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VAEFESIWSDLQGVAFEQGYLDAGGIRTRYLRAGDPGKPVLVLLHGSGGHAEAYVRNLAAHADHFWTWSI DMLGHGYTDKPGHPLEVRHYVEHLMTVLRTIGVERASISGESLGGWVAARAAIDHPDVVDRLVLNTAGGS QADPVVMQRIIALSMAAAENPTWETVQARIKWLMADKSRDYDDLVASRQRVYRQPGFVAAMRDIMALQDP EIRARNILGPAEYGSIIAPTLVLWTSDDPTADVSEGRRIASMIPGARFEVMPGCGHWPQYEDAKTFNRLH LDFLLGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0877 | - | - | 100% (287) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. avium 104 | MAV_1905 | - | 3e-53 | 36.11% (288) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. avium 104 | MAV_2616 | - | 4e-51 | 36.14% (285) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 8e-23 | 29.56% (274) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. gilvum PYR-GCK | Mflv_2400 | - | 1e-145 | 84.67% (287) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3569c | bphD | 9e-23 | 29.56% (274) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | MLBr_02269 | - | 3e-08 | 22.39% (259) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3034 | - | 7e-23 | 29.17% (264) | hydrolase |
| M. marinum M | MMAR_4778 | bphD_1 | 1e-149 | 86.06% (287) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD_1 |
| M. smegmatis MC2 155 | MSMEG_4867 | - | 1e-142 | 83.39% (289) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. thermoresistible (build 8) | TH_4528 | - | 1e-141 | 83.27% (281) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_4140 | bphD | 1e-25 | 31.16% (276) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. vanbaalenii PYR-1 | Mvan_4246 | - | 1e-145 | 84.67% (287) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3600c|M.bovis_AF2122/97 ----------------MTATEELTFESTSRFAEVDVDG-PLKLHYHEAGV
Rv3569c|M.tuberculosis_H37Rv ----------------MTATEELTFESTSRFAEVDVDG-PLKLHYHEAGV
MUL_4140|M.ulcerans_Agy99 ------------MTVTQSKTAEHTFESTSRYAEVDVDG-PLKLHYHEAGV
MAV_0877|M.avium_104 -----------MAEFESIWSDLQGVAFEQGYLD-AGG---IRTRYLRAGD
MMAR_4778|M.marinum_M -----------MTDFESVWSDLQGVMFEQGYLTTAQG---VRTRYLRAGE
Mflv_2400|M.gilvum_PYR-GCK -----------MAEFESVWSDLQGVAFSQGYLDAGG----VRTRYLHAGD
Mvan_4246|M.vanbaalenii_PYR-1 -----------MTEFESVWSDLQGVPFSQGYLDAGG----VRTRYLHAGD
TH_4528|M.thermoresistible__bu -----------------VWSDLQGVAFTQGYLDAGG----VRTRYLHAGE
MSMEG_4867|M.smegmatis_MC2_155 MTSTAAAGTASAVEFESIWSDLQGVAFSQGYLDVPVGDRKIRTRYLHAGN
MAB_3034|M.abscessus_ATCC_1997 --------MNPPPRLLRPVPDTEHIDGVDGGGDTPSAATSTRPRLAFRTI
MLBr_02269|M.leprae_Br4923 ---------------------------------------MINLAYEDRGT
.
Mb3600c|M.bovis_AF2122/97 G----------NDQTVVLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQ
Rv3569c|M.tuberculosis_H37Rv G----------NDQTVVLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQ
MUL_4140|M.ulcerans_Agy99 G----------NDQTVVLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQ
MAV_0877|M.avium_104 P----------GKPVLVLLHGSGGHAEAY---VRNLAAHADHFWTWSIDM
MMAR_4778|M.marinum_M P----------DRPLLMLLHGSGGHAEAY---VRNLAAHAEHFWTWAIDM
Mflv_2400|M.gilvum_PYR-GCK P----------ADPALVFLHGSGGHAEAY---VRNLEAHAEHFSTWSIDM
Mvan_4246|M.vanbaalenii_PYR-1 P----------GKPALVFLHGSGGHAEAY---VRNLEAHAEHFSTWSIDM
TH_4528|M.thermoresistible__bu A----------DKPVLIFLHGSGGHAEAY---VRNLEAHAEHFSTWSIDM
MSMEG_4867|M.smegmatis_MC2_155 P----------QAPALLFLHGSGGHAEAY---VRNLAAHAEHFSTWSIDM
MAB_3034|M.abscessus_ATCC_1997 HGYRRAYRIAGSGPVLLLIHGIGDNSATWD---SVHAQLAEHFTVIAPDL
MLBr_02269|M.leprae_Br4923 G------------EPVVFIAGRGGAGRTWQP-HQVPAFLAAGYRVITFDN
:::: * * . :: * : . : *
Mb3600c|M.bovis_AF2122/97 PGYGHSDKRAEHGQFNRYAAMALKGLFDQLGLGRVPLVGNSLGGGTAVRF
Rv3569c|M.tuberculosis_H37Rv PGYGHSDKRAEHGQFNRYAAMALKGLFDQLGLGRVPLVGNSLGGGTAVRF
MUL_4140|M.ulcerans_Agy99 PGYGHSDKRAEHGQFNHYAARALKELFDQLGLGRVLLVGNSLGGGTAVRF
MAV_0877|M.avium_104 LGHGYTDKPGHPLEVRHYVEHLMT-VLRTIGVERASISGESLGGWVAARA
MMAR_4778|M.marinum_M LGHGYTDKPGHPLEIRHYVEHLMA-VLRAIGAQRASISGESLGGWVAARA
Mflv_2400|M.gilvum_PYR-GCK LGHGYTDKPGHPLEIPHYVDHLAA-FLDAIGARRAHISGESLGGWVAARI
Mvan_4246|M.vanbaalenii_PYR-1 LGHGYTDKPGHPLEIAHYVEHLAG-FLDAIGASRAHISGESLGGWVAARF
TH_4528|M.thermoresistible__bu LGHGYTDKPGHPLEVRHYVEHLAA-VLDAIGADRAHISGESLGGWVASRF
MSMEG_4867|M.smegmatis_MC2_155 LGHGYTDKPGHPLEVAHYVDHVIA-FLDTIGAQRAHISGESLGGWVAARV
MAB_3034|M.abscessus_ATCC_1997 LGHGQSDKPRADYSVAAYANGMRD-LLAVLDIERVTVVGHSLGGGVAMQF
MLBr_02269|M.leprae_Br4923 RGIGATEN-TEGFTTQTMVADTAV-LIESLGAVPARIVGVSMGSFIAQEL
* * ::: . .: :. . : * *:*. * .
Mb3600c|M.bovis_AF2122/97 ALDYPARAGRLVLMGPGGLS------INLFAPDPTEGVKRLSKFSVA-PT
Rv3569c|M.tuberculosis_H37Rv ALDYPARAGRLVLMGPGGLS------INLFAPDPTEGVKRLSKFSVA-PT
MUL_4140|M.ulcerans_Agy99 ALDYPDRAGRLVLMGPGGLS------INLFAPDPTEGVKRLGKFSVA-PT
MAV_0877|M.avium_104 AIDHPDVVDRLVLNTAGGS---------QADPVVMQRIIALSMAAAENPT
MMAR_4778|M.marinum_M AVDHPEAVERLVLNTAGGS---------QADPEVMARIVTLSMAAAENPT
Mflv_2400|M.gilvum_PYR-GCK AADRPERVDRLVLNTAGGS---------QADPEVMKRIITLSMAAAENPT
Mvan_4246|M.vanbaalenii_PYR-1 AADRPERVERLVLNTAGGS---------QADPEVMKRIVTLSMAAAENPT
TH_4528|M.thermoresistible__bu AIDRPDRLDRLVLNTAGGS---------QADPEVMKRIITLSMAAAENPS
MSMEG_4867|M.smegmatis_MC2_155 AVDHPDRVEKLVLNTAGGS---------QADPEVMKRIITLSMAAAENPT
MAB_3034|M.abscessus_ATCC_1997 TYQFPHLVERLILVAPGGVTKDVNIVLRCASLPFIGDALGLLRLPMAMPM
MLBr_02269|M.leprae_Br4923 MVARPELVRAAVLMATRGR-------LDRTRQFFHAAEAEFHDSGIQLPS
* :* . * : *
Mb3600c|M.bovis_AF2122/97 REN--LEAFLRVMVYDKNLITPELVDQRFALASTPESLTATRAMGKSFAG
Rv3569c|M.tuberculosis_H37Rv REN--LEAFLRVMVYDKNLITPELVDQRFALASTPESLTATRAMGKSFAG
MUL_4140|M.ulcerans_Agy99 REN--LEAFLRVMVYDQKLITPELVDQRFELARTPESLAATRAMGKSFAA
MAV_0877|M.avium_104 WET--VQARIKWLMADKSRDYDDLVASRQRVYRQPGFVAAMRDIMALQDP
MMAR_4778|M.marinum_M WET--VQARIKWLMADKSKDYDDLVASRQRIYRQPGFVAAMRDIMALQDP
Mflv_2400|M.gilvum_PYR-GCK WDT--VQARIKWLMADKSKDYDDIVASRQRVYRQPGFANAMRDIMALQDP
