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QRTHTAPRGLPHAGELPRRPRVVVVGAGIAGLAAATGMAERGVEVTVIERENYLGGRVGGWSEQHDGAEY AMNRGFHAFFRQYYNLRALLARVDPQLRMLTPVEDYPLIDGEGRRESFRRLPHTPPWNALWFALRSPTFR LRDLMRLDAKAAAPLAAVSVPGIYDRLDHIDAETFLKDINFPPAARHLAFEVFSRSFFADPSNLSAAELA TMFHIYFLGSSEGLVFDVPTSNYDTALWEPLRRYLHEHGVRFHLGASVTRIDPVTTSPDAFAVHTDSGER LDADAVVLAADIAGLQRIVASSPGLGDDRWRARVQGLRTAPPFAVHRLWLDRPVTADRPAFMGTAGHKPL DNISVLERYERQSAQWARDNGGSAVELHAYALDTAESGPGALAQLHRLYPETATAEPVFERVLVRDDCPL FAPGSHADRPGVVTGVPGLVLAGDGIRLDLPAALMERAATTGWAAANVLLNRWGVAGHALRSVPTAGRFA PLRWLATREERRAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2344 | - | - | 100% (505) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2347 | - | 1e-13 | 26.87% (469) | phytoene dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2884 | - | 1e-07 | 33.72% (86) | cyclohexanone monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3754 | - | 4e-05 | 35.29% (85) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1844 | - | 1e-175 | 62.62% (503) | amine oxidase |
| M. tuberculosis H37Rv | Rv3727 | - | 4e-05 | 35.29% (85) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4806 | crtI | 1e-08 | 25.57% (348) | phytoene dehydrogenase CrtI |
| M. avium 104 | MAV_3890 | - | 0.0 | 71.74% (499) | dehydrogenase |
| M. thermoresistible (build 8) | TH_1483 | - | 0.0 | 67.98% (506) | dehydrogenase |
| M. ulcerans Agy99 | MUL_1880 | - | 7e-05 | 33.33% (54) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_1580 | - | 1e-179 | 68.89% (479) | amine oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3754|M.bovis_AF2122/97 ---------------------MKPSPADTHVVIAGAGIAGLAAAMILAEA
Rv3727|M.tuberculosis_H37Rv ---------------------MKPSPADTHVVIAGAGIAGLAAAMILAEA
MSMEG_2344|M.smegmatis_MC2_155 --------MQRTHTAPRGLPHAGELPRRPRVVVVGAGIAGLAAATGMAER
MAV_3890|M.avium_104 MTAGATDRRRRILPAPTGLPDAGALPSRPRVAVVGGGIAGLTAATGLAER
Mflv_1844|M.gilvum_PYR-GCK ----MNDPRRVLHPAAAALPSASALGAQPKAAVIGGGIAGLAAATSLAER
Mvan_1580|M.vanbaalenii_PYR-1 ------------------------------MVVVGGGIAGLAAATGLAER
TH_1483|M.thermoresistible__bu ----LTDPRRVHHHAPPGLPDARGLARRPHVVVVGAGIAGLAAATGLAER
MMAR_4806|M.marinum_M --------------------MRTIEGTADHVVVIGAGLAGLATALHLAGR
MUL_1880|M.ulcerans_Agy99 ---MTDVVIPSTETTASGEPQAPTPPVKTRAVIIGTGFSGLGMAIALQKQ
.: * *::** * :
Mb3754|M.bovis_AF2122/97 GVRVTLCEAASEAGGKAKSLRLADGHP------TEHSLRVYTDTYQTLLT
Rv3727|M.tuberculosis_H37Rv GVRVTLCEAASEAGGKAKSLRLADGHP------TEHSLRVYTDTYQTLLT
MSMEG_2344|M.smegmatis_MC2_155 GVEVTVIERENYLGGRVGGWSEQHDGAEY---AMNRGFHAFFRQYYNLRA
MAV_3890|M.avium_104 GVAVEVIEREHYLGGRVGGWTEHHDGTDL---AMNRGFHAFFRQYYNLRA
Mflv_1844|M.gilvum_PYR-GCK GVAVRLYERQSYLGGRVGGWQDTLDDGTT--VAMNRGFHAFFRQYYNLRG
Mvan_1580|M.vanbaalenii_PYR-1 GVAVEVIEKHGYLGGRVGGWSDTLADGTP--VAMNRGFHAFFRQYYNLRA
TH_1483|M.thermoresistible__bu GVTVDVVEQAGYLGGRVGGWTEDIGPDVPGGAAMNRGFHAFFRQYYNLRT
MMAR_4806|M.marinum_M GRSVTVVEREAWPGGRAGRLDIDGYRIDT-----GPTVLTMPDLIDEVFA
MUL_1880|M.ulcerans_Agy99 GVDFVILEKSDDVGG---TWRDNSYPG------CACDIPSHLYSFSFEPK
* . : * ** .
