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VGSRNGSENGSEHTSPPAVGDQPPAVVRKAVAASAIGNATEWFDYGIYAYGVTYISAAIFPGDAGTATLL ALMTFAVSFLVRPLGGFVWGPLGDRLGRKRVLAITILMMAGATLCVGLVPTYASIGIWAPITLVVLRMIQ GFSTGGEYGGAATFMAEYAPTRKRGFLGSFLEFGTLAGFSLGALLMLGCSLVLGENDMQAWGWRLPFLVA APLGLVGIYLRTRLEDTPVFRELAEKGGTEEQATKAFRDLIVEYWRPILRLAGLVVALNVVNYTLLSYMP TYLENEIGLSTDSSLVVPIIGMLTMMVFLPFAGRLSDRVGRKPLWWFSLAGLFVAGLPMFMLMGTGMAGA VIGFAVLGLLYVPQLATISATFPAMFPTHVRYAGFAIAYNVSTSLFGGTAPAVNEWLIGRTGDGLIPAYY MMAACVVGAIALISVPETSRCPINGTHIPGTAEAPRALSYHARPTAPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2486 | - | - | 100% (468) | major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_1477 | - | 0.0 | 77.02% (457) | major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4889 | - | 1e-99 | 43.98% (432) | integral membrane transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1232 | - | 1e-57 | 34.27% (426) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_0953 | - | 0.0 | 81.60% (451) | general substrate transporter |
| M. tuberculosis H37Rv | Rv1200 | - | 1e-57 | 34.27% (426) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 7e-09 | 29.30% (157) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_2263c | - | 1e-145 | 56.57% (449) | major facilitator transporter |
| M. marinum M | MMAR_4238 | - | 1e-59 | 33.72% (427) | integral membrane transport protein |
| M. avium 104 | MAV_4627 | - | 2e-65 | 35.58% (416) | major facilitator superfamily protein |
| M. thermoresistible (build 8) | TH_3400 | - | 0.0 | 75.77% (454) | PUTATIVE General substrate transporter |
| M. ulcerans Agy99 | MUL_0949 | - | 6e-60 | 33.72% (427) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_5839 | - | 0.0 | 82.92% (439) | general substrate transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1232|M.bovis_AF2122/97 -------------------------------------------MK---RV
Rv1200|M.tuberculosis_H37Rv -------------------------------------------MK---RV
MMAR_4238|M.marinum_M -------------------------------------------MS---RV
MUL_0949|M.ulcerans_Agy99 -------------------------------------------MS---RV
MAV_4627|M.avium_104 --------------MAATLPAPAPAGLADGHPLDESAEQQRRRLR---IV
Mflv_0953|M.gilvum_PYR-GCK -----------------MDSRDAR-------PPTIEKEQPPAVLK---KA
Mvan_5839|M.vanbaalenii_PYR-1 ----------------------MG-------MPTTHEDPPPGVLK---KA
MSMEG_2486|M.smegmatis_MC2_155 -----------------MGSRNGSENGSEHTSPPAVGDQPPAVVR---KA
TH_3400|M.thermoresistible__bu -----------------LTTERTDP----PQDPSVEQEQPPGVLR---KA
MAB_2263c|M.abscessus_ATCC_199 --------------MSSAGPREGETEPPPVPRPDFQSPEGRRQLH---RA
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
:
Mb1232|M.bovis_AF2122/97 ALACLVGSAIEFYDFLIYGTAAALVFPTVFFPHLDPTVAAVASMGTFAVA
Rv1200|M.tuberculosis_H37Rv ALACLVGSAIEFYDFLIYGTAAALVFPTVFFPHLDPTVAAVASMGTFAVA
MMAR_4238|M.marinum_M ALACVVGSTVEYYDFCIYGTAAALVFPAVFYPGLSPALATIASMGTFATA
MUL_0949|M.ulcerans_Agy99 ALACVVGSTVEYYDFCIYGTAAALVFPAVFYPGLSPALATIASMGTFATA
MAV_4627|M.avium_104 VAASLLGTTVEWYDFFLYATAAGLVFNKVFFPNESSLVGTLLAFATFAVG
Mflv_0953|M.gilvum_PYR-GCK IAASAIGNATEWFDYGIYAYGVTYISAAIFPG--DAANATLLALMTFAVS
Mvan_5839|M.vanbaalenii_PYR-1 ISASAIGNATEWFDYGIYAYGVSYISAAIFPG--DAANATLLALMTFAVS
MSMEG_2486|M.smegmatis_MC2_155 VAASAIGNATEWFDYGIYAYGVTYISAAIFPG--DAGTATLLALMTFAVS
TH_3400|M.thermoresistible__bu IAASAVGNATEWFDYGLYAYGVTYISVAIFPG--DGATATLLALMTFAVS
MAB_2263c|M.abscessus_ATCC_199 IAASAMGNATEWYDYGVYAATTTFLTQAFFP-----TLGTAFTMLGYAIS
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
. :. . . : . : : : .
