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MHCLIVDDSAQFRAAASGMLERAGITVDLACNGAEALQCYRTRPPDVTLVDVDLGPESGFDVAEQLHHSE PAGIPVIMISTHSELDLAEMIADSSAVGFLPKFALSPAAIKELLDT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2251 | - | - | 100% (116) | nitrate/nitrite response regulator protein |
| M. smegmatis MC2 155 | MSMEG_0981 | - | 2e-27 | 56.78% (118) | two-component system regulator |
| M. smegmatis MC2 155 | MSMEG_4378 | - | 4e-11 | 33.33% (117) | two-component system response regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1652 | - | 4e-08 | 29.46% (112) | two-component system transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2266 | - | 8e-08 | 30.63% (111) | two component transcriptional regulator |
| M. tuberculosis H37Rv | Rv1626 | - | 4e-08 | 29.46% (112) | two-component system transcriptional regulator |
| M. leprae Br4923 | MLBr_01286 | - | 2e-08 | 29.46% (112) | putative two-component response regulatory protein |
| M. abscessus ATCC 19977 | MAB_4498c | - | 7e-09 | 31.73% (104) | two-component LuxR family response regulator |
| M. marinum M | MMAR_4529 | mprA | 2e-08 | 31.53% (111) | two component response transcriptional regulatory protein |
| M. avium 104 | MAV_0304 | - | 5e-08 | 29.82% (114) | DNA-binding response regulator |
| M. thermoresistible (build 8) | TH_1732 | phoP | 9e-08 | 30.63% (111) | DNA-binding response regulator PhoP |
| M. ulcerans Agy99 | MUL_4701 | mprA | 1e-08 | 31.53% (111) | two component response transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_2072 | - | 2e-29 | 60.53% (114) | response regulator receiver protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2251|M.smegmatis_MC2_155 ----------------------MH---CLIVDDSAQFRAAASGMLERAGI
Mvan_2072|M.vanbaalenii_PYR-1 MVVPNFPVNRNANGLRSCQARRMNGPRCLIVDDSADFRDAARAMLERGGI
Mb1652|M.bovis_AF2122/97 --MTGPTTDAD----------AAVPRRVLIAEDEALIRMDLAEMLREEGY
Rv1626|M.tuberculosis_H37Rv --MTGPTTDAD----------AAVPRRVLIAEDEALIRMDLAEMLREEGY
MLBr_01286|M.leprae_Br4923 --MTGPTTDAD----------AATPHRVLIAEDEALIRLDLAEMLRDEGY
Mflv_2266|M.gilvum_PYR-GCK --MAHPQSDPEDPARVVMRRADGSPIRVLVVDDEAVLAELMSMALRYEGW
MAV_0304|M.avium_104 --MSQPRASAE---RVVMCRADGNPINVLVVDDEAVLAEMVSMALRYEGW
MMAR_4529|M.marinum_M -----------------------MSVRILVVDDDRAVRESLRRSLSFNGY
MUL_4701|M.ulcerans_Agy99 -----------------------MSVRILVVDDDRAVRESLRRSLSFNGY
TH_1732|M.thermoresistible__bu -----------------------VAVRILVVDDDRAVRESLRRSLSFNGY
MAB_4498c|M.abscessus_ATCC_199 ----------------------MSAIRVLVADDDTLLREGVASVLEKAGF
*:.:*. . * *
MSMEG_2251|M.smegmatis_MC2_155 TVD-LACNGAEALQCYRTRPPDVTLVDVDLG---PESGFDVAEQLHHSEP
Mvan_2072|M.vanbaalenii_PYR-1 VVVGTARDAAEALRRAQELHPDVALVDVDLG---AESGFDVAERLDD---
Mb1652|M.bovis_AF2122/97 EIVGEAGDGQEAVELAELHKPDLVIMDVKMP---RRDGIDAASEIASKR-
Rv1626|M.tuberculosis_H37Rv EIVGEAGDGQEAVELAELHKPDLVIMDVKMP---RRDGIDAASEIASKR-
MLBr_01286|M.leprae_Br4923 DIVGEAADGQEAVELAERHKPDLVIMDVKMP---RRDGIDAASEIASKR-
Mflv_2266|M.gilvum_PYR-GCK DIS-TAGDGATAIALARQNPPDVVVLDVMLP---DMSGLEVLRTLREQIP
MAV_0304|M.avium_104 NIA-TASDGASAIAAARNQRPDVVVLDVMLP---DMSGLDVLHKLREENP
MMAR_4529|M.marinum_M TVE-LAHDGVEALEMIASDRPDALVLDVMMP---RLDGLEVCRQLRSTGD
MUL_4701|M.ulcerans_Agy99 TVE-LAHDGVEALEMIASDRPDALVLDVMMP---RLDGLEVCRQLRSTGD