Mb3754|M.bovis_AF2122/97 LFSRIPTEHDRTMLDNLVGVSMVSATAQGVIGRIAAPVALQRRRPTFARI
Rv3727|M.tuberculosis_H37Rv LFSRIPTEHDRTVLDNLVGVSMVSATAQGVIGRIAAPVALQRRRPTFARI
MSMEG_2344|M.smegmatis_MC2_155 LLARV--DPQLRMLTPVEDYPLIDGEGR------RESFRRLPHTPPWNAL
MAV_3890|M.avium_104 LLARL--DPRLRMLVPVNDYPLIDAAGR------RDSFRGLPRTPPLNAM
Mflv_1844|M.gilvum_PYR-GCK ILSRI--DPSLSMLSPLTDYPLVDALGR------RDTFRGLPRTPPFNAM
Mvan_1580|M.vanbaalenii_PYR-1 LLRRS--DPGLSALTPVEDYPLIDGAGR------RDTFRGLPQTPPLNAL
TH_1483|M.thermoresistible__bu LLRRI--DPGLGMLTPVDDYPLVDAHGR------RDTFRGLPKTPPFNAM
MMAR_4806|M.marinum_M AVGET-ISDRLELLPVDPAYTAMFADGS--------SIDVHCDADRMVAA
MUL_1880|M.ulcerans_Agy99 PDWRNPFSYQPEIWDYLKGVTEKYGLRR------YVEFNSLVDRAYWDDE
. . . . .
Mb3754|M.bovis_AF2122/97 IGKVVEPPRQLVRILLRGPMVIVGLAQRGVPATDVLHYLYAHLRLLWMCR
Rv3727|M.tuberculosis_H37Rv IGKVVEPPRQLVRILLRGPMVIVGLAQRGVPATDVLHYLYAHLRLLWMCR
MSMEG_2344|M.smegmatis_MC2_155 WFALRSPTFRLRDLMRLDAKAAAPLAAVSVPG------------------
MAV_3890|M.avium_104 AFAVRSPTFRLRDFARIDARAAAPLAAVSVPG------------------
Mflv_1844|M.gilvum_PYR-GCK AFALRSPTFRVRDLIRLDARAAAPLAAVSVPG------------------
Mvan_1580|M.vanbaalenii_PYR-1 AFALRSPTFRLRDLVRLDAKAAAPLAAVSVPE------------------
TH_1483|M.thermoresistible__bu AFALRSPTFRLRDLIRLNARAAAPLAAVELPG------------------
MMAR_4806|M.marinum_M IENFAGPE-QATGYLRLREWLTR-LYRIEFAG------------------
MUL_1880|M.ulcerans_Agy99 ECRWHVFTSDGREYVAQFLISGAGALHIPSSP------------------
.
