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GRFHRHDDGTVHTHDHDHDGHVHDHAHGDHSGYQTGTERIEVLESIFAENDIRADINRGLFAEHGVRALN LMSSPGSGKTTLLARTLDDLGADVSVGIVEGDIETDLDAAKLGGRGAQISLLNTANGFGGECHLDAPMVN RALQGLDLTRLDLVIIENVGNLVCPAEFDVGEHAKVMVYSVTEGEDKPLKYPVMFRAVDVVLLNKIDLVA HLDADVRTYTSRVREVNPTTEILPVSARTGEGMEAWYDWLRRFLTAGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2271 | hypB | - | 100% (259) | hydrogenase accessory protein HypB |
| M. smegmatis MC2 155 | MSMEG_2721 | hypB | 3e-62 | 51.46% (239) | hydrogenase accessory protein HypB |
| M. smegmatis MC2 155 | MSMEG_1095 | ureG | 5e-08 | 26.49% (185) | urease accessory protein UreG |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1883 | ureG | 3e-05 | 29.17% (168) | urease accessory protein ureG |
| M. gilvum PYR-GCK | Mflv_3978 | - | 4e-60 | 49.39% (245) | hydrogenase accessory protein HypB |
| M. tuberculosis H37Rv | Rv1852 | ureG | 3e-05 | 29.17% (168) | urease accessory protein ureG |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2427 | - | 1e-06 | 29.28% (181) | urease accessory protein (UreG) |
| M. marinum M | MMAR_1871 | hypB | 1e-115 | 77.17% (254) | nickel cation-binding GTPase, HypB |
| M. avium 104 | MAV_2680 | hypB | 4e-51 | 82.05% (117) | hydrogenase accessory protein HypB |
| M. thermoresistible (build 8) | TH_2818 | - | 1e-120 | 80.00% (255) | PUTATIVE nickel cation-binding GTPase, HypB |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2357 | - | 1e-113 | 75.59% (254) | hydrogenase accessory protein HypB |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1871|M.marinum_M -MGRFHRHDDGTVHTHEH-----EH-HQHG---DHTGYQT--GPARIEVL
TH_2818|M.thermoresistible__bu -VGRFHRHDDGTVHSHEHGDHAHEHPHDHG---DHSGYQT--GGQRIEVL
MAV_2680|M.avium_104 --------------------------------------------------
MSMEG_2271|M.smegmatis_MC2_155 -MGRFHRHDDGTVHTHDHDHDGHVHDHAHG---DHSGYQT--GTERIEVL
Mvan_2357|M.vanbaalenii_PYR-1 -MGRFHRHDDGTAHTHDHDG---SPSHDHG---DHSGYHT--AAERVDVL
Mflv_3978|M.gilvum_PYR-GCK MCATCGCGEDGTTITVPVQGHDHHHNHPHDQPDDHHQHHHPHPTETVTLE
Mb1883|M.bovis_AF2122/97 -----------------------------------------------MAT
Rv1852|M.tuberculosis_H37Rv -----------------------------------------------MAT
MAB_2427|M.abscessus_ATCC_1997 -----------------------------------------------MPP
MMAR_1871|M.marinum_M EEIFAENDVRADLNRRAFETNGIRALNLMSSPGSGKTTVLQATLDQLASE
TH_2818|M.thermoresistible__bu ESIFAENDSRAAINRKIFEENGIRALNLMSSPGSGKTTVLAATLDELANQ
MAV_2680|M.avium_104 --------------------------------------------------
MSMEG_2271|M.smegmatis_MC2_155 ESIFAENDIRADINRGLFAEHGVRALNLMSSPGSGKTTLLARTLDDLGAD
Mvan_2357|M.vanbaalenii_PYR-1 EAIFSENDLRAAANRNAFEENGIRALNLMSSPGSGKTSLLAVTLDELVGE
Mflv_3978|M.gilvum_PYR-GCK QKVLAKNDGIAARNRRWLTERDIVAFNMTSSPGSGKTTLLERTIRDLHPT
Mb1883|M.bovis_AF2122/97 HSHP-HSHTVPARPRRVRKPGEPLRIGVGGPVGSGKTALVAALCRQLRGE
Rv1852|M.tuberculosis_H37Rv HSHP-HSHTVPARPRRVRKPGEPLRIGVGGPVGSGKTALVAALCRQLRGE
MAB_2427|M.abscessus_ATCC_1997 HLIDGQPHQHIDRPRRVRQPGEPLRIGIGGPVGSGKTALVAALCRTLRDE
MMAR_1871|M.marinum_M FAIGVIEGDIATDLDAAKLSGRGAQ----VSLLNTSNGFGGECHLDAPMV
TH_2818|M.thermoresistible__bu IAIGIIEGDIATDLDAAKLGGRGAQ----ISLLNTNNGFGGECHLDAPMV
MAV_2680|M.avium_104 ------------------------------------------------MV
MSMEG_2271|M.smegmatis_MC2_155 VSVGIVEGDIETDLDAAKLGGRGAQ----ISLLNTANGFGGECHLDAPMV
Mvan_2357|M.vanbaalenii_PYR-1 IAIGVIEGDIATDLDAARLEGRGAQ----ISLLNTDNGFGGECHLDAPMV
Mflv_3978|M.gilvum_PYR-GCK RSVAVIEGDQETLLDAERIQATGAR----VVQVNTGAG----CHLDAEMI
Mb1883|M.bovis_AF2122/97 LSLAVLTNDIYTTEDADFLRTHAVLPDDRIAAVQTGGCPHTAIRDDITAN
Rv1852|M.tuberculosis_H37Rv LSLAVLTNDIYTTEDADFLRTHAVLPDDRIAAVQTGGCPHTAIRDDITAN
MAB_2427|M.abscessus_ATCC_1997 ISVAVLTNDIYTTEDADFLRRHAVLPDERITAVQTGGCPHTAIRDDITAN
MMAR_1871|M.marinum_M NRALPGLDLPN--LDLVIVENVGNLVCPAEFDVGEHAKAMVYSVTEGEDK
TH_2818|M.thermoresistible__bu NRALQDLDLDH--LELVVIENVGNLVCPAEFDVGEHAKAMVYSVAEGEDK
MAV_2680|M.avium_104 NRALQGLDLTT--LDLVIIENVGNLVCPAEFDVGEHAKAMVYSVTKGDDK
MSMEG_2271|M.smegmatis_MC2_155 NRALQGLDLTR--LDLVIIENVGNLVCPAEFDVGEHAKVMVYSVTEGEDK
Mvan_2357|M.vanbaalenii_PYR-1 HRALAGLNLAG--LDLVVIENVGNLVCPAEFDVGEHAKVMVYSLTEGEDK
Mflv_3978|M.gilvum_PYR-GCK RRALDTLAPRR--ARVLFIENVGNLVCPALFDLGETSKVVVISVTEGADK
Mb1883|M.bovis_AF2122/97 LDAIDELMAAHDALDLILVESGGDNLTATFSSGLVDAQIFVIDVAGGDKV
Rv1852|M.tuberculosis_H37Rv LDAIDELMAAHDALDLILVESGGDNLTATFSSGLVDAQIFVIDVAGGDKV
MAB_2427|M.abscessus_ATCC_1997 LDAIEDLIATNEPLDLILVESGGDNLTATFSSGLIDVQIFVIDVAGGDKV
*: * ::.:*. *: : .: . : .* .:: * .
MMAR_1871|M.marinum_M PLKYPVMFRCVDVVLLNKIDLVPYLDADVDTYVAHIREVNAHATILPVSA
TH_2818|M.thermoresistible__bu PLKYPVMFRAVDVVLLNKIDLVPYLDVDVDRYIAHIREVNPTARILPVSA
MAV_2680|M.avium_104 PMKYPVMFRAVDVVLLNKIDLVPYLDVDVDSYIGHVREVNPTATILPVSA
MSMEG_2271|M.smegmatis_MC2_155 PLKYPVMFRAVDVVLLNKIDLVAHLDADVRTYTSRVREVNPTTEILPVSA
Mvan_2357|M.vanbaalenii_PYR-1 PLKYPVMFRAVDVVLLNKIDLAPYLDADVATYTERIRQVNPTATVLPVSA
Mflv_3978|M.gilvum_PYR-GCK PLKYPHMFAAADLVLINKSDLLPYVDFDIDACASAARSVNPGVGILTLSA
Mb1883|M.bovis_AF2122/97 PRKGGPGVTYSDLLVVNKTDLAALVGADLAVMARDADAVRDGRPTVLQSL
Rv1852|M.tuberculosis_H37Rv PRKGGPGVTYSDLLVVNKTDLAALVGADLAVMARDADAVRDGRPTVLQSL
MAB_2427|M.abscessus_ATCC_1997 PRKGGPGVTFSDLLVINKTDLAPMVGADLTVMARDAAAVREGRPTAMISL
* * . *::::** ** . :. *: *. *
MMAR_1871|M.marinum_M RTGAGMTAWFDWLRR---------FAQGLPPE-----------
TH_2818|M.thermoresistible__bu RTGEGMDAWFDWLRQ---------FLRG---------------
MAV_2680|M.avium_104 RTGVGMPDWLAWLRR---------FMEGTPTA-----------
MSMEG_2271|M.smegmatis_MC2_155 RTGEGMEAWYDWLRR---------FLTAGR-------------
Mvan_2357|M.vanbaalenii_PYR-1 KTGEGMSEWYRWLRA---------FAKD---------------
Mflv_3978|M.gilvum_PYR-GCK KTGDGVEEWYDWISQRSIYDARVPIAGGRPAPEVRPHQEIRRR
Mb1883|M.bovis_AF2122/97 TEDPAASDVVAWVRS--------QLAADGV-------------
Rv1852|M.tuberculosis_H37Rv TEDPAASDVVAWVRS--------QLAADGV-------------
MAB_2427|M.abscessus_ATCC_1997 TEDPAASEVLAWVRA--------HLTEAHQTDHAH--------
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