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M. smegmatis MC2 155 MSMEG_2170 (-)

annotation: 3-hydroxyisobutyrate dehydrogenase family protein
coordinates: 2244650 - 2245630
length: 326

MAAVTRDADVQRVGFLGLGNMGRPMARRLVASGTPLTVYNRTAAKCAEFADLGCEVAESVARMGHCSVLL
TMLGTDDDVAQVYLGDDGLVANARAGAVLVDCSTISPDMSARVRARCDRAGVHFLAAPVAGGPPVIESGG
LAMAVSGDRQAFEHAADVLRVVAPNLIYVGPGDTSRLVKICHNLLVAATLEVLGELCVLAESHGASRQAL
LSFLRSTAISSRFIEYKAPLLESLDFTPAFTSSLMQKDLELGLGLAGQADVTMPVTAQVHATYRAANESG
LAELDAAAVYLYLAGSNPPERAGGGDDRSGRNGGPARPDGAPDPHR
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_2170--100% (326)3-hydroxyisobutyrate dehydrogenase family protein
M. smegmatis MC2 155MSMEG_5884-6e-3534.56% (298) 3-hydroxyisobutyrate dehydrogenase family protein
M. smegmatis MC2 155MSMEG_5477-1e-3227.69% (307) 2-hydroxy-3-oxopropionate reductase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0773cmmsB1e-2729.86% (288) 3-hydroxyisobutyrate dehydrogenase MmsB
M. gilvum PYR-GCKMflv_2481-1e-3032.00% (250) 6-phosphogluconate dehydrogenase, NAD-binding
M. tuberculosis H37RvRv0751cmmsB1e-2729.86% (288) 3-hydroxyisobutyrate dehydrogenase MmsB
M. leprae Br4923MLBr_02065gnd2e-0821.41% (327) 6-phosphogluconate dehydrogenase
M. abscessus ATCC 19977MAB_1043c-7e-2829.75% (279) putative oxidoreductase
M. marinum MMMAR_1077mmsB8e-2929.73% (296) 3-hydroxyisobutyrate dehydrogenase, MmsB
M. avium 104MAV_4419mmsB9e-2829.83% (295) 3-hydroxyisobutyrate dehydrogenase
M. thermoresistible (build 8)TH_2512-7e-3233.33% (252) PUTATIVE 6-phosphogluconate dehydrogenase, NAD-binding
M. ulcerans Agy99MUL_0835mmsB1e-2829.69% (293) 3-hydroxyisobutyrate dehydrogenase, MmsB
M. vanbaalenii PYR-1Mvan_5187-1e-3231.56% (301) 6-phosphogluconate dehydrogenase, NAD-binding

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2481|M.gilvum_PYR-GCK          ----------MRVGFIGLGSQGGPMARRIAEGGFETTLWARRQASLEPYS
TH_2512|M.thermoresistible__bu      ----------MRVGFIGLGSQGGPMARRIAENGYETTLWARRAATLEPFA
MAB_1043c|M.abscessus_ATCC_199      ---------MSTIAVIGLGAMGKAMADNLVQAGHQVSVWNRSPAPVAELA
Mvan_5187|M.vanbaalenii_PYR-1       ----------MKIGFIGLGNMGSAMAANLLSAGHEVLAYNRSRDRVVALA
Mb0773c|M.bovis_AF2122/97           ---------MTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAA
Rv0751c|M.tuberculosis_H37Rv        ---------MTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAA
MMAR_1077|M.marinum_M               ------MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASAAA
MUL_0835|M.ulcerans_Agy99           ------MTKSCQIAFLGLGHMGAPMSANLIGAGHTVRGFDPVPAAASATA
MAV_4419|M.avium_104                ----------MVVAFLGLGNMGAPMAANLVAAQHAVRGFDPVPAALSAAT
MSMEG_2170|M.smegmatis_MC2_155      MAAVTRDADVQRVGFLGLGNMGRPMARRLVASGTPLTVYNRTAAKCAEFA
MLBr_02065|M.leprae_Br4923          MSAPESKTAIAQIGVTGLAVMGSNIARNFARHGYTVALHNRSIAKTDTLL
                                                :.. **.  *  :: .:                     

Mflv_2481|M.gilvum_PYR-GCK          DTP--------AKTASTPAELGAASDLVCLCVVGDDDVREVLYGEQGVLA
TH_2512|M.thermoresistible__bu      DTP--------AKTAGSPAELGAASDLVCLCVVGDDDVREVLYGDTGVLA
MAB_1043c|M.abscessus_ATCC_199      AVG--------ARPLDSVAQA-FDSGVVFSVLADDHAVTETLL--TPEVL
Mvan_5187|M.vanbaalenii_PYR-1       ERG--------ATPVPTVAAA-CEGDVVFTMLADDTAVESVTFGDTGIVA
Mb0773c|M.bovis_AF2122/97           AHG--------VAVFRSAPEA-VAEADVVITMLPTGEVVRRCY--TDVLA
Rv0751c|M.tuberculosis_H37Rv        AHG--------VAVFRSAPEA-VAEADVVITMLPTGEVVRRCY--TDVLA
MMAR_1077|M.marinum_M               AKG--------ATMFDSAAEA-VAGADVVITMLPNGAVVKRCY--AEVLP
MUL_0835|M.ulcerans_Agy99           AKG--------ATMFDSAAEA-VARADVVITMLPNGAVVKRCY--AEVLP
MAV_4419|M.avium_104                ASG--------VTGFDTATDA-VTGADVVITMLPNGEVVKRCY--AEILP
MSMEG_2170|M.smegmatis_MC2_155      DLG--------CEVAESVARM-GHCSVLLTMLGTDDDVAQVYLGDDGLVA
MLBr_02065|M.leprae_Br4923          KEHGSEGNFVRTETIPEFLAALQTPRRVLIMVKAGDATDAVIN---ELAD
                                                               :   :     .            

Mflv_2481|M.gilvum_PYR-GCK          GLAEGGIIAIHSTVHPQTCQEIAEKGAAQGVSVIDAPVSGGGPAVEQGTL
TH_2512|M.thermoresistible__bu      GLAPGGVVAIHSTVHPDTCREISEKAAAQQVSVIDAPVSGGGPAVEEGKL
MAB_1043c|M.abscessus_ATCC_199      AAGHGALHVNLATVSARLADRATALHDEHGVGYVAAPVFGRVPVAQAGQL
Mvan_5187|M.vanbaalenii_PYR-1       ALAPGAIHVSASTISVALSEKLTAAHAEAGQMFVSAPVFGRPEAAAAAKL
Mb0773c|M.bovis_AF2122/97           AARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATL
Rv0751c|M.tuberculosis_H37Rv        AARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATL
MMAR_1077|M.marinum_M               AARSGALFIDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTL
MUL_0835|M.ulcerans_Agy99           AARSGALFIDSSTISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTL
MAV_4419|M.avium_104                AARPGALFIDSSTISVADAREVHAQAQSHGVAQLDAPVSGGVKGAVAGTL
MSMEG_2170|M.smegmatis_MC2_155      NARAGAVLVDCSTISPDMSARVRARCDRAGVHFLAAPVAGGPPVIESGGL
MLBr_02065|M.leprae_Br4923          VMEPSDIIIDGGNSLFTDTIRREKAMRERGLHFVGAGISGGEEGALNG-P
                                        . :    ..       .            : * : *       .  

Mflv_2481|M.gilvum_PYR-GCK          LVMVGGDEEVAERCRPVFATYADPIVHLG------PLGSGQNTKILNNLL
TH_2512|M.thermoresistible__bu      LVMVGGDEEVVERCRPVFASYADPIVHLG------PLGSGQVTKILNNLL
MAB_1043c|M.abscessus_ATCC_199      QVLAAGAAAQIDKAQSFFDVIGARTWRLGD-----APRQANVVKIIGNFL
Mvan_5187|M.vanbaalenii_PYR-1       FVVAAGPHDAVTSLQPAFEAIGQRTYVMSE-----EPKTANLVKLSGNFL
Mb0773c|M.bovis_AF2122/97           AFMVGGDESTLRRARPVLEPMAGKIIHCG------AAGAGQAAKVCNNMV
Rv0751c|M.tuberculosis_H37Rv        AFMVGGDESTLRRARPVLEPMAGKIIHCG------AAGAGQAAKVCNNMV
MMAR_1077|M.marinum_M               AFMVGGDQSALAQARPVLEPMAGKIIHCG------AAGAGQAAKVCNNMV
MUL_0835|M.ulcerans_Agy99           AFMVGGDQSALAQARPVLEPMAGKIIHCG------AAGAGQAAKVCNNMV
MAV_4419|M.avium_104                AFMVGGEPEALERARPVLEPMAGKIIHCG------AAGAGQAAKVCNNMV
MSMEG_2170|M.smegmatis_MC2_155      AMAVSGDRQAFEHAADVLRVVAPNLIYVG------PGDTSRLVKICHNLL
MLBr_02065|M.leprae_Br4923          SIMPGGPAESYTSLGPLLEEISAHVDGVSCCTHIGPGGSGHFVKMVHNGI
                                     .  .*           :   .      .          .. .*:  * :

