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MALTAEEETIVKTVHDFVEKQVKPVVRELEHANTYPEELIETMKEIGIFGLAIPEPYGFGAVSMPCYVQV AEELARGWMSLAGAMGGHTVVSKLLLLFGTEEQKQKYLPRMATGELRATMALTEPGGGSDLQAMRTVARR DGDDYVINGSKTWISNARRSDLVALMCKTDPDAQPAHKGVSILLVEKVPGFDVSRDLPKLGYKGVESCEL NFTDARVPVSSLLGDDEGRGFAQMMKGLEVGRLQVAARATGVARAAFEDALRYSQERESFGKPIWQHQSV GNMLADMGTKLYAARSLLLSAAEKFDAGQRCDMEAGMAKLFASETAMQIALDAVRVHGGYGYSTEYDVER YFRDAPLMIVGEGTNEIQRNVIAKQLVARGGLDI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1991 | - | - | 100% (384) | isovaleryl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2208 | - | e-103 | 47.15% (386) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0108 | - | 6e-74 | 40.05% (372) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0221c | fadE3 | 1e-161 | 73.44% (384) | acyl-CoA dehydrogenase FADE3 |
| M. gilvum PYR-GCK | Mflv_0446 | - | 1e-165 | 74.02% (381) | butyryl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv0215c | fadE3 | 1e-144 | 71.88% (352) | acyl-CoA dehydrogenase FADE3 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 5e-59 | 34.75% (377) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2081 | - | 7e-64 | 39.38% (353) | acyl CoA dehydrogenase |
| M. marinum M | MMAR_0455 | fadE3_2 | 1e-161 | 72.44% (381) | acyl-CoA dehydrogenase FadE3_2 |
| M. avium 104 | MAV_2590 | - | 1e-170 | 76.44% (382) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3837 | - | 1e-160 | 72.97% (381) | PUTATIVE Butyryl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4024 | fadE3 | 1e-161 | 72.18% (381) | acyl-CoA dehydrogenase FadE3 |
| M. vanbaalenii PYR-1 | Mvan_0221 | - | 1e-162 | 74.02% (381) | butyryl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0221c|M.bovis_AF2122/97 -----MRN-----ELNDDEAMLVATVRAFIDRDVKPTVREVEHANSYPEA
Rv0215c|M.tuberculosis_H37Rv -----MRN-----ELNDDEAMLVATVRAFIDRDVKPTVREVEHANSYPEA
MMAR_0455|M.marinum_M -----MDNQRADSQLDEDEAMLVATVRAFIDRDVKPSVREVEHANTYPQA
MUL_4024|M.ulcerans_Agy99 ----MMNNDSPDSQLDEDEAMLVATVRAFIDRDVRPSVREVEHANTYPQA
TH_3837|M.thermoresistible__bu ------VN----VVLNDEETMLVETVRAFIDRDVKPTVREVEHANEYPQA
Mflv_0446|M.gilvum_PYR-GCK -----MVDG-----LSSEEAMLVQTVRAFIDRDVKPTVRDVEHANTYPEA
Mvan_0221|M.vanbaalenii_PYR-1 -----MVEG-----LSSEEAMLVETVRTFIDREVRPTVRDVEHANTYPEA
MAV_2590|M.avium_104 -----MTVA-----LSDEETMLVETVRAFVDRDVKPTVRAVEHANEYPEA
MSMEG_1991|M.smegmatis_MC2_155 ------------MALTAEEETIVKTVHDFVEKQVKPVVRELEHANTYPEE
MAB_2081|M.abscessus_ATCC_1997 ------MSSPISPWMNAELLELRDLAAKFFSAELAPHANRFADQHHVDRE
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
: : : : . :: * . . . .
