegmatis_MC2_155 AQPGGFIAFEQWQRDQVRWNRQRTDYTDRLR-TFPRPALIVHGGRDTGVP
MLBr_02297|M.leprae_Br4923 PAAAHCALEYQRWAVRSQLRNEGRKFMKSMSRPFSVPLLHVRGDADPYLL
. : : * *
Mb3600c|M.bovis_AF2122/97 LDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNKLTIEFLGGGR----
Rv3569c|M.tuberculosis_H37Rv LDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNKLTIEFLGGGR----
TH_1741|M.thermoresistible__bu LDGALVALKQIPRVQLHVFGQCGHWAQVEKFDEFNRLTIDFLEDGAKEAK
Mflv_2367|M.gilvum_PYR-GCK VDHGFALDQHRPGCRLEILDGVGHFPHVEKPDAVVDLLDDFIATTHASV-
MAV_4567|M.avium_104 VDHAYAAHEARTDARLEVLPDVGHFAQVEAPMRVVELIEDFIATGER---
Mvan_2912|M.vanbaalenii_PYR-1 PAHGEAAHAALPGSRLVILPAVGHFPQVEAPLAVADTLDDFIANSSPWHG
MMAR_1997|M.marinum_M VRHAEMAHAAMPGSKLEVFEGSGHFPFHDDPARFIDIVLRFIDSTQPPEY
MUL_3358|M.ulcerans_Agy99 VRHAEMAHAAMPGSKLEVFEGSGHFPFHDDPARFIDIVLRFIDSTQPPEY
MAB_3034|M.abscessus_ATCC_1997 VSHGHLAHAAMPGSALEIFDKSGHFPFHDDPERFIGIVRQFIASTEPGEY
MSMEG_2517|M.smegmatis_MC2_155 VAHARAAARLIPDATLKVVAEAGHWVQRDAPDVVLDAMTTFLARISATA-
MLBr_02297|M.leprae_Br4923 ADSVDRTRRYAPHGRYVSVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRL
. . **: : . *:
Mb3600c|M.bovis_AF2122/97 ----------------------------------------
Rv3569c|M.tuberculosis_H37Rv ----------------------------------------
TH_1741|M.thermoresistible__bu S---------------------------------------
Mflv_2367|M.gilvum_PYR-GCK ------------------------RPADVPER--------
MAV_4567|M.avium_104 ------------------------RDATSPQPG-------
Mvan_2912|M.vanbaalenii_PYR-1 ----------------------PPRHADHAEAD-------
MMAR_1997|M.marinum_M DQAALRELLRTGGGERTVSGPADTRVAVLSAMGSDERSAT
MUL_3358|M.ulcerans_Agy99 DQAALRELLRTGGGERTVSDPADTRVAVLSAMGSDERSAT
MAB_3034|M.abscessus_ATCC_1997 NEDELRRLLRTGVTEHAISGAARTRMAVLDAMGTDERSAT
MSMEG_2517|M.smegmatis_MC2_155 ----------------------------------------
MLBr_02297|M.leprae_Br4923 S---------------------------------------