Mflv_2481|M.gilvum_PYR-GCK          FSANLGSAVSTLELGES-LGIPRAKLVEVLSKG-----------------
TH_2512|M.thermoresistible__bu      FTANLGSALSTLELGES-LGIPRVKLAEVLNGG-----------------
MAB_1043c|M.abscessus_ATCC_199      IASAIQSLSEAVSMAER-SGVDSALLVELLTST-----------------
Mvan_5187|M.vanbaalenii_PYR-1       IASVIESLGEAMALVSK-AGVDRQTYLELLTST-----------------
Mb0773c|M.bovis_AF2122/97           LAVQQIAIAEAFVLAEK-LGLSAQSLFDVITGA-----------------
Rv0751c|M.tuberculosis_H37Rv        LAVQQIAIAEAFVLAEK-LGLSAQSLFDVITGA-----------------
MMAR_1077|M.marinum_M               LAVQQIAIGEAFVLAEN-LGLDAQSLFDVITGA-----------------
MUL_0835|M.ulcerans_Agy99           LAVQQIAIGEAFVLAEN-LGLDAQSLFDVITGA-----------------
MAV_4419|M.avium_104                LAVQQIAIGEAFILAEK-LGLSAQSLFDVITGA-----------------
MSMEG_2170|M.smegmatis_MC2_155      VAATLEVLGELCVLAES-HGASRQALLSFLRST-----------------
MLBr_02065|M.leprae_Br4923          EYSDMQLIGEAYQLLRDGLGMSAPQIADVFTEWNRGDLNSYLVEITAEVL
                                             .   :     *       ..:                    

Mflv_2481|M.gilvum_PYR-GCK          ---------------------SATSKAVSSIS-MFGGTLDGLAP------
TH_2512|M.thermoresistible__bu      ---------------------SATSKALGSIS-VFGGTVEGLAP------
MAB_1043c|M.abscessus_ATCC_199      ---------------------LFQGPAYSSYGKLIATSAYEPAG------
Mvan_5187|M.vanbaalenii_PYR-1       ---------------------LFAAPAYQTYGGLLARKQFEPAG------
Mb0773c|M.bovis_AF2122/97           ---------------------TGNCWAVHTNCPVPGPVPTSPANNDFKPG
Rv0751c|M.tuberculosis_H37Rv        ---------------------TGNCWAVHTNCPVPGPVPTSPANNDFKPG
MMAR_1077|M.marinum_M               ---------------------TGNCWAVHTNCPVPGPVPTSPANNDFKPG
MUL_0835|M.ulcerans_Agy99           ---------------------TGNCWAVHTNCPVPGPVPTSPANNDFKPG
MAV_4419|M.avium_104                ---------------------TGNCWAVHTNCPVPGPVPTSPANNDFKPG
MSMEG_2170|M.smegmatis_MC2_155      ---------------------AISSRFIEYKAPLLESLDFTPAF------
MLBr_02065|M.leprae_Br4923          RQTDIKTGRPLVDVILDKAEQKGTGRWTVQSALDLGVPITGIAEAVFARA
                                                                              *       

