For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
CATCGCGGTDGAGVPVTLAGETPPHHHEHDHDHDHPHTHDHPPTETVTLEQRVLAKNDMLAQQNREWLTA RGIVALNITSSPGAGKTTLLERTIRDLGRDHAVAVIEGDQETLLDADRIRAAGARAVQVNTGAGCHLDAS MVHRAIDALDPSPGSLLFIENVGNLVCPALFDLGEYQKVVVISVTEGTDKPLKYPHMFAAAGLVILNKID LLPYVNFDIETCCRYARSVNPAVTILQTSATRGDGLSAWYEWLGERIH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2721 | hypB | - | 100% (259) | hydrogenase accessory protein HypB |
| M. smegmatis MC2 155 | MSMEG_2271 | hypB | 3e-62 | 51.46% (239) | hydrogenase accessory protein HypB |
| M. smegmatis MC2 155 | MSMEG_1095 | ureG | 1e-13 | 31.58% (190) | urease accessory protein UreG |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1883 | ureG | 1e-07 | 26.45% (242) | urease accessory protein ureG |
| M. gilvum PYR-GCK | Mflv_3978 | - | 1e-99 | 69.38% (258) | hydrogenase accessory protein HypB |
| M. tuberculosis H37Rv | Rv1852 | ureG | 2e-07 | 26.45% (242) | urease accessory protein ureG |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2427 | - | 3e-08 | 26.52% (230) | urease accessory protein (UreG) |
| M. marinum M | MMAR_1871 | hypB | 1e-57 | 47.64% (233) | nickel cation-binding GTPase, HypB |
| M. avium 104 | MAV_2680 | hypB | 7e-31 | 53.98% (113) | hydrogenase accessory protein HypB |
| M. thermoresistible (build 8) | TH_2818 | - | 4e-59 | 48.95% (239) | PUTATIVE nickel cation-binding GTPase, HypB |
| M. ulcerans Agy99 | MUL_3027 | ureG | 5e-11 | 27.82% (248) | urease accessory protein UreG |
| M. vanbaalenii PYR-1 | Mvan_2417 | - | 5e-95 | 66.14% (254) | hydrogenase accessory protein HypB |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2721|M.smegmatis_MC2_155 MCATCGCGGTDGAGVPVTLAGETPPHHHEHDHDHDHPHTHDHPPTETVTL
Mflv_3978|M.gilvum_PYR-GCK MCATCGCG-EDGTTITVPVQGHDHHHNHPHDQPDDHHQHHHPHPTETVTL
Mvan_2417|M.vanbaalenii_PYR-1 MCATCGCG-DDRSTITVP--GASPEHHHPHEHNHPH--------TRTVEL
MMAR_1871|M.marinum_M --MGRFHRHDDGTVHTHEH-----EH-HQHGDHTGYQT-----GPARIEV
TH_2818|M.thermoresistible__bu --VGRFHRHDDGTVHSHEHGDHAHEHPHDHGDHSGYQT-----GGQRIEV
MAV_2680|M.avium_104 --------------------------------------------------
Mb1883|M.bovis_AF2122/97 ------------------------------------------------MA
Rv1852|M.tuberculosis_H37Rv ------------------------------------------------MA
MUL_3027|M.ulcerans_Agy99 ------------------------------------------------MA
MAB_2427|M.abscessus_ATCC_1997 ------------------------------------------------MP
MSMEG_2721|M.smegmatis_MC2_155 EQRVLAKNDMLAQQNREWLTARGIVALNITSSPGAGKTTLLERTIRDLGR
Mflv_3978|M.gilvum_PYR-GCK EQKVLAKNDGIAARNRRWLTERDIVAFNMTSSPGSGKTTLLERTIRDLHP
Mvan_2417|M.vanbaalenii_PYR-1 EHRVLARNDAIAEQNRRWLEHRRILALNLTSSPGSGKTTLLERTIRDLGT
MMAR_1871|M.marinum_M LEEIFAENDVRADLNRRAFETNGIRALNLMSSPGSGKTTVLQATLDQLAS
TH_2818|M.thermoresistible__bu LESIFAENDSRAAINRKIFEENGIRALNLMSSPGSGKTTVLAATLDELAN
MAV_2680|M.avium_104 --------------------------------------------------
Mb1883|M.bovis_AF2122/97 THSHP-HSHTVPARPRRVRKPGEPLRIGVGGPVGSGKTALVAALCRQLRG
Rv1852|M.tuberculosis_H37Rv THSHP-HSHTVPARPRRVRKPGEPLRIGVGGPVGSGKTALVAALCRQLRG
MUL_3027|M.ulcerans_Agy99 KHSHD-HTHDHHDRPRRVRKPGEPLRIGVGGPVGSGKTALVAAICRQLRD
MAB_2427|M.abscessus_ATCC_1997 PHLIDGQPHQHIDRPRRVRQPGEPLRIGIGGPVGSGKTALVAALCRTLRD
