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MEVAVPQVNIASRWSRGGLGAFVGETAFAHYLDAYRAGMALLPPHETFDVPTAFGTVRSYRFAGPECGAP VVLLPGRNAAAPMYATNLTALLRHRTVYAVDLLGEAGLSVQHTPIRTVEDQARWLDDALGGLGLDRAHLF GVSVGGWTAVNAAVHRPGRIASLTLLDPVFTFVRIPLAPIAASVLMFAPGVPERWRRRVQSWIAGGADLD AAAPEATLIGAGATDFTLRTPMPKLFTDEQLRAVDLPVLALIAGSSVMLDPQRAVARARALLPRGQVELW PDASHAINGEYPDEIAERARRMWDQVDGVRRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1570 | - | - | 100% (312) | carboxylesterase |
| M. smegmatis MC2 155 | MSMEG_2913 | - | 5e-10 | 27.08% (277) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_4867 | - | 1e-09 | 31.40% (121) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 3e-06 | 27.24% (268) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. gilvum PYR-GCK | Mflv_1348 | - | 1e-10 | 28.51% (242) | 3-oxoadipate enol-lactonase |
| M. tuberculosis H37Rv | Rv3569c | bphD | 3e-06 | 27.24% (268) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3742c | - | 6e-79 | 47.06% (306) | hypothetical protein MAB_3742c |
| M. marinum M | MMAR_4778 | bphD_1 | 2e-08 | 32.46% (114) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD_1 |
| M. avium 104 | MAV_0877 | - | 2e-08 | 32.14% (112) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. thermoresistible (build 8) | TH_1700 | - | 1e-107 | 63.40% (306) | carboxylesterase |
| M. ulcerans Agy99 | MUL_4140 | bphD | 4e-05 | 35.04% (117) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. vanbaalenii PYR-1 | Mvan_0538 | - | 2e-10 | 29.02% (255) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4778|M.marinum_M ---------------------------------MTDFESVWSDLQGVMFE
MAV_0877|M.avium_104 ---------------------------------MAEFESIWSDLQGVAFE
Mvan_0538|M.vanbaalenii_PYR-1 ---------------------------------MLKDASICVSLLG---T
Mb3600c|M.bovis_AF2122/97 ---------------------------------MTATEELTFESTS---R
Rv3569c|M.tuberculosis_H37Rv ---------------------------------MTATEELTFESTS---R
MUL_4140|M.ulcerans_Agy99 -----------------------------MTVTQSKTAEHTFESTS---R
MSMEG_1570|M.smegmatis_MC2_155 ---MEVAVPQVNIASRWSRGGLGAFVGETAFAHYLDAYRAGMALLPPHE-
TH_1700|M.thermoresistible__bu MTPTDLAVPDVRIG---PHRDIGHFRDAAAFDRFLEVYRRGMATLPTFE-
MAB_3742c|M.abscessus_ATCC_199 --MSPVAVPEHRVGKHWAVQKLGHFVDASGYARFVAAYRAGMARLPQIAR
Mflv_1348|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4778|M.marinum_M QGYLTTAQGVRTRYLRAGEPDRPLLMLLHGSG---GHAEAYVRNLAAHAE