Mflv_2481|M.gilvum_PYR-GCK          IAGGLLQKDVRHAASLAAA--AKAPEGAVFTAADAALEAMDHRR------
TH_2512|M.thermoresistible__bu      IAGALLQKDVRHAANIAAS--ASVPEGTVFTVADTALTAMGHARR-----
MAB_1043c|M.abscessus_ATCC_199      FTTTLGRKDVGLALEVAADTGLRLPFGEILRTVFDEALAGGHANLDWSSI
Mvan_5187|M.vanbaalenii_PYR-1       FAAHLGLKDVRLVLAAGEQLEVPLPVASLIRDRFLTLLAGGGRDLDWSAL
Mb0773c|M.bovis_AF2122/97           FSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKFAAD-HADLDFSAV
Rv0751c|M.tuberculosis_H37Rv        FSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKFAAD-HADLDFSAV
MMAR_1077|M.marinum_M               FATALMNKDLGLAMDAVTSTGSAAPLGSHAAEIYAKFAAD-HADQDFSAV
MUL_0835|M.ulcerans_Agy99           FATALMNKDLGLAMDAVTSTASAAPLGSHAAEIYAKFATD-HADQDFSAV
MAV_4419|M.avium_104                FAAALMNKDLGLAMDAVTSTGAAAPLGRHAAEIYAKFAAS-HGDKDFSAV
MSMEG_2170|M.smegmatis_MC2_155      -TSSLMQKDLELGLGLAGQADVTMPVTAQVHATYRAANESGLAELDAAAV
MLBr_02065|M.leprae_Br4923          LSGSVLQRKAAIGLASGKLGNKPTDRETFIEDVRQALYASKIVAYAQGFN
                                     :  :  :.                                         

Mflv_2481|M.gilvum_PYR-GCK          --------------------------------------------------
TH_2512|M.thermoresistible__bu      --------------------------------------------------
MAB_1043c|M.abscessus_ATCC_199      ADLQRARDAE----------------------------------------
Mvan_5187|M.vanbaalenii_PYR-1       GALADWEAGGPRPGSG----------------------------------
Mb0773c|M.bovis_AF2122/97           IHTLRARADA----------------------------------------
Rv0751c|M.tuberculosis_H37Rv        IHTLRARADA----------------------------------------
MMAR_1077|M.marinum_M               IEMLRGS-------------------------------------------
MUL_0835|M.ulcerans_Agy99           IEMLRGS-------------------------------------------
MAV_4419|M.avium_104                IEMLRGAC------------------------------------------
MSMEG_2170|M.smegmatis_MC2_155      YLYLAGSNPPERAGGGDDRSGRNGGPARPDGAPDPHR-------------
MLBr_02065|M.leprae_Br4923          HIQTGSTEFGWNITPGDLATIWRGGCIIRAKFLNRIKEAFDAAPDLASLI
                                                                                      

Mflv_2481|M.gilvum_PYR-GCK          --------------------------------------------------
TH_2512|M.thermoresistible__bu      --------------------------------------------------
MAB_1043c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_5187|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb0773c|M.bovis_AF2122/97           --------------------------------------------------
Rv0751c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1077|M.marinum_M               --------------------------------------------------
MUL_0835|M.ulcerans_Agy99           --------------------------------------------------
MAV_4419|M.avium_104                --------------------------------------------------
MSMEG_2170|M.smegmatis_MC2_155      --------------------------------------------------
MLBr_02065|M.leprae_Br4923          VAPYFRSAVESAIDSWRRVVSTATQLGIPNPGFSSALSYYDALRTERLPA
                                                                                      

Mflv_2481|M.gilvum_PYR-GCK          -------------------------------------
TH_2512|M.thermoresistible__bu      -------------------------------------
MAB_1043c|M.abscessus_ATCC_199      -------------------------------------
Mvan_5187|M.vanbaalenii_PYR-1       -------------------------------------
Mb0773c|M.bovis_AF2122/97           -------------------------------------
Rv0751c|M.tuberculosis_H37Rv        -------------------------------------
MMAR_1077|M.marinum_M               -------------------------------------
MUL_0835|M.ulcerans_Agy99           -------------------------------------
MAV_4419|M.avium_104                -------------------------------------
MSMEG_2170|M.smegmatis_MC2_155      -------------------------------------
MLBr_02065|M.leprae_Br4923          ALTQAQRDFFGAHSYGRVDARGKFHTLWSEDRSEVTV