Mb3754|M.bovis_AF2122/97 ERLLAELGDISYADYLQ-LGCKSAQAQEFFSAVPRIYVAARTSAEAAAIA
Rv3727|M.tuberculosis_H37Rv ERLLAELGDISYADYLQ-LGCKSAQAQEFFSAVPRIYVAARTSAEAAAIA
MSMEG_2344|M.smegmatis_MC2_155 --IYDRLDHIDAETFLKDINFPPAARHLAFEVFSRSFFADPSNLSAAELA
MAV_3890|M.avium_104 --TYRRLDHIDAATFLEDIRFPEAARHLAFEVFSRSFFADPAKLSAAELA
Mflv_1844|M.gilvum_PYR-GCK --TYDELDDQDAESFLRDINFPDAARHLAFEVFSRSFFTRPAALSAAELA
Mvan_1580|M.vanbaalenii_PYR-1 --TYDLLDGRDAETFLRDINFPEAARHLAFEVFARSFFARPETLSAGELV
TH_1483|M.thermoresistible__bu --IYRHLDDTDAESFLRAINFPPAARHLAFEVFSRSFFAQPSQLSAAELA
MMAR_4806|M.marinum_M -FIGSNFDSPLSLLTPQLARLAAAGGFRNWDSMVKRHITDPRLRRVFTFQ
MUL_1880|M.ulcerans_Agy99 ---EIEGREEFAGPAFHSAEWDHSVDLTGKRVAIIGAGASAIQIVPEIVE
. : : .
Mb3754|M.bovis_AF2122/97 PIVLKGLFRLKSNCPSALNDAKLPAIMMMDGPTSERMVDPWIRHLTRLGV
Rv3727|M.tuberculosis_H37Rv PIVLKGLFRLKSNCPSALNDAKLPAIMMMDGPTSERMVDPWIRHLTRLGV
MSMEG_2344|M.smegmatis_MC2_155 TMFHIYFLGSSEGLVFDVPTSNY----------DTALWEPLRRYLHEHGV
MAV_3890|M.avium_104 TMFHIYFLGSAEGLIFDVPSANY----------DSALWQPLRSYLEQRHV
Mflv_1844|M.gilvum_PYR-GCK TMFHIYFLGSSEGLVFDVATSNF----------DVALWNPLASYLERLGA
Mvan_1580|M.vanbaalenii_PYR-1 TMFHIYFLGSSEGLIFDVANANF----------DVALWNPLRRYLEGRGV
TH_1483|M.thermoresistible__bu TMFHIYFLGSSEGLVFDVVNANF----------DVALWNPLRDQLESRGV
MMAR_4806|M.marinum_M SLYAGVAPQDALAAYAVIAYMDTISGVFFPRGGVRALPDALAAAAACAGV
MUL_1880|M.ulcerans_Agy99 QVGELQLYQRTPPWVVPRSNPEIPPALR-----RAMENVPGLRALARLGI
: . .
Mb3754|M.bovis_AF2122/97 DIHFNTRVGDLEFDD--GRVTALISSDGRRFACDYALLAVPYLTLRELAK
Rv3727|M.tuberculosis_H37Rv DIHFNTRVGDLEFDD--GRVTALISSDGRRFACDYALLAVPYLTLRELAK
MSMEG_2344|M.smegmatis_MC2_155 RFHLGASVTRIDPVTTSPDAFAVHTDSGERLDADAVVLAADIAGLQRIVA
MAV_3890|M.avium_104 RFRLGTSVGSID----AANRFAVHTDTDEELEVDAVVLATDVAGLQRIVA
Mflv_1844|M.gilvum_PYR-GCK HVHTGTAVDSVTATS--QNSFIVTDGAGDENEVDGVVLATDVSALQSIVS
Mvan_1580|M.vanbaalenii_PYR-1 VFHTGAEVDSVTVA----DEVTVTGSRAQVWSADAAVLATDPGSLRRVVA
TH_1483|M.thermoresistible__bu RFHTGVGVRAVDAG----ARFRVSCDSGDELTADGVVLATDVTGLQRIVA
MMAR_4806|M.marinum_M QFHYGSQVSELERDD--ARITAVRTDRGERIACDAVVLTTELPTTYRLLG
MUL_1880|M.ulcerans_Agy99 YWAQEALAFGMTK-------RPNVLKVGEAYAKYNIRRSVKDRELRRKLT
. : :.
Mb3754|M.bovis_AF2122/97 SAHVKRYLPQLTQQHALALEASNGIQCFLRDLPATWPPFIRPGVVTTHLQ
Rv3727|M.tuberculosis_H37Rv SAHVKRYLPQLTQQHALALEASNGIQCFLRDLPATWPPFIRPGVVTTHLQ
MSMEG_2344|M.smegmatis_MC2_155 SSPGLGDDRWRARVQGLRTAPPFAVHRLWLDRPVTAD---RPAFMGTAGH
MAV_3890|M.avium_104 ASRGLANGEWRDRIAGLRTAPPFAVHRFWLDRPVSPR---RPAFLGTAGH
Mflv_1844|M.gilvum_PYR-GCK SSESLGDPEWREKIHRMGTALPFVVQRLWLDRPVRGD---RPAFLGTGGL
Mvan_1580|M.vanbaalenii_PYR-1 ASPGLGDPSWRERVAAIGTAPPFVVLRLWLDRPVRHD---RAAFVGTGGR
TH_1483|M.thermoresistible__bu ASPGLGDAGWRDRIAGLHTAPPFVVHRLWLDRPVAPD---RPPFLGTGGW
MMAR_4806|M.marinum_M RTP-RRLRRLRAAPSAVVVHAGCRSASTASEPAAHHTILFGQAWEQTFTD
MUL_1880|M.ulcerans_Agy99 PHYRIGCKRILN-SSSYYPAVANPKTRLITDRIARIT---RNGIVTADGV
: . :
Mb3754|M.bovis_AF2122/97 SQWSLVCVLQGEGFWKNVRLPEGTRYVLSITWSDVETPGPVFDRPLSECT
Rv3727|M.tuberculosis_H37Rv SQWSLVCVLQGEGFWKNVRLPEGTRYVLSITWSDVETPGPVFDRPLSECT
MSMEG_2344|M.smegmatis_MC2_155 KPLDNISVLER---------------------------------------
MAV_3890|M.avium_104 KPLDNISVLDR---------------------------------------
Mflv_1844|M.gilvum_PYR-GCK PPLDNISVLER---------------------------------------
Mvan_1580|M.vanbaalenii_PYR-1 DPLDNISVLER---------------------------------------
TH_1483|M.thermoresistible__bu SPLDNVSVLET---------------------------------------
MMAR_4806|M.marinum_M IIRDGRLMRDPS----------------------------------LLVT
MUL_1880|M.ulcerans_Agy99 EHQADVIVYATG----------------------------------FHVT
:
Mb3754|M.bovis_AF2122/97 PDEILTECLTQCGLDKSNVLGWRIDHELKHLDEAEYEKVASELPPHLVSA
Rv3727|M.tuberculosis_H37Rv PDEILTECLTQCGLDKSNVLGWRIDHELKHLDEAEYEKVASELPPHLVSA
MSMEG_2344|M.smegmatis_MC2_155 YERQSAQWARDNGGSAVELHAYALDTAESGP--GALAQLH-RLYPETATA
MAV_3890|M.avium_104 YEREARAWAGAHHGSVVELHSYALDSAPSGA--AALRELR-RIYPETAAA
Mflv_1844|M.gilvum_PYR-GCK YEHEARDWCARTGGSVVELHAYSVDQDSPELRRALISRLH-DLYPETVDA
Mvan_1580|M.vanbaalenii_PYR-1 YEREAAQWCSRTGGSVVELHAYSVRDEDADVRDRLIARMH-ELYPETATA
TH_1483|M.thermoresistible__bu YEHQARDWARCTGGSVVELHSYAVTEPTDGLRDALLDRLH-ALYPETADA
MMAR_4806|M.marinum_M RPTAGDPALAPPGRDLLYLLAPAPNLTAGRVDWGSAGGSYAQSMIDTVAS
MUL_1880|M.ulcerans_Agy99 DSYTYVQIKGQHGEDLVDRWNREGIGAHRGIAVADVPNLFFLLGPNTGLG
. . .
Mb3754|M.bovis_AF2122/97 PARGQRMVNFSPLTVLMPGARHRSPGICTSVPNLLLAGEVIYSPDLTLFV
Rv3727|M.tuberculosis_H37Rv PARGQRMVNFSPLTVLMPGARHRSPGICTSVPNLLLAGEVIYSPDLTLFV
MSMEG_2344|M.smegmatis_MC2_155 EPVFERVLVRDDCPLFAPGSHADRPGVVTGVPGLVLAGDGIR---LDLPA
MAV_3890|M.avium_104 QIVHETLLHRSDCPLFAPGGYPHRPTVVTPTPGLLLASDTVR---IDLPV
Mflv_1844|M.gilvum_PYR-GCK TIVGEKTLCRNDCPRLAPGDFAQRPTVRTPHPGLALAGDGIR---IDLPV
Mvan_1580|M.vanbaalenii_PYR-1 SIVAERLLRRDDCPRFAPGDFADRPTVSTPDPRLKLAGDGIR---IDLPV
TH_1483|M.thermoresistible__bu GIVAERVLCRQDCPRFAPGDHAGRPGVAGPHPALALAGDGIR---IDLPV
MMAR_4806|M.marinum_M RLLPDLRDSVELLDVVTPLDWARQGMAAGTPFALAHTFGQTG----PFRP
MUL_1880|M.ulcerans_Agy99 HNSVVFMIESQIHYVADAIAKCDKRGAQALAPTRAAQDRFNEELQRRLAG
. . :
Mb3754|M.bovis_AF2122/97 PTMEKAACSGYLAARQIMNMVASHAAPLRIDFRDPAPFAVLRRVDRWFWS
Rv3727|M.tuberculosis_H37Rv PTMEKAACSGYLAARQIMNMVASHAAPLRIDFRDPAPFAVLRRVDRWFWS
MSMEG_2344|M.smegmatis_MC2_155 ALMERAATTGWAAANVLLNRWGVAGHALRS-----VPTAGRFAPLRWLAT
MAV_3890|M.avium_104 ALMERAATTGWSAANHLLKRWGLAGHPLVT-----VPTEGRSRLLRWLAN
Mflv_1844|M.gilvum_PYR-GCK ALMERAATTGIAAANSLLAHFGVTGHDMYT-----VPVRGRSPVLRHLAN
Mvan_1580|M.vanbaalenii_PYR-1 ALMERAATTGWTAANELLTGFGLAGHTLHT-----VPNRGRSAVLRRLAT
TH_1483|M.thermoresistible__bu ALMERAATTGWSAANRLLTHFGLAGHPLYT-----VPTRGRSAALRRLAR
MMAR_4806|M.marinum_M ANTVRGIDNAVLAGSSTVPGVGVPTTLISGRLAADRITGNTTRSIRHLDL
MUL_1880|M.ulcerans_Agy99 SVWNSGGCSSWYLDEHGRNTVLWCGYTWQY----WLATRSVKPEEYQFFK
. . .. :
Mb3754|M.bovis_AF2122/97 RRRRPPDRSTFATPPTAMPAPSHLTDVDRSAS
Rv3727|M.tuberculosis_H37Rv RRRRPPDRSTFATPPTAMPAPSHLTDVDRSAS
MSMEG_2344|M.smegmatis_MC2_155 REERRAS-------------------------
MAV_3890|M.avium_104 REGATRS-------------------------
Mflv_1844|M.gilvum_PYR-GCK RVERRVLR------------------------
Mvan_1580|M.vanbaalenii_PYR-1 SAGG--VR------------------------
TH_1483|M.thermoresistible__bu REVR-QVR------------------------
MMAR_4806|M.marinum_M KAQLS---------------------------
MUL_1880|M.ulcerans_Agy99 AGAKSSVNG-----------------------