MAV_0877|M.avium_104 QGYLD-AGGIRTRYLRAGDPGKPVLVLLHGSG---GHAEAYVRNLAAHAD
Mvan_0538|M.vanbaalenii_PYR-1 ETRFVDVDGVRTRTIQAGE--GPDLILMHGGG---GHAEAFARNVTALSR
Mb3600c|M.bovis_AF2122/97 FAEVDVDGPLKLHYHEAGVGNDQTVVLLHGGGPGAASWTNFSRNIAVLAR
Rv3569c|M.tuberculosis_H37Rv FAEVDVDGPLKLHYHEAGVGNDQTVVLLHGGGPGAASWTNFSRNIAVLAR
MUL_4140|M.ulcerans_Agy99 YAEVDVDGPLKLHYHEAGVGNDQTVVLLHGGGPGASSWSNFARNIEVLAQ
MSMEG_1570|M.smegmatis_MC2_155 TFDVPTAFGTVRSYRFAGPECGAPVVLLPGRN---AAAPMYATNLTALLR
TH_1700|M.thermoresistible__bu VRDVTTAFGTVRAYRFDGP-AGPPVVLLPGRN---AATPMYRGNLPTLLR
MAB_3742c|M.abscessus_ATCC_199 SFDVPTRLGSVRAYRFGAC-GGVPLLLLTGRG---GSTPLWRANLTSLLS
Mflv_1348|M.gilvum_PYR-GCK ------MSAVDVHVIESGLPDGPAVVLSNSLG---ATHRMWDAQLDALER
. ::* . . . : ::
MMAR_4778|M.marinum_M HFWTWAIDMLGHGYTDKPGHPLEIRHYVEHLMA-VLRAIGAQRASISGES
MAV_0877|M.avium_104 HFWTWSIDMLGHGYTDKPGHPLEVRHYVEHLMT-VLRTIGVERASISGES
Mvan_0538|M.vanbaalenii_PYR-1 HFRVHALDLLGHGLTSGCEVAPKRKDYVSHLLG-YMDQEGIDRAHLAGES
Mb3600c|M.bovis_AF2122/97 HFHVLAVDQPGYGHSDKRAEHGQFNRYAAMALKGLFDQLGLGRVPLVGNS
Rv3569c|M.tuberculosis_H37Rv HFHVLAVDQPGYGHSDKRAEHGQFNRYAAMALKGLFDQLGLGRVPLVGNS
MUL_4140|M.ulcerans_Agy99 QFHVLAVDQPGYGHSDKRAEHGQFNHYAARALKELFDQLGLGRVLLVGNS
MSMEG_1570|M.smegmatis_MC2_155 HRTVYAVDLLGEAGLSVQHTPIRTVEDQARWLDDALGGLGLDRAHLFGVS
TH_1700|M.thermoresistible__bu QRTVYGIDLLGEAGLSVQHTPIRSADDIAHWLDDALAGLGLPHAHLLGVS
MAB_3742c|M.abscessus_ATCC_199 RRSVYCIDLLGEPGMSVQDKPITGPQDHADWLEDVMAGLNLGAVHVVGLS
Mflv_1348|M.gilvum_PYR-GCK RFRVLRYDTRGHGASPVPDGPYSIDDLADDVVG-ILDRRGIDTAHLVGLS
: . * * : : . . : * *
MMAR_4778|M.marinum_M LGGWVAARAAVDHPEAVERLVLNTAG------GSQADPEVMAR---IVTL
MAV_0877|M.avium_104 LGGWVAARAAIDHPDVVDRLVLNTAG------GSQADPVVMQR---IIAL
Mvan_0538|M.vanbaalenii_PYR-1 LGGWIAAWTALEHPDRVDRLIYVCGARLTLEVGADAEARTAAGRAELARV
Mb3600c|M.bovis_AF2122/97 LGGGTAVRFALDYPARAGRLVLMGPG------GLSINLFAPDPTEGVKRL
Rv3569c|M.tuberculosis_H37Rv LGGGTAVRFALDYPARAGRLVLMGPG------GLSINLFAPDPTEGVKRL
MUL_4140|M.ulcerans_Agy99 LGGGTAVRFALDYPDRAGRLVLMGPG------GLSINLFAPDPTEGVKRL
MSMEG_1570|M.smegmatis_MC2_155 VGGWTAVNAAVHRPGRIASLTLLDPV----------FTFVRIPLAPIAAS
TH_1700|M.thermoresistible__bu IGGWTAMNLAVRRPQRVASLTLLDPV----------FTFAPVRTTPMLAS
MAB_3742c|M.abscessus_ATCC_199 IGGWAAVNHAIRYPCRVRSLVLLDPA----------LTFAPLTWKMVLVS
Mflv_1348|M.gilvum_PYR-GCK LGGMTAMRVAARNPDRVNRMVLLCTA--------AELAPAQAWTDRAAAV
:** * * * : .
MMAR_4778|M.marinum_M SMAAAENPTWETVQARIKWLMADKSKDY-DDLVASRQRIYRQPGFVAAMR
MAV_0877|M.avium_104 SMAAAENPTWETVQARIKWLMADKSRDY-DDLVASRQRVYRQPGFVAAMR
Mvan_0538|M.vanbaalenii_PYR-1 TRQFLADPSPANVRERMAWLFHHPDRDLTDELVALRWALYQSEESRSALT
Mb3600c|M.bovis_AF2122/97 S-KFSVAPTRENLEAFLRVMVYDKNLIT-PELVDQRFALASTPESLTATR
Rv3569c|M.tuberculosis_H37Rv S-KFSVAPTRENLEAFLRVMVYDKNLIT-PELVDQRFALASTPESLTATR
MUL_4140|M.ulcerans_Agy99 G-KFSVAPTRENLEAFLRVMVYDQKLIT-PELVDQRFELARTPESLAATR
MSMEG_1570|M.smegmatis_MC2_155 VLMFAPGVPERWRRRVQSWIAGGADLDAAAPEATLIGAGATDFTLRTPMP
TH_1700|M.thermoresistible__bu IALIAPGVPPALRRRVLRWISGGADIDAAADEAALIATASRNFVLRQPIP
MAB_3742c|M.abscessus_ATCC_199 LGSVIPGTPQAIRNRLLSWSAGGAQVDESLPEAALISAAARDFRICLPSP
Mflv_1348|M.gilvum_PYR-GCK RAGGAESVAPAVIARWFTLSHLETHPAERAEWVDMIAATPAEGYASCCEA
. .
MMAR_4778|M.marinum_M DIMALQDPQIRARNLLGPAEYGAIKAPTLVLWTSHDPTADVT-EGRRIAS
MAV_0877|M.avium_104 DIMALQDPEIRARNILGPAEYGSIIAPTLVLWTSDDPTADVS-EGRRIAS
Mvan_0538|M.vanbaalenii_PYR-1 NATAPP-SAATAEDNLTAERLTSLTRPTLVLWTSHNPSATVE-FGRRAAE
Mb3600c|M.bovis_AF2122/97 -AMGKSFAGADFEAGMMWREVYRLRQPVLLIWGREDRVNPLD-GALVALK
Rv3569c|M.tuberculosis_H37Rv -AMGKSFAGADFEAGMMWREVYRLRQPVLLIWGREDRVNPLD-GALVALK
MUL_4140|M.ulcerans_Agy99 -AMGKSFAAADFELGMMWREVYKLRQPVLLIWGREDRVNPLD-GALVALK
MSMEG_1570|M.smegmatis_MC2_155 -------------KLFTDEQLRAVDLPVLALIAGSSVMLDPQRAVARARA
TH_1700|M.thermoresistible__bu -------------RSFSDDQLRSVTRPVLALIAGRSVMLDAQRATRRARS
MAB_3742c|M.abscessus_ATCC_199 -------------KVFSDKQLRRLSMPVLTVIAGRTIVHDARRAAQRARS
Mflv_1348|M.gilvum_PYR-GCK -----------IAELDLREQLPTITAPTLAIAGADDPATPPA-KLEQIVS
. : *.* :
MMAR_4778|M.marinum_M MIPGARFEVMSGCGHWPQYEDAKSFNRRHLDFLMGH--------
MAV_0877|M.avium_104 MIPGARFEVMPGCGHWPQYEDAKTFNRLHLDFLLGR--------
Mvan_0538|M.vanbaalenii_PYR-1 LIPGAEFALMEDCGHWPQWERPEEFNQILTNYLQGDRESRGQR-
Mb3600c|M.bovis_AF2122/97 TIPRAQLHVFGQCGHWVQVEKFDEFNKLTIEFLGGGR-------
Rv3569c|M.tuberculosis_H37Rv TIPRAQLHVFGQCGHWVQVEKFDEFNKLTIEFLGGGR-------
MUL_4140|M.ulcerans_Agy99 TIPRAQLHVFGQCGHWAQVEKFDEFNRLTIDFLGGAR-------
MSMEG_1570|M.smegmatis_MC2_155 LLPRGQVELWPDASHAINGEYPDEIAERARRMWDQVDG--VRRG
TH_1700|M.thermoresistible__bu MLPHGEVELWPAASHAINGEYPERIAQRAAEFWTRVDSDSPHRG
MAB_3742c|M.abscessus_ATCC_199 AVPDNRVHVWPDASHALNGEFPGRISELTHEFLDTVEAA-----
Mflv_1348|M.gilvum_PYR-GCK AIPGARLLVVDGAAHLANAEQPEQITPAIIEHLEQR--------
:* .. : ..* : * :