Mb1232|M.bovis_AF2122/97 FLSRPFGAAVFG-YFGDRLGRKKTLVATLLIMGLATVTVGLVPTTVAIGA
Rv1200|M.tuberculosis_H37Rv FLSRPFGAAVFG-YFGDRLGRKKTLVATLLIMGLATVTVGLVPTTVAIGA
MMAR_4238|M.marinum_M FLSRPLGAAVFG-HFGDRLGRKKTLVATLLIMALSTVTVGVVPSTATIGV
MUL_0949|M.ulcerans_Agy99 FLSRPLGAAVFG-HFGDRLGRKKTLVATLLIMALSTVTVGVVPSTATIGV
MAV_4627|M.avium_104 FVMRPIGGLVFG-HIGDRIGRKRSLALTMLIMGGATALIGVLPTAAQIGA
Mflv_0953|M.gilvum_PYR-GCK FLVRPLGGFVWG-PLGDRLGRKRVLAMTILLMAGATFCVGLVPTYAAIGM
Mvan_5839|M.vanbaalenii_PYR-1 FLVRPLGGFVWG-PLGDRLGRKRVLAITIVLMAGATFCVALVPTYDMIGM
MSMEG_2486|M.smegmatis_MC2_155 FLVRPLGGFVWG-PLGDRLGRKRVLAITILMMAGATLCVGLVPTYASIGI
TH_3400|M.thermoresistible__bu FLVRPLGGFVWG-PLGDRLGRRQVLAITILLMAGATFCVGLVPSYDSIGL
MAB_2263c|M.abscessus_ATCC_199 FLLRPLGGMVWG-PLGDRLGRKSVMAITIVLMALSTTLIGILPSWATIGM
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVA--------
:: * : * :** :**: : : :: :: .:
Mb1232|M.bovis_AF2122/97 AAPLILTTMRLLQGFAVGGEWAG-----SALLSAEYAPASKRGWYGMFTV
Rv1200|M.tuberculosis_H37Rv AAPLILTTMRLLQGFAVGGEWAG-----SALLSAEYAPASKRGWYGMFTV
MMAR_4238|M.marinum_M SAPLILVALRLLQGFAVGGEWAG-----SALLSIESAPAHKRGYYGMFTV
MUL_0949|M.ulcerans_Agy99 SAPLILVALRLLQGFAVGGEWAG-----SALLSIESAPAHKRGYYGMFTV
MAV_4627|M.avium_104 WAPVLLLVLRVLQGFALGGEWGG-----AVLLAVEHSPGDRRGRYGAVPQ
Mflv_0953|M.gilvum_PYR-GCK WAPFLLVLLRMIQGFSTGGEYGG-----AATFMAEYSPSRRRGLLGSFLE
Mvan_5839|M.vanbaalenii_PYR-1 WAPFLLVLLRMIQGFSTGGEYGG-----AATFMAEYAPNRRRGLLGSFLE
MSMEG_2486|M.smegmatis_MC2_155 WAPITLVVLRMIQGFSTGGEYGG-----AATFMAEYAPTRKRGFLGSFLE
TH_3400|M.thermoresistible__bu WAPVLMVILRMIQGFSTGGEYGG-----AATFMAEYAPSRRRGLLGSFLE
MAB_2263c|M.abscessus_ATCC_199 AAPALLILLRVIQGFSTGGEYGG-----AATFMAEFAPDKKRGKYGSFLE
MLBr_01562|M.leprae_Br4923 WDEVTLVIARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTA
: *::**:. . :. : : . . .
Mb1232|M.bovis_AF2122/97 VGGGIALVLTSLTFLG-------VNYTIGESSPTFMQWGWRIPFLVSAAL
Rv1200|M.tuberculosis_H37Rv VGGGIALVLTSLTFLG-------VNYTIGESSPTFMQWGWRIPFLVSAAL
MMAR_4238|M.marinum_M LGGGVALVVSGLTFLG-------VNYTIGESSSAFLQWGWRVPFLLSALL
MUL_0949|M.ulcerans_Agy99 LGGGVALVVSGLTFLG-------VNYTIGESSSALLQWGWRVPFLLSALL
MAV_4627|M.avium_104 VGLALGLALGTGIFAF-------LQIVLG--PARFLSYGWRIGFLLSVLL
Mflv_0953|M.gilvum_PYR-GCK FGTLAGFSCGALLMLG-------CSLVLG--DEDMQAWGWRLPFLVAAPL
Mvan_5839|M.vanbaalenii_PYR-1 FGTLGGFSLGALLMLG-------CSLVLG--DEQMHAWGWRLPFLVAAPL
MSMEG_2486|M.smegmatis_MC2_155 FGTLAGFSLGALLMLG-------CSLVLG--ENDMQAWGWRLPFLVAAPL
TH_3400|M.thermoresistible__bu FGTLAGFSLGALMMLG-------VSLMLS--DDQMNTWGWRVPFLIAAPL
MAB_2263c|M.abscessus_ATCC_199 FGTLGGFAVGAAFVLV-------LDATLS--DDAMHTWGWRIPFLVALPM
MLBr_01562|M.leprae_Br4923 IGSVMGLVVGGALTEVSWRLAFLVNVPIGLVMIYLARTALHETHKERMKL
.* .: . :. : . : . :
Mb1232|M.bovis_AF2122/97 IAVALYVRFNIDETPVFAR--ERADEKTRLGPAETPIAQVLR--------
Rv1200|M.tuberculosis_H37Rv IAVALYVRFNIDETPVFAR--ERADEKTRLGPAETPIAQVLR--------
MMAR_4238|M.marinum_M IAFALYVRLEINETPVFARAMAQADDQESTAAARAPLAAVLC--------
MUL_0949|M.ulcerans_Agy99 IAFALYVRLEINETPVFARAMAQADDQESTAAARAPLAAVLC--------
MAV_4627|M.avium_104 VAIGIVVRLRVEETPAFREL------QDLQAASTVPIRDILRER------
Mflv_0953|M.gilvum_PYR-GCK GLIGVYLRSRLEDTPVYRELEQE--GRT-EESTSMQFRDLVV--------
Mvan_5839|M.vanbaalenii_PYR-1 GLIGLYLRSRLEDTPVFRELEAK--GGT-EPETTTQFRDLLG--------
MSMEG_2486|M.smegmatis_MC2_155 GLVGIYLRTRLEDTPVFRELAEK--GGT-EEQATKAFRDLIV--------
TH_3400|M.thermoresistible__bu GLIGLYLRSRLDDTPIFRELQES--DRE-EKSIWTEFKDLLV--------
MAB_2263c|M.abscessus_ATCC_199 GLIGWYLRSRLDDPPLFKEMQEQ--EPEGRETAFERLRDLVR--------
MLBr_01562|M.leprae_Br4923 DAAGAILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVE
. : .. : : ::
Mb1232|M.bovis_AF2122/97 ------------RQRREIVLAAGSAVCCFGFVYLASTYLASYAQTRLGYS
Rv1200|M.tuberculosis_H37Rv ------------RQRREIVLAAGSAVCCFGFVYLASTYLASYAQTRLGYS
MMAR_4238|M.marinum_M ------------RQRREIVLAAGAMLAAFGCLYLASTFLPSYAQLHLGYS
MUL_0949|M.ulcerans_Agy99 ------------RQRREIVLAAGAMLAAFGCLYLASTFLPSYAQLHLGYS
MAV_4627|M.avium_104 ------------RSRRNTVLGLLSRWAEGSAFNTWGVFAISYATGALGLN
Mflv_0953|M.gilvum_PYR-GCK ------------RYWRPILQMGGLVVALNVVNYTLLTYMPTYLENSIGLS
Mvan_5839|M.vanbaalenii_PYR-1 ------------RYWRPILQLGGLVVALNVVNYTLLSYMPTYLENRIGLS
MSMEG_2486|M.smegmatis_MC2_155 ------------EYWRPILRLAGLVVALNVVNYTLLSYMPTYLENEIGLS
TH_3400|M.thermoresistible__bu ------------EYRGQILRLGGLVVALNVVNYTLLSYMPTYLQTSIGLS
MAB_2263c|M.abscessus_ATCC_199 ------------DYRRPMVVMMLLVIALNITNYTLLSYQPTYLKTRLGMS
MLBr_01562|M.leprae_Br4923 RTAENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYS
: * :* .