MSMEG_2721|M.smegmatis_MC2_155 DHAVAVIEGDQETLLDADRIRAAGAR----AVQVNT----GAGCHLDASM
Mflv_3978|M.gilvum_PYR-GCK TRSVAVIEGDQETLLDAERIQATGAR----VVQVNT----GAGCHLDAEM
Mvan_2417|M.vanbaalenii_PYR-1 RSPVSVIEGDQETLLDVERIRATGVP----AVQINT----GAGCHLDAQM
MMAR_1871|M.marinum_M EFAIGVIEGDIATDLDAAKLSGRGAQ----VSLLNTSNGFGGECHLDAPM
TH_2818|M.thermoresistible__bu QIAIGIIEGDIATDLDAAKLGGRGAQ----ISLLNTNNGFGGECHLDAPM
MAV_2680|M.avium_104 -------------------------------------------------M
Mb1883|M.bovis_AF2122/97 ELSLAVLTNDIYTTEDADFLRTHAVLPDDRIAAVQTGGCPHTAIRDDITA
Rv1852|M.tuberculosis_H37Rv ELSLAVLTNDIYTTEDADFLRTHAVLPDDRIAAVQTGGCPHTAIRDDITA
MUL_3027|M.ulcerans_Agy99 ELSLAVLTNDIYTTEDADFLRKHAVLPDSRIIAVQTGGCPHTAIRDDITA
MAB_2427|M.abscessus_ATCC_1997 EISVAVLTNDIYTTEDADFLRRHAVLPDERITAVQTGGCPHTAIRDDITA
MSMEG_2721|M.smegmatis_MC2_155 VHRAIDALDPS--PGSLLFIENVGNLVCPALFDLGEYQKVVVISVTEGTD
Mflv_3978|M.gilvum_PYR-GCK IRRALDTLAPR--RARVLFIENVGNLVCPALFDLGETSKVVVISVTEGAD
Mvan_2417|M.vanbaalenii_PYR-1 VAGALTALDPP--QRSLLFIENVGNLVCPALFDLGERSKVVIISVTEGAD
MMAR_1871|M.marinum_M VNRALPGLDLP--NLDLVIVENVGNLVCPAEFDVGEHAKAMVYSVTEGED
TH_2818|M.thermoresistible__bu VNRALQDLDLD--HLELVVIENVGNLVCPAEFDVGEHAKAMVYSVAEGED
MAV_2680|M.avium_104 VNRALQGLDLT--TLDLVIIENVGNLVCPAEFDVGEHAKAMVYSVTKGDD
Mb1883|M.bovis_AF2122/97 NLDAIDELMAAHDALDLILVESGGDNLTATFSSGLVDAQIFVIDVAGGDK
Rv1852|M.tuberculosis_H37Rv NLDAIDELMAAHDALDLILVESGGDNLTATFSSGLVDAQIFVIDVAGGDK
MUL_3027|M.ulcerans_Agy99 NLDAIDDLIAAHDALDLILVESGGDNLTATFSSGLVDVQIFVIDVAGGDK
MAB_2427|M.abscessus_ATCC_1997 NLDAIEDLIATNEPLDLILVESGGDNLTATFSSGLIDVQIFVIDVAGGDK
*: * ::.:*. *: : .: . : .: .*: * .
MSMEG_2721|M.smegmatis_MC2_155 KPLKYPHMFAAAGLVILNKIDLLPYVNFDIETCCRYARSVNPAVTILQTS
Mflv_3978|M.gilvum_PYR-GCK KPLKYPHMFAAADLVLINKSDLLPYVDFDIDACASAARSVNPGVGILTLS
Mvan_2417|M.vanbaalenii_PYR-1 KPLKYPHMFAAAGLVLINKSDLLPYVDFDVDRCTGYARSVHPGVDVMTLS
MMAR_1871|M.marinum_M KPLKYPVMFRCVDVVLLNKIDLVPYLDADVDTYVAHIREVNAHATILPVS
TH_2818|M.thermoresistible__bu KPLKYPVMFRAVDVVLLNKIDLVPYLDVDVDRYIAHIREVNPTARILPVS
MAV_2680|M.avium_104 KPMKYPVMFRAVDVVLLNKIDLVPYLDVDVDSYIGHVREVNPTATILPVS
Mb1883|M.bovis_AF2122/97 VPRKGGPGVTYSDLLVVNKTDLAALVGADLAVMARDADAVRDGRPTVLQS
Rv1852|M.tuberculosis_H37Rv VPRKGGPGVTYSDLLVVNKTDLAALVGADLAVMARDADAVRDGRPTVLQS
MUL_3027|M.ulcerans_Agy99 VPRKGGPGVTFSDLLVVNKTDLAPLVGADLKVMARDAEAVRDGRPTVLQS
MAB_2427|M.abscessus_ATCC_1997 VPRKGGPGVTFSDLLVINKTDLAPMVGADLTVMARDAAAVREGRPTAMIS
* * . .::::** ** . :. *: *. *
MSMEG_2721|M.smegmatis_MC2_155 ATRGDGLSAWYEWLGER-IH------------------------
Mflv_3978|M.gilvum_PYR-GCK AKTGDGVEEWYDWISQRSIYDARVPIAGGRPAPEVRPHQEIRRR
Mvan_2417|M.vanbaalenii_PYR-1 AKTGEGTADWYRWIDAQREHPGADPSSG--PTVDNGYPRE----
MMAR_1871|M.marinum_M ARTGAGMTAWFDWLRRFAQGLPPE--------------------
TH_2818|M.thermoresistible__bu ARTGEGMDAWFDWLRQFLRG------------------------
MAV_2680|M.avium_104 ARTGVGMPDWLAWLRRFMEGTPTA--------------------
Mb1883|M.bovis_AF2122/97 LTEDPAASDVVAWVRSQLAADGV---------------------
Rv1852|M.tuberculosis_H37Rv LTEDPAASDVVAWVRSQLAADGV---------------------
MUL_3027|M.ulcerans_Agy99 LTEDPAATKVLDWVRSQLAAAG----------------------
MAB_2427|M.abscessus_ATCC_1997 LTEDPAASEVLAWVRAHLTEAHQTDHAH----------------
. . *: