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MTQSLRLGIALEGNGPVSDLVEEARKAEAAGFDVVLVPDHLGNASPLVSLTAIGAAVPTVQLSPMVLNAA FYSPALIARDLAAVDSATDGRLIIAFGAGYVEAEFDAAGIPFPSPAQRVSIVGNTLREVRRLLSDPDHNP TPRQLPPPILVAGAGNKLLTLAAREADIVGIASRGDETDLAERVAFVKHAAGQRFDDIELQFGFFQTSLD DPRDLSVARLLGIDAPDAEIGKLPTVLNGSIDAAIERIQRFRDDLGITYFSFLKTDATSWDTFGSLVKAL REAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3977 | - | - | 100% (284) | hypothetical protein MSMEG_3977 |
| M. smegmatis MC2 155 | MSMEG_5592 | - | 2e-45 | 36.01% (286) | hypothetical protein MSMEG_5592 |
| M. smegmatis MC2 155 | MSMEG_2516 | - | 1e-23 | 28.88% (277) | putative oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2917 | - | 5e-29 | 31.43% (315) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1815 | - | 3e-48 | 38.19% (288) | luciferase family protein |
| M. tuberculosis H37Rv | Rv2893 | - | 5e-29 | 31.43% (315) | oxidoreductase |
| M. leprae Br4923 | MLBr_00348 | - | 5e-07 | 25.40% (189) | putative coenzyme F420-dependent oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4277 | - | 2e-14 | 29.21% (267) | luciferase-like monooxygenase superfamily protein |
| M. marinum M | MMAR_4587 | - | 5e-45 | 37.76% (286) | oxidoreductase |
| M. avium 104 | MAV_1042 | - | 1e-47 | 36.81% (288) | hypothetical protein MAV_1042 |
| M. thermoresistible (build 8) | TH_2824 | - | 4e-12 | 26.59% (267) | PUTATIVE luciferase family protein |
| M. ulcerans Agy99 | MUL_2972 | - | 7e-31 | 33.10% (281) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4930 | - | 4e-51 | 39.93% (283) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1815|M.gilvum_PYR-GCK MPLPPAVQTWTYDHDVAKEFRFGVGVTRVSTRAKLEDDARRAEALGFDVL
Mvan_4930|M.vanbaalenii_PYR-1 ---------------MATEFRFGVGVTRARSRAELVDSARRAEDLGFDVL
MMAR_4587|M.marinum_M ---------------MAKDFRFGLSVRFIKSRAALQELAKRAEDLGFDIL
MAV_1042|M.avium_104 ---------------MAKDFRFGMSMRFYKSREALLDKAKRAEDAGFDIL
MSMEG_3977|M.smegmatis_MC2_155 ---------------MTQSLRLGIALEGNGPVSDLVEEARKAEAAGFDVV
Mb2917|M.bovis_AF2122/97 -------MTVASTAHHTRRLRFGLAAPLPRAGTQMRAFAQAVEAAGFDVL
Rv2893|M.tuberculosis_H37Rv -------MTVASTAHHTRRLRFGLAAPLPRAGTQMRAFAQAVEAAGFDVL
MUL_2972|M.ulcerans_Agy99 ----------------MPEFRFSFNVFRIDPVHTFIETCRRAEQWGYDAV
MAB_4277|M.abscessus_ATCC_1997 -----------------MDFRVFVEPQQGATYSDQLRVAQAAEELGFSAF
TH_2824|M.thermoresistible__bu -----------------MDFRVFVEPQQGGTYADQLAVARAAEDLGYSAF
MLBr_00348|M.leprae_Br4923 ----------MVERANAMKLGLQLGYWAAQPPGNAAELVAAAEGAGFDAV
: . . . .* *:. .
Mflv_1815|M.gilvum_PYR-GCK HVP---------DHLG-GSAPFPVMTAVAMATTSLRVGTFVLNSAFYRPA
Mvan_4930|M.vanbaalenii_PYR-1 HVP---------DHLG-GPAPFPVMTTIAMATTTLRVGTFVINSAFYRPA
MMAR_4587|M.marinum_M CVP---------DHLG-AAAPFPTLTAAAMVTTKMRLSMYVLNAAFYKPA
MAV_1042|M.avium_104 CVP---------DHLG-AAAPFPTLTAVAMVTTTLRLSMYVLNSAFYKPA
MSMEG_3977|M.smegmatis_MC2_155 LVP---------DHLG-NASPLVSLTAIGAAVPTVQLSPMVLNAAFYSPA
Mb2917|M.bovis_AF2122/97 AFP---------DHLVPSVSPFAGATAAAMATQRLHTGTLVLNNDFRHPV
Rv2893|M.tuberculosis_H37Rv AFP---------DHLVPSVSPFAGATAAAMATQRLHTGTLVLNNDFRHPV
MUL_2972|M.ulcerans_Agy99 FAA---------DHLG-IAAPFMTLVAAAAATDRMRVGILLLNAPWWNPA
MAB_4277|M.abscessus_ATCC_1997 FRSDHYLAMGGADGLPGPTDAWVTLGAIARETTAIRLGTLVTSATFRHPG
TH_2824|M.thermoresistible__bu FRSDHYLAMSG-DGLPGPTDSWVTLAGIARETTSIRLGTLVTSATFRYPG
MLBr_00348|M.leprae_Br4923 FTG---------EAWG--SDAYTPLAWWGSSTQRVRLGTSVVQLSARTPT
: . . . :: . : . *
Mflv_1815|M.gilvum_PYR-GCK LLARDVAALNDLSDGRVELGLGTGYVREEFDAAGIPYPTAGERVDHLKLT
Mvan_4930|M.vanbaalenii_PYR-1 LLARDVAALHDLSEGRFELGLGTGYVKEEFDAAGIPFPSARERVDHLKLT
MMAR_4587|M.marinum_M LLSRDAEALDLLSEGRLELGLGTGYVREEFDAAELPYPSAGARVDYLEHM
MAV_1042|M.avium_104 LLSRDMQALDLLSDGRLEIGLGTGYVREEFEAAEIPYPSARERVDYLEHM
MSMEG_3977|M.smegmatis_MC2_155 LIARDLAAVDSATDGRLIIAFGAGYVEAEFDAAGIPFPSPAQRVSIVGNT
Mb2917|M.bovis_AF2122/97 DTAREAAGVATLAEGRFELGLGAGHRRSEYDAAGITFDSGATRVARLIES
Rv2893|M.tuberculosis_H37Rv DTAREAAGVATLAEGRFELGLGAGHRRSEYDAAGITFDSGATRVARLIES
MUL_2972|M.ulcerans_Agy99 LLARDIATTDVLTGGRLEVGLGAGHMKWEYDQADIPFPSFTTRTARLRQT
MAB_4277|M.abscessus_ATCC_1997 PLAVTVAQVDEMSSGRVDFGLGAGWFSEEHEAYAIPFPSLGERFDRLEEQ
TH_2824|M.thermoresistible__bu PLAISVAQVDEMSGGRVEFGLGSGWFEPEHQAYAIPFPPLGERFDRLTEQ
MLBr_00348|M.leprae_Br4923 ACAMAALTLDHLSGGRHILGLGVSGPQVVEGWYGQPFPKPLSRTREYIDI
: : ** ..:* . .: *
Mflv_1815|M.gilvum_PYR-GCK AAHIA----------------EHLPD------------------------
Mvan_4930|M.vanbaalenii_PYR-1 IEYMT----------------EHLPD------------------------
MMAR_4587|M.marinum_M TAYLK----------------QHHPT------------------------
MAV_1042|M.avium_104 TKYLK----------------EHHPS------------------------
MSMEG_3977|M.smegmatis_MC2_155 LREVRRLLSDP----------DHNPTPRQL-------------------P
Mb2917|M.bovis_AF2122/97 AHLIRALLDAE----PVDFDGQHYRVHAEAGSLVAP----------PKVR
Rv2893|M.tuberculosis_H37Rv AHLIRALLDAE----PVDFDGQHYRVHAEAGSLVAP----------PKVR
MUL_2972|M.ulcerans_Agy99 IEELASRFAEDGFAQQAELREAHNIAVLRPTQRRGF----------GGYG
MAB_4277|M.abscessus_ATCC_1997 LEILTGLWTTPT-GDTYSYAGKHYTVTDSPALPKPV----------QEPH
TH_2824|M.thermoresistible__bu LEIITGLWTTPS-GEKYDFTGKHYTVVDSPGLPKPV----------QDPY
MLBr_00348|M.leprae_Br4923 VRQVWAREAPVVS------DGQHYPLPLTGAGATGLGKALKPITHPLRAD
: *
Mflv_1815|M.gilvum_PYR-GCK VPIMIAGNG-DRVLRTAARFADIVGFTGGDR--------AATGDEDPLGD
Mvan_4930|M.vanbaalenii_PYR-1 VPIMIAGNG-DRVLRIAARSADIIGFTGGDR--------AATADEDPLAD
MMAR_4587|M.marinum_M VPILIAGNG-NRVMTLAAQQADIVGLTGSN----------VHGADDPLAE
MAV_1042|M.avium_104 TPLIIAGNG-DRVLTIAARNADIIGLTGAK----------VRDVEDPFAE
MSMEG_3977|M.smegmatis_MC2_155 PPILVAGAG-NKLLTLAAREADIVGIASRG-------------DETDLAE
Mb2917|M.bovis_AF2122/97 VPLLVGGNG-TEVLRLGGRIADIVGLAGISHNRDATQVRFTHFDADGLAD
Rv2893|M.tuberculosis_H37Rv VPLLVGGNG-TEVLRLGGRIADIVGLAGISHNRDATQVRFTHFDADGLAD
MUL_2972|M.ulcerans_Agy99 PPLLVGGTG-DQVLRLAAQYADTVSIACLYQVKGRPPGTMRLAIVAEIEQ
MAB_4277|M.abscessus_ATCC_1997 PPIVIGGLGVKRTPALAARFATEFNLPFQP-----------VDVITDQYA
TH_2824|M.thermoresistible__bu PPIIIGGQGPKRTPALAARFANEFNIPFVR-----------LDALKAQFE
MLBr_00348|M.leprae_Br4923 IPIMLGAEGPKNVALAAEICDGWLPIFFSPR----------MADMYNEWL
*:::.. * . . . :
Mflv_1815|M.gilvum_PYR-GCK RIGFVRAAAGERFAALELNIAITAIPLDSSGQPDLTIPRISLPGLSDD--
Mvan_4930|M.vanbaalenii_PYR-1 RIAFVRDAAGERFGDLELNLAVTAMPVDDSGRPDLTIPRISLPGLSDE--
MMAR_4587|M.marinum_M RVDFVRRAAGDRFDALELNLAITALPNEGETAPDLAMTRRYAPELSDE--
MAV_1042|M.avium_104 RVEFVRNAAGDRFDSLELNLAITAMPRVGETEPDLKLTRSYSPELTDE--
MSMEG_3977|M.smegmatis_MC2_155 RVAFVKHAAGQRFDDIELQFGFFQTSLDDPR--DLSVARLLGIDAPDA--
Mb2917|M.bovis_AF2122/97 RIAVVRHAAGDRFEAIELNALIQAVVCTNDRNAAAAELAATLGGITPE--
Rv2893|M.tuberculosis_H37Rv RIAVVRHAAGDRFEAIELNALIQAVVCTNDRNAAAAELAATLGGITPE--
MUL_2972|M.ulcerans_Agy99 RVAYVRRCAGAARHPELHTLIQEVVLTDDRREVAGMLAAKYGNLLTAN--
MAB_4277|M.abscessus_ATCC_1997 RVAHAVEAAGRPADSMTYSAAFALCIG----DTDADIARRAANIGREV--
TH_2824|M.thermoresistible__bu RVAAAVAEAGREPDSMIYSAAFVLCAG----RDDAEIARRAAAINREV--
MLBr_00348|M.leprae_Br4923 DEGFARTGARRSREDFEICASAQIVVTEDRAAAFAGIKPFLALYMGGMGA
. *
Mflv_1815|M.gilvum_PYR-GCK ----------------ELLRHPSVLSGSTTE------IADRIHGYRDVYG
Mvan_4930|M.vanbaalenii_PYR-1 ----------------ELLRHPGVLSGSVDE------IADRIRGYRDVYG
MMAR_4587|M.marinum_M ----------------QILALHSVLGGSPRE------IADTLAGYRDIYG
MAV_1042|M.avium_104 ----------------QILSMPSVLSGSPRD------IADTLSAYRDKYG
MSMEG_3977|M.smegmatis_MC2_155 ----------------EIGKLPTVLNGSIDA------AIERIQRFRDDLG
Mb2917|M.bovis_AF2122/97 ----------------QVLESPFLLLGTHEQ------MAEALAARQRRFG
Rv2893|M.tuberculosis_H37Rv ----------------QVLESPFLLLGTHEQ------MAEALAARQRRFG
MUL_2972|M.ulcerans_Agy99 ----------------EILQSPTLLIGTVEQ------IARQLRANRERYG
MAB_4277|M.abscessus_ATCC_1997 ----------------EEITENSPLAGTPDA------VAEKLSIYVDAGV
TH_2824|M.thermoresistible__bu ----------------DELRSNSPVVGTPAE------IVDRLGPFIEAGV
MLBr_00348|M.leprae_Br4923 EGTNFHADVYRRMGYAEVVDEVTALFRSNQKDKAAEIIPNELVDSTMIVG
: : : :
Mflv_1815|M.gilvum_PYR-GCK ISYVIVQMRHA---------EAFGAVIDLLR------
Mvan_4930|M.vanbaalenii_PYR-1 ISYLIVQMRHA---------EAFGKVIELLR------
MMAR_4587|M.marinum_M VTSFTVQDNHL---------DNFAKVIAELR------
MAV_1042|M.avium_104 VSSFTVQDNHI---------DNFAKVIAELR------
MSMEG_3977|M.smegmatis_MC2_155 ITYFSFLKTDAT------SWDTFGSLVKALREAA---
Mb2917|M.bovis_AF2122/97 VSYWTVFDEWAGRAS---AMRDIAEVIALLRYG----
Rv2893|M.tuberculosis_H37Rv VSYWTVFDEWAGRAS---AMRDIAEVIALLRYG----
MUL_2972|M.ulcerans_Agy99 FTHYTIPQPHV---------AAFAPVITVLGDLN---
MAB_4277|M.abscessus_ATCC_1997 QRVYVQLLDIRDLDH---LEFFASTVIPQFS------
TH_2824|M.thermoresistible__bu QRVYLQLLDMSDLDH---LELIATQVVPQLR------
MLBr_00348|M.leprae_Br4923 DVDYVCKQIAAWSAAGVTMMMVSASSVEQVRDLAGLF
: .