Mvan_4246|M.vanbaalenii_PYR-1 WET--VQARIKWLMADKTKDYDDIVASRQRVYRQPGFVNAMRDIMALQDP
TH_4528|M.thermoresistible__bu WDT--VQARITWLMADKSKGYDDIVASRQKIYRQPGFVDAMRNIMALQDP
MSMEG_4867|M.smegmatis_MC2_155 WDT--VQARIKWLMADKSKDYDDIVASRQRVYRQPGFVAAMSDIMALQDP
MAB_3034|M.abscessus_ATCC_1997 LRLGGAVARATFGRASMARDIPDVLRVLADLPEPRASAAFTRTLRAVVDW
MLBr_02269|M.leprae_Br4923 GYN--AKVRLLENLSRKTLNDDVAVADWIAMFN----MWPIKSTPGLRCQ
. : :
Mb3600c|M.bovis_AF2122/97 ADFEAGMMWREVY-RLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHV
Rv3569c|M.tuberculosis_H37Rv ADFEAGMMWREVY-RLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHV
MUL_4140|M.ulcerans_Agy99 ADFELGMMWREVY-KLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHV
MAV_0877|M.avium_104 EIRARNILGPAEYGSIIAPTLVLWTSDDPTADVSEGRRIASMIPGARFEV
MMAR_4778|M.marinum_M QIRARNLLGPAEYGAIKAPTLVLWTSHDPTADVTEGRRIASMIPGARFEV
Mflv_2400|M.gilvum_PYR-GCK EIRQRNLLGPNEYGAITAPTLVVWTSDDPTADVEEGRRIASMIPGARFEV
Mvan_4246|M.vanbaalenii_PYR-1 EIRARNLLGTNEYGAITAPTLVVWTSDDPTADVKEGRRIASMIPGARFEV
TH_4528|M.thermoresistible__bu EIRARNLLGPEEYGAITAPTLVVWTSDDPTADVDEGKRIASMIPGARFEV
MSMEG_4867|M.smegmatis_MC2_155 QIRARNLLGQAEYGSITAPTLVVWTSDDPTADVAEGRRIASMIPGARFEV
MAB_3034|M.abscessus_ATCC_1997 RGQVVTMLD-RCYLTESVPVQLIWGSDDLVIPVSHGHLAHAAMPGSALEI
MLBr_02269|M.leprae_Br4923 TDVAPQNNRLPAYRSIAAPVLVIGFAEDVVTPPSLGREVADVLPNGRYLQ
* *. :: .* . . :* .
Mb3600c|M.bovis_AF2122/97 FGQCGHWVQVEKFDEFNKLTIEFLGGGR----------------------
Rv3569c|M.tuberculosis_H37Rv FGQCGHWVQVEKFDEFNKLTIEFLGGGR----------------------
MUL_4140|M.ulcerans_Agy99 FGQCGHWAQVEKFDEFNRLTIDFLGGAR----------------------
MAV_0877|M.avium_104 MPGCGHWPQYEDAKTFNRLHLDFLLGR-----------------------
MMAR_4778|M.marinum_M MSGCGHWPQYEDAKSFNRRHLDFLMGH-----------------------
Mflv_2400|M.gilvum_PYR-GCK MPGCGHWPQYEDPKTFDRLHLDFLLGRA----------------------
Mvan_4246|M.vanbaalenii_PYR-1 MPGCGHWPQYEDPKTFDRLHLDFLLGRA----------------------
TH_4528|M.thermoresistible__bu MPGCGHWPQYEDPATFNRLHIDFLLGRS----------------------
MSMEG_4867|M.smegmatis_MC2_155 MPGCGHWPQYEDPATFNALHLDFLLGR-----------------------
MAB_3034|M.abscessus_ATCC_1997 FDKSGHFPFHDDPERFIGIVRQFIASTEPGEYNEDELRRLLRTGVTEHAI
MLBr_02269|M.leprae_Br4923 IPDAGHLGFFERPEAVNAAALQFFAGVKGEWP------------------
: .** : . :*: .
Mb3600c|M.bovis_AF2122/97 ----------------------
Rv3569c|M.tuberculosis_H37Rv ----------------------
MUL_4140|M.ulcerans_Agy99 ----------------------
MAV_0877|M.avium_104 ----------------------
MMAR_4778|M.marinum_M ----------------------
Mflv_2400|M.gilvum_PYR-GCK ----------------------
Mvan_4246|M.vanbaalenii_PYR-1 ----------------------
TH_4528|M.thermoresistible__bu ----------------------
MSMEG_4867|M.smegmatis_MC2_155 ----------------------
MAB_3034|M.abscessus_ATCC_1997 SGAARTRMAVLDAMGTDERSAT
MLBr_02269|M.leprae_Br4923 ----------------------