TH_1732|M.thermoresistible__bu SVE-LAEDGVEALDLIANDRPDAVVLDVMMP---RLDGLEVCRQLRSTGD
MAB_4498c|M.abscessus_ATCC_199 EVVGRAGDATALLELVRTESPNLVVVDIRMPPTHTTEGLEAAQKIRGEHP
: * :. : *: ::*: : .*::. :
MSMEG_2251|M.smegmatis_MC2_155 AGIPVIMISTHSELDLAEMIADSS-AVGFLPKFALSPAAIKELLDT----
Mvan_2072|M.vanbaalenii_PYR-1 --VPVILTSTHDEQDFADLIAASP-ALGFLPKLTLSPAAVRKLLDRVSGS
Mb1652|M.bovis_AF2122/97 -IAPIVVLTAFSQRDLVERARDAG-AMAYLVKPFSISDLIPAIELAVSRF
Rv1626|M.tuberculosis_H37Rv -IAPIVVLTAFSQRDLVERARDAG-AMAYLVKPFSISDLIPAIELAVSRF
MLBr_01286|M.leprae_Br4923 -IAPIVVLTAFSQRDLVERARDAG-AMAYLVKPFTISDLIPAIALAMSRF
Mflv_2266|M.gilvum_PYR-GCK -GLPLLLLTAKDSVEDRIAGLTAG-GDDYVTKPFSIEEVVLRLRALLRRT
MAV_0304|M.avium_104 -QLPVLLLTAKDAVEDRIAGLTAG-GDDYVTKPFSIEEVVLRLRALLRRT
MMAR_4529|M.marinum_M -DLPILVLTARDSVSERVAGLDAG-ADDYLPKPFALEELLARMRALLRRT
MUL_4701|M.ulcerans_Agy99 -DLPILVLTARDSVSERVAGLDAG-ADDYLPKPFALEELLARMRALLRRT
TH_1732|M.thermoresistible__bu -DLPILVLTARDSVSERVAGLDAG-ADDYLPKPFALEELLARLRALLRRT
MAB_4498c|M.abscessus_ATCC_199 -GIGVLVLSAHVEVEYAAELITSGDGVGYLLK--SRIGDVGEFADACTRV
::: :: . : . :: * : :
MSMEG_2251|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2072|M.vanbaalenii_PYR-1 PGT-----------------------------------------------
Mb1652|M.bovis_AF2122/97 RE-----ITALEGEVATLSERLETRKLVERAKGLLQTKHGMTEPDAFKWI
Rv1626|M.tuberculosis_H37Rv RE-----ITALEGEVATLSERLETRKLVERAKGLLQTKHGMTEPDAFKWI
MLBr_01286|M.leprae_Br4923 SE-----LTALEREVATLADRLETRKLVERAKGLLQVKQGMTEPEAFKWI
Mflv_2266|M.gilvum_PYR-GCK GV--ATATGGAKLVVGDLVLDEDSHEVTRGGDLITLTATEFELLRFMMRN
MAV_0304|M.avium_104 GV--TTVDSGAQLVVGDLVLDEDSHEVTRAGEPISLTSTEFELLRFMMRN
MMAR_4529|M.marinum_M KPEDDEAADSVAMTFSDLSLDPVTREVTRGARRISLTRTEFALLEMLIAN
MUL_4701|M.ulcerans_Agy99 KLEDDEAADSVAMTFSDLSLDPVTREVTRGARRISLTRTEFALLEMLIAN
TH_1732|M.thermoresistible__bu TP--DDAADSQKLTFADLTLDPVTREVTRGNRQISLTRTEFALLELLIAN
MAB_4498c|M.abscessus_ATCC_199 AG------GGSIVDPELVRELLSARRKDDPLSALSQRELEVLELMAQGLS
MSMEG_2251|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2072|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1652|M.bovis_AF2122/97 QRAAMDRRTTMKRVAEVVLETLGTPKDT----------------------
Rv1626|M.tuberculosis_H37Rv QRAAMDRRTTMKRVAEVVLETLGTPKDT----------------------
MLBr_01286|M.leprae_Br4923 QRAAMDRRTTMKRVAEVVLETLDTPKDT----------------------
Mflv_2266|M.gilvum_PYR-GCK ARCVLSKAQILDRVWSYDFGGRSNIVELYVSYLRKKIDSGREP-MIHTLR
MAV_0304|M.avium_104 SKRVLSKAQILDRVWSYDFGGRSNIVELYISYLRKKIDNGREP-MIHTLR
MMAR_4529|M.marinum_M PRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEAEGEPRLIHTVR
MUL_4701|M.ulcerans_Agy99 PRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEAEGEPRLIHTVR
TH_1732|M.thermoresistible__bu PRRVLSRSRILEEVWGFDFPTSGNALEVYIGYLRRKTEAEGEPRLIHTVR
MAB_4498c|M.abscessus_ATCC_199 NSGIAGRLWITESTVEKHVHSVMRRLDLGHADEYHRRVLAVLAFLTHR--
MSMEG_2251|M.smegmatis_MC2_155 -----------
Mvan_2072|M.vanbaalenii_PYR-1 -----------
Mb1652|M.bovis_AF2122/97 -----------
Rv1626|M.tuberculosis_H37Rv -----------
MLBr_01286|M.leprae_Br4923 -----------
Mflv_2266|M.gilvum_PYR-GCK GAGYVLKPAR-
MAV_0304|M.avium_104 GAGYVLKPAR-
MMAR_4529|M.marinum_M GVGYVLRETPP
MUL_4701|M.ulcerans_Agy99 GVGYVLRETPP
TH_1732|M.thermoresistible__bu GVGYVLRETPP
MAB_4498c|M.abscessus_ATCC_199 -----------