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MKPSPADTHVVIAGAGIAGLAAAMILAEAGVRVTLCEAASEAGGKAKSLRLADGHPTEHSLRVYTDTYQT LLTLFSRIPTEHDRTVLDNLVGVSMVSATAQGVIGRIAAPVALQRRRPTFARIIGKVVEPPRQLVRILLR GPMVIVGLAQRGVPATDVLHYLYAHLRLLWMCRERLLAELGDISYADYLQLGCKSAQAQEFFSAVPRIYV AARTSAEAAAIAPIVLKGLFRLKSNCPSALNDAKLPAIMMMDGPTSERMVDPWIRHLTRLGVDIHFNTRV GDLEFDDGRVTALISSDGRRFACDYALLAVPYLTLRELAKSAHVKRYLPQLTQQHALALEASNGIQCFLR DLPATWPPFIRPGVVTTHLQSQWSLVCVLQGEGFWKNVRLPEGTRYVLSITWSDVETPGPVFDRPLSECT PDEILTECLTQCGLDKSNVLGWRIDHELKHLDEAEYEKVASELPPHLVSAPARGQRMVNFSPLTVLMPGA RHRSPGICTSVPNLLLAGEVIYSPDLTLFVPTMEKAACSGYLAARQIMNMVASHAAPLRIDFRDPAPFAV LRRVDRWFWSRRRRPPDRSTFATPPTAMPAPSHLTDVDRSAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3727 | - | - | 100% (602) | POSSIBLE OXIDOREDUCTASE |
| M. tuberculosis H37Rv | Rv0449c | - | 1e-05 | 27.54% (138) | hypothetical protein Rv0449c |
| M. tuberculosis H37Rv | Rv0897c | - | 2e-05 | 44.44% (54) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3754 | - | 0.0 | 99.83% (602) | oxidoreductase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2963 | - | 0.0 | 68.95% (583) | oxidoreductase |
| M. avium 104 | MAV_0198 | - | 8e-05 | 36.36% (66) | FAD dependent oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_2347 | - | 5e-05 | 52.27% (44) | phytoene dehydrogenase |
| M. thermoresistible (build 8) | TH_1483 | - | 1e-05 | 39.47% (76) | dehydrogenase |
| M. ulcerans Agy99 | MUL_1404 | - | 2e-05 | 29.93% (137) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4388 | - | 1e-05 | 59.46% (37) | amine oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3727|M.tuberculosis_H37Rv -------MKPSPAD----------THVVIAGAGIAGLAAAMILAEAGVRV
Mb3754|M.bovis_AF2122/97 -------MKPSPAD----------THVVIAGAGIAGLAAAMILAEAGVRV
MMAR_2963|M.marinum_M -------MRHPEKSP--------IPHVVIAGAGIAGMAAAMILAEAGVRV
TH_1483|M.thermoresistible__bu LTDPRRVHHHAPPGLPDARGLARRPHVVVVGAGIAGLAAATGLAERGVTV
MSMEG_2347|M.smegmatis_MC2_155 -------MSRAIPGP--------TDHVVVVGAGLSGLSAALHLAGRGRRV
MAV_0198|M.avium_104 -------MN--------------DYDAIVIGAGHNGLTAAVLLQKAGLRT
MUL_1404|M.ulcerans_Agy99 -------MQQKTLTQR---------SIAVIGSGVAGLTAAYLLSGRD-RV
Mvan_4388|M.vanbaalenii_PYR-1 -------MLALTRR------------QFTLGLGAVAATPLLTSCGGGGDT
* * . :. . .
Rv3727|M.tuberculosis_H37Rv TLCEAASEAGGKAK------SLRLADGHPTEHSLRVYTDTYQTLLTLF--
Mb3754|M.bovis_AF2122/97 TLCEAASEAGGKAK------SLRLADGHPTEHSLRVYTDTYQTLLTLF--
MMAR_2963|M.marinum_M TVCEAAPEAGGKAK------SLRRPDGHPTEHSLRVYLDYYQTLLTLF--
TH_1483|M.thermoresistible__bu DVVEQAGYLGGRVGGWTEDIGPDVPGGAAMNRGFHAFFRQYYNLRTLL--
MSMEG_2347|M.smegmatis_MC2_155 TVVEREPWPGGRAG--------RIDTGGYRIDTGPTVLTMPDILDDVF--
MAV_0198|M.avium_104 LCLDAKLYAGGMAS------TVELFDGYRFEIAGSVQFPTSQAVVDELGL
MUL_1404|M.ulcerans_Agy99 TLYEADTRLGGHAHT----HCLDAGDGTFVGVDSAFLVHNDRTYPTLC--
Mvan_4388|M.vanbaalenii_PYR-1 TRGHVVVVGAGMSG----------LAAARRLTDAGVPVTVVEARSRIG--
. .* .
Rv3727|M.tuberculosis_H37Rv ---SRIPTEHDRTVLDNLVGVSMVSATAQGVIGRIAAPVALQRRRPTFAR
Mb3754|M.bovis_AF2122/97 ---SRIPTEHDRTMLDNLVGVSMVSATAQGVIGRIAAPVALQRRRPTFAR
MMAR_2963|M.marinum_M ---LRIPTESGKTVLDNLVGVNAVRVYRHRTFGRAAAPAPARRRRTTFA-
TH_1483|M.thermoresistible__bu ---RRIDPGLG--MLTPVDDYPLVDAHGRRDTFRGLP------KTPPFNA
MSMEG_2347|M.smegmatis_MC2_155 ---AAVGESVGDRLQLLPVDPAYRAQFADGSALEVHS------DADRMAA
MAV_0198|M.avium_104 DTIPTIDLDVMSVAVRGVGDDPLVQYSDPVKLFTHLNEVHGADAVNGMAG
MUL_1404|M.ulcerans_Agy99 ----RLFAELGVATQESEMSMSVRADDIGLEYAGALG-------PRGLFA
Mvan_4388|M.vanbaalenii_PYR-1 ----------GRTWTDTSLGLPVDLGAAWIHGSQGNP-------LTGLAA
. :
Rv3727|M.tuberculosis_H37Rv IIGKVVEPPRQLVRILLRGPMVIVGLAQRGVPATDVLHYLYAHLRLLWMC
Mb3754|M.bovis_AF2122/97 IIGKVVEPPRQLVRILLRGPMVIVGLAQRGVPATDVLHYLYAHLRLLWMC
MMAR_2963|M.marinum_M LLARVFEPLAQFSRMVVRSALVIVGMASRGVSPIDAIRYLHAHVRLLWMC
TH_1483|M.thermoresistible__bu MAFALRSPTFRLRDLIRLNARAAAPLAAVELPG-----------------
MSMEG_2347|M.smegmatis_MC2_155 AIADLAGPSEAAG--YRRLRDWLTRLYRIEIDG-----------------
MAV_0198|M.avium_104 LMAWAQAPTRALDRFEAGTPPKSLDEMYACATN-----------------
MUL_1404|M.ulcerans_Agy99 CSAALRPRYLMMLAEILRFHRAASRLLREDTAG-----------------
Mvan_4388|M.vanbaalenii_PYR-1 QAGARTVETNFDDVVVLDGGRAVDPAAVEEVSR-----------------
Rv3727|M.tuberculosis_H37Rv RERLLAELGDISYADYLQLG--CKSAQAQEFFSAVPRIYVAARTSAEAAA
Mb3754|M.bovis_AF2122/97 RERLLAELGDISYADYLQLG--CKSAQAQEFFSAVPRIYVAARTSAEAAA
MMAR_2963|M.marinum_M PERLTAELADVAYEDYLQLG--KKAPRAQAFFSALPRIFVAARPNAEAAA
TH_1483|M.thermoresistible__bu ---IYRHLDDTDAESFLRAIN-FPPAARHLAFEVFSRSFFAQPSQLSAAE
MSMEG_2347|M.smegmatis_MC2_155 --FIGANFDSPLSLLTPQLAQ-LAAIGGFGKWDHMVRRHLRDPRLQRVFT
MAV_0198|M.avium_104 -EFERSAIDDMLFGSVTDILDRYLPDREKHGALRGSMTVLAVNTLYRGPA
MUL_1404|M.ulcerans_Agy99 ----------SAGDDLETLEAFLKRHRFSSFFVDYFITPLVAAVWSCTAG
Mvan_4388|M.vanbaalenii_PYR-1 -----DWMGVLDEIEPMTADAAPDVSLADGLVWAGADLEDPLMQWMVSAA
Rv3727|M.tuberculosis_H37Rv IAPIVLKGLFRLKSNCPSALNDAKLPAIMMMDGPTSERMVDPWIRHLTRL
Mb3754|M.bovis_AF2122/97 IAPIVLKGLFRLKSNCPSALNDAKLPAIMMMDGPTSERMVDPWIRHLTRL
MMAR_2963|M.marinum_M IAPIILKGLFHFTS-RPAALNGITAPSIMMMNGPTSERMVDPWIRHLQTL
TH_1483|M.thermoresistible__bu LATMFH--IYFLGSSEGLVFDVVNANFDVALWNPLRDQLES---------
MSMEG_2347|M.smegmatis_MC2_155 FQSLYAGVSPQRALAAYAVIAYMDTISGVFFPKGGVRAVPDALAAAGADA
MAV_0198|M.avium_104 TPGSAAALAFGLGVPDGDTMQMKKLRGGIGALTS---HLCDVLERHGGEL
MUL_1404|M.ulcerans_Agy99 DALRYPARYLFVFLEHHGMLSVFGSPTWRTVTGGSVNYVRAIASS-----
Mvan_4388|M.vanbaalenii_PYR-1 IGAEYAADPEELALRWFGHEGEFDGPD--LILPGGYRQLIDHLAR-----
:
Rv3727|M.tuberculosis_H37Rv GVDIHFNTRVGDLEFDDGRVTALISSDGRRFACDYALLAVPYLTLRELAK
Mb3754|M.bovis_AF2122/97 GVDIHFNTRVGDLEFDDGRVTALISSDGRRFACDYALLAVPYLTLRELAK
MMAR_2963|M.marinum_M GVDLKFDTRIDDLEFRDGRVTALVSADGRRFGCDFAVLALPYLTLRRLAE
TH_1483|M.thermoresistible__bu -RGVRFHTGVGVRAVDAGARFRVSCDSGDELTADGVVLAT----------
MSMEG_2347|M.smegmatis_MC2_155 GVRFHYGATVNCLERSADRVTAVHTDTGERIPCDAVVLTT----------
MAV_0198|M.avium_104 RLRTKVTEILVEHAGSGGRVTGVRTESGETLSAPIVVSGI----------
MUL_1404|M.ulcerans_Agy99 LDEVRTGAAVHSLRRTADGVVIRAGGDAPRCFDAAVVAVH----------
Mvan_4388|M.vanbaalenii_PYR-1 DLDIRLDAEVTRIAYDDVGVTVETAQEVLRADRVIVTVPLG---------
: : .
Rv3727|M.tuberculosis_H37Rv SAHVKRYLPQLTQQHALALEASNGIQCFLRDLPATWPPFIRPGVVTTHLQ
Mb3754|M.bovis_AF2122/97 SAHVKRYLPQLTQQHALALEASNGIQCFLRDLPATWPPFIRPGVVTTHLQ
MMAR_2963|M.marinum_M RDCVSRHLPHLTQQHAIALESSNGLQFFLRDIPPTWPAHVRPGVVGTHFE
TH_1483|M.thermoresistible__bu --------------------DVTGLQRIVAASPGLGDAGWRDRIAGLHTA
MSMEG_2347|M.smegmatis_MC2_155 -------------------ELPRTYELLGRTPRRPRPWRASPSAVVVHVG
MAV_0198|M.avium_104 ---------------------APDVTLNELLDPAALPADLRARYARIDHR
MUL_1404|M.ulcerans_Agy99 ----------------------PDQALLLLDDPTTWERNVLGAIPYSTNR
Mvan_4388|M.vanbaalenii_PYR-1 -------------------VLKAGVIVFDPPLPQAKRAAVERLGFGLLDK
Rv3727|M.tuberculosis_H37Rv SQWSLVCVLQGEGFWKNVRLPEGTRYVLSITWSDVETPGPVFDRPLSECT
Mb3754|M.bovis_AF2122/97 SQWSLVCVLQGEGFWKNVRLPEGTRYVLSITWSDVETPGPVFDRPLSECT
MMAR_2963|M.marinum_M SEWALVSVLQGEGFWADVALPAGTKYVLSITWSDVDTPGPVFGRPASECT
TH_1483|M.thermoresistible__bu PPFVVHRLWLDR-----PVAPDRPPFLGTGGWSPLDN-------VSVLET
MSMEG_2347|M.smegmatis_MC2_155 CRRIDRPVAHHN-----ILFGD----AWHDTFTDIIDDGRLMRDPSLLVT
MAV_0198|M.avium_104 GSYLQMHFALQEAP-------------VFAAPYQVLNEPAMQASIGLFCT
MUL_1404|M.ulcerans_Agy99 ALLHTDGSVLPR------------------------------------HH
Mvan_4388|M.vanbaalenii_PYR-1 VVLVFDEPFWTEA---------------FDIHSDMLGIAGGAQPVSDLVN
.
Rv3727|M.tuberculosis_H37Rv PDEILTECLTQCGLDKSNVLGWRIDHELKHLDEAEYEKVASELPPHLVSA
Mb3754|M.bovis_AF2122/97 PDEILTECLTQCGLDKSNVLGWRIDHELKHLDEAEYEKVASELPPHLVSA
MMAR_2963|M.marinum_M PDEIATECLAQCGLDRSHIAGWHIDDELKHLSEADYQSLASDLPPHLASA
TH_1483|M.thermoresistible__bu YEHQARDWARCTGGSVVELHSYAVTEPTDGLRDALLDRLH-ALYPETADA
MSMEG_2347|M.smegmatis_MC2_155 RPTRGDPALAPAGRDLLYLLAPTPNLSSTAIDWETEGPAYAQRVVDTVAE
MAV_0198|M.avium_104 PEEVQQQWEQARRG--VVPADPTVVLQIPSQNDPGLAPEGKHAASAFALW
MUL_1404|M.ulcerans_Agy99 RARASWNYLVATGQDHVVVS-----YDVSRLMRIRGNRRFVVTLGGHDRV
Mvan_4388|M.vanbaalenii_PYR-1 GLRFTDVPLLVGLRGGANARAREADSDQQTVGEVLAALRAPDPVGVFVTR
Rv3727|M.tuberculosis_H37Rv PARGQRMVNFSPLTVLMPGARHRSPGICTSVPNLLLAGEVIYSPDLTLFV
Mb3754|M.bovis_AF2122/97 PARGQRMVNFSPLTVLMPGARHRSPGICTSVPNLLLAGEVIYSPDLTLFV
MMAR_2963|M.marinum_M PARGQRMVNLSPLTILLPGARDRSPRIRTEVGNLFLAGEASYSPELTFLV
TH_1483|M.thermoresistible__bu GIVAERVLCRQDCPRFAPGDHAGRPGVAGPHPALALAGDGIR---IDLPV
MSMEG_2347|M.smegmatis_MC2_155 RLLPELRDDAQVLQVVTPADWARQGMVAGTPFALAHTFSQTG----PFRP
MAV_0198|M.avium_104 FPIEGEVDYGQAKIEMGQRVIDKITRLAPNFEDSIIRHTTFTPRHMGVMF
MUL_1404|M.ulcerans_Agy99 DTRSVIAEMTYSHPLYTPESVVAQRVLPTLDDDRVVFAGAYHG------W
Mvan_4388|M.vanbaalenii_PYR-1 WAADPYARGSYSFLAVGSSPADQQALAEPVADRVAFAGEATHP----EFF
Rv3727|M.tuberculosis_H37Rv PTMEKAACSGYLAARQIMNMVASHAAP-LRIDFRDPAPFAVLRRVDRWFW
Mb3754|M.bovis_AF2122/97 PTMEKAACSGYLAARQIMNMVASHAAP-LRIDFRDPAPFAVLRRVDRWFW
MMAR_2963|M.marinum_M PTMEKAASSGYLAAHNILGVGAADAAPELRIDFNDPVPFAGLRRVDRWFW
TH_1483|M.thermoresistible__bu ALMERAATTGWSAANRLLTHFGLAGHPLYTVPTRGRS--AALRRLARREV
MSMEG_2347|M.smegmatis_MC2_155 GNTVRGVANAVLAGSSTVPGVGVPTALLSGRLAADRVTGTVRRTRTHHDI
MAV_0198|M.avium_104 GAPGGDYCHGLLNANQVGPNRPGPRGFLGQPIPIEGLYLGSAGCHGGPGI
MUL_1404|M.ulcerans_Agy99 GFHEDGAASGLRAARRLGADWPARTRPEAMLSC-----------------
Mvan_4388|M.vanbaalenii_PYR-1 ATVHGAYLSGLREADRILR-------------------------------
. .
Rv3727|M.tuberculosis_H37Rv SRRRRPP---DRSTFATPPTAMPAPSHLTDVDRSAS----
Mb3754|M.bovis_AF2122/97 SRRRRPP---DRSTFATPPTAMPAPSHLTDVDRSAS----
MMAR_2963|M.marinum_M NRRRPPESPCDPPGAACPSENGVPHGCPTPVPHPESAPRR
TH_1483|M.thermoresistible__bu RQVR------------------------------------
MSMEG_2347|M.smegmatis_MC2_155 NSVTAATADRKARMP-------------------------
MAV_0198|M.avium_104 TFIPGYNAARQALTDRSG----------------------
MUL_1404|M.ulcerans_Agy99 ----------------------------------------
Mvan_4388|M.vanbaalenii_PYR-1 ----------------------------------------