Mb1232|M.bovis_AF2122/97 RGSILFDSVLGGLLCIVFTALSSALCDQLGRRRVLLAGWAVALPWSLLVM
Rv1200|M.tuberculosis_H37Rv RGSILFDSVLGGLLCIVFTALSSALCDQLGRRRVLLAGWAVALPWSLLVM
MMAR_4238|M.marinum_M RNLVLLIGVLGGLVCIGFVALSAILCDRFGRRRVMLVGWAVGLFWSPLVM
MUL_0949|M.ulcerans_Agy99 RNLVLLIGVLGGLVCIGFVALSAILCDRFGRRRVMLVGWAVGLFWSPLVM
MAV_4627|M.avium_104 RVSVLIAVTIAALLMAVLLPVSGVLTDRFGARRVYLAGIACYGLAAFPAF
Mflv_0953|M.gilvum_PYR-GCK ADQSLMVPIIGMLAMMVFVPFAGLLSDRVGRKPLWWFSLIGLFVAGIPAF
Mvan_5839|M.vanbaalenii_PYR-1 PDQSLIVPVIGMLSMMVFVPFAGLLSDRVGRKPLWWFSLIGLFVAGVPMF
MSMEG_2486|M.smegmatis_MC2_155 TDSSLVVPIIGMLTMMVFLPFAGRLSDRVGRKPLWWFSLAGLFVAGLPMF
TH_3400|M.thermoresistible__bu TDTALVVPIIGMLSMMVFLPFAGLLSDRFGRKPMWWISLGGLLALVVPMF
MAB_2263c|M.abscessus_ATCC_199 ETQGQIVILIGEVAMMAFLPFCGALSDRVGRKPMWAFSLTGLLVLSLPMF
MLBr_01562|M.leprae_Br4923 ALRAGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGW
. : ... * .:.. : : .
Mb1232|M.bovis_AF2122/97 PLIDSGSPSLFAVAVVGMY-AIGGFGFGPTASFIPELFATSYRYTGSALA
Rv1200|M.tuberculosis_H37Rv PLIDSGSPSLFAVAVVGMY-AIGGFGFGPTASFIPELFATSYRYTGSALA
MMAR_4238|M.marinum_M PLIGSGDTVGFTVALLGLY-AVAASGFGPAASLIPELFATRYRYTGTALA
MUL_0949|M.ulcerans_Agy99 PLIGSGDTVGFTVALLGLY-AVAASGFGPAASLIPELFATRYRYTGTALA
MAV_4627|M.avium_104 ALFGTKKLLWFGLAMVIVFGVVHALFYGAQGTLYSALYPTNTRYTGLSFV
Mflv_0953|M.gilvum_PYR-GCK LLMGTN--LAGAVIGFAILGLLYVPQLATISATFPAMFPTQVRYAGFAIA
Mvan_5839|M.vanbaalenii_PYR-1 LLMGTN--LWGAVIGFAVLGLLYVPQLATISATFPAMFPTQVRYAGFAIA
MSMEG_2486|M.smegmatis_MC2_155 MLMGTG--MAGAVIGFAVLGLLYVPQLATISATFPAMFPTHVRYAGFAIA
TH_3400|M.thermoresistible__bu MLMSTS--VPGAIIGFAVLGLLYVPQLATISATFPAMFPTHVRYAGFAIA
MAB_2263c|M.abscessus_ATCC_199 WLMGQG--FGWAIVGFAVLGLLYIPQLSTITATFPCMFPTQVRYAGFAIS
MLBr_01562|M.leprae_Br4923 AFMNRGVPYFPNLLAPIVVGGIGIG-MAVVPLTLSAIAGVGFDRIGPVSA
::. : : : . . : . *
Mb1232|M.bovis_AF2122/97 ANLAGVAGG-----------------------ALPPVIAGALVATYG--S
Rv1200|M.tuberculosis_H37Rv ANLAGVAGG-----------------------ALPPVIAGALVATYG--S