Mb0221c|M.bovis_AF2122/97 WIEQMKHIGIYGLAIDEQYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
Rv0215c|M.tuberculosis_H37Rv WIEQMKHIGIYGLAIDEQYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
MMAR_0455|M.marinum_M WIEQMKRIGIYGLAIGEAYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
MUL_4024|M.ulcerans_Agy99 WIEQMKRIGIYGLAIGEAYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
TH_3837|M.thermoresistible__bu WIEQMKRIGIYGLAIPESYGGSPVSMPCYVEVTQELSRGWMSLAGAMGGH
Mflv_0446|M.gilvum_PYR-GCK WIDQMKQIGIYGLAVPESYGGTPVSTRCYVLVTQELARGWMSLAGAMGGH
Mvan_0221|M.vanbaalenii_PYR-1 WIEKMKQIGIFGLAIPESEGGAPVSTRCYVLVTQELARGWMSLAGAMGGH
MAV_2590|M.avium_104 WIEQMKRIGIFGLAVPEEYGGSPVSMPCYVKVTEELARGWMSLAGAMGGH
MSMEG_1991|M.smegmatis_MC2_155 LIETMKEIGIFGLAIPEPYGFGAVSMPCYVQVAEELARGWMSLAGAMGGH
MAB_2081|M.abscessus_ATCC_1997 LWNRAGELGLLCMSIPEEYGGGGGTFAHEAVVLEEQARIGDSSWGAGLHS
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
*: : : * * * :* :* *
Mb0221c|M.bovis_AF2122/97 TVVAKLLTLFGTEEQRRTYLPPMASGELRATMALTEPGGGSDLQNMSTTA
Rv0215c|M.tuberculosis_H37Rv TVVAKLLTLFGTEEQRRTYLPPMASGELRATMALTEPGGGSDLQNMSTTA
MMAR_0455|M.marinum_M TVVAKLLMLFGTDEQKSTYLPAMATGELRATMALTEPGGGSDLQNMSTTA
MUL_4024|M.ulcerans_Agy99 TVVAKLLMLFGTDEQKSTYLPAMATGELRATMALTEPGGGSDLQNMSTTA
TH_3837|M.thermoresistible__bu TVVAKLLTLFGTEEQKQRYLPAMATGEIRATMALTEPGGGSDLQNMTTTA
Mflv_0446|M.gilvum_PYR-GCK TVVAKLLTLFGTEEQKQRYLPAMATGEIRATMALTEPGGGSDLQAMGTVA
Mvan_0221|M.vanbaalenii_PYR-1 TVVAKLLSLFGTDEQKQRYLPPMATGELRATMALTEPGGGSDLQAMSTVA
MAV_2590|M.avium_104 TVVAKLISLYGTEEQKQKYLPRMASGEMRATMALTEPGGGSDLQAMTTTA
MSMEG_1991|M.smegmatis_MC2_155 TVVSKLLLLFGTEEQKQKYLPRMATGELRATMALTEPGGGSDLQAMRTVA
MAB_2081|M.abscessus_ATCC_1997 GIVAHYILQYATEELRAQWLPKMASGEMIGAIAMTEPGTGSDLQSVKTKA
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
: : : .::* : ** :*: .: *::* *** : * *
Mb0221c|M.bovis_AF2122/97 LADGPEGSAGLLINGCKTWISNARRSGLFAVLCKTDPNATPRHQGMSIVL
Rv0215c|M.tuberculosis_H37Rv LADGPEGSAGLLINGCKTWISNARRSGLFAVLCKTDPNATPRHQGMSIVL
MMAR_0455|M.marinum_M MADGPDQ---LLITGAKTWISNARRSGLIALLCKTDPHATPRHHGISIVL
MUL_4024|M.ulcerans_Agy99 MADGPDQ---LLITGAKTWISNARRSGLIALLCKTDPHATPRHHGISIVL
TH_3837|M.thermoresistible__bu LP-GPGG--GLVINGAKTWISNARRSGLIALLCKTDPDATPRHRGISVVL
Mflv_0446|M.gilvum_PYR-GCK RRDGDD----LVLSGTKTWISNARRSGLIALLCKTDPDATPKHSGISVVL
Mvan_0221|M.vanbaalenii_PYR-1 RRDGDE----LVISGAKTWISNARRSGLIALLCKTDPEATPRHSGISVVL
MAV_2590|M.avium_104 RAEGNE----LVINGAKTWISNARRSGLIALLCKTDPQAQPRHKGISIVL
MSMEG_1991|M.smegmatis_MC2_155 RRDGDD----YVINGSKTWISNARRSDLVALMCKTDPDAQPAHKGVSILL
MAB_2081|M.abscessus_ATCC_1997 LLDGDE----YVITGSKTFITNGQQADLIIVVAKTDPSQG--AAGISLIV
MLBr_00737|M.leprae_Br4923 KADGDD----WILNGFKCWITNGGKSTWYTVMAVTDPDKG--ANGISAFI
* ::.* * :*:*. :: ::. *** *:* .:
Mb0221c|M.bovis_AF2122/97 VEPGP-GLTVSRDLPKLGYKGVESCELSFDNLRVPVSAILGGAMGQGFSQ
Rv0215c|M.tuberculosis_H37Rv VEPGP-GLTVSRDLPKLGYKGVESCELSFDNLRVPVSAILGGAMGQGFSQ
MMAR_0455|M.marinum_M VEPGP-GLNISADLPKLGYKGVEACELSFDNYRAPTSAILGGQPGQGFSQ
MUL_4024|M.ulcerans_Agy99 VEPGP-GLNISADLPKLGYKGVEACELSFDNYRAPTSAILGGQPGQGFSQ
TH_3837|M.thermoresistible__bu VEQGTTGLSVSRDLPKLGYKGVESCELVFDDCRVPASAILGGEPGKGFTQ
Mflv_0446|M.gilvum_PYR-GCK VDNPTPGLTVSRDLPKLGYKGVESCELAFDACRVPASAILGGTPGKGFSQ
Mvan_0221|M.vanbaalenii_PYR-1 VDNPTDGLTVSRDLPKLGYKGVESCELTFDGCRVPESAILGGAAGRGFAQ
MAV_2590|M.avium_104 VEHGQ-GLTVSRDLPKLGYKGVESCELSFDECRVPAAAILGDEPGRGFAQ
MSMEG_1991|M.smegmatis_MC2_155 VEKVP-GFDVSRDLPKLGYKGVESCELNFTDARVPVSSLLGDDEGRGFAQ
MAB_2081|M.abscessus_ATCC_1997 VEADRAGFRRGKVLDKIGQRGQDTSELFFDEVRVPRSHLLGQAEGQGFIQ
MLBr_00737|M.leprae_Br4923 VHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIG-EPGTGFKT
*. *: . *:* :* : ** * * * ::* * **
Mb0221c|M.bovis_AF2122/97 MMKGLETGRIQVAARALGVATAALEDSLAYAQQRESFGRPIWQHQAVGNY
Rv0215c|M.tuberculosis_H37Rv MMKGLETGRIQVAARALGVATAALEDSLAYAQQRESFGRPIWQHQAVGNY
MMAR_0455|M.marinum_M MMKGLETGRIQVAARALGVASAALDDALAYAQQRHSFGQPIWKHQAIGNY
MUL_4024|M.ulcerans_Agy99 MMKGLETGRIQVAARALGVASAALDDALAYAQQRHSFGQPIWKHQAIGNY
TH_3837|M.thermoresistible__bu MMKGLETGRIQVAARALGVATAALEDALAYAQQRESFGQPIWKHQAIGHY
Mflv_0446|M.gilvum_PYR-GCK MMKGLETGRIQVASRALGVASAALEDALAYAQDRESFGRPIWKHQAVGHY
Mvan_0221|M.vanbaalenii_PYR-1 MMKGLETGRIQVASRALGVASAALADALAYAQDRESFGQPIWKHQAVGHY
MAV_2590|M.avium_104 MMKGLETGRIQVASRALGVASAALEDALKYAQERESFGQPIWKHQSVGNY
MSMEG_1991|M.smegmatis_MC2_155 MMKGLEVGRLQVAARATGVARAAFEDALRYSQERESFGKPIWQHQSVGNM
MAB_2081|M.abscessus_ATCC_1997 LMTQLPQERLIVAVGAVAAMELALEQTLKYTREREAFGRPVFGFQNTKFT
MLBr_00737|M.leprae_Br4923 ALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFM
: * * :. * . *: :: *:::*. **..: .*
Mb0221c|M.bovis_AF2122/97 LADMATKLTAARQLTRYAAERYDSGQR-CDMEAGMAKLFASEVAMEIALN
Rv0215c|M.tuberculosis_H37Rv LADMATKLTAARQLTRYAAERYDSGQR-CDMEAGMAKLFASEVAMEIALN
MMAR_0455|M.marinum_M LADMATKLTAARQLTHYAAQRYDSGQR-CDMEAGMAKLFASETAMEIALN
MUL_4024|M.ulcerans_Agy99 LADMATKLTAARQLTHYAAQRYDSGQR-CDMEAGMAKLFASETAMEIALN
TH_3837|M.thermoresistible__bu LADMATKLTAARQLTRYAAERYDSGQR-CDMEAGMAKLFASEVAMEIALN
Mflv_0446|M.gilvum_PYR-GCK LADMATKLTAARQLTLYAADRYDSGER-ADMEAGMAKLFASEVAMEIALN
Mvan_0221|M.vanbaalenii_PYR-1 LADMATKLTAARQLTLYAADRYDSGAR-ADMEAGMAKLFASEVAMEIALN
MAV_2590|M.avium_104 LADMATKLTAARQLTRYAAEKYDSGER-CDMEAGMAKLFASEVAMEIALN
MSMEG_1991|M.smegmatis_MC2_155 LADMGTKLYAARSLLLSAAEKFDAGQR-CDMEAGMAKLFASETAMQIALD
MAB_2081|M.abscessus_ATCC_1997 LAEAATETRIARVFLDYCIDLHLAGQL-DVQTVAMAKWWTTERAMKVLDD
MLBr_00737|M.leprae_Br4923 LADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTD
**: . : ** : . * . :* :::: **:: :
Mb0221c|M.bovis_AF2122/97 AVRIHGGYGYSTEYDVERYFRDAPLMILGEGTNEIQRNVIAGQLVARGGI
Rv0215c|M.tuberculosis_H37Rv AVRIHGGYGYSTEYDVERR-------------------------------
MMAR_0455|M.marinum_M AVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIARQLIARGGI
MUL_4024|M.ulcerans_Agy99 AVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIARQLIARGGI
TH_3837|M.thermoresistible__bu AVRIHGGYGYSTEFDVERYFRDAPLMIVGEGTNEIQRNVIVSQLVARNTV
Mflv_0446|M.gilvum_PYR-GCK AVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIAGQLVARGGI
Mvan_0221|M.vanbaalenii_PYR-1 AVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIAGQLVARGGI
MAV_2590|M.avium_104 AVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIAAQLVSRGKL
MSMEG_1991|M.smegmatis_MC2_155 AVRVHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIAKQLVARGGL
MAB_2081|M.abscessus_ATCC_1997 CMQLHGGYGYMTEYPISRLWVDQRVQKIYAGTNEVMKEIISRSL------
MLBr_00737|M.leprae_Br4923 AVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR----
.:::.** ** ::: :.*
Mb0221c|M.bovis_AF2122/97 --
Rv0215c|M.tuberculosis_H37Rv --
MMAR_0455|M.marinum_M --
MUL_4024|M.ulcerans_Agy99 --
TH_3837|M.thermoresistible__bu --
Mflv_0446|M.gilvum_PYR-GCK --
Mvan_0221|M.vanbaalenii_PYR-1 --
MAV_2590|M.avium_104 --
MSMEG_1991|M.smegmatis_MC2_155 DI
MAB_2081|M.abscessus_ATCC_1997 --
MLBr_00737|M.leprae_Br4923 --