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TDTIHPSDGPQLALSAGPLADLTVVDLTRALAGPHAAMMLGDLGADVIKVESPVGGDDTRGWGPPFIEPT GAERESTYFLSANRNKKSVTLDLKSPLGRDALTELLRRADVLMENFRPGVLDRLGFSEEVLQELNPRLII LSISGFGHDGPEAGRAGYDQIAQGEAGLMSLTGANPHDLQRVGVPIADLLAGMYGAFGVLAALNERARTG RGQVVRASLLAAVVGVHAFQGTKWTVAGQIGEATGNHHPSICPYGLFDTADGAVQIAVGSEGLWKRFCDG FHLDAHAPGMATNPERVANQKRVNDLVQNVFSLYSTDELLGILDQIGVPAGRIRNLREVYEWEQTRSQGL LIDVDHATLGKITLPGPPLRFFDVAGPERTRRDHSAPPVLGADNHLIDELTAGRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2171 | - | - | 100% (406) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. smegmatis MC2 155 | MSMEG_6689 | - | 2e-70 | 43.54% (333) | CAIB/BAIF family protein |
| M. smegmatis MC2 155 | MSMEG_4120 | - | 1e-67 | 38.64% (383) | CAIB/BAIF family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 3e-31 | 33.33% (273) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_4465 | - | 3e-53 | 33.98% (359) | Formyl-CoA transferase |
| M. tuberculosis H37Rv | Rv3272 | - | 4e-31 | 33.33% (273) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0824 | - | 2e-68 | 40.90% (357) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_1494 | - | 8e-53 | 34.18% (354) | hypothetical protein MMAR_1494 |
| M. avium 104 | MAV_2651 | - | 6e-54 | 39.56% (321) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. thermoresistible (build 8) | TH_3339 | - | 4e-61 | 37.11% (353) | PUTATIVE putative L-carnitine dehydratase/bile acid-inducible |
| M. ulcerans Agy99 | MUL_2446 | - | 2e-52 | 33.90% (354) | hypothetical protein MUL_2446 |
| M. vanbaalenii PYR-1 | Mvan_1855 | - | 1e-71 | 41.73% (381) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2171|M.smegmatis_MC2_155 MTDTIHPSDGPQLALSAGPLADLTVVDLTRALAGPHAAMMLGDLGADVIK
MAV_2651|M.avium_104 -------------------------MSLEQAVAAPYATRQLADLGARVIK
MAB_0824|M.abscessus_ATCC_1997 --------------MTAAALDGLLVVDFSRVLAGPYATMMLGDFGAEVIK
Mvan_1855|M.vanbaalenii_PYR-1 --------------MTG-ALDGVVVVDFSRVLAGPYATMMLGDFGAEVIK
MMAR_1494|M.marinum_M -------------MTEPGALDGIRVLELGTLIAGPFAGRLLGDMGADVIK
MUL_2446|M.ulcerans_Agy99 -------------MTEPGALDGIRVLELGTLIAGPFAGRLLGDMGADVIK
Mflv_4465|M.gilvum_PYR-GCK -------------MTT-GPLDGIRVIEVGTLISGPFAGRLLGDMGAEVIK
TH_3339|M.thermoresistible__bu ---MTTEVETTATQPTTGPLHGIRVVEMGSLLAGPIVGQMMGDLGADVVK
Mb3300|M.bovis_AF2122/97 ----------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIK
Rv3272|M.tuberculosis_H37Rv ----------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIK
:.. ::.* . : *:** *:*
MSMEG_2171|M.smegmatis_MC2_155 VESPVGGDDTRGWGPPFIEPTGAERESTYFLSANRNKKSVTLDLKSPLGR
MAV_2651|M.avium_104 VERPQGGDFARGYDR------TVHGESSYFVWLNRGKESLTVDLKQPEGR
MAB_0824|M.abscessus_ATCC_1997 IERPVLGDDTRQWGPP----YDSDGQATYFNSVNRNKQSVVLDLTSPDGQ
Mvan_1855|M.vanbaalenii_PYR-1 VERPGVGDDTRQWGPP----YDSSGVATYFNAVNRNKRSVVLDLSTPDGR
MMAR_1494|M.marinum_M VEAPGAPDPLRTWGQA-----EVDGHHVFWTVHARNKRAITLDLRRPQGR
MUL_2446|M.ulcerans_Agy99 VEAPGAPDPLRTWGQA-----EVDGHHVFWTVHARNKRAITLDLRRPQGR
Mflv_4465|M.gilvum_PYR-GCK VEPPGAPDPLRTWGQA-----ELDGHHFFWTVHARNKKAVTLNLRVPEGR
TH_3339|M.thermoresistible__bu IEDPGKGDPLRQWGQN-----RPKGQSLWFSIVGRNKRSVTINLREPRGQ
Mb3300|M.bovis_AF2122/97 VEAPG-GEAARQITSVLP---GRPPLATYFLPNNRGKKSVTVDLTTEQAK
Rv3272|M.tuberculosis_H37Rv VEAPG-GEAARQITSVLP---GRPPLATYFLPNNRGKKSVTVDLTTEQAK
:* * : * :: *.*.::.::* .:
MSMEG_2171|M.smegmatis_MC2_155 DALTELLRRADVLMENFRPGVLDRLGFSEEVLQELNPRLIILSISGFGHD
MAV_2651|M.avium_104 RIVERLLEGADVLVQNLAPGAAARMGLDTESVARAHPRTITATISGYGQD
MAB_0824|M.abscessus_ATCC_1997 HRARELAGRADVVVENFRAGTMEKFGLGYQSLKQLNPGLIYCAITGFGR-
Mvan_1855|M.vanbaalenii_PYR-1 QQARDLVAGADIVVENFRPGTMERLGLGYEDLRAVRPDVIYCSITGFGR-
MMAR_1494|M.marinum_M ELFLELVDKSDIVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQT
MUL_2446|M.ulcerans_Agy99 ELFLELVDKSDIVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQT
Mflv_4465|M.gilvum_PYR-GCK DLFLDLVERSDVIVENFRPGTLEKWNLGYDVLRERNRGIILVRVSGYGQT
TH_3339|M.thermoresistible__bu ELVRQLVAEADVLVENFRPGTMERWGLGYSDLAEINPRLVIVRVSGFGQD
Mb3300|M.bovis_AF2122/97 QQMLRLADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGN
Rv3272|M.tuberculosis_H37Rv QQMLRLADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGN
* :*:::: : .*. : .:. . : . : ::.:*
MSMEG_2171|M.smegmatis_MC2_155 GPEAGRAGYDQIAQGEAGLMSLTGANPHDLQRVGVPIADLLAGMYGAFGV
MAV_2651|M.avium_104 GPWRDRKAYDLLVQAEAGLLSVTGS-PAEVARTGVSIADIAAGMFAFSGI
MAB_0824|M.abscessus_ATCC_1997 GAGADLPGYDLLVQAVGGLMSVTGPDAAHPSKVGVALVDVLTALHALSGI
Mvan_1855|M.vanbaalenii_PYR-1 GGGAALPGYDLLVQAVGGLMSVTGTEPGDPTKAGVALVDVLAGLHALSGI
MMAR_1494|M.marinum_M GPDAHKAGYASVAEAASGLRHLNGFPGGPPPRLALSLGDSLAGMFGAQGA
MUL_2446|M.ulcerans_Agy99 GPDAHKAGYASVAEAASGLRHLNGFPGGPPPRLALSLGDSLAGMFGPQGA
Mflv_4465|M.gilvum_PYR-GCK GPDAHKAGYASVAEAASGLRHMNGFPGGPPPRLALSLGDSLAGMFAAQGA
TH_3339|M.thermoresistible__bu GPYASRPGYGAIGEAMGGLRYVVGDPSTPPSRVGISIGDTLAALFATIGA
Mb3300|M.bovis_AF2122/97 GPHGSRPGIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAV
Rv3272|M.tuberculosis_H37Rv GPHGSRPGIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAV
* . : . .*: . : * :. .
MSMEG_2171|M.smegmatis_MC2_155 LAALNERARTGRGQVVRASLLAAVVGVHAFQGTKWTVAGQIGEATGNHHP
MAV_2651|M.avium_104 LTALYTRATTGAVRPVSVSLFDALVEWMSQPLYYGRYGGKAPPRTGARHP
MAB_0824|M.abscessus_ATCC_1997 LAALSYRDRTGQGQRVDTDLMSVLLSSLVNQASGYLGAGVVPEALGNRHP
Mvan_1855|M.vanbaalenii_PYR-1 LAALHHRGRTGEGQRVDTDLLSVLLSSMVNQASGFLGAGVVPAMMGNRHP
MMAR_1494|M.marinum_M LAALYRRSVTGTGQVVDVALTESCLALQESTISDYDVGGVVRGPSGTRLE
MUL_2446|M.ulcerans_Agy99 LAALYRRSVTGTGQVVDVALTESCLALQESTISDYDVGGVVRGPSGTRLK
Mflv_4465|M.gilvum_PYR-GCK LAALYRRSVTGEGQIVDAALTESCLAVQESTIPDYDVGGVVRGPSGTRLE
TH_3339|M.thermoresistible__bu LAALREREISGRGQMVDSAIYEAVLGVMESLVPEWTVSGYQRERTGAILP
Mb3300|M.bovis_AF2122/97 LAALLHRERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAP
Rv3272|M.tuberculosis_H37Rv LAALLHRERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAP
*:** * .* * : : .
MSMEG_2171|M.smegmatis_MC2_155 ----------SICPYGLFDTADG-AVQIAVGSEGLWKRFCDGFHLD---A
MAV_2651|M.avium_104 ----------TIAPYGPVTAGDGGTVLLGVQNSAEWLRFCEIVLERRDLV
MAB_0824|M.abscessus_ATCC_1997 ----------SIAPYQTFETADR-PIAIAVGNDKQFRLLVQALEMPR-LA
Mvan_1855|M.vanbaalenii_PYR-1 ----------SIAPYQTFDTADR-PIAVAVGNDKQFRAFSTAIGQPE-LA
MMAR_1494|M.marinum_M ----------GIAPSNIYRSADESWVVIAANQDTVFTRLCQAMGCPE-LA
MUL_2446|M.ulcerans_Agy99 ----------GIAPSNIYRSADESWVVIAANQDTVFTRLCQAMGCPE-LA
Mflv_4465|M.gilvum_PYR-GCK ----------GIAPSNIYPTADGSWVVIAANQDTVFRRLCAAMGQPE-LA
TH_3339|M.thermoresistible__bu ----------KIAPSNVYPTSDDTWILIAANQDTVFRRLAEAMGRPE-LA
Mb3300|M.bovis_AF2122/97 KAKRRKGVGFATQPSDAFRTADG-YIVISAYVPKHWQKLCYLIGRPD-LV
Rv3272|M.tuberculosis_H37Rv KAKRRKGVGFATQPSDAFRTADG-YIVISAYVPKHWQKLCYLIGRPD-LV
* :.* : :.. : : . .
MSMEG_2171|M.smegmatis_MC2_155 HAPGMATNPERVANQKRVNDLVQNVFSLYSTDELLGILDQIGVPAGRIRN
MAV_2651|M.avium_104 DEPRFATNPDRVAHRDELESIITTVAARLSAEELEARLQSAGVAHARMNG
MAB_0824|M.abscessus_ATCC_1997 RDDRFATNPLRVRHRGELVRVLEQRLREKNADDWYDTLTAVGVPAGPIND
Mvan_1855|M.vanbaalenii_PYR-1 DDPRFVTNPARVANRDALCALIVPALKAHGADHWYAKLTTVGVPAGPIND
MMAR_1494|M.marinum_M TDDRFATHRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPINT
MUL_2446|M.ulcerans_Agy99 TDDRFATHRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPINT
Mflv_4465|M.gilvum_PYR-GCK TDERFADHVARGRNQDEIDKIIGGWAAQRQPDEIISTLSEAGVISGPINT
TH_3339|M.thermoresistible__bu EDERYATHVARGEHQAELDEIVAEFTRRHTAAEVEALMHKHNVPVGKIYR
Mb3300|M.bovis_AF2122/97 EDQRFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHT
Rv3272|M.tuberculosis_H37Rv EDQRFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHT
. : * : : : . . : .:
MSMEG_2171|M.smegmatis_MC2_155 LREVYEWEQTRSQGLLIDVDHATLG-----KITLPGPP--LRFFDVAGPE
MAV_2651|M.avium_104 VDHLWLHPVLVGRDRWHEIQTPGGP-----AAALPPPAGLAGVDPVIGDV
MAB_0824|M.abscessus_ATCC_1997 IAEAFRFAERLGLDVAVTVPGSPEP-----QVANPISMSKTPVVYRNGP-
Mvan_1855|M.vanbaalenii_PYR-1 LSEAFAFARGLGIDAAVQVPGSPAP-----QVANPVTMSATPVSYRSGP-
MMAR_1494|M.marinum_M VAEVVKDRQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGPA
MUL_2446|M.ulcerans_Agy99 VAEVVKDRQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGPA
Mflv_4465|M.gilvum_PYR-GCK VAEVVEDPQLQARGMIADHWDERIGRNVKGPGVVPVLSETPGTIRSAGSA
TH_3339|M.thermoresistible__bu PKEMLADPQFRARESITSVDHPVLG-EIQMQNVFPRLSRTRGSIRWPGPG
Mb3300|M.bovis_AF2122/97 WKQVVDTPLFAESDLTLEVGRGADT-----ITVIRTPARYASFRAVVTDP
Rv3272|M.tuberculosis_H37Rv WKQVVDTPLFAENDLTLEVGRGADT-----ITVIRTPARYASFRAVVTDP
.
MSMEG_2171|M.smegmatis_MC2_155 RTRRDHS--APPVLGADNHLIDELTAGRR---
MAV_2651|M.avium_104 PALGEHSRKILHELGYSAQATDELIAAGVTTA
MAB_0824|M.abscessus_ATCC_1997 -----------PRLGQSRA-------------
Mvan_1855|M.vanbaalenii_PYR-1 -----------PALGDSPIAEKP---------
MMAR_1494|M.marinum_M RPGQHNDDVYIGLLGKSIEELEQLRAEEVL--
MUL_2446|M.ulcerans_Agy99 RPGQHNDDVYIGLLGKSIEELEQLRAVEVL--
Mflv_4465|M.gilvum_PYR-GCK RPGQHNDEIYRDLLGRSAAELDKLQEEGVL--
TH_3339|M.thermoresistible__bu -LGEHTDEVLR-QLGLSDEELQKLHDAGVV--
Mb3300|M.bovis_AF2122/97 ----------PPTAGEHNAVFLARP-------
Rv3272|M.tuberculosis_H37Rv ----------PPTAGEHNAVFLARP-------
*