MMAR_4238|M.marinum_M LNVAGIVGG-----------------------AAPPLIAGTLLASYG--S
MUL_0949|M.ulcerans_Agy99 LNVAGIVGG-----------------------AAPPLIAGTLLASYG--S
MAV_4627|M.avium_104 YQFSGVYAS-----------------------GVTPMILTALIAALGGAP
Mflv_0953|M.gilvum_PYR-GCK YNVSTSIFG-----------------------GTAPAVNDWLVGATG-DN
Mvan_5839|M.vanbaalenii_PYR-1 YNVSTSLFG-----------------------GTAPAINQWLTGETG-DL
MSMEG_2486|M.smegmatis_MC2_155 YNVSTSLFG-----------------------GTAPAVNEWLIGRTG-DG
TH_3400|M.thermoresistible__bu YNVSTSLFG-----------------------GTAPAANDWLIQQTG-NN
MAB_2263c|M.abscessus_ATCC_199 YNLSTAAFG-----------------------GTAPLVNDLVVARTG-WD
MLBr_01562|M.leprae_Br4923 IALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHGY
. . . .
Mb1232|M.bovis_AF2122/97 WAIGVMLAILALISLVCTYRLPETAGSALVSR------------------
Rv1200|M.tuberculosis_H37Rv WAIGVMLAILALISLVCTYRLPETAGSALVSR------------------
MMAR_4238|M.marinum_M SAVGLMMTALVAASLLCTYLLPETAGAPLTAA------------------
MUL_0949|M.ulcerans_Agy99 SAVGLMMTALVAASLLCTYLLPETAGAPLTAA------------------
MAV_4627|M.avium_104 WLACGYLVATAVISVLATALIRDRD---LYL-------------------
Mflv_0953|M.gilvum_PYR-GCK LVPAYYMMGACVIGALALIRIPETTRCPLNGTATPGTDEAPAPVEYEKSS
Mvan_5839|M.vanbaalenii_PYR-1 LFPAYYMMGACVIGAIALIKVPETARCPIGGTVTPGTEEAADPVPFEKQN
MSMEG_2486|M.smegmatis_MC2_155 LIPAYYMMAACVVGAIALISVPETSRCPINGTHIPGTAEAPRALSYHARP
TH_3400|M.thermoresistible__bu LMPAFYMMAACLVGMLALVKLPETARCPIGGTEIPGTEDAPPPVEYDLVG
MAB_2263c|M.abscessus_ATCC_199 LFPAAYLMVACVVGLCALPFLIETAGASIAGTEIP-CNEAAVPTDTVRA-
MLBr_01562|M.leprae_Br4923 TYGLLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL-------
: . :
Mb1232|M.bovis_AF2122/97 ----
Rv1200|M.tuberculosis_H37Rv ----
MMAR_4238|M.marinum_M ----
MUL_0949|M.ulcerans_Agy99 ----
MAV_4627|M.avium_104 ----
Mflv_0953|M.gilvum_PYR-GCK A---
Mvan_5839|M.vanbaalenii_PYR-1 A---
MSMEG_2486|M.smegmatis_MC2_155 TAPA
TH_3400|M.thermoresistible__bu NR--
MAB_2263c|M.abscessus_ATCC_199 ----
MLBr_01562|M.leprae